{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:37:18Z","timestamp":1789522638246,"version":"build-2803163510"},"reference-count":39,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>\n                    This article describes the kinetic modeling of [\n                    <jats:sup>11<\/jats:sup>\n                    C]SL25.1188 ([(S)-5-methoxymethyl-3-[6-(4,4,4-trifluorobutoxy)-benzo[ d]isoxazol-3-yl]-oxazolidin-2-[\n                    <jats:sup>11<\/jats:sup>\n                    C]one]) binding to monoamine oxidase B (MAO-B) in the human brain using high-resolution positron emission tomography (PET). Seven healthy subjects underwent two separate 90-minute PET scans after an intravenous injection of [\n                    <jats:sup>11<\/jats:sup>\n                    C]SL25.1188. Complementary arterial blood sampling was acquired. Radioactivity was quickly eliminated from plasma with 80% of parent compound remaining at 90 minutes. Metabolites were more polar than the parent compound. Time-activity curves showed high brain uptake, early peak and washout rate consistent with known regional MAO-B concentration. A two-tissue compartment model (2-TCM) provided better fits to the data than a 1-TCM. Measurement of total distribution volume ( V\n                    <jats:sub>T<\/jats:sub>\n                    ) showed very good identifiability (based on coefficient of variation (COV)) for all regions of interest (ROIs) (COV( V\n                    <jats:sub>T<\/jats:sub>\n                    )&lt;8%), low between-subject variability (\u02dc20%), and quick temporal convergence (within 5% of final value at 45 minutes). Logan graphical method produces very good estimation of V\n                    <jats:sub>T<\/jats:sub>\n                    . Regional V\n                    <jats:sub>T<\/jats:sub>\n                    highly correlated with previous postmortem report of MAO-B level ( r\n                    <jats:sup>2<\/jats:sup>\n                    = \u22640.9). Specific binding would account from 70% to 90% of V\n                    <jats:sub>T<\/jats:sub>\n                    . Hence, V\n                    <jats:sub>T<\/jats:sub>\n                    measurement of [\n                    <jats:sup>11<\/jats:sup>\n                    C]SL25.1\n                    <jats:sup>1<\/jats:sup>\n                    88 PET is an excellent estimation of MAO-B concentration.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2014.34","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T04:05:22Z","timestamp":1392177922000},"page":"883-889","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":81,"title":["Kinetic Modeling of the Monoamine Oxidase B Radioligand [\n                    <sup>11<\/sup>\n                    C]SL25.1188 in Human Brain with High-Resolution Positron Emission Tomography"],"prefix":"10.1177","volume":"34","author":[{"given":"Pablo M","family":"Rusjan","sequence":"first","affiliation":[{"name":"Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan A","family":"Wilson","sequence":"additional","affiliation":[{"name":"Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada"},{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Miler","sequence":"additional","affiliation":[{"name":"Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Fan","sequence":"additional","affiliation":[{"name":"Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Mizrahi","sequence":"additional","affiliation":[{"name":"Research Imaging Centre, 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