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Repair of white matter involves the ability of oligodendrocyte precursors to proliferate and mature. However, replacement of lost oligodendrocytes may not be the only mechanism for white-matter recovery. Emerging data now suggest that coordinated signaling between neural, glial, and vascular cells in the entire neurovascular unit may be required. In this mini-review, we discuss how oligodendrocyte lineage cells participate in signaling and crosstalk with other cell types to underlie function and recovery in various experimental models of subcortical white-matter injury.<\/jats:p>","DOI":"10.1038\/jcbfm.2015.80","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T04:04:34Z","timestamp":1430280274000},"page":"187-198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Subcortical ischemic vascular disease: Roles of oligodendrocyte function in experimental models of subcortical white-matter injury"],"prefix":"10.1177","volume":"36","author":[{"given":"Akihiro","family":"Shindo","sequence":"first","affiliation":[{"name":"Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA"},{"name":"Department of 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