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Here, we apply resting-state magnetic resonance imaging and data-driven whole-brain imaging analysis methods (eigenvector centrality) to investigate changes of the functional connectome in early small vessel disease. We show reduced connectivity in frontoparietal networks, whereas connectivity increases in the cerebellum. These functional changes are closely related to white matter lesions and typical neuropsychological deficits associated with small vessel disease.<\/jats:p>","DOI":"10.1038\/jcbfm.2014.70","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T04:00:58Z","timestamp":1398830458000},"page":"1091-1095","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":74,"title":["Early Small Vessel Disease Affects Frontoparietal and Cerebellar Hubs in Close Correlation with Clinical Symptoms\u2014A Resting-State fMRI Study"],"prefix":"10.1177","volume":"34","author":[{"given":"Alexander","family":"Schaefer","sequence":"first","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M","family":"Quinque","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy A","family":"Kipping","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Ar\u00e9lin","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"},{"name":"Leipzig Research Center for Civilization Diseases, University Leipzig, Leipzig, Germany"},{"name":"Clinic of Cognitive Neurology, University Leipzig, Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Roggenhofer","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"},{"name":"Clinic of Cognitive Neurology, University Leipzig, Leipzig, Leipzig, Germany"},{"name":"Integrated Research and Treatment Center Adiposity Diseases, University Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Frisch","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"},{"name":"Department of Neurology, J. 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