{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:07:30Z","timestamp":1762866450248},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T00:00:00Z","timestamp":1411516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T00:00:00Z","timestamp":1411516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Expo Sci Environ Epidemiol"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1038\/jes.2014.64","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T10:38:03Z","timestamp":1411555083000},"page":"417-419","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ultrasonographic measurement of the femoral cartilage thickness in patients with occupational lead exposure"],"prefix":"10.1038","volume":"25","author":[{"given":"Mustafa T","family":"Y\u0131ld\u0131zg\u00f6ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali E","family":"Baki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Kara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timur","family":"Ekiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fclay","family":"Tiftik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Engin","family":"Tutkun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u0131n\u00e7","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"\u00d6z\u00e7akar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,9,24]]},"reference":[{"key":"BFjes201464_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2478\/v10102-012-0009-2","volume":"5","author":"G Flora","year":"2012","unstructured":"Flora G, Gupta D, Tiwari A . Toxicity of lead: a review with recent updates. Interdiscip Toxicol 2012: 5: 47\u201358.","journal-title":"Interdiscip Toxicol"},{"key":"BFjes201464_CR2","first-page":"689","volume":"11","author":"A Rosin","year":"2009","unstructured":"Rosin A . The long-term consequences of exposure to lead. Isr Med Assoc J 2009: 11: 689\u2013694.","journal-title":"Isr Med Assoc J"},{"key":"BFjes201464_CR3","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1289\/ehp.9782","volume":"115","author":"BS Schwartz","year":"2007","unstructured":"Schwartz BS, Hu H . Adult lead exposure: time for change. Environ Health Perspect 2007: 115: 451\u2013454.","journal-title":"Environ Health Perspect"},{"key":"BFjes201464_CR4","first-page":"783","volume":"13","author":"JE Puzas","year":"1992","unstructured":"Puzas JE, Sickel MJ, Felter ME . Osteoblasts and chondrocytes are important target cells for the toxic effects of lead. Neurotoxicology 1992: 13: 783\u2013788.","journal-title":"Neurotoxicology"},{"key":"BFjes201464_CR5","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1006\/enrs.1997.3760","volume":"74","author":"J Gonzales-Riola","year":"1997","unstructured":"Gonzales-Riola J, Hernandez ER, Escribano A, Revilla M, Seco Ca-, Villa LF et al. Effect of lead on bone and cartilage in sexually mature rats: a morphometric and histomorphometry study. Environ Res 1997: 74: 91\u201393.","journal-title":"Environ Res"},{"key":"BFjes201464_CR6","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.scitotenv.2007.07.050","volume":"388","author":"E Kalisi\u0144ska","year":"2007","unstructured":"Kalisi\u0144ska E, Salicki W, Kavetska KM, Ligocki M . Trace metal concentrations are higher in cartilage than in bones of scaup and pochard wintering in Poland. Sci Total Environ 2007: 388: 90\u2013103.","journal-title":"Sci Total Environ"},{"key":"BFjes201464_CR7","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1289\/ehp.7596","volume":"113","author":"JJ Carmouche","year":"2005","unstructured":"Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R et al. Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environ Health Perspect 2005: 113: 749\u2013755.","journal-title":"Environ Health Perspect"},{"key":"BFjes201464_CR8","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1007\/s00167-003-0489-x","volume":"12","author":"O Mathiesen","year":"2004","unstructured":"Mathiesen O, Konradsen L, Torp-Pedersen S, Jorgensen U . Ultrasonography and articular cartilage defects in the knee: an in vitro evaluation of the accuracy of cartilage thickness and defect size assessment. Knee Surg Sports Traumatol Arthrosc 2004: 12: 440\u2013443.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"BFjes201464_CR9","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.joca.2007.07.013","volume":"16","author":"CL Lee","year":"2008","unstructured":"Lee CL, Huang MH, Chai CY, Chen CH, Su JY, Tien YC . The validity of in vivo ultrasonographic grading of osteoarthritic femoral condylar cartilage: a comparison with in vitro ultrasonographic and histologic gradings. Osteoarthritis Cartilage 2008: 16: 352\u2013358.","journal-title":"Osteoarthritis Cartilage"},{"key":"BFjes201464_CR10","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1007\/s10067-008-0956-3","volume":"27","author":"CH Yoon","year":"2008","unstructured":"Yoon CH, Kim HS, Ju JH, Jee WH, Park SH, Kim HY . Validity of the sonographic longitudinal sagittal image for assessment of the cartilage thickness in the knee osteoarthritis. Clin Rheumatol 2008: 27: 1507\u20131516.","journal-title":"Clin Rheumatol"},{"key":"BFjes201464_CR11","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1146\/annurev.med.55.091902.103653","volume":"55","author":"H Needleman","year":"2004","unstructured":"Needleman H . Lead poisoning. Annu Rev Med 2004: 55: 209\u2013222.","journal-title":"Annu Rev Med"},{"key":"BFjes201464_CR12","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1007\/s002239900214","volume":"60","author":"A Escribano","year":"1997","unstructured":"Escribano A, Revilla M, Hernandez ER, Seco C, Gonzalez- Riola J, Villa LF et al. Effect of lead on bone development and bone mass: a morphometric, densitometric, and histomorphometric study in growing rats. Calcif Tissue Int 1997: 60: 200\u2013203.","journal-title":"Calcif Tissue Int"},{"key":"BFjes201464_CR13","first-page":"65","volume":"23","author":"HE Gruber","year":"1997","unstructured":"Gruber HE, Gonick HC, Khalil-manesh F, Sanchez TV, Motsinger S, Meyer M et al. Osteopenia induced by long-term, low- and high-level exposure of the adult rat to lead. Miner Electrolyte Metab 1997: 23: 65\u201373.","journal-title":"Miner Electrolyte Metab"},{"key":"BFjes201464_CR14","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0378-4274(99)00272-6","volume":"112-113","author":"M Berglund","year":"2000","unstructured":"Berglund M, Akesson A, Bjellerup P, Vahter M . Metal-bone interactions. Toxicol Lett 2000: 112-113: 219\u2013225.","journal-title":"Toxicol Lett"},{"key":"BFjes201464_CR15","doi-asserted-by":"publisher","first-page":"R37","DOI":"10.1186\/ar3270","volume":"13","author":"AE Nelson","year":"2011","unstructured":"Nelson AE, Shi XA, Schwartz TA, Chen JC, Renner JB, Caldwell KL et al. Whole blood lead levels are associated with radiographic and symptomatic knee osteoarthritis: a cross-sectional analysis in the Johnston County Osteoarthritis Project. Arthritis Res Ther 2011: 13: R37.","journal-title":"Arthritis Res Ther"},{"key":"BFjes201464_CR16","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0048-9697(95)04844-8","volume":"175","author":"J Kwapuli\u0144ski","year":"1995","unstructured":"Kwapuli\u0144ski J, Miros\u0142awski J, Wiechu\u0142a D, Jurkiewicz A, Tokarowski A . The femur capitulum as a biomarker of contamination due to indicating lead content in the air by participation of the other metals. Sci Total Environ 1995: 175: 57\u201364.","journal-title":"Sci Total Environ"},{"key":"BFjes201464_CR17","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/BF00317832","volume":"12","author":"KA Milachowski","year":"1988","unstructured":"Milachowski KA . Investigation of ischaemic necrosis of the femoral head with trace elements. Int Orthop 1988: 12: 323\u2013330.","journal-title":"Int Orthop"},{"key":"BFjes201464_CR18","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1385\/BTER:75:1-3:253","volume":"75","author":"M Krachler","year":"2000","unstructured":"Krachler M, Domej W, Irgolic KJ . Concentrations of trace elements in osteoarthritic knee-joint effusions. Biol Trace Elem Res 2000: 75: 253\u2013263.","journal-title":"Biol Trace Elem Res"},{"key":"BFjes201464_CR19","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1601-6343.2004.00308.x","volume":"8","author":"G Shen","year":"2005","unstructured":"Shen G The role of type X collagen in facilitating and regulating endochondral ossification of articular cartilage. Orthod Craniofac Res 2005: 8: 11\u201317.","journal-title":"Orthod Craniofac Res"},{"key":"BFjes201464_CR20","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1016\/j.bbamcr.2008.04.005","volume":"1783","author":"HY Qureshi","year":"2008","unstructured":"Qureshi HY, Ricci G, Zafarullah M . Smad signaling pathway is a pivotal component of tissue inhibitor of metalloproteinases- 3 regulation by transforming growth factor beta in human chondrocytes. Biochim Biophys Acta 2008: 1783: 1605\u20131612.","journal-title":"Biochim Biophys Acta"},{"key":"BFjes201464_CR21","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1089\/ten.tea.2009.0531","volume":"16","author":"L Kupcsik","year":"2010","unstructured":"Kupcsik L, Stoddart MJ, Li Z, Benneker LM, Alini M . Improving chondrogenesis: potential and limitations of SOX9 gene transfer and mechanical stimulation for cartilage tissue engineering. Tissue Eng Part A 2010: 16: 1845\u20131855.","journal-title":"Tissue Eng Part A"},{"key":"BFjes201464_CR22","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/S0736-0266(02)00007-4","volume":"20","author":"MJ Zuscik","year":"2002","unstructured":"Zuscik MJ, Pateder DB, Puzas JE, Schwarz EM, Rosier RN, O'Keefe RJ . Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes. J Orthop Res 2002: 20: 811\u2013818.","journal-title":"J Orthop Res"},{"key":"BFjes201464_CR23","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1006\/taap.1996.0209","volume":"140","author":"DG Hicks","year":"1996","unstructured":"Hicks DG, O'Keefe RJ, Reynolds KJ, Cory-Slechta DA, Puzas JE, Judkins A et al. Effects of lead on growth plate chondrocyte phenotype. Toxicol Appl Pharmacol 1996: 140: 164\u2013172.","journal-title":"Toxicol Appl Pharmacol"},{"key":"BFjes201464_CR24","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1093\/toxsci\/kfj093","volume":"90","author":"MJ Zuscik","year":"2006","unstructured":"Zuscik MJ, Puzas E, O\u2019Keefe RJ, Sheu T, Holz JD, Schwarz EM et al. Pb exposure regulates a complex interplay of signaling pathways in articular chondrocytes that ultimately leads to phenotypic changes resembling osteoarthritis. J Soc Toxicol 2006: 90: S1.","journal-title":"J Soc Toxicol"},{"key":"BFjes201464_CR25","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.joca.2004.07.007","volume":"12","author":"E Calvo","year":"2004","unstructured":"Calvo E, Palacios I, Delgado E, S\u00e1nchez-Pernaute O, Largo R, Egido J et al. Histopathological correlation of cartilage swelling detected by magnetic resonance imaging in early experimental osteoarthritis. Osteoarthritis Cartilage 2004: 12: 878\u2013886.","journal-title":"Osteoarthritis Cartilage"},{"key":"BFjes201464_CR26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0046-8177(88)80353-8","volume":"19","author":"G Herrero-Beaumont","year":"1988","unstructured":"Herrero-Beaumont G, Slavin RE, Swedo J, Cartwright JJ, Viegas S, Custer EM . Lead arthritis and lead poisoning following bullet wounds: a clinicopathologic, ultrastructural, and microanalytic study of two cases. Hum Pathol 1988: 19: 223\u2013235.","journal-title":"Hum Pathol"},{"key":"BFjes201464_CR27","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.2214\/ajr.176.5.1761144","volume":"176","author":"J DeMartini","year":"2001","unstructured":"DeMartini J, Wilson A, Powell JS, Powell CS . Lead arthropathy and systemic lead poisoning from an intraarticular bullet. AJR Am J Roentgenol 2001: 176: 1144.","journal-title":"AJR Am J Roentgenol"},{"key":"BFjes201464_CR28","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1097\/00005373-199911000-00025","volume":"47","author":"NR Harding","year":"1999","unstructured":"Harding NR, Lipton JF, Vigorita VJ, Bryk E . Experimental lead arthropathy: an animal model. J Trauma 1999: 47: 951\u2013955.","journal-title":"J Trauma"},{"key":"BFjes201464_CR29","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1097\/00005373-199504000-00038","volume":"38","author":"AA Bolanos","year":"1995","unstructured":"Bolanos AA, Vigorita VJ, Meyerson RI, D\u2019Ambrosio FG, Bryk E . Intra-articular histopathologic changes secondary to local lead intoxication in rabbit knee joints. J Trauma 1995: 38: 668\u2013671.","journal-title":"J Trauma"},{"key":"BFjes201464_CR30","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.joca.2006.03.001","volume":"14","author":"N Zoeger","year":"2006","unstructured":"Zoeger N, Roschger P, Hofstaetter JG, Jokubonis C, Pepponi G, Falkenberg G et al. Lead accumulation in tidemark of articular cartilage. Osteoarthritis Cartilage 2006: 14: 906\u2013913.","journal-title":"Osteoarthritis Cartilage"},{"key":"BFjes201464_CR31","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s002560000320","volume":"30","author":"SC Faber","year":"2001","unstructured":"Faber SC, Eckstein F, Lukasz S, M\u00fchlbauer R, Hohe J, Englmeier KH et al. Gender differences in knee joint cartilage thickness, volume and articular surface areas: assessment with quantitative three-dimensional MR imaging. Skeletal Radiol 2001: 30: 144\u2013150.","journal-title":"Skeletal Radiol"}],"container-title":["Journal of Exposure Science &amp; Environmental Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jes201464.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jes201464","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jes201464.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T15:16:34Z","timestamp":1647443794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jes201464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,24]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["BFjes201464"],"URL":"https:\/\/doi.org\/10.1038\/jes.2014.64","relation":{},"ISSN":["1559-0631","1559-064X"],"issn-type":[{"value":"1559-0631","type":"print"},{"value":"1559-064X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,24]]},"assertion":[{"value":"6 May 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}