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Wild-type (WT) and MMP9-deficient mice (MMP9\/KO) were subjected to cerebral ischemia and treated with vehicle or outgrowth EPCs. After 3 weeks, we observed an increase in the peri-infarct vessel density in WT animals but not in MMP9\/KO mice; no differences were found in the vehicle-treated groups. Our data suggest that tissue MMP9 has a crucial role in EPC-induced vascular remodeling after stroke.<\/jats:p>","DOI":"10.1038\/jcbfm.2015.180","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T04:02:01Z","timestamp":1438142521000},"page":"1547-1551","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Impaired Vascular Remodeling after Endothelial Progenitor Cell Transplantation in MMP9-Deficient Mice Suffering Cortical Cerebral Ischemia"],"prefix":"10.1177","volume":"35","author":[{"given":"Anna","family":"Morancho","sequence":"first","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Ma","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Barcel\u00f3","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolors","family":"Giralt","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Montaner","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rosell","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,7,29]]},"reference":[{"key":"bibr1-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1038\/7434"},{"key":"bibr2-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000114236.77009.06"},{"key":"bibr3-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-010-9157-y"},{"key":"bibr4-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073244"},{"key":"bibr5-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21919"},{"key":"bibr6-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12116"},{"key":"bibr7-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2007.12.001"},{"key":"bibr8-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05734.x"},{"key":"bibr9-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-19-07724.2001"},{"key":"bibr10-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01275.2004"},{"key":"bibr11-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600040"},{"key":"bibr12-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-012-0234-1"},{"key":"bibr13-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074857"},{"key":"bibr14-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1038\/nm1387"},{"key":"bibr15-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000111527.42357.62"},{"key":"bibr16-jcbfm.2015.180","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00457.2005"}],"container-title":["Journal of Cerebral Blood Flow &amp; 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