{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:27:41Z","timestamp":1791980861206,"version":"4.4.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T00:00:00Z","timestamp":1289952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T00:00:00Z","timestamp":1289952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Expo Sci Environ Epidemiol"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1038\/jes.2010.50","type":"journal-article","created":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T11:40:29Z","timestamp":1289994029000},"page":"5-9","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":406,"title":["Implications of the exposome for exposure science"],"prefix":"10.1038","volume":"21","author":[{"given":"Stephen M","family":"Rappaport","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,17]]},"reference":[{"issue":"4617","key":"BFjes201050_CR1","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1126\/science.6351251","volume":"221","author":"BN Ames","year":"1983","unstructured":"Ames B.N. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 1983: 221 (4617): 1256\u20131264.","journal-title":"Science"},{"key":"BFjes201050_CR2","unstructured":"CDC. Fourth National Report on Human Exposure to Environmental Chemicals. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, 2009."},{"issue":"3","key":"BFjes201050_CR3","first-page":"179","volume":"47","author":"JW Cherrie","year":"2003","unstructured":"Cherrie J.W. The beginning of the science underpinning occupational hygiene. Ann Occup Hyg 2003: 47 (3): 179\u2013185.","journal-title":"Ann Occup Hyg"},{"issue":"7289","key":"BFjes201050_CR4","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/464674a","volume":"464","author":"F Collins","year":"2010","unstructured":"Collins F. Has the revolution arrived? Nature 2010: 464 (7289): 674\u2013675.","journal-title":"Nature"},{"issue":"5617","key":"BFjes201050_CR5","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1126\/science.1084564","volume":"300","author":"FS Collins","year":"2003","unstructured":"Collins F.S., Morgan M., and Patrinos A. The Human Genome Project: lessons from large-scale biology. Science 2003: 300 (5617): 286\u2013290.","journal-title":"Science"},{"issue":"6990","key":"BFjes201050_CR6","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nature02628","volume":"429","author":"FS Collins","year":"2004","unstructured":"Collins F.S. The case for a US prospective cohort study of genes and environment. Nature 2004: 429 (6990): 475\u2013477.","journal-title":"Nature"},{"issue":"4","key":"BFjes201050_CR7","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1373\/clinchem.2005.061408","volume":"52","author":"I Dalle-Donne","year":"2006","unstructured":"Dalle-Donne I., Rossi R., Colombo R., Giustarini D., and Milzani A. Biomarkers of oxidative damage in human disease. Clin Chem 2006: 52 (4): 601\u2013623.","journal-title":"Clin Chem"},{"issue":"Suppl 1","key":"BFjes201050_CR8","doi-asserted-by":"publisher","first-page":"i23","DOI":"10.1093\/ije\/dym281","volume":"37","author":"WB Dunn","year":"2008","unstructured":"Dunn W.B., Broadhurst D., Ellis D.I., Brown M., Halsall A., and O\u2019Hagan S., et al. A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols. Int J Epidemiol 2008: 37 (Suppl 1): i23\u2013i30.","journal-title":"Int J Epidemiol"},{"key":"BFjes201050_CR9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0165-1110(83)90024-6","volume":"123","author":"L Ehrenberg","year":"1983","unstructured":"Ehrenberg L., Moustacchi E., and Osterman Golkar S. Dosimetry of genotoxic agents and dose-response relationships of their effects. Mut Res 1983: 123: 121\u2013182.","journal-title":"Mut Res"},{"issue":"49","key":"BFjes201050_CR10","doi-asserted-by":"publisher","first-page":"17312","DOI":"10.1073\/pnas.0407162101","volume":"101","author":"ES Epel","year":"2004","unstructured":"Epel E.S., Blackburn E.H., Lin J., Dhabhar F.S., Adler N.E., and Morrow J.D., et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA 2004: 101 (49): 17312\u201317315.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFjes201050_CR11","doi-asserted-by":"publisher","DOI":"10.1201\/b14095","volume-title":"Pharmacokinetics, Second Edition, Revised and Expanded","author":"M Gibaldi","year":"1982","unstructured":"Gibaldi M., and Perrier D. Pharmacokinetics, Second Edition, Revised and Expanded. Marcel Dekker, New York, 1982."},{"key":"BFjes201050_CR12","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.2307\/4577948","volume":"41","author":"L Greenburg","year":"1926","unstructured":"Greenburg L. Benzol poisoning as an industrial hazard. US Pub Health Repts 1926: 41: 1516\u20131539.","journal-title":"US Pub Health Repts"},{"key":"BFjes201050_CR13","unstructured":"Greenburg L.W., and Smith G.W. A new instrument for sampling aerial dust. US Bur Mines Rept Invest 1922, 2392."},{"key":"BFjes201050_CR14","unstructured":"Hindorff L.A., Junkins H.A., Hall P.N., Mehta J.P., and Manolio T.A. A Catalog of Published Genome-Wide Association Studies. www.genome.gov\/gwastudiesAccessed Sep. 10, 2010."},{"issue":"5696","key":"BFjes201050_CR15","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1126\/science.1104635","volume":"306","author":"L Hood","year":"2004","unstructured":"Hood L., Heath J.R., Phelps M.E., and Lin B. Systems biology and new technologies enable predictive and preventative medicine. Science 2004: 306 (5696): 640\u2013643.","journal-title":"Science"},{"key":"BFjes201050_CR16","unstructured":"Li H., Grigoryan H., Funk W.E., Lu S.S., Rose S., and Williams E.R., et al. Adductomics of Human Serum Albumin by Fixed-Step Selected Reaction Monitoring. Mol Cell Proteomics, in press."},{"issue":"2","key":"BFjes201050_CR17","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1056\/NEJM200007133430201","volume":"343","author":"P Lichtenstein","year":"2000","unstructured":"Lichtenstein P., Holm N.V., Verkasalo P.K., Iliadou A., Kaprio J., and Koskenvuo M., et al. Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000: 343 (2): 78\u201385.","journal-title":"N Engl J Med"},{"issue":"1","key":"BFjes201050_CR18","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1021\/tx700235t","volume":"21","author":"DC Liebler","year":"2008","unstructured":"Liebler D.C. Protein damage by reactive electrophiles: targets and consequences. Chem Res Toxicol 2008: 21 (1): 117\u2013128.","journal-title":"Chem Res Toxicol"},{"issue":"7265","key":"BFjes201050_CR19","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/nature08494","volume":"461","author":"TA Manolio","year":"2009","unstructured":"Manolio T.A., Collins F.S., Cox N.J., Goldstein D.B., Hindorff L.A., and Hunter D.J., et al. Finding the missing heritability of complex diseases. Nature 2009: 461 (7265): 747\u2013753.","journal-title":"Nature"},{"issue":"4","key":"BFjes201050_CR20","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1039\/b713633c","volume":"38","author":"S Mounicou","year":"2009","unstructured":"Mounicou S., Szpunar J., and Lobinski R. Metallomics: the concept and methodology. Chem Soc Rev 2009: 38 (4): 1119\u20131138.","journal-title":"Chem Soc Rev"},{"issue":"6","key":"BFjes201050_CR21","doi-asserted-by":"publisher","first-page":"639","DOI":"10.2217\/14622416.6.6.639","volume":"6","author":"W Ollier","year":"2005","unstructured":"Ollier W., Sprosen T., and Peakman T. UK Biobank: from concept to reality. Pharmacogenomics 2005: 6 (6): 639\u2013646.","journal-title":"Pharmacogenomics"},{"issue":"5","key":"BFjes201050_CR22","doi-asserted-by":"publisher","first-page":"e10746","DOI":"10.1371\/journal.pone.0010746","volume":"5","author":"CJ Patel","year":"2010","unstructured":"Patel C.J., Bhattacharya J., and Butte A.J. An Environment-Wide Association study (EWAS) on type 2 diabetes mellitus. PLoS One 2010: 5 (5): e10746.","journal-title":"PLoS One"},{"issue":"4","key":"BFjes201050_CR23","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/ajim.4700060407","volume":"6","author":"SM Rappaport","year":"1984","unstructured":"Rappaport S.M. The rules of the game: an analysis of OSHA's enforcement strategy. Am J Ind Med 1984: 6 (4): 291\u2013303.","journal-title":"Am J Ind Med"},{"issue":"7","key":"BFjes201050_CR24","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1136\/oem.2006.027052","volume":"66","author":"SM Rappaport","year":"2009","unstructured":"Rappaport S.M. Assessing workplace exposures: turning to the past for guidance. Occup Environ Med 2009: 66 (7): 429\u2013430.","journal-title":"Occup Environ Med"},{"key":"BFjes201050_CR25","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1126\/science.1192603","volume":"330","author":"SM Rappaport","year":"2010","unstructured":"Rappaport S.M., and Smith M.T. Environment and disease risks. Science 2010: 330: 460\u2013461.","journal-title":"Science"},{"key":"BFjes201050_CR26","first-page":"220","volume":"10","author":"SA Roach","year":"1953","unstructured":"Roach S.A. A method of relating the incidence of pneumoconiosis to airborne dust exposure. Brit J Ind Med 1953: 10: 220\u2013226.","journal-title":"Brit J Ind Med"},{"key":"BFjes201050_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00028896609342786","volume":"27","author":"SA Roach","year":"1966","unstructured":"Roach S.A. A more rational basis for air-sampling programs. Am Ind Hyg Assoc J 1966: 27: 1\u201312.","journal-title":"Am Ind Hyg Assoc J"},{"issue":"1","key":"BFjes201050_CR28","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1371\/journal.pmed.0010027","volume":"1","author":"A Rodgers","year":"2004","unstructured":"Rodgers A., Ezzati M., Vander Hoorn S., Lopez A.D., Lin R.B., and Murray C.J. Distribution of major health risks: findings from the Global Burden of Disease study. PLoS Med 2004: 1 (1): e27.","journal-title":"PLoS Med"},{"issue":"5","key":"BFjes201050_CR29","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1002\/mas.20207","volume":"28","author":"FM Rubino","year":"2009","unstructured":"Rubino F.M., Pitton M., Di Fabio D., and Colombi A. Toward an \u201comic\u201d physiopathology of reactive chemicals: Thirty years of mass spectrometric study of the protein adducts with endogenous and xenobiotic compounds. Mass Spectrom Rev 2009: 28 (5): 725\u2013784.","journal-title":"Mass Spectrom Rev"},{"key":"BFjes201050_CR30","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1476-069X-6-38","volume":"6","author":"R Saracci","year":"2007","unstructured":"Saracci R., and Vineis P. Disease proportions attributable to environment. Environ Health 2007: 6: 38.","journal-title":"Environ Health"},{"key":"BFjes201050_CR31","first-page":"127","volume":"2","author":"RJ Sherwood","year":"1960","unstructured":"Sherwood R.J., and Greenhalgh D.M.S. A personal air sampler. Ann Occup Hyg 1960: 2: 127\u2013132.","journal-title":"Ann Occup Hyg"},{"issue":"6","key":"BFjes201050_CR32","first-page":"163","volume":"10","author":"HF Smyth","year":"1928","unstructured":"Smyth H.F., and Smyth Jr H.F. Spray painting hazards as determined by the Pennsylvania and the National Safety Council surveys. J Ind Hyg 1928: 10 (6): 163\u2013214.","journal-title":"J Ind Hyg"},{"issue":"7239","key":"BFjes201050_CR33","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/nature07943","volume":"458","author":"MR Stratton","year":"2009","unstructured":"Stratton M.R., Campbell P.J., and Futreal P.A. The cancer genome. Nature 2009: 458 (7239): 719\u2013724.","journal-title":"Nature"},{"key":"BFjes201050_CR34","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1476-069X-8-54","volume":"8","author":"P Vineis","year":"2009","unstructured":"Vineis P., Khan A.E., Vlaanderen J., and Vermeulen R. The impact of new research technologies on our understanding of environmental causes of disease: the concept of clinical vulnerability. Environ Health 2009: 8: 54.","journal-title":"Environ Health"},{"issue":"8","key":"BFjes201050_CR35","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1158\/1055-9965.EPI-05-0456","volume":"14","author":"CP Wild","year":"2005","unstructured":"Wild C.P. Complementing the genome with an \u201cexposome\u201d: the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Biomarkers Prev 2005: 14 (8): 1847\u20131850.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5568","key":"BFjes201050_CR36","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1126\/science.1071055","volume":"296","author":"WC Willett","year":"2002","unstructured":"Willett W.C. Balancing life-style and genomics research for disease prevention. Science 2002: 296 (5568): 695\u2013698.","journal-title":"Science"}],"container-title":["Journal of Exposure Science &amp; Environmental Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jes201050.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jes201050","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jes201050.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T16:26:56Z","timestamp":1647448016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jes201050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,17]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["BFjes201050"],"URL":"https:\/\/doi.org\/10.1038\/jes.2010.50","relation":{},"ISSN":["1559-0631","1559-064X"],"issn-type":[{"value":"1559-0631","type":"print"},{"value":"1559-064X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,17]]},"assertion":[{"value":"17 November 2010","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author declares no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}