{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:41:08Z","timestamp":1790192468384,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T00:00:00Z","timestamp":1340150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T00:00:00Z","timestamp":1340150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Expo Sci Environ Epidemiol"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1038\/jes.2012.37","type":"journal-article","created":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T10:55:06Z","timestamp":1340189706000},"page":"533-538","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Population study on chronic and acute conjunctivitis associated with ambient environment in urban and rural areas"],"prefix":"10.1038","volume":"22","author":[{"given":"Chun-Chi","family":"Chiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiang-Chang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yu","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,6,20]]},"reference":[{"key":"BFjes201237_CR1","unstructured":"American Academy of Ophthalmology. Cornea and External Eye Disease (2007)."},{"key":"BFjes201237_CR2","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1038\/sj.eye.6701369","volume":"18","author":"GJ Johnson","year":"2004","unstructured":"Johnson G.J. The environment and the eye. Eye (2004): 18: 1235\u20131250.","journal-title":"Eye"},{"key":"BFjes201237_CR3","first-page":"123","volume":"10","author":"G D\u2019Amato","year":"2000","unstructured":"D\u2019Amato G., Liccardi G., and D\u2019Amato M. Environmental risk factors outdoor air pollution and climatic changes) and increased trend of respiratory allergy. J Investig Allergol Clin Immunol (2000): 10: 123\u2013128.","journal-title":"J Investig Allergol Clin Immunol"},{"key":"BFjes201237_CR4","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1111\/j.1365-2222.2005.02328.x","volume":"35","author":"G D\u2019Amato","year":"2005","unstructured":"D\u2019Amato G., Liccardi G., D\u2019Amato M., and Holgate S. Environmental risk factors and allergic bronchial asthma. Clin Exp Allergy (2005): 35: 1113\u20131124.","journal-title":"Clin Exp Allergy"},{"key":"BFjes201237_CR5","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/00130832-200410000-00003","volume":"4","author":"J Heinrich","year":"2004","unstructured":"Heinrich J., and Wichmann H.E. Traffic related pollutants in Europe and their effect on allergic disease. Curr Opin Allergy Clin Immunol (2004): 4: 341\u2013348.","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"BFjes201237_CR6","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1185\/03007990802222774","volume":"24","author":"A Leonardi","year":"2008","unstructured":"Leonardi A., and Lanier B. Urban eye allergy syndrome: a new clinical entity? Curr Med Res Opin (2008): 24: 2295\u20132302.","journal-title":"Curr Med Res Opin"},{"key":"BFjes201237_CR7","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S1081-1206(10)62246-6","volume":"87","author":"M Riediker","year":"2001","unstructured":"Riediker M., Monn C., Koller T., Stahel W.A., and Wuthrich B. Air pollutants enhance rhinoconjunctivitis symptoms in pollen-allergic individuals. Ann Allergy Asthma Immunol (2001): 87: 311\u2013318.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"BFjes201237_CR8","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.jaci.2004.08.030","volume":"114","author":"JA Bernstein","year":"2004","unstructured":"Bernstein J.A., Alexis N., Barnes C., Bernstein I.L., Bernstein J.A., Nel A., Peden D., Diaz-Sanchez D., Tarlo S.M., and Williams P.B. Health effects of air pollution. J Allergy Clin Immunol (2004): 114: 1116\u20131123.","journal-title":"J Allergy Clin Immunol"},{"key":"BFjes201237_CR9","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.jaci.2005.06.002","volume":"116","author":"A Bacsi","year":"2005","unstructured":"Bacsi A., Dharajiya N., Choudhury B.K., Sur S., and Boldogh I. Effect of pollen-mediated oxidative stress on immediate hypersensitivity reactions and late-phase inflammation in allergic conjunctivitis. J Allergy Clin Immunol (2005): 116: 836\u2013843.","journal-title":"J Allergy Clin Immunol"},{"key":"BFjes201237_CR10","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1136\/bjo.87.7.809","volume":"87","author":"T Bourcier","year":"2003","unstructured":"Bourcier T., Viboud C., Cohen J.C., Thomas F., Bury T., Cadiot L., Mestre O., Flahault A., Borderie V., and Laroche L. Effects of air pollution and climatic conditions on the frequency of ophthalmological emergency examinations. Br J Ophthalmol (2003): 87: 809\u2013811.","journal-title":"Br J Ophthalmol"},{"key":"BFjes201237_CR11","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1034\/j.1600-0420.2003.00119.x","volume":"81","author":"R Saxena","year":"2003","unstructured":"Saxena R., Srivastava S., Trivedi D., Anand E., Joshi S., and Gupta S.K. Impact of environmental pollution on the eye. Acta Ophthalmol Scand 2003: 81: 491\u2013494.","journal-title":"Acta Ophthalmol Scand"},{"key":"BFjes201237_CR12","unstructured":"The Central Weather Bureau Online Information 2011a. Available at: http:\/\/www.cwb.gov.tw\/eng\/index.htm (accessed date: 12 May 2011)."},{"key":"BFjes201237_CR13","unstructured":"Taiwan Air Quality Monitoring Network 2011. Available at: http:\/\/taqm.epa.gov.tw\/taqm\/en\/PsiAreaHourly.aspx (accessed date: 12 May 2011)."},{"key":"BFjes201237_CR14","unstructured":"Taiwan National Health Insurance Research Database. Available at: http:\/\/w3.nhri.org.tw\/nhird\/en\/Data_Subsets.htmlS3 (accessed date: 12 May 2011) 2011."},{"key":"BFjes201237_CR15","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1001\/jama.278.2.89","volume":"278","author":"SH Cheng","year":"1997","unstructured":"Cheng S.H., and Chiang T.L. The effect of universal health insurance on health care utilization in Taiwan. Results from a natural experiment. JAMA 1997: 278: 89\u201393.","journal-title":"JAMA"},{"key":"BFjes201237_CR16","unstructured":"Illustrations of Surface Observation Data 2011b. Available at: http:\/\/www.cwb.gov.tw\/v7e\/observe\/real\/ALLData.htm (accessed date: 9 May 2012)."},{"key":"BFjes201237_CR17","unstructured":"The republic of China Year Book 2008: Chapter 12 Environmental Protection 2008. Available at: http:\/\/www.gio.gov.tw\/taiwan-website\/5-gp\/yearbook\/2008\/ch12.html (accessed date: 12 May 2011)."},{"key":"BFjes201237_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-3242-6","volume-title":"Generalized Linear Models","author":"P McCullagh","year":"1989","unstructured":"McCullagh P., and Nelder J.A. Generalized Linear Models, 2 edn. Chapman & Hall\/CRC Boca Raton Florida, 1989."},{"key":"BFjes201237_CR19","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.envres.2010.01.001","volume":"110","author":"LJ Akinbami","year":"2010","unstructured":"Akinbami L.J., Lynch C.D., Parker J.D., and Woodruff T.J. The association between childhood asthma prevalence and monitored air pollutants in metropolitan areas, United States, 2001\u20132004. Environ Res 2010: 110: 294\u2013301.","journal-title":"Environ Res"},{"key":"BFjes201237_CR20","first-page":"175","volume":"81","author":"RJ Laumbach","year":"2010","unstructured":"Laumbach R.J. Outdoor air pollutants and patient health. Am Fam Physician 2010: 81: 175\u2013180.","journal-title":"Am Fam Physician"},{"key":"BFjes201237_CR21","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/S1081-1206(10)60263-3","volume":"103","author":"TF Mar","year":"2009","unstructured":"Mar T.F., and Koenig J.Q. Relationship between visits to emergency departments for asthma and ozone exposure in greater Seattle, Washington. Ann Allergy Asthma Immunol 2009: 103: 474\u2013479.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"BFjes201237_CR22","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1755-3768.1992.tb04136.x","volume":"70","author":"M Norn","year":"1992","unstructured":"Norn M. Pollution keratoconjunctivitis. A review. Acta Ophthalmol Copenh 1992: 70: 269\u2013273.","journal-title":"Acta Ophthalmol Copenh"},{"key":"BFjes201237_CR23","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1111\/j.1399-3038.2005.00325.x","volume":"16","author":"G Zhang","year":"2005","unstructured":"Zhang G., Spickett J., Lee A.H., Rumchev K., and Stick S. Household hygiene practices in relation to dampness at home and current wheezing and rhino-conjunctivitis among school age children. Pediatr Allergy Immunol 2005: 16: 587\u2013592.","journal-title":"Pediatr Allergy Immunol"},{"key":"BFjes201237_CR24","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1289\/ehp.10363","volume":"115","author":"P Novaes","year":"2007","unstructured":"Novaes P., do Nascimento Saldiva P.H., Kara-Jose N., Macchione M., Matsuda M., Racca L., and Berra A. Ambient levels of air pollution induce goblet-cell hyperplasia in human conjunctival epithelium. Environ Health Perspect 2007: 115: 1753\u20131756.","journal-title":"Environ Health Perspect"},{"key":"BFjes201237_CR25","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1289\/ehp.0800467","volume":"117","author":"B Brunekreef","year":"2009","unstructured":"Brunekreef B., Stewart A.W., Anderson H.R., Lai C.K., Strachan D.P., and Pearce N. Self-reported truck traffic on the street of residence and symptoms of asthma and allergic disease: a global relationship in ISAAC phase 3. Environ Health Perspect 2009: 117: 1791\u20131798.","journal-title":"Environ Health Perspect"},{"key":"BFjes201237_CR26","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/EDE.0b013e3181673bab","volume":"19","author":"S Van Roosbroeck","year":"2008","unstructured":"Van Roosbroeck S., Li R., Hoek G., Lebret E., Brunekreef B., and Spiegelman D. Traffic-related outdoor air pollution and respiratory symptoms in children: the impact of adjustment for exposure measurement error. Epidemiology 2008: 19: 409\u2013416.","journal-title":"Epidemiology"},{"key":"BFjes201237_CR27","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1183\/09031936.99.13225799","volume":"13","author":"RW Atkinson","year":"1999","unstructured":"Atkinson R.W., Anderson H.R., Strachan D.P., Bland J.M., Bremner S.A., and Ponce de Leon A. Short-term associations between outdoor air pollution and visits to accident and emergency departments in London for respiratory complaints. Eur Respir J 1999: 13: 257\u2013265.","journal-title":"Eur Respir J"},{"key":"BFjes201237_CR28","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1067\/mai.2001.111141","volume":"107","author":"H Bayram","year":"2001","unstructured":"Bayram H., Sapsford R.J., Abdelaziz M.M., and Khair O.A. Effect of ozone and nitrogen dioxide on the release of proinflammatory mediators from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients in vitro. J Allergy Clin Immunol 2001: 107: 287\u2013294.","journal-title":"J Allergy Clin Immunol"},{"key":"BFjes201237_CR29","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1164\/ajrccm.159.3.9804143","volume":"159","author":"JM Peters","year":"1999","unstructured":"Peters J.M., Avol E., Navidi W., London S.J., Gauderman W.J., Lurmann F., Linn W.S., Margolis H., Rappaport E., Gong H., and Thomas D.C. A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. Am J Respir Crit Care Med 1999: 159: 760\u2013767.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFjes201237_CR30","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S0031-9422(97)00634-1","volume":"47","author":"DA Bagarozzi Jr","year":"1998","unstructured":"Bagarozzi Jr D.A., and Travis J. Ragweed pollen proteolytic enzymes: possible roles in allergies and asthma. Phytochemistry 1998: 47: 593\u2013598.","journal-title":"Phytochemistry"},{"key":"BFjes201237_CR31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0300-483X(97)03664-0","volume":"120","author":"B Hitzfeld","year":"1997","unstructured":"Hitzfeld B., Friedrichs K.H., Ring J., and Behrendt H. Airborne particulate matter modulates the production of reactive oxygen species in human polymorphonuclear granulocytes. Toxicology 1997: 120: 185\u2013195.","journal-title":"Toxicology"},{"key":"BFjes201237_CR32","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1159\/000027401","volume":"213","author":"P Versura","year":"1999","unstructured":"Versura P., Profazio V., Cellini M., Torreggiani A., and Caramazza R. Eye discomfort and air pollution. Ophthalmologica 1999: 213: 103\u2013109.","journal-title":"Ophthalmologica"},{"key":"BFjes201237_CR33","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1136\/oem.55.10.651","volume":"55","author":"BG Armstrong","year":"1998","unstructured":"Armstrong B.G. Effect of measurement error on epidemiological studies of environmental and occupational exposures. Occup Environ Med 1998: 55: 651\u2013656.","journal-title":"Occup Environ Med"},{"key":"BFjes201237_CR34","unstructured":"Directorate-General of Budget, Accounting and Statistics, Executive Yuan, R.O.C. (Taiwan). National Statistics Vol. 2009 2012. Available at: http:\/\/www.dgbas.gov.tw\/mp.asp?mp=(accessed date: 25 January 2012)."}],"container-title":["Journal of Exposure Science & Environmental Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jes201237.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jes201237","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jes201237.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T15:15:25Z","timestamp":1647443725000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jes201237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,20]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["BFjes201237"],"URL":"https:\/\/doi.org\/10.1038\/jes.2012.37","relation":{},"ISSN":["1559-0631","1559-064X"],"issn-type":[{"value":"1559-0631","type":"print"},{"value":"1559-064X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,20]]},"assertion":[{"value":"2 December 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}