{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:44:47Z","timestamp":1792719887945,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Genet"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1038\/jhg.2014.98","type":"journal-article","created":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T12:02:05Z","timestamp":1415880125000},"page":"35-40","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association of neonatal hyperbilirubinemia in breast-fed infants with UGT1A1 or SLCOs polymorphisms"],"prefix":"10.1038","volume":"60","author":[{"given":"Hiroko","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Toyota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Tamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyako","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeko","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuraaki","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Hayasaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,13]]},"reference":[{"key":"BFjhg201498_CR1","first-page":"1345","volume-title":"In Neonatal-Perinatal Medicine","author":"LP Halamek","year":"1997","unstructured":"Halamek, L. P . & Stevenson, D. K . In Neonatal-Perinatal Medicine (eds Fanaroff A. A., Martin R. J.) 1345\u20131389 (Mosby-Year Book: St. Louis, 1997)."},{"key":"BFjhg201498_CR2","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1042\/bj1960257","volume":"196","author":"N Kawade","year":"1981","unstructured":"Kawade, N . & Onishi, S . The prenatal and postnatal development of UDPglucuronyltransferase activity towards bilirubin and the effect of premature birth on this activity in the human liver. Biochem. J. 196, 257\u2013260 (1981).","journal-title":"Biochem. J"},{"key":"BFjhg201498_CR3","doi-asserted-by":"publisher","first-page":"12128","DOI":"10.1073\/pnas.94.22.12128","volume":"94","author":"M Kaplan","year":"1997","unstructured":"Kaplan, M ., Renbaum, P ., Levy-Lahad, E ., Hammerman, C ., Lahad, A . & Beutler, E . Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: a dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia. Proc. Natl Acad. Sci. USA 94, 12128\u201312132 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFjhg201498_CR4","first-page":"21","volume":"46","author":"K Akaba","year":"1998","unstructured":"Akaba, K ., Kimura, T ., Sasaki, A ., Tanabe, S ., Ikegami, T ., Hashimoto, M . et al. Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: a common missense mutation among Japanese, Koreans and Chinese. Biochem. Mol. Biol. Int. 46, 21\u201326 (1998).","journal-title":"Biochem. Mol. Biol. Int"},{"key":"BFjhg201498_CR5","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s100380050100","volume":"44","author":"K Akaba","year":"1999","unstructured":"Akaba, K ., Kimura, T ., Sasaki, A ., Tanabe, S ., Wakabayashi, T ., Hiroi, M . et al. Neonatal hyperbilirubinemia and a common mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese. J. Hum. Genet. 44, 22\u201325 (1999).","journal-title":"J. Hum. Genet"},{"key":"BFjhg201498_CR6","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1111\/j.1442-200X.2011.03337.x","volume":"53","author":"J Long","year":"2011","unstructured":"Long, J ., Zhang, S ., Fang, X ., Luo, Y . & Liu, J . Association of neonatal hyperbilirubinemia with uridine diphosphate-glucuronosyltransferase 1A1 gene polymorphisms: meta-analysis. Pediatr. Int. 53, 530\u2013540 (2011).","journal-title":"Pediatr. Int"},{"key":"BFjhg201498_CR7","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1203\/PDR.0b013e31820263d2","volume":"69","author":"HC Chou","year":"2011","unstructured":"Chou, H. C ., Chen, M. H ., Yang, H. I ., Su, Y. N ., Hsieh, W. S ., Chen, C. Y . et al. 211 G to A variation of UDP-glucuronosyltransferase 1A1 gene and neonatal breastfeeding jaundice. Pediatr. Res. 69, 170\u2013174 (2011).","journal-title":"Pediatr. Res"},{"key":"BFjhg201498_CR8","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.jpeds.2011.03.042","volume":"159","author":"PF Chang","year":"2011","unstructured":"Chang, P. F ., Lin, Y. C ., Liu, K ., Yeh, S. J . & Ni, Y. H . Risk of hyperbilirubinemia in breast-fed Infants. J. Pediatr. 159, 561\u2013565 (2011).","journal-title":"J. Pediatr"},{"key":"BFjhg201498_CR9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1053\/siny.2002.0101","volume":"7","author":"GR Gourley","year":"2002","unstructured":"Gourley, G. R . Breast-feeding, neonatal jaundice and kernicterus. Semin. Neonatol. (2002) 7, 135\u2013141.","journal-title":"Semin. Neonatol"},{"key":"BFjhg201498_CR10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/jhg.2012.116","volume":"58","author":"H Sato","year":"2013","unstructured":"Sato, H ., Uchida, T ., Toyota, K ., Kanno, M ., Hashimoto, T ., Watanabe, M . et al. Association of breast-fed neonatal hyperbilirubinemia with UGT1A1 polymorphisms: 211 G>A (G71R) mutation becomes a risk factor under inadequate feeding. J. Hum. Genet. 58, 7\u201310 (2013).","journal-title":"J. Hum. Genet"},{"key":"BFjhg201498_CR11","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1203\/01.PDR.0000141846.37253.AF","volume":"56","author":"M Huang","year":"2004","unstructured":"Huang, M ., Kua, K ., Teng, H ., Tang, K ., Weng, H . & Huang, C . Risk factors for severe hyperbilirubinemia in neonates. Pediatr. Res. 56, 682\u2013689 (2004).","journal-title":"Pediatr. Res"},{"key":"BFjhg201498_CR12","doi-asserted-by":"publisher","first-page":"2942","DOI":"10.1172\/JCI42168","volume":"120","author":"E van de Steeg","year":"2010","unstructured":"van de Steeg, E ., Wagenaar, E ., van der Kruijssen, C. M ., Burggraaff, J. E ., de Waart, D. R ., Elferink, R. P . et al. Organic anion transporting polypeptide 1a\/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. J. Clin. Invest. 120, 2942\u20132952 (2010).","journal-title":"J. Clin. Invest"},{"key":"BFjhg201498_CR13","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1053\/j.gastro.2014.03.047","volume":"146","author":"S Erlinger","year":"2014","unstructured":"Erlinger, S ., Arias, I. M . & Dhumeaux, D . Inherited disorders of bilirubin transport and conjugation: new insights into molecular mechanisms and consequences. Gastroenterology 146, 1625\u20131638 (2014).","journal-title":"Gastroenterology"},{"key":"BFjhg201498_CR14","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/pr.2012.60","volume":"72","author":"L Alencastro de Azevedo","year":"2012","unstructured":"Alencastro de Azevedo, L ., Reverbel da Silveira, T ., Carvalho, C. G ., Martins de Castro, S ., Giugliani, R . & Matte, U . UGT1A1, SLCO1B1, and SLCO1B3 polymorphisms vs. neonatal hyperbilirubinemia: is there an association? Pediatr. Res. 72, 169\u2013173 (2012).","journal-title":"Pediatr. Res"},{"key":"BFjhg201498_CR15","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/BF00283692","volume":"81","author":"DC Jinks","year":"1989","unstructured":"Jinks, D. C ., Minter, M ., Tarver, D. A ., Vanderford, M ., Hejtmancik, J. F . & McCabe, E. R . Molecular genetic diagnosis of sickle cell disease using dried blood specimens on blotters used for neonate screening. Hum. Genet. 81, 363\u2013366 (1989).","journal-title":"Hum. Genet"},{"key":"BFjhg201498_CR16","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.clinbiochem.2007.03.007","volume":"40","author":"LM Baudhuin","year":"2007","unstructured":"Baudhuin, L. M ., Highsmith, W. E ., Skierka, J ., Holtegaard, L ., Moore, B. E . & O'Kane, D. J . Comparison of three methods for genotyping the UGT1A1 (TA)n repeat polymorphism. Clin. Biochem. 40, 710\u2013717 (2007).","journal-title":"Clin. Biochem"},{"key":"BFjhg201498_CR17","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0925-4439(98)00013-1","volume":"1406","author":"K Yamamoto","year":"1998","unstructured":"Yamamoto, K ., Sato, H ., Fujiyama, Y ., Doida, Y . & Bamba, T . Contribution of two missense mutations (G71R and Y486D) of the bilirubin UDP glycosyltransferase UGT1A1\/ gene to phenotypes of Gilbert\u2019s syndrome and Crigler\u2013Najjar syndrome type II. Biophys. Biochim. Acta 1406, 267\u2013273 (1998).","journal-title":"Biophys. Biochim. Acta"},{"key":"BFjhg201498_CR18","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/j.1442-200x.2005.02030.x","volume":"47","author":"M Kanai","year":"2005","unstructured":"Kanai, M ., Kijima, K ., Shirahata, E ., Sasaki, A ., Akaba, K ., Umetsu, K . et al. Neonatal hyperbilirubinemia and the bilirubin uridine diphosphate-glucuronosyl- transferase gene: the common -3263T >G mutation of phenobarbital response enhancer module is not associated with the neonatal hyperbilirubinemia in Japanese. Pediatr. Int. 47, 137\u2013141 (2005).","journal-title":"Pediatr. Int"},{"key":"BFjhg201498_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1203\/01.PDR.0000072329.56635.35","volume":"54","author":"M Kanai","year":"2003","unstructured":"Kanai, M ., Akaba, K ., Sasaki, A ., Sato, M ., Harano, T ., Shibahara, S . et al. Neonatal hyperbilirubinemia in Japanese neonates: analysis of the heme oxygenase-1 gene and fetal hemoglobin composition in cord blood. Pediatr. Res. 54, 165\u2013171 (2003).","journal-title":"Pediatr. Res"},{"key":"BFjhg201498_CR20","doi-asserted-by":"publisher","first-page":"8170","DOI":"10.1073\/pnas.95.14.8170","volume":"95","author":"E Beutler","year":"1998","unstructured":"Beutler, E ., Gelbart, T . & Demina, A . Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc. Natl Acad. Sci. USA 95, 8170\u20138174 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFjhg201498_CR21","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1056\/NEJM199511023331802","volume":"333","author":"PJ Bosma","year":"1995","unstructured":"Bosma, P. J ., Chowdhury, J. R ., Bakker, C ., Gantla, S ., de Boer, A ., Oostra, B. A . et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N. Engl. J. Med. 333, 1171\u20131175 (1995).","journal-title":"N. Engl. J. Med"},{"key":"BFjhg201498_CR22","doi-asserted-by":"publisher","first-page":"9626","DOI":"10.1074\/jbc.M004968200","volume":"276","author":"Y Cui","year":"2001","unstructured":"Cui, Y ., Konig, J ., Leier, I ., Buchholz, U . & Keppler, D . Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J. Biol. Chem. 276, 9626\u20139963 (2001).","journal-title":"J. Biol. Chem"},{"key":"BFjhg201498_CR23","doi-asserted-by":"publisher","first-page":"20695","DOI":"10.1074\/jbc.M301100200","volume":"278","author":"P Wang","year":"2003","unstructured":"Wang, P ., Kim, R. B ., Chowdhury, J. R . & Wolkoff, A. W . The human organic anion transport protein is not sufficient for bilirubin transport. J. Biol. Chem. 278, 20695\u201320699 (2003).","journal-title":"J. Biol. Chem"},{"key":"BFjhg201498_CR24","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1080\/00498250801986951","volume":"38","author":"B Hagenbuch","year":"2008","unstructured":"Hagenbuch, B . & Gui, C . Xenobiotic ransporters of the human organic anion transporting polypeptides (OATP) family. Xenobiotica 38, 778\u2013801 (2008).","journal-title":"Xenobiotica"},{"key":"BFjhg201498_CR25","doi-asserted-by":"publisher","first-page":"106","DOI":"10.2133\/dmpk.DMPK-11-RV-099","volume":"27","author":"T Nakanishi","year":"2012","unstructured":"Nakanishi, T . & Tamai, I . Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs. Drug Metab. Pharmacokinet. 27, 106\u2013121 (2012).","journal-title":"Drug Metab. Pharmacokinet"},{"key":"BFjhg201498_CR26","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1172\/JCI59526","volume":"122","author":"E Steeg","year":"2012","unstructured":"Steeg, E ., Stranecky, V ., Hartmannova, H ., Noskova, L ., Hrebicek, M ., Wagenaar, E . et al. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J. Clin. Invest. 122, 519\u2013528 (2012).","journal-title":"J. Clin. Invest"},{"key":"BFjhg201498_CR27","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1542\/peds.112.3.607","volume":"112","author":"KG Dewey","year":"2003","unstructured":"Dewey, K. G ., Nommsen-Rivers, L. A ., Heinig, M. J . & Cohen, R. J . Risk factors for suboptimal infant breastfeeding behavior, delayed onset of lactation, and excess neonatal weight loss. Pediatrics 112, 607\u2013619 (2003).","journal-title":"Pediatrics"},{"key":"BFjhg201498_CR28","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1136\/adc.2004.060079","volume":"90","author":"R Keren","year":"2005","unstructured":"Keren, R ., Bhutani, V. K ., Luan, X ., Nihtianova, S ., Cnaan, A . & Schwartz, J. S . Identifying newborns at risk of significant hyperbilirubinaemia: a comparison of two recommended approaches. Arch. Dis. Child. 90, 415\u2013421 (2005).","journal-title":"Arch. Dis. Child"},{"key":"BFjhg201498_CR29","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/S0140-6736(74)92212-0","volume":"2","author":"AA Calder","year":"1974","unstructured":"Calder, A. A ., Ounsted, M. K ., Moar, V. A . & Turnbull, A. C . Increased bilirubin levels in neonates after induction of labour by intravenous prostaglandin E2 or oxytocin. Lancet 2, 1339\u20131342 (1974).","journal-title":"Lancet"}],"container-title":["Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/jhg201498.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/jhg201498","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/jhg201498.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:33:24Z","timestamp":1684431204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jhg201498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,13]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["BFjhg201498"],"URL":"https:\/\/doi.org\/10.1038\/jhg.2014.98","relation":{},"ISSN":["1434-5161","1435-232X"],"issn-type":[{"value":"1434-5161","type":"print"},{"value":"1435-232X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,13]]},"assertion":[{"value":"30 July 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors decalre no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}