{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:25:56Z","timestamp":1788877556895,"version":"build-2803163510"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T00:00:00Z","timestamp":1430265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Apolipoprotein E ( APOE) increases the risk for Alzheimer\u2019s disease ( \u025b4 allele) and cerebral amyloid angiopathy ( \u025b2 and \u025b4), but its role in small vessel disease (SVD) is debated. Here we studied the effects of APOE on white matter hyperintensity volume (WMHV) in CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), a nonamyloidogenic angiopathy and inherited early-onset form of pure SVD. Four hundred and eighty-eight subjects were recruited through a multicenter consortium. Compared with APOE \u025b3\/ \u025b3, WMHV was increased in APOE \u025b2 ( P\u2009=\u20090.02) but not APOE \u025b4. The results remained significant when controlled for genome-wide genetic background variation. Our findings suggest a modifying influence of APOE \u025b2 on WMHV caused by pure SVD.<\/jats:p>","DOI":"10.1038\/jcbfm.2015.85","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T04:04:34Z","timestamp":1430280274000},"page":"199-203","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["<i>APOE \u025b<\/i>\n                    2 is associated with white matter hyperintensity volume in CADASIL"],"prefix":"10.1177","volume":"36","author":[{"given":"Benno","family":"Gesierich","sequence":"first","affiliation":[{"name":"Institute for Stroke and Dementia Research, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximilians-University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Opherk","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximilians-University, Munich, Germany"},{"name":"Department of Neurology, SLK-Kliniken Heilbronn, Heilbronn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Rosand","sequence":"additional","affiliation":[{"name":"Center for Human Genetic Research and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariya","family":"Gonik","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximilians-University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Malik","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximilians-University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Jouvent","sequence":"additional","affiliation":[{"name":"Department of Neurology, DHU NeuroVasc, Hopital Lariboisiere, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Herv\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, G\u00e9n\u00e9tique des Maladies vasculaires INSERM UMR-S740, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poneh","family":"Adib-Samii","sequence":"additional","affiliation":[{"name":"Stroke and Dementia Research Centre, St. George\u2019s, University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Bevan","sequence":"additional","affiliation":[{"name":"Stroke and Dementia Research Centre, St. George\u2019s, University of 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"van der Grond","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elles M J","family":"Boon","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pescini","sequence":"additional","affiliation":[{"name":"Stroke Unit and Neurology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Rost","sequence":"additional","affiliation":[{"name":"Center for Human Genetic Research and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, 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S","family":"Markus","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Tournier-Lasserve","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, G\u00e9n\u00e9tique des Maladies vasculaires INSERM UMR-S740, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Chabriat","sequence":"additional","affiliation":[{"name":"Department of Neurology, DHU NeuroVasc, Hopital Lariboisiere, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Dichgans","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximilians-University, Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), Munich, 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