{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:09:15Z","timestamp":1790467755745,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Atraumatic convexal subarachnoid hemorrhage (cSAH) in elderly patients is a rare entity that has been associated with cerebral amyloid angiopathy (CAA) and intracerebral hematomas (ICH). To characterize this entity and to study these associations, 22 patients over 60 with cSAH were included in a multicenter ambispective cohort study. Clinical data, magnetic resonance imaging (MRI) studies, APOE genotyping, and cerebrospinal fluid (CSF) biomarkers were evaluated. Results were compared with data from healthy controls (HC), non-cSAH CAA patients (CAAo), and Alzheimer disease patients. Convexal subarachnoid hemorrhage presented with transient sensory or motor symptoms. At follow-up (median 30.7 months), 5 patients had died, 6 survivors showed functional disability (modified Rankins Scale (mRS) &gt; 2), and 12 cognitive impairment. Four patients had prior ICH and six had an ICH during follow-up. CSF-A\u03b240 and A\u03b242 levels were lower in cSAH and CAAo compared with HC. Convexal subarachnoid hemorrhage presented an APOE-\u03b52 overrepresentation and CAAo had an APOE-\u03b54 overrepresentation. On MRI, all patients fulfilled CAA-modified Boston criteria and 9 showed cortical ischemia in the surrounding cortex or the vicinity of superficial siderosis. The neuropathologic study, available in one patient, showed severe CAA and advanced Alzheimer-type pathology. Convexal subarachnoid hemorrhage in the elderly is associated with cognitive impairment and lobar ICH occurrence. Our findings support the existence of an underlying CAA pathology.<\/jats:p>","DOI":"10.1038\/jcbfm.2015.25","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T03:53:47Z","timestamp":1425441227000},"page":"710-717","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Cerebral Amyloid Angiopathy-Related Atraumatic Convexal Subarachnoid Hemorrhage: An ARIA before the Tsunami"],"prefix":"10.1177","volume":"35","author":[{"given":"Eva","family":"Mart\u00ednez-Lizana","sequence":"first","affiliation":[{"name":"Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Carmona-Iragui","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Alcolea","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"G\u00f3mez-Choco","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital de Sant Joan Desp\u00ed Mois\u00e8s Broggi, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Vilaplana","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda B","family":"S\u00e1nchez-Saudin\u00f3s","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Clarim\u00f3n","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Hern\u00e1ndez-Guillamon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Vall d'Hebron, Vall d'Hebron Research Insitute. Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Munuera","sequence":"additional","affiliation":[{"name":"MRI Unit Badalona, Institut de Diagn\u00f2stic per la Imatge, Hospital Germans Trias i Pujol, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Gelpi","sequence":"additional","affiliation":[{"name":"Neurological Tissue Bank of the Biobanc-Hospital Clinic-Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"G\u00f3mez-Anson","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Department of Radiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"de Juan-Delago","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Department of Radiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Delgado-Mederos","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Montaner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Vall d'Hebron, Vall d'Hebron Research Insitute. Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Ois","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital del Mar, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Amaro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Cl\u00ednic, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Blesa","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Mart\u00ed-F\u00e0bregas","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Lle\u00f3","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Fortea","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,3,4]]},"reference":[{"key":"bibr1-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d55efa"},{"key":"bibr2-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.621847"},{"key":"bibr3-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2351"},{"key":"bibr4-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.4.537"},{"key":"bibr5-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dad605"},{"key":"bibr6-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21164"},{"key":"bibr7-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21694"},{"key":"bibr8-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6520-8"},{"key":"bibr9-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1159\/000357426"},{"key":"bibr10-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303898"},{"key":"bibr11-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22134"},{"key":"bibr12-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.643262"},{"key":"bibr13-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.8.1333"},{"key":"bibr14-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1159\/000339685"},{"key":"bibr15-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.3171\/JNS.2008.109.12.1034"},{"key":"bibr16-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2003.00506.x"},{"key":"bibr17-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2011.01219.x"},{"key":"bibr18-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2004.00586.x"},{"key":"bibr19-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318266efb1"},{"key":"bibr20-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.657759"},{"key":"bibr21-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.169"},{"key":"bibr22-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.01.054"},{"key":"bibr23-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000143224.36527.44"},{"key":"bibr24-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.12.1497"},{"key":"bibr25-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.548974"},{"key":"bibr26-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a08f2c"},{"key":"bibr27-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181ae7c5e"},{"key":"bibr28-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.10.011"},{"key":"bibr29-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194266.55694.1e"},{"key":"bibr30-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70096-1"},{"key":"bibr31-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.961"},{"key":"bibr32-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2006.11.028"},{"key":"bibr33-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2011.7.1.1"},{"key":"bibr34-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70157-0"},{"key":"bibr35-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6610-7"},{"key":"bibr36-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10383"},{"key":"bibr37-jcbfm.2015.25","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-007-0294-1"},{"key":"bibr38-jcbfm.2015.25","first-page":"236","volume":"26","author":"Silvera S","year":"2005","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2015.25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1038\/jcbfm.2015.25","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2015.25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:12:35Z","timestamp":1777493555000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.2015.25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,4]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1038\/jcbfm.2015.25"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.2015.25","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,4]]}}}