{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:34:07Z","timestamp":1790404447688,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T00:00:00Z","timestamp":1394582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>\n                    By detecting \u03b2-amyloid ( A\u03b2) in the wall of cortical arterioles, amyloid positron emission tomography (PET) imaging might help diagnose cerebral amyloid angiopathy (CAA) in patients with lobar intracerebral hemorrhage (I-ICH). No previous study has directly assessed the diagnostic value of\n                    <jats:sup>11<\/jats:sup>\n                    -Pittsburgh compound B (PiB) PET in probable CAA-related I-ICH against healthy controls (HCs).\n                    <jats:sup>11<\/jats:sup>\n                    C-PiB-PET and magnetic resonance imaging (MRI) including T2* were obtained in 11 nondemented patients fulfilling the Boston criteria for probable CAA-related symptomatic I-ICH (sl-ICH) and 20 HCs without cognitive complaints or impairment. After optimal spatial normalization, cerebral spinal fluid (CSF)-corrected PiB distribution volume ratios (DVRs) were obtained. There was no significant difference in whole cortex or regional DVRs between CAA patients and age-matched HCs. The whole cortex DVR was above the 95% confidence limit in 4\/9 HCs and 10\/11 CAA patients (sensitivity = 91%, specificity = 55%). Region\/frontal or occipital ratios did not have better discriminative value. Similar but less accurate results were found using visual analysis. In patients with sl-ICH,\n                    <jats:sup>11<\/jats:sup>\n                    C-PiB-PET has low specificity for CAA due to the frequent occurrence of high\n                    <jats:sup>11<\/jats:sup>\n                    C-PiB uptake in the healthy elderly reflecting incipient Alzheimer's disease (AD), which might also be present in suspected CAA. However, a negative PiB scan rules out CAA with excellent sensitivity, which has clinical implications for prognostication and selection of candidates for drug trials.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2014.43","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T05:02:00Z","timestamp":1394600520000},"page":"753-758","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":64,"title":["Diagnostic Utility of Amyloid PET in Cerebral Amyloid Angiopathy-Related Symptomatic Intracerebral Hemorrhage"],"prefix":"10.1177","volume":"34","author":[{"given":"Jean-Claude","family":"Baron","sequence":"first","affiliation":[{"name":"Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"},{"name":"INSERM U894, Centre Hospitalier Sainte Anne, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Farid","sequence":"additional","affiliation":[{"name":"APHP, Hotel-Dieu Hospital, Department of Nuclear Medicine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eamon","family":"Dolan","sequence":"additional","affiliation":[{"name":"Stroke Unit, Addenbrooke's Hospital, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Turc","sequence":"additional","affiliation":[{"name":"INSERM U894, Centre Hospitalier Sainte Anne, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siva T","family":"Marrapu","sequence":"additional","affiliation":[{"name":"Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoin","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Stroke Unit, Addenbrooke's Hospital, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin I","family":"Aigbirhio","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim D","family":"Fryer","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K","family":"Menon","sequence":"additional","affiliation":[{"name":"Division of Anaesthesia, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A","family":"Warburton","sequence":"additional","affiliation":[{"name":"Stroke Unit, Addenbrooke's Hospital, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young T","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3,12]]},"reference":[{"key":"bibr1-jcbfm.2014.43","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301308"},{"key":"bibr2-jcbfm.2014.43","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.18.2.311"},{"key":"bibr3-jcbfm.2014.43","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dad605"},{"key":"bibr4-jcbfm.2014.43","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2377-07.2008"},{"key":"bibr5-jcbfm.2014.43","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20009"},{"key":"bibr6-jcbfm.2014.43","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21164"},{"key":"bibr7-jcbfm.2014.43","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21528"},{"key":"bibr8-jcbfm.2014.43","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22099"},{"key":"bibr9-jcbfm.2014.43","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826043a9"},{"key":"bibr10-jcbfm.2014.43","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cef7e3"},{"key":"bibr11-jcbfm.2014.43","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22072"},{"key":"bibr12-jcbfm.2014.43","doi-asserted-by":"crossref","unstructured":"12Gurol ME, Viswanathan A, Gidicsin C, Hedden T, Martinez-Ramirez S, Dumas A, Cerebral amyloid angiopathy burden associated with leukoaraiosis: a positron emission tomography\/magnetic resonance imaging study. 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