{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:54:03Z","timestamp":1770537243980,"version":"3.49.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T00:00:00Z","timestamp":1242950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hum Genet"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1038\/jhg.2009.46","type":"journal-article","created":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T09:17:59Z","timestamp":1242983879000},"page":"437-439","source":"Crossref","is-referenced-by-count":16,"title":["No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population"],"prefix":"10.1038","volume":"54","author":[{"given":"Takeshi","family":"Otowa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiya","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagisa","family":"Sugaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanobu","family":"Minato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Nakagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Tochigi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Umekage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoto","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobumasa","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Tanii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisanobu","family":"Kaiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,5,22]]},"reference":[{"key":"BFjhg200946_CR1","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1176\/ajp.151.3.413","volume":"151","author":"WW Eaton","year":"1994","unstructured":"Eaton, W. W., Kessler, R. C., Wittchen, H. U. & Magee, W. J. Panic and panic disorder in the United States. Am. J. Psychiatry 151, 413\u2013420 (1994).","journal-title":"Am. J. Psychiatry"},{"key":"BFjhg200946_CR2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1001\/archpsyc.1997.01830160021003","volume":"54","author":"MM Weissman","year":"1997","unstructured":"Weissman, M. M., Bland, R. C., Canino, G. J., Faravelli, C., Greenwald, S. & Hwu, H. G. et al. The cross-national epidemiology of panic disorder. Arch. Gen. Psychiatry 54, 305\u2013309 (1997).","journal-title":"Arch. Gen. Psychiatry"},{"key":"BFjhg200946_CR3","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1001\/archpsyc.1983.01790090027004","volume":"40","author":"RR Crowe","year":"1983","unstructured":"Crowe, R. R., Noyes, R., Pauls, D. L. & Slymen, D. A family study of panic disorder. Arch. Gen. Psychiatry 40, 1065\u20131069 (1983).","journal-title":"Arch. Gen. Psychiatry"},{"key":"BFjhg200946_CR4","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1001\/archpsyc.1997.01830150097014","volume":"54","author":"RB Goldstein","year":"1997","unstructured":"Goldstein, R. B., Wickramaratne, P. J., Horwath, E. & Weissman, M. M. Familial aggregation and phenomenology of \u2018early\u2019-onset (at or before age 20 years) panic disorder. Arch. Gen. Psychiatry 54, 271\u2013278 (1997).","journal-title":"Arch. Gen. Psychiatry"},{"key":"BFjhg200946_CR5","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1176\/appi.ajp.158.10.1568","volume":"158","author":"JM Hettema","year":"2001","unstructured":"Hettema, J. M., Neale, M. C. & Kendler, K. S. A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am. J. Psychiatry 158, 1568\u20131578 (2001).","journal-title":"Am. J. Psychiatry"},{"key":"BFjhg200946_CR6","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1001\/archpsyc.1992.01820090044008","volume":"49","author":"KS Kendler","year":"1992","unstructured":"Kendler, K. S., Neale, M. C., Kessler, R. C., Heath, A. C. & Eaves, L. J. Major depression and generalized anxiety disorder. Same genes, (partly) different environments? Arch. Gen. Psychiatry 49, 716\u2013722 (1992).","journal-title":"Arch. Gen. Psychiatry"},{"key":"BFjhg200946_CR7","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1192\/bjp.142.2.126","volume":"142","author":"S Torgersen","year":"1983","unstructured":"Torgersen, S. Genetics of neurosis. The effects of sampling variation upon the twin concordance ratio. Br. J. Psychiatry 142, 126\u2013132 (1983).","journal-title":"Br. J. Psychiatry"},{"key":"BFjhg200946_CR8","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/0896-6273(93)90326-M","volume":"10","author":"VE Koliatsos","year":"1993","unstructured":"Koliatsos, V. E., Clatterbuck, R. E., Winslow, J. W., Cayouette, M. H. & Price, D. L. Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo. Neuron 10, 359\u2013367 (1993).","journal-title":"Neuron"},{"key":"BFjhg200946_CR9","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/0166-2236(94)90099-X","volume":"17","author":"RM Lindsay","year":"1994","unstructured":"Lindsay, R. M., Wiegand, S. J., Altar, C. A. & DiStefano, P. S. Neurotrophic factors: from molecule to man. Trends Neurosci. 17, 182\u2013190 (1994).","journal-title":"Trends Neurosci."},{"key":"BFjhg200946_CR10","doi-asserted-by":"publisher","first-page":"7929","DOI":"10.1523\/JNEUROSCI.15-12-07929.1995","volume":"15","author":"LA Mamounas","year":"1995","unstructured":"Mamounas, L. A., Blue, M. E., Siuciak, J. A. & Altar, C. A. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. J. Neurosci. 15, 7929\u20137939 (1995).","journal-title":"J. Neurosci."},{"key":"BFjhg200946_CR11","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/35075076","volume":"411","author":"O Guillin","year":"2001","unstructured":"Guillin, O., Diaz, J., Carroll, P., Griffon, N., Schwartz, J. C. & Sokoloff, P. BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization. Nature 411, 86\u201389 (2001).","journal-title":"Nature"},{"key":"BFjhg200946_CR12","doi-asserted-by":"publisher","first-page":"7539","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995","volume":"15","author":"M Nibuya","year":"1995","unstructured":"Nibuya, M., Morinobu, S. & Duman, R. S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci. 15, 7539\u20137547 (1995).","journal-title":"J. Neurosci."},{"key":"BFjhg200946_CR13","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1111\/j.1600-0447.1997.tb09654.x","volume":"95","author":"E Jonsson","year":"1997","unstructured":"Jonsson, E., Brene, S., Zhang, X. R., Nimgaonkar, V. L., Tylec, A., Schalling, M. et al. Schizophrenia and neurotrophin-3 alleles. Acta. Psychiatr. Scand. 95, 414\u2013419 (1997).","journal-title":"Acta. Psychiatr. Scand."},{"key":"BFjhg200946_CR14","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0168-0102(97)00030-8","volume":"28","author":"T Ueyama","year":"1997","unstructured":"Ueyama, T., Kawai, Y., Nemoto, K., Sekimoto, M., Tone, S. & Senba, E. Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain. Neurosci. Res. 28, 103\u2013110 (1997).","journal-title":"Neurosci. Res."},{"key":"BFjhg200946_CR15","doi-asserted-by":"publisher","first-page":"15239","DOI":"10.1073\/pnas.96.26.15239","volume":"96","author":"WE Lyons","year":"1999","unstructured":"Lyons, W. E., Mamounas, L. A., Ricaurte, G. A., Coppola, V., Reid, S. W., Bora, S. H. et al. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc. Natl Acad. Sci. USA 96, 15239\u201315244 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFjhg200946_CR16","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/sj.mp.4000952","volume":"7","author":"M Ventriglia","year":"2002","unstructured":"Ventriglia, M., Bocchio Chiavetto, L., Benussi, L., Binetti, G., Zanetti, O., Riva, M. A. et al. Association between the BDNF 196 A\/G polymorphism and sporadic Alzheimer's disease. Mol. Psychiatry 7, 136\u2013137 (2002).","journal-title":"Mol. Psychiatry"},{"key":"BFjhg200946_CR17","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1086\/377003","volume":"73","author":"D Hall","year":"2003","unstructured":"Hall, D., Dhilla, A., Charalambous, A., Gogos, J. A. & Karayiorgou, M. Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Am. J. Hum. Genet. 73, 370\u2013376 (2003).","journal-title":"Am. J. Hum. Genet."},{"key":"BFjhg200946_CR18","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/sj.mp.4001058","volume":"7","author":"P Sklar","year":"2002","unstructured":"Sklar, P., Gabriel, S. B., McInnis, M. G., Bennett, P., Lim, Y. M., Tsan, G. et al. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol. Psychiatry 7, 579\u2013593 (2002).","journal-title":"Mol. Psychiatry"},{"key":"BFjhg200946_CR19","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/ajmg.b.20153","volume":"127B","author":"H Koizumi","year":"2004","unstructured":"Koizumi, H., Hashimoto, K., Itoh, K., Nakazato, M., Shimizu, E., Ohgake, S. et al. Association between the brain-derived neurotrophic factor 196G\/A polymorphism and eating disorders. Am. J. Med. Genet. B Neuropsychiatr. Genet. 127B, 125\u2013127 (2004).","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"BFjhg200946_CR20","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","volume":"112","author":"MF Egan","year":"2003","unstructured":"Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A. et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257\u2013269 (2003).","journal-title":"Cell"},{"key":"BFjhg200946_CR21","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/sj.npp.1300053","volume":"28","author":"S Sen","year":"2003","unstructured":"Sen, S., Nesse, R. M., Stoltenberg, S. F., Li, S., Gleiberman, L. Chakravarti, A. et al. A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsychopharmacology 28, 397\u2013401 (2003).","journal-title":"Neuropsychopharmacology"},{"key":"BFjhg200946_CR22","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s00213-004-2137-7","volume":"180","author":"UE Lang","year":"2005","unstructured":"Lang, U. E., Hellweg, R., Kalus, P., Bajbouj, M., Lenzen, K. P., Sander, T. et al. Association of a functional BDNF polymorphism and anxiety-related personality traits. Psychopharmacology (Berl) 180, 95\u201399 (2005).","journal-title":"Psychopharmacology (Berl)"},{"key":"BFjhg200946_CR23","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/ajmg.b.20118","volume":"126B","author":"E Shimizu","year":"2004","unstructured":"Shimizu, E., Hashimoto, K. & Iyo, M. Ethnic difference of the BDNF 196G\/A (val66met) polymorphism frequencies: the possibility to explain ethnic mental traits. Am. J. Med. Genet. B Neuropsychiatr. Genet. 126B, 122\u2013123 (2004).","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"BFjhg200946_CR24","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.pnpbp.2005.04.018","volume":"29","author":"E Shimizu","year":"2005","unstructured":"Shimizu, E., Hashimoto, K., Koizumi, H., Kobayashi, K., Itoh, K., Mitsumori, M. et al. No association of the brain-derived neurotrophic factor (BDNF) gene polymorphisms with panic disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 29, 708\u2013712 (2005).","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"BFjhg200946_CR25","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1159\/000077362","volume":"49","author":"P Lam","year":"2004","unstructured":"Lam, P., Cheng, C. Y., Hong, C. J. & Tsai, S. J. Association study of a brain-derived neurotrophic factor (Val66Met) genetic polymorphism and panic disorder. Neuropsychobiology 49, 178\u2013181 (2004).","journal-title":"Neuropsychobiology"},{"issue":"Suppl 20","key":"BFjhg200946_CR26","first-page":"22","volume":"59","author":"DV Sheehan","year":"1998","unstructured":"Sheehan, D. V., Lecrubier, Y., Sheehan, K. H., Amorim, P., Janavs, J., Weiller, E. et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 59 (Suppl 20), 22\u201333; quiz 34\u201357 (1998).","journal-title":"J. Clin. Psychiatry"},{"key":"BFjhg200946_CR27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/genetics\/49.1.49","volume":"49","author":"RC Lewontin","year":"1964","unstructured":"Lewontin, R. C. The interaction of selection and linkage. I. General considerations; heterotic models. Genetics 49, 49\u201367 (1964).","journal-title":"Genetics"},{"key":"BFjhg200946_CR28","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1126\/science.1069424","volume":"296","author":"SB Gabriel","year":"2002","unstructured":"Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J. Blumenstiel, B. et al. The structure of haplotype blocks in the human genome. Science 296, 2225\u20132229 (2002).","journal-title":"Science"},{"key":"BFjhg200946_CR29","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett, J. C., Fry, B., Maller, J. & Daly, M. J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263\u2013265 (2005).","journal-title":"Bioinformatics"}],"container-title":["Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/jhg200946.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/jhg200946","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/jhg200946.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:26:01Z","timestamp":1684430761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jhg200946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,22]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["BFjhg200946"],"URL":"https:\/\/doi.org\/10.1038\/jhg.2009.46","relation":{},"ISSN":["1434-5161","1435-232X"],"issn-type":[{"value":"1434-5161","type":"print"},{"value":"1435-232X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,22]]}}}