{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:34:05Z","timestamp":1777793645401,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>\n                    Small vessel disease is associated with white-matter (WM) magnetic resonance imaging (MRI) hyperintensities (WMHs) in patients with vascular cognitive impairment (VCI) and subsequent damage to the WM. Although WM is vulnerable to hypoxic-ischemic injury and O\n                    <jats:sub>2<\/jats:sub>\n                    is critical in brain physiology, tissue O\n                    <jats:sub>2<\/jats:sub>\n                    level in the WM has not been measured and explored in vivo. We hypothesized that spontaneously hypertensive stroke-prone rat (SHR\/SP) fed a Japanese permissive diet (JPD) and subjected to unilateral carotid artery occlusion (UCAO), a model to study VCI, would lead to reduced tissue oxygen (pO\n                    <jats:sub>2<\/jats:sub>\n                    ) in the deep WM. We tested this hypothesis by monitoring WM tissue pO\n                    <jats:sub>2<\/jats:sub>\n                    using in vivo electron paramagnetic resonance (EPR) oximetry in SHR\/SP rats over weeks before and after JPD\/UCAO. The SHR\/SP rats experienced an increase in WM pO\n                    <jats:sub>2<\/jats:sub>\n                    from 9 to 12 weeks with a maximal 32% increase at week 12, followed by a dramatic decrease in WM pO\n                    <jats:sub>2<\/jats:sub>\n                    to near hypoxic conditions during weeks 13 to 16 after JPD\/UCAO. The decreased WM pO\n                    <jats:sub>2<\/jats:sub>\n                    was accompanied with WM damage and hemorrhages surrounding microvessels. Our findings suggest that changes in WM pO\n                    <jats:sub>2<\/jats:sub>\n                    may contribute to WM damage in SHR\/SP rat model, and that EPR oximetry can monitor brain pO\n                    <jats:sub>2<\/jats:sub>\n                    in the WM of small animals.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2014.35","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T04:04:39Z","timestamp":1392782679000},"page":"890-896","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Tissue Oxygen is Reduced in White Matter of Spontaneously Hypertensive-Stroke Prone Rats: A Longitudinal Study with Electron Paramagnetic Resonance"],"prefix":"10.1177","volume":"34","author":[{"given":"John","family":"Weaver","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA"},{"name":"These authors contributed equally to this work"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fakhreya Y","family":"Jalal","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA"},{"name":"Departments of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE"},{"name":"These authors contributed equally to this work"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary A","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA"},{"name":"Department of Neuroscience, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA"},{"name":"Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke J","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA"},{"name":"Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"key":"bibr1-jcbfm.2014.35","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318227b1e7"},{"key":"bibr2-jcbfm.2014.35","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600455"},{"key":"bibr3-jcbfm.2014.35","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.5.1162"},{"key":"bibr4-jcbfm.2014.35","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.611731"},{"key":"bibr5-jcbfm.2014.35","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.172072"},{"key":"bibr6-jcbfm.2014.35","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.91"},{"key":"bibr7-jcbfm.2014.35","doi-asserted-by":"publisher","DOI":"10.1161\/hs0302.104111"},{"key":"bibr8-jcbfm.2014.35","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.643080"},{"key":"bibr9-jcbfm.2014.35","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-19-07724.2001"},{"key":"bibr10-jcbfm.2014.35","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600375"},{"key":"bibr11-jcbfm.2014.35","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.248"},{"key":"bibr12-jcbfm.2014.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb48463.x"},{"key":"bibr13-jcbfm.2014.35","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-004-0684-y"},{"key":"bibr14-jcbfm.2014.35","doi-asserted-by":"crossref","unstructured":"14Ben-Assayag E, Mijajlovic M, Shenhar-Tsarfaty S, Bova I, Shopin L, Bornstein NM. 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