{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:31:03Z","timestamp":1779377463007,"version":"3.53.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:00:00Z","timestamp":1497484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Genet"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1038\/jhg.2017.61","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T06:21:05Z","timestamp":1497507665000},"page":"903-909","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Meta-analysis of genome-wide SNP- and pathway-based associations for facets of neuroticism"],"prefix":"10.1038","volume":"62","author":[{"given":"Song E","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Na","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeo-Jun","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Gu","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Jung","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoosoo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungho","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hocheol","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chol","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam H","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Ah","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Lae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"BFjhg201761_CR1","doi-asserted-by":"publisher","first-page":"e32413","DOI":"10.1371\/journal.pone.0032413","volume":"7","author":"E Reynaud","year":"2012","unstructured":"Reynaud, E., El Khoury-Malhame, M., Rossier, J., Blin, O. & Khalfa, S. Neuroticism modifies psychophysiological responses to fearful films. PLoS ONE 7, e32413 (2012).","journal-title":"PLoS ONE"},{"key":"BFjhg201761_CR2","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.cpr.2013.04.003","volume":"33","author":"J Ormel","year":"2013","unstructured":"Ormel, J., Jeronimus, B. F., Kotov, R., Riese, H., Bos, E. H., Hankin, B. et al. Neuroticism and common mental disorders: meaning and utility of a complex relationship. Clin. Psychol. Rev. 33, 686\u2013697 (2013).","journal-title":"Clin. Psychol. Rev."},{"key":"BFjhg201761_CR3","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1037\/a0023035","volume":"120","author":"TA Brown","year":"2011","unstructured":"Brown, T. A. & Rosellini, A. J. The direct and interactive effects of neuroticism and life stress on the severity and longitudinal course of depressive symptoms. J. Abnormal. Psychol. 120, 844\u2013856 (2011).","journal-title":"J. Abnormal. Psychol."},{"key":"BFjhg201761_CR4","volume-title":"Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) Professional Manual","author":"P Costa","year":"1992","unstructured":"Costa, P. & McCrae, R. Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) Professional Manual, Psychological Assessment Resources, Odessa, FL, USA, (1992)."},{"key":"BFjhg201761_CR5","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/sj.mp.4002048","volume":"13","author":"S Shifman","year":"2008","unstructured":"Shifman, S., Bhomra, A., Smiley, S., Wray, N. R., James, M. R., Martin, N. G. et al. A whole genome association study of neuroticism using DNA pooling. Mol. Psychiatry 13, 302\u2013312 (2008).","journal-title":"Mol. Psychiatry"},{"key":"BFjhg201761_CR6","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/mp.2008.113","volume":"15","author":"A Terracciano","year":"2010","unstructured":"Terracciano, A., Sanna, S., Uda, M., Deiana, B., Usala, G., Busonero, F. et al. Genome-wide association scan for five major dimensions of personality. Mol. Psychiatry 15, 647\u2013656 (2010).","journal-title":"Mol. Psychiatry"},{"key":"BFjhg201761_CR7","doi-asserted-by":"publisher","first-page":"e11504","DOI":"10.1371\/journal.pone.0011504","volume":"5","author":"FC Calboli","year":"2010","unstructured":"Calboli, F. C., Tozzi, F., Galwey, N. W., Antoniades, A., Mooser, V., Preisig, M. et al. A genome-wide association study of neuroticism in a population-based sample. PLoS ONE 5, e11504 (2010).","journal-title":"PLoS ONE"},{"key":"BFjhg201761_CR8","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/jhg.2013.75","volume":"58","author":"HN Kim","year":"2013","unstructured":"Kim, H. N., Roh, S. J., Sung, Y. A., Chung, H. W., Lee, J. Y., Cho, J. et al. Genome-wide association study of the five-factor model of personality in young Korean women. J. Hum. Genet. 58, 667\u2013674 (2013).","journal-title":"J. Hum. Genet."},{"key":"BFjhg201761_CR9","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.biopsych.2010.06.030","volume":"68","author":"A Terracciano","year":"2010","unstructured":"Terracciano, A., Tanaka, T., Sutin, A. R., Sanna, S., Deiana, B., Lai, S. et al. Genome-wide association scan of trait depression. Biol. Psychiatry 68, 811\u2013817 (2010).","journal-title":"Biol. Psychiatry"},{"key":"BFjhg201761_CR10","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1038\/mp.2016.177","volume":"21","author":"DJ Smith","year":"2016","unstructured":"Smith, D. J., Escott-Price, V., Davies, G., Bailey, M. E., Colodro-Conde, L., Ward, J. et al. Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci. Mol. Psychiatry 21, 1644 (2016).","journal-title":"Mol. Psychiatry"},{"key":"BFjhg201761_CR11","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/ng.3552","volume":"48","author":"A Okbay","year":"2016","unstructured":"Okbay, A., Baselmans, B. M., De Neve, J. E., Turley, P., Nivard, M. G., Fontana, M. A. et al. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat. Genet. 48, 624\u2013633 (2016).","journal-title":"Nat. Genet."},{"key":"BFjhg201761_CR12","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1001\/jamapsychiatry.2015.0554","volume":"72","author":"MH de Moor","year":"2015","unstructured":"de Moor, M. H., van den Berg, S. M., Verweij, K. J., Krueger, R. F., Luciano, M., Arias Vasquez, A. et al. Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder. JAMA Psychiatry 72, 642\u2013650 (2015).","journal-title":"JAMA Psychiatry"},{"key":"BFjhg201761_CR13","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1037\/0022-3514.74.6.1556","volume":"74","author":"KL Jang","year":"1998","unstructured":"Jang, K. L., McCrae, R. R., Angleitner, A., Riemann, R. & Livesley, W. J. Heritability of facet-level traits in a cross-cultural twin sample: support for a hierarchical model of personality. J. Personal. Soc. Psychol. 74, 1556\u20131565 (1998).","journal-title":"J. Personal. Soc. Psychol."},{"key":"BFjhg201761_CR14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nrg1521","volume":"6","author":"JN Hirschhorn","year":"2005","unstructured":"Hirschhorn, J. N. & Daly, M. J. Genome-wide association studies for common diseases and complex traits. Nat. Rev. Genet. 6, 95\u2013108 (2005).","journal-title":"Nat. Rev. Genet."},{"key":"BFjhg201761_CR15","doi-asserted-by":"publisher","first-page":"e1001058","DOI":"10.1371\/journal.pgen.1001058","volume":"6","author":"AV Segre","year":"2010","unstructured":"Segre, A. V., Groop, L., Mootha, V. K., Daly, M. J. & Altshuler, D. Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet 6, e1001058 (2010).","journal-title":"PLoS Genet"},{"key":"BFjhg201761_CR16","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/gbb.12212","volume":"14","author":"HN Kim","year":"2015","unstructured":"Kim, H. N., Kim, B. H., Cho, J., Ryu, S., Shin, H., Sung, J. et al. Pathway analysis of genome-wide association datasets of personality traits. Genes Brain Behav 14, 345\u2013356 (2015).","journal-title":"Genes Brain Behav"},{"key":"BFjhg201761_CR17","doi-asserted-by":"publisher","first-page":"e89441","DOI":"10.1371\/journal.pone.0089441","volume":"9","author":"LE Duncan","year":"2014","unstructured":"Duncan, L. E., Holmans, P. A., Lee, P. H., O'Dushlaine, C. T., Kirby, A. W., Smoller, J. W. et al. Pathway analyses implicate glial cells in schizophrenia. PLoS ONE 9, e89441 (2014).","journal-title":"PLoS ONE"},{"key":"BFjhg201761_CR18","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/ng.357","volume":"41","author":"YS Cho","year":"2009","unstructured":"Cho, Y. S., Go, M. J., Kim, Y. J., Heo, J. Y., Oh, J. H., Ban, H. J. et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat. Genet. 41, 527\u2013534 (2009).","journal-title":"Nat. Genet."},{"key":"BFjhg201761_CR19","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/jhg.2015.52","volume":"60","author":"BH Kim","year":"2015","unstructured":"Kim, B. H., Kim, H. N., Roh, S. J., Lee, M. K., Yang, S., Lee, S. K. et al. GWA meta-analysis of personality in Korean cohorts. J. Hum. Genet. 60, 455\u2013460 (2015).","journal-title":"J. Hum. Genet."},{"key":"BFjhg201761_CR20","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jhep.2013.03.035","volume":"59","author":"CW Kim","year":"2013","unstructured":"Kim, C. W., Yun, K. E., Jung, H. S., Chang, Y., Choi, E. S., Kwon, M. J. et al. Sleep duration and quality in relation to non-alcoholic fatty liver disease in middle-aged workers and their spouses. J. Hepatol 59, 351\u2013357 (2013).","journal-title":"J. Hepatol"},{"key":"BFjhg201761_CR21","first-page":"443","volume":"9","author":"C Ahn","year":"1997","unstructured":"Ahn, C. & Chae, J. Standardization of the Korean version of the Revised NEO Personality Inventory. Korean J. Counsel. Psychother. 9, 443\u2013473 (1997).","journal-title":"Korean J. Counsel. Psychother."},{"key":"BFjhg201761_CR22","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nrg2796","volume":"11","author":"J Marchini","year":"2010","unstructured":"Marchini, J. & Howie, B. Genotype imputation for genome-wide association studies. Nat. Rev. Genet. 11, 499\u2013511 (2010).","journal-title":"Nat. Rev. Genet."},{"key":"BFjhg201761_CR23","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/gepi.20297","volume":"32","author":"F Dudbridge","year":"2008","unstructured":"Dudbridge, F. & Gusnanto, A. Estimation of significance thresholds for genomewide association scans. Genet. Epidemiol. 32, 227\u2013234 (2008).","journal-title":"Genet. Epidemiol."},{"key":"BFjhg201761_CR24","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1126\/science.2017683","volume":"252","author":"EA Finch","year":"1991","unstructured":"Finch, E. A., Turner, T. J. & Goldin, S. M. Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release. Science 252, 443\u2013446 (1991).","journal-title":"Science"},{"key":"BFjhg201761_CR25","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1007\/s12311-011-0270-5","volume":"10","author":"J Goto","year":"2011","unstructured":"Goto, J. & Mikoshiba, K. Inositol 1,4,5-trisphosphate receptor-mediated calcium release in Purkinje cells: from molecular mechanism to behavior. Cerebellum 10, 820\u2013833 (2011).","journal-title":"Cerebellum"},{"key":"BFjhg201761_CR26","doi-asserted-by":"publisher","first-page":"23757","DOI":"10.1038\/srep23757","volume":"6","author":"S Chung","year":"2016","unstructured":"Chung, S., Kim, I. H., Lee, D., Park, K., Kim, J. Y., Lee, Y. K. et al. The role of inositol 1,4,5-trisphosphate 3-kinase A in regulating emotional behavior and amygdala function. Sci. Rep. 6, 23757 (2016).","journal-title":"Sci. Rep."},{"key":"BFjhg201761_CR27","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.neuroscience.2012.09.029","volume":"227","author":"K Kurokawa","year":"2012","unstructured":"Kurokawa, K., Mizuno, K. & Ohkuma, S. Possible involvement of type 1 inositol 1,4,5-trisphosphate receptors up-regulated by dopamine D1 and D2 receptors in mouse nucleus accumbens neurons in the development of methamphetamine-induced place preference. Neuroscience 227, 22\u201329 (2012).","journal-title":"Neuroscience"},{"key":"BFjhg201761_CR28","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1007\/s11920-012-0264-0","volume":"14","author":"S Pasche","year":"2012","unstructured":"Pasche, S. Exploring the comorbidity of anxiety and substance use disorders. Curr. Psychiatry Rep. 14, 176\u2013181 (2012).","journal-title":"Curr. Psychiatry Rep."},{"key":"BFjhg201761_CR29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fpsyt.2012.00039","volume":"3","author":"N Mellios","year":"2012","unstructured":"Mellios, N. & Sur, M. The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders. Front. Psychiatry 3, 39 (2012).","journal-title":"Front. Psychiatry"},{"key":"BFjhg201761_CR30","doi-asserted-by":"publisher","first-page":"208","DOI":"10.2174\/1871527314666150116124253","volume":"14","author":"V Caputo","year":"2015","unstructured":"Caputo, V., Ciolfi, A., Macri, S. & Pizzuti, A. The emerging role of MicroRNA in schizophrenia. CNS Neurol. Disord. Drug Targets 14, 208\u2013221 (2015).","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"BFjhg201761_CR31","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/sj.cr.7290260","volume":"15","author":"R Nusse","year":"2005","unstructured":"Nusse, R. Wnt signaling in disease and in development. Cell Res. 15, 28\u201332 (2005).","journal-title":"Cell Res."},{"key":"BFjhg201761_CR32","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1001\/archpsyc.65.7.785","volume":"65","author":"PP Zandi","year":"2008","unstructured":"Zandi, P. P., Belmonte, P. L., Willour, V. L., Goes, F. S., Badner, J. A., Simpson, S. G. et al. Association study of Wnt signaling pathway genes in bipolar disorder. Arch. Gen. Psychiatry 65, 785\u2013793 (2008).","journal-title":"Arch. Gen. Psychiatry"},{"key":"BFjhg201761_CR33","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/j.neuroimage.2010.02.065","volume":"53","author":"B Inkster","year":"2010","unstructured":"Inkster, B., Nichols, T. E., Saemann, P. G., Auer, D. P., Holsboer, F., Muglia, P. et al. Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression. NeuroImage 53, 908\u2013917 (2010).","journal-title":"NeuroImage"},{"key":"BFjhg201761_CR34","doi-asserted-by":"publisher","first-page":"15506","DOI":"10.1073\/pnas.0406788101","volume":"101","author":"SJ Evans","year":"2004","unstructured":"Evans, S. J., Choudary, P. V., Neal, C. R., Li, J. Z., Vawter, M. P., Tomita, H. et al. Dysregulation of the fibroblast growth factor system in major depression. Proc. Natl Acad. Sci. USA 101, 15506\u201315511 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFjhg201761_CR35","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/ajmg.b.32230","volume":"165B","author":"EM Byrne","year":"2014","unstructured":"Byrne, E. M., Heath, A. C., Madden, P. A., Pergadia, M. L., Hickie, I. B., Montgomery, G. W. et al. Testing the role of circadian genes in conferring risk for psychiatric disorders. Am. J. Med. Genet. B Neuropsychiatr. Genet. 165B, 254\u2013260 (2014).","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"BFjhg201761_CR36","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1097\/YPG.0b013e32834acd07","volume":"22","author":"AC Edwards","year":"2012","unstructured":"Edwards, A. C., Aliev, F., Bierut, L. J., Bucholz, K. K., Edenberg, H., Hesselbrock, V. et al. Genome-wide association study of comorbid depressive syndrome and alcohol dependence. Psychiatr. Genet. 22, 31\u201341 (2012).","journal-title":"Psychiatr. Genet."},{"key":"BFjhg201761_CR37","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1002\/ajmg.b.32072","volume":"159B","author":"M Luciano","year":"2012","unstructured":"Luciano, M., Huffman, J. E., Arias-Vasquez, A., Vinkhuyzen, A. A., Middeldorp, C. M., Giegling, I. et al. Genome-wide association uncovers shared genetic effects among personality traits and mood states. Am J. Med. Genet. B Neuropsychiatr. Genet. 159B, 684\u2013695 (2012).","journal-title":"Am J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"BFjhg201761_CR38","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.neuroscience.2006.02.033","volume":"140","author":"N Franco-Pons","year":"2006","unstructured":"Franco-Pons, N., Virgos, C., Vogel, W. F., Urena, J. M., Soriano, E., del Rio, J. A. et al. Expression of discoidin domain receptor 1 during mouse brain development follows the progress of myelination. Neuroscience 140, 463\u2013475 (2006).","journal-title":"Neuroscience"},{"key":"BFjhg201761_CR39","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/sj.mp.4001995","volume":"12","author":"B Roig","year":"2007","unstructured":"Roig, B., Virgos, C., Franco, N., Martorell, L., Valero, J., Costas, J. et al. The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia. Mol. Psychiatry 12, 833\u2013841 (2007).","journal-title":"Mol. Psychiatry"},{"key":"BFjhg201761_CR40","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/jhg.2008.17","volume":"54","author":"T Otowa","year":"2009","unstructured":"Otowa, T., Yoshida, E., Sugaya, N., Yasuda, S., Nishimura, Y., Inoue, K. et al. Genome-wide association study of panic disorder in the Japanese population. J. Hum. Genet 54, 122\u2013126 (2009).","journal-title":"J. Hum. Genet"},{"key":"BFjhg201761_CR41","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1146\/annurev.cb.10.110194.001343","volume":"10","author":"P van der Geer","year":"1994","unstructured":"van der Geer, P., Hunter, T. & Lindberg, R. A. Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10, 251\u2013337 (1994).","journal-title":"Annu. Rev. Cell Biol."},{"key":"BFjhg201761_CR42","doi-asserted-by":"publisher","first-page":"e116","DOI":"10.1038\/tp.2012.37","volume":"2","author":"SK Service","year":"2012","unstructured":"Service, S. K., Verweij, K. J., Lahti, J., Congdon, E., Ekelund, J., Hintsanen, M. et al. A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. Transl. Psychiatry 2, e116 (2012).","journal-title":"Transl. Psychiatry"},{"key":"BFjhg201761_CR43","doi-asserted-by":"publisher","first-page":"611","DOI":"10.3109\/15622975.2013.782107","volume":"14","author":"A Schosser","year":"2013","unstructured":"Schosser, A., Butler, A. W., Uher, R., Ng, M. Y., Cohen-Woods, S., Craddock, N. et al. Genome-wide association study of co-occurring anxiety in major depression. World J. Biol. Psychiatry 14, 611\u2013621 (2013).","journal-title":"World J. Biol. Psychiatry"},{"key":"BFjhg201761_CR44","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/mp.2014.43","volume":"20","author":"M Mattheisen","year":"2015","unstructured":"Mattheisen, M., Samuels, J. F., Wang, Y., Greenberg, B. D., Fyer, A. J., McCracken, J. T. et al. Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. Mol. Psychiatry 20, 337\u2013344 (2015).","journal-title":"Mol. Psychiatry"},{"key":"BFjhg201761_CR45","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/aur.1536","volume":"9","author":"X Liu","year":"2016","unstructured":"Liu, X., Shimada, T., Otowa, T., Wu, Y. Y., Kawamura, Y., Tochigi, M. et al. Genome-wide association study of autism spectrum disorder in the east asian populations. Autism Res. 9, 340\u2013349 (2016).","journal-title":"Autism Res."},{"key":"BFjhg201761_CR46","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/mp.2009.57","volume":"15","author":"J Elia","year":"2010","unstructured":"Elia, J., Gai, X., Xie, H. M., Perin, J. C., Geiger, E., Glessner, J. T. et al. Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes. Mol. Psychiatry 15, 637\u2013646 (2010).","journal-title":"Mol. Psychiatry"},{"key":"BFjhg201761_CR47","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ydbio.2004.08.009","volume":"275","author":"SE Ensslen-Craig","year":"2004","unstructured":"Ensslen-Craig, S. E. & Brady-Kalnay, S. M. Receptor protein tyrosine phosphatases regulate neural development and axon guidance. Dev. Biol 275, 12\u201322 (2004).","journal-title":"Dev. Biol"},{"key":"BFjhg201761_CR48","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nrm2957","volume":"11","author":"JT Parsons","year":"2010","unstructured":"Parsons, J. T., Horwitz, A. R. & Schwartz, M. A. Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat. Rev. Mol. Cell Biol. 11, 633\u2013643 (2010).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFjhg201761_CR49","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.biopsych.2013.01.020","volume":"74","author":"Y Fan","year":"2013","unstructured":"Fan, Y., Abrahamsen, G., Mills, R., Calderon, C. C., Tee, J. Y., Leyton, L. et al. Focal adhesion dynamics are altered in schizophrenia. Biol. Psychiatry 74, 418\u2013426 (2013).","journal-title":"Biol. Psychiatry"},{"key":"BFjhg201761_CR50","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2458-9-13","volume":"9","author":"DJ Terasaki","year":"2009","unstructured":"Terasaki, D. J., Gelaye, B., Berhane, Y. & Williams, M. A. Anger expression, violent behavior, and symptoms of depression among male college students in Ethiopia. BMC Public Health 9, 13 (2009).","journal-title":"BMC Public Health"},{"key":"BFjhg201761_CR51","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0896-6273(00)80510-3","volume":"21","author":"MJ Berridge","year":"1998","unstructured":"Berridge, M. J. Neuronal calcium signaling. Neuron 21, 13\u201326 (1998).","journal-title":"Neuron"},{"key":"BFjhg201761_CR52","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/0024-3205(77)90471-4","volume":"20","author":"JD Lane","year":"1977","unstructured":"Lane, J. D. & Aprison, M. H. Calcium-dependent release of endogenous serotonin, dopamine and norepinephrine from nerve endings. Life Sci 20, 665\u2013671 (1977).","journal-title":"Life Sci"},{"key":"BFjhg201761_CR53","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3389\/fnhum.2015.00489","volume":"9","author":"DJ Stein","year":"2015","unstructured":"Stein, D. J. Social anxiety disorder and the psychobiology of self-consciousness. Front. Hum. Neurosci. 9, 489 (2015).","journal-title":"Front. Hum. Neurosci."},{"key":"BFjhg201761_CR54","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/mp.2016.49","volume":"21","author":"DJ Smith","year":"2016","unstructured":"Smith, D. J., Escott-Price, V., Davies, G., Bailey, M. E., Colodro-Conde, L., Ward, J. et al. Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci. Mol. Psychiatry 21, 749\u2013757 (2016).","journal-title":"Mol. Psychiatry"}],"container-title":["Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/jhg201761.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/jhg201761","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/jhg.2017.61","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/jhg201761.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:36:14Z","timestamp":1684431374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jhg201761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,15]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["BFjhg201761"],"URL":"https:\/\/doi.org\/10.1038\/jhg.2017.61","relation":{},"ISSN":["1434-5161","1435-232X"],"issn-type":[{"value":"1434-5161","type":"print"},{"value":"1435-232X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,15]]},"assertion":[{"value":"7 March 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}