{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:40:16Z","timestamp":1791589216716,"version":"4.3.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T00:00:00Z","timestamp":1423612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>\n                    As P-glycoprotein (Pgp) inhibition at the blood\u2013brain barrier (BBB) after administration of a single dose of tariquidar is transient, we performed positron emission tomography (PET) scans with the Pgp substrate ( R)-[\n                    <jats:sup>11<\/jats:sup>\n                    C]verapamil in five healthy volunteers during continuous intravenous tariquidar infusion. Total distribution volume ( V\n                    <jats:sub>T<\/jats:sub>\n                    ) of ( R)-[\n                    <jats:sup>11<\/jats:sup>\n                    C]verapamil in whole-brain gray matter increased by 273 \u00b1 78% relative to baseline scans without tariquidar, which was higher than previously reported V\n                    <jats:sub>T<\/jats:sub>\n                    increases. During tariquidar infusion whole-brain V\n                    <jats:sub>T<\/jats:sub>\n                    was comparable to V\n                    <jats:sub>T<\/jats:sub>\n                    in the pituitary gland, a region not protected by the BBB, which suggested that we were approaching complete Pgp inhibition at the human BBB.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2015.19","type":"journal-article","created":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T03:57:16Z","timestamp":1423627036000},"page":"743-746","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":93,"title":["Approaching Complete Inhibition of P-Glycoprotein at the Human Blood\u2013Brain Barrier: An (\n                    <i>R<\/i>\n                    )-[\n                    <sup>11<\/sup>\n                    C]Verapamil PET Study"],"prefix":"10.1177","volume":"35","author":[{"given":"Martin","family":"Bauer","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Karch","sequence":"additional","affiliation":[{"name":"Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Zeitlinger","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Philippe","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"R\u00f6mermann","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"},{"name":"Department of Pharmacology, Toxicology and Pharmacy, Center for Systems Neuroscience, University of Veterinary Medicine, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Stanek","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"},{"name":"Health and Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Maier-Salamon","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wadsak","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria"},{"name":"Medical Imaging Cluster, Medical University of Vienna, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Hacker","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria"},{"name":"Medical Imaging Cluster, Medical University of Vienna, Vienna, 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