{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:13:14Z","timestamp":1774264394760,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2009,8,28]],"date-time":"2009-08-28T00:00:00Z","timestamp":1251417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hum Genet"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1038\/jhg.2009.83","type":"journal-article","created":{"date-parts":[[2009,8,28]],"date-time":"2009-08-28T09:16:44Z","timestamp":1251451004000},"page":"595-602","source":"Crossref","is-referenced-by-count":11,"title":["Impact of ACE and ApoE polymorphisms on myocardial perfusion: correlation with myocardial single photon emission computed tomographic imaging"],"prefix":"10.1038","volume":"54","author":[{"given":"Panagiotis","family":"Georgoulias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greta","family":"Wozniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Samara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioanna","family":"Chiotoglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelos","family":"Kontos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chara","family":"Tzavara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varvara","family":"Valotassiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianthi","family":"Georgitsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassiliki","family":"Aleporou-Marinou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George P","family":"Patrinos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagoula","family":"Kollia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,8,28]]},"reference":[{"key":"BFjhg200983_CR1","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1016\/S0140-6736(96)07492-2","volume":"349","author":"CJ Murray","year":"1997","unstructured":"Murray, C. J & Lopez, A. D. Alternative projections of mortality and disability by cause 1990\u20132020: global burden of disease study. Lancet 349, 1498\u20131504 (1997).","journal-title":"Lancet"},{"key":"BFjhg200983_CR2","doi-asserted-by":"publisher","first-page":"309S","DOI":"10.1093\/ajh\/6.11.309S","volume":"6","author":"PW Wilson","year":"1993","unstructured":"Wilson, P. W. & Evans, J. C. Coronary artery disease prediction. Am. J. Hypertens. 6, 309S\u2013313S (1993).","journal-title":"Am. J. Hypertens."},{"key":"BFjhg200983_CR3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0009-8981(96)06443-1","volume":"257","author":"DJ Galton","year":"1997","unstructured":"Galton, D. J. Genetic determinants of atherosclerosis-related dyslipidemias and their clinical implications. Clin. Chim. Acta. 257, 181\u2013197 (1997).","journal-title":"Clin. Chim. Acta."},{"key":"BFjhg200983_CR4","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1126\/science.1061815","volume":"292","author":"JL Goldstein","year":"2001","unstructured":"Goldstein, J. L. & Brown, M. S. The cholesterol quartet. Science 292, 1310\u20131312 (2001).","journal-title":"Science"},{"key":"BFjhg200983_CR5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1517\/14622416.1.1.73","volume":"1","author":"BR Winkelmann","year":"2000","unstructured":"Winkelmann, B. R. & Hager, J. Genetic variation in coronary heart disease and myocardial infarction methodological overview and clinical evidence. Pharmacogenomics 1, 73\u201394 (2000).","journal-title":"Pharmacogenomics"},{"key":"BFjhg200983_CR6","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0167-5273(01)00466-1","volume":"80","author":"PA Doevendans","year":"2001","unstructured":"Doevendans, P. A., Jukema, W., Spiering, W., Defesche, J. C. & Kastelein, J. J. Molecular genetics and gene expression in atherosclerosis. Int. J. Cardiol. 80, 105\u2013106 (2001).","journal-title":"Int. J. Cardiol."},{"key":"BFjhg200983_CR7","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.cpcardiol.2006.05.002","volume":"31","author":"RR Russell","year":"2006","unstructured":"Russell, R. R. & Zaret, L. B. Nuclear Cardiology: present and future. Curr. Probl. Cardiol. 31, 557\u2013629 (2006).","journal-title":"Curr. Probl. Cardiol."},{"key":"BFjhg200983_CR8","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1146\/annurev.genom.1.1.507","volume":"1","author":"RW Mahley","year":"2000","unstructured":"Mahley, R. W. & Rall, S. C. Apolipoprotein E: far more than a lipid transport protein. Annu. Rev. Genomics Hum. Genet. 1, 507\u2013537 (2000).","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"BFjhg200983_CR9","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1093\/hmg\/7.3.533","volume":"7","author":"JC Lambert","year":"1998","unstructured":"Lambert, J. C., Pasquier, F., Cottel, D., Frigard, B., Amouyel, P. & Chartier-Harlin, M. C. A new polymorphism in the ApoE promoter associated with risk of developing Alzheimer's disease. Hum. Mol. Genet. 7, 533\u2013540 (1998).","journal-title":"Hum. Mol. Genet."},{"key":"BFjhg200983_CR10","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/0002-9149(93)90732-R","volume":"71","author":"JE Eichner","year":"1993","unstructured":"Eichner, J. E., Kuller, L. H., Orchard, T. J., Gradits, G. A., McCallum, L. M., Ferrell, R. E. et al. Relation of apolipoprotein E phenotype to myocardial infarction and mortality from coronary artery disease. Am. J. Cardiol. 71, 160\u2013165 (1993).","journal-title":"Am. J. Cardiol."},{"key":"BFjhg200983_CR11","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/jcla.20044","volume":"18","author":"T Sakuma","year":"2004","unstructured":"Sakuma, T., Hirata, R. D. & Hirata, M. H. Five polymorphisms in gene candidates for cardiovascular disease in Afro\u2013Brazilian individuals. J. Clin. Lab. Anal. 18, 309\u2013316 (2004).","journal-title":"J. Clin. Lab. Anal."},{"key":"BFjhg200983_CR12","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s00259-005-1779-y","volume":"32","author":"B Hesse","year":"2005","unstructured":"Hesse, B., T\u00e4gil, K., Cuocolo, A., Anagnostopoulos, C., Bardies, M., Bax, J. et al. EANM\/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology. Eur. J. Nucl. Med. 32, 855\u2013897 (2005).","journal-title":"Eur. J. Nucl. Med."},{"key":"BFjhg200983_CR13","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1097\/MNM.0b013e328013ebd7","volume":"28","author":"P Georgoulias","year":"2007","unstructured":"Georgoulias, P., Demakopoulos, N., Orfanakis, A., Xydis, K., Xaplanteris, P., Vardas, P. et al. Evaluation of abnormal heart-rate recovery after exercise testing in patients with diabetes mellitus: correlation with myocardial SPECT and chronotropic parameters. Nucl. Med. Commun. 28, 165\u2013171 (2007).","journal-title":"Nucl. Med. Commun."},{"key":"BFjhg200983_CR14","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"SA Miller","year":"1988","unstructured":"Miller, S. A., Dykes, D. D. & Polesky, H. F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids. Res. 16, 1215\u20131216 (1988).","journal-title":"Nucleic Acids. Res."},{"key":"BFjhg200983_CR15","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1093\/nar\/20.6.1433-a","volume":"20","author":"B Rigat","year":"1992","unstructured":"Rigat, B., Hubert, C., Corvol, P. & Soubrier, F. PCR detection of the insertion\/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids. Res. 20, 1433\u20131438 (1992).","journal-title":"Nucleic Acids. Res."},{"key":"BFjhg200983_CR16","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1101\/gr.3.2.120","volume":"3","author":"V Shanmugam","year":"1993","unstructured":"Shanmugam, V., Sell, K. W. & Saha, B. K. Mistyping ACE heterozygotes. PCR Methods Appl. 3, 120\u2013121 (1993).","journal-title":"PCR Methods Appl."},{"key":"BFjhg200983_CR17","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-2275(20)43176-1","volume":"31","author":"JE Hixson","year":"1990","unstructured":"Hixson, J. E. & Vernier, D. T. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J. Lipid Res. 31, 545\u2013548 (1990).","journal-title":"J. Lipid Res."},{"key":"BFjhg200983_CR18","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1161\/01.CIR.91.2.580","volume":"91","author":"GF Fletcher","year":"1995","unstructured":"Fletcher, G. F., Balady, G., Froelicher, V. F., Hartley, L. H., Haskell, W. L. & Pollock, M. L. Exercise standards. A statement for healthcare professionals from the American Heart Association Writing Group. Circulation 91, 580\u2013615 (1995).","journal-title":"Circulation"},{"key":"BFjhg200983_CR19","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/S1071-3581(03)00530-0","volume":"10","author":"P Georgoulias","year":"2003","unstructured":"Georgoulias, P., Orfanakis, A., Demakopoulos, N., Xaplanteris, P., Mortzos, G., Vardas, P. et al. Abnormal heart rate recovery immediately after treadmill testing: correlation with clinical, exercise testing, and myocardial perfusion parameters. J. Nucl. Cardiol. 10, 498\u2013505 (2003).","journal-title":"J. Nucl. Cardiol."},{"key":"BFjhg200983_CR20","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1007\/s00259-002-0998-8","volume":"29","author":"A Kapur","year":"2002","unstructured":"Kapur, A., Latus, K. A., Davies, G., Dhawan, R. T., Eastick, S., Jarrit, P. H. et al. A comparison of three radionuclide myocardial perfusion tracers in clinical practice: the ROBUST study. Eur. J. Nucl. Med. 29, 1608\u20131616 (2002).","journal-title":"Eur. J. Nucl. Med."},{"key":"BFjhg200983_CR21","first-page":"240","volume":"9","author":"MD Cerquira","year":"2002","unstructured":"Cerquira, M. D., Weissman, N. J., Dilsizian, V., Jacobs, A. K., Kaul, S., Laskey, W. K. et al. Standarized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. J. Nucl. Med. 9, 240\u2013245 (2002).","journal-title":"J. Nucl. Med."},{"key":"BFjhg200983_CR22","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S1071-3581(99)90070-3","volume":"6","author":"AE Iskarndrian","year":"1999","unstructured":"Iskarndrian, A. E. Risk assessment of stable patients (panel III). In Wintergreen panel summaries. J. Nucl. Cardiol. 6, 93\u201397 (1999).","journal-title":"J. Nucl. Cardiol."},{"key":"BFjhg200983_CR23","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.1547-5069.2005.00055.x","volume":"37","author":"L Frazier","year":"2005","unstructured":"Frazier, L., Johnson, R. L. & Sparks, E. Genomics and cardiovascular disease. J. Nurs. Scholarship 37, 315\u2013321 (2005).","journal-title":"J. Nurs. Scholarship"},{"key":"BFjhg200983_CR24","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00259-003-1344-5","volume":"31","author":"SR Underwood","year":"2004","unstructured":"Underwood, S. R., Anagnostopoulos, C., Cerquira, M., Ell, P. J., Flint, J., Harbinson, M. et al. Myocardial perfusion scintigraphy: the evidence of a consensus conference organised by the British Cardiac Society, the British Nuclear Cardiology Society and the British Nuclear Medicine Society, endorsed by the Royal College of Physicians of London and the Royal College of Radiologists. Eur. J. Nucl. Med. 31, 261\u2013291 (2004).","journal-title":"Eur. J. Nucl. Med."},{"key":"BFjhg200983_CR25","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s004390000358","volume":"107","author":"K Uemura","year":"2000","unstructured":"Uemura, K., Nakura, J., Kohara, K. & Miki, T. Association of ACE I\/D polymorphism with cardiovascular risk factors. Hum. Genet. 107, 239\u2013242 (2000).","journal-title":"Hum. Genet."},{"key":"BFjhg200983_CR26","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1161\/01.ATV.20.2.484","volume":"20","author":"B Agerholm-Larsen","year":"2000","unstructured":"Agerholm-Larsen, B., Nordestgaard, B. G. & Tybjaerg-Hansen, A. ACE gene polymorphism in cardiovascular disease. Meta-analyses of small and large studies in whites. Arterioscler. Thromb. Vasc. Biol. 20, 484\u2013492 (2000).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"BFjhg200983_CR27","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1536\/ihj.38.227","volume":"38","author":"FT Chiang","year":"1997","unstructured":"Chiang, F. T., Lai, Z. P., Chern, T. H., Tseng, C. D., Hsu, K. L., Lo, H. M. et al. Lack of association between angiotensin-converting enzyme gene polymorphism and coronary heart disease in a Chinese population. Jpn. Heart. J. 38, 227\u2013236 (1997).","journal-title":"Jpn. Heart. J."},{"key":"BFjhg200983_CR28","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1016\/S0895-7061(97)00323-3","volume":"10","author":"T Fujimura","year":"1997","unstructured":"Fujimura, T., Yokota, M., Kato, S., Hirayama, H., Tsunekawa, A., Inaqaki, H. et al. Lack of association of angiotensin converting enzyme gene polymorphism or serum enzyme activity with coronary heart disease in Japanese subjects. Am. J. Hypertens. 10, 1384\u20131390 (1997).","journal-title":"Am. J. Hypertens."},{"key":"BFjhg200983_CR29","first-page":"31","volume":"10","author":"J Barley","year":"1996","unstructured":"Barley, J., Blackwood, A., Miller, M., Markandu, N. D., Carter, N. D., Jeffery, S. et al. Angiotensin-converting enzyme gene I\/D polymorphism, blood pressure and the rennin-angiotensin system in Caucasian and Afro\u2013Caribbean peoples. J. Hum. Hypertens. 10, 31\u201335 (1996).","journal-title":"J. Hum. Hypertens."},{"key":"BFjhg200983_CR30","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1053\/euhj.1999.1738","volume":"21","author":"C Fatini","year":"2000","unstructured":"Fatini, C., Abbate, R., Pepe, G., Battaqlini, B., Gensini, F., Ruqqiano, G. et al. Searching for a better assessment of the individual coronary risk profile. The role of angiotensin-converting enzyme, angiotensin II type 1 receptor and angiotensinogen gene polymorphisms. Eur. Heart. J. 21, 633\u2013638 (2000).","journal-title":"Eur. Heart. J."},{"key":"BFjhg200983_CR31","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0021-9150(00)00570-0","volume":"154","author":"C Lahoz","year":"2001","unstructured":"Lahoz, C., Schaefer, E. J., Cupples, L. A., Wilson, P. W., Levy, D., Osqood, D. et al. Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis 154, 529\u2013537 (2001).","journal-title":"Atherosclerosis"},{"key":"BFjhg200983_CR32","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1093\/aje\/155.6.487","volume":"155","author":"JE Eichner","year":"2002","unstructured":"Eichner, J. E., Dunn, S. T., Preveen, G., Thompson, D. M., Stuart, K. E. & Stroehla, C. B. Apolipoprtotein E polymorphism and cardiovasular disease: a huge review. Am. J. Epidemiol. 155, 487\u2013495 (2002).","journal-title":"Am. J. Epidemiol."},{"key":"BFjhg200983_CR33","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/clc.4960230506","volume":"23","author":"AP Mansur","year":"2000","unstructured":"Mansur, A. P., Annicchio-Bizzacchi, J., Favarato, D., Avakian, S. D., Cesar, L. A. & Ramires, J. A. Angiotensin-converting enzyme and apolipoproteins genes polymorphism in coronary artery disease. Clin. Cardiol. 23, 335\u2013340 (2000).","journal-title":"Clin. Cardiol."},{"key":"BFjhg200983_CR34","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1185\/030079902125000444","volume":"18","author":"G Kolovou","year":"2002","unstructured":"Kolovou, G., Yiannakouris, N., Hatzivassiliou, M., Malakos, J., Daskalova, D., Hatzigeorgiou, G. et al. Association of apoliprotein E polymorphism with myocardial infarction in Greek patients with coronary artery disease. Curr. Med. Res. Opin. 18, 118\u2013124 (2002).","journal-title":"Curr. Med. Res. Opin."},{"key":"BFjhg200983_CR35","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1177\/000331970305400107","volume":"54","author":"GD Kolovou","year":"2003","unstructured":"Kolovou, G. D., Daskalova, D. C., Hatzivassiliou, M., Yiannakouris, N., Pilatis, N. D., Elisaf, M. et al. The epsilon 2 and 4 alleles of apolipoprotein E and ischemic vascular events in the Greek population-implications for the interpretation of similar studies. Angiology 54, 51\u201358 (2003).","journal-title":"Angiology"},{"key":"BFjhg200983_CR36","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1177\/147323000703500114","volume":"35","author":"G Giassakis","year":"2006","unstructured":"Giassakis, G., Veletza, S., Papanas, N., Heliopoulos, I. & Piperidou, H. Apolipoprotein E and first-ever ischaemic stroke in Greek hospitalized patients. J. Int. Med. Res. 35, 127\u2013133 (2006).","journal-title":"J. Int. Med. Res."},{"key":"BFjhg200983_CR37","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1067\/mhj.2000.106165","volume":"139","author":"E Brscic","year":"2000","unstructured":"Brscic, E., Bergerone, S., Gagnor, A., Colajanni, E., Matullo, G., Scaglione, L. et al. Acute myocardial infarction in young adults: prognostic role of angiotensin-converting enzyme, angiotensin II type I receptor, apolipoprotein E, endothelial constitutive nitric oxide synthase and glycoprotein IIIa genetic polymorphisms at medium-term follow-up. Am. Heart. J. 139, 979\u2013984 (2000).","journal-title":"Am. Heart. J."},{"key":"BFjhg200983_CR38","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/sj.ejhg.5200983","volume":"11","author":"S Ye","year":"2003","unstructured":"Ye, S., Dunleavey, L., Bannister, W., Day, L. B., Tapper, W., Collins, A. R. et al. Independent effects of the -219 G>T and \u025b2\/\u025b3\/\u025b4 polymorphisms in the apolipoprotein E gene on the coronary artery disease: the Southampton Atherosclerosis study. Eur. J. Hum. Genet. 11, 437\u2013443 (2003).","journal-title":"Eur. J. Hum. Genet."},{"key":"BFjhg200983_CR39","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0014-5793(97)01543-3","volume":"421","author":"MJ Artiga","year":"1998","unstructured":"Artiga, M. J., Bullido, M. J., Sastre, I., Recuero, M., Garc\u00eda, M. A., Aldudo, J. et al. Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene. FEBS Lett. 421, 105\u2013108 (1998).","journal-title":"FEBS Lett."},{"key":"BFjhg200983_CR40","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00259-004-1745-0","volume":"32","author":"G Sambuceti","year":"2005","unstructured":"Sambuceti, G. Differences and similarities between coronary atherosclerosis and ischaemic heart disease: implications for cardiac imaging. Eur. J. Nucl. Med. Mol. Imaging 32, 385\u2013388 (2005).","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"}],"container-title":["Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/jhg200983.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/jhg200983","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/jhg200983.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:26:25Z","timestamp":1684430785000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jhg200983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,28]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["BFjhg200983"],"URL":"https:\/\/doi.org\/10.1038\/jhg.2009.83","relation":{},"ISSN":["1434-5161","1435-232X"],"issn-type":[{"value":"1434-5161","type":"print"},{"value":"1435-232X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,28]]}}}