{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:57:36Z","timestamp":1791107856373,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Hypertens"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1038\/jhh.2013.106","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T09:15:44Z","timestamp":1382606144000},"page":"316-322","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Do level and variability of systolic blood pressure predict arterial properties or vice versa?"],"prefix":"10.1038","volume":"28","author":[{"given":"Y-P","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-M","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Thijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Asayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kuznetsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Verhamme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Van Bortel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H A J","family":"Struijker-Boudier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Staessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,10,24]]},"reference":[{"key":"BFjhh2013106_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacc.2006.12.050","volume":"50","author":"MF O'Rourke","year":"2007","unstructured":"O'Rourke MF, Hashimoto J . Mechanical factors in arterial aging. A clinical perspective. J Am Coll Cardiol 2007; 50: 1\u201313.","journal-title":"J Am Coll Cardiol"},{"key":"BFjhh2013106_CR2","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.1161\/01.CIR.0000069826.36125.B4","volume":"107","author":"ME Safar","year":"2003","unstructured":"Safar ME, Levy BI, Struijker-Boudier H . Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases. Circulation 2003; 107: 2864\u20132869.","journal-title":"Circulation"},{"key":"BFjhh2013106_CR3","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1097\/00004872-199005000-00001","volume":"8","author":"J Staessen","year":"1990","unstructured":"Staessen J, Amery A, Fagard R . Editorial review. Isolated systolic hypertension in the elderly. J Hypertens 1990; 8: 393\u2013405.","journal-title":"J Hypertens"},{"key":"BFjhh2013106_CR4","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1097\/HJH.0b013e32834f41b1","volume":"30","author":"J Sung","year":"2012","unstructured":"Sung J, Choi SH, Choi YH, Kim DK, Park WH . The relationship between arterial stiffness and increase in blood pressure during exercise in normtensive persons. J Hypertens 2012; 30: 587\u2013591.","journal-title":"J Hypertens"},{"key":"BFjhh2013106_CR5","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s00421-009-1299-8","volume":"108","author":"K Moriyama","year":"2010","unstructured":"Moriyama K, Ifuku H . Increased cardiovascular reactivity to the cold pressor test is not associated with increased reactivity to isometric handgrip exercise. Eur J Appl Physiol 2010; 108: 837\u2013843.","journal-title":"Eur J Appl Physiol"},{"key":"BFjhh2013106_CR6","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S0140-6736(10)60308-X","volume":"375","author":"PM Rothwell","year":"2010","unstructured":"Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahl\u00f6f B et al. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 2010; 375: 895\u2013905.","journal-title":"Lancet"},{"key":"BFjhh2013106_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1161\/01.HYP.34.1.51","volume":"34","author":"TA Lakka","year":"1999","unstructured":"Lakka TA, Salonen R, Kaplan GA, Salonen JT . Blood pressure and the progression of carotid atherosclerosis in middle-aged men. Hypertension 1999; 34: 51\u201356.","journal-title":"Hypertension"},{"key":"BFjhh2013106_CR8","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1161\/01.CIR.102.13.1536","volume":"102","author":"D Sander","year":"2000","unstructured":"Sander D, Kukla C, Klingelh\u00f6fer J, Winbeck K, Conrad B . Relationship between circadian blood pressure patterns and progression of early carotid atherosclerosis. A 3-year follow-up study. Circulation 2000; 102: 1536\u20131541.","journal-title":"Circulation"},{"key":"BFjhh2013106_CR9","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1161\/hc1002.105135","volume":"105","author":"A Benetos","year":"2002","unstructured":"Benetos A, Adamopoulos C, Bureau JM, Temmar M, Labat C, Bean K et al. Determinants of accelerated progression of arterial stiffness in normotensive subjects and in treated hypertensive subjects over a 6-year period. Circulation 2002; 105: 1202\u20131207.","journal-title":"Circulation"},{"key":"BFjhh2013106_CR10","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1161\/01.HYP.0000115922.98155.23","volume":"43","author":"S Li","year":"2004","unstructured":"Li S, Chen W, Srinivasan SR, Berenson GS . Childhood blood pressure as a predictor of arterial stiffness in young adults. The Bogalusa Heart Study. Hypertension 2004; 43: 541\u2013546.","journal-title":"Hypertension"},{"key":"BFjhh2013106_CR11","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1161\/HYPERTENSIONAHA.110.150896","volume":"56","author":"CM McEniery","year":"2010","unstructured":"McEniery CM, Spratt M, Munnery M, Yarnell J, Lowe GD, Gallacher J et al. An analysis of prospective risk factors for aortic stiffness in men: 20-year follow-up from the Caerphilly prospective study. Hypertension 2010; 56: 36\u201343.","journal-title":"Hypertension"},{"key":"BFjhh2013106_CR12","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1161\/STROKEAHA.111.646596","volume":"43","author":"M Herder","year":"2012","unstructured":"Herder M, Johnsen SH, Arntzen KA, Mathiesen EB . Risk factors for progression of carotid intima-media thickness and total plaque area. A 13-year follow-up study: the Throms\u00f8 Study. Stroke 2012; 43: 1818\u20131823.","journal-title":"Stroke"},{"key":"BFjhh2013106_CR13","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1161\/CIRCULATIONAHA.112.107565","volume":"126","author":"G Mancia","year":"2012","unstructured":"Mancia G, Facchetti R, Parati G, Zanchetti A . Visit-to-visit blood pressure variability, carotid atherosclerosis, and cardiovascular events in the European Lacidipine Study on Atherosclerosis. Circulation 2012; 126: 569\u2013578.","journal-title":"Circulation"},{"key":"BFjhh2013106_CR14","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1001\/2012.jama.10503","volume":"308","author":"BM Kaess","year":"2012","unstructured":"Kaess BM, Rong J, Larson MG, Hamburg NM, Vita JA, Levy D et al. Aortic stiffness, blood pressure progression, and incident hypertension. J Am Med Ass 2012; 308: 875\u2013881.","journal-title":"J Am Med Ass"},{"key":"BFjhh2013106_CR15","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1097\/00004872-200108000-00002","volume":"19","author":"JA Staessen","year":"2001","unstructured":"Staessen JA, Wang JG, Brand E, Barlassina C, Birkenhager WH, Hermann SM et al. Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population. J Hypertens 2001; 19: 1349\u20131358.","journal-title":"J Hypertens"},{"key":"BFjhh2013106_CR16","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1161\/HYPERTENSIONAHA.106.085498","volume":"49","author":"Y Li","year":"2007","unstructured":"Li Y, Zagato L, Kuznetsova T, Tripodi G, Zerbini G, Richart T et al. Angiotensin-converting enzyme I\/D and a-adducin Gly460Trp polymorphisms. From angiotensin-converting enzyme activity to cardiovascular outcome. Hypertension 2007; 49: 1291\u20131297.","journal-title":"Hypertension"},{"key":"BFjhh2013106_CR17","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1161\/hy1101.095992","volume":"38","author":"EJ Balkestein","year":"2001","unstructured":"Balkestein EJ, Staessen JA, Wang JG, van der Heijden-Spek JJ, Van Bortel L, Barlassina C et al. Carotid and femoral artery stiffness in relation to three candidate genes in a white population. Hypertension 2001; 38: 1190\u20131197.","journal-title":"Hypertension"},{"key":"BFjhh2013106_CR18","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1097\/00004872-200208000-00018","volume":"20","author":"EJ Balkestein","year":"2002","unstructured":"Balkestein EJ, Wang JG, Struijker-Boudier HA, Barlassina C, Bianchi G, Birkenhager WH et al. Carotid and femoral intima-media thickness in relation to three candidate genes in a Caucasian population. J Hypertens 2002; 20: 1551\u20131561.","journal-title":"J Hypertens"},{"key":"BFjhh2013106_CR19","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/jhh.2008.113","volume":"23","author":"J Seidlerov\u00e1","year":"2009","unstructured":"Seidlerov\u00e1 J, Staessen JA, Nawrot T, Brand E, Brand-Herrmann SM, Casamassima N et al. Arterial properties in relation to genetic variation in alpha-adducin and the renin-angiotensin system in a White population. J Hum Hypertens 2009; 23: 55\u201364.","journal-title":"J Hum Hypertens"},{"key":"BFjhh2013106_CR20","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1097\/00004872-200106000-00007","volume":"19","author":"LM Van Bortel","year":"2001","unstructured":"Van Bortel LM, Balkestein EJ, van der Heijden-Spek JJ, Vanmolkot FH, Staessen JA, Kragten JA et al. Non-invasive assessment of local arterial pulse pressure: comparison of applanation tonometry and echo-tracking. J Hypertens 2001; 19: 1037\u20131044.","journal-title":"J Hypertens"},{"key":"BFjhh2013106_CR21","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.2337\/diacare.26.11.3160","volume":"26","author":"Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","year":"2003","unstructured":"Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabet Care 2003; 26: S5\u2013S20.","journal-title":"Diabet Care"},{"key":"BFjhh2013106_CR22","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S1474-4422(10)70066-1","volume":"9","author":"PM Rothwell","year":"2010","unstructured":"Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahl\u00f6f B et al. Effects of beta-blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke. Lancet Neurol 2010; 9: 469\u2013480.","journal-title":"Lancet Neurol"},{"key":"BFjhh2013106_CR23","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1097\/01.hjh.0000160205.81652.5a","volume":"23","author":"L Mena","year":"2005","unstructured":"Mena L, Pintos S, Queipo NV, Aizp\u00farua JA, Maestre G, Sulbar\u00e1n T . A reliable index for the prognostic significance of blood pressure variability. J Hypertens 2005; 23: 505\u2013511.","journal-title":"J Hypertens"},{"key":"BFjhh2013106_CR24","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/0895-7061(94)00249-B","volume":"8","author":"RS Cunha","year":"1995","unstructured":"Cunha RS, Benetos A, Laurent S, Safar ME, Asmar RG . Distension capacity of the carotid artery and ambulatory blood pressure monitoring. Am J Hypertens 1995; 8: 343\u2013352.","journal-title":"Am J Hypertens"},{"key":"BFjhh2013106_CR25","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1212\/WNL.47.2.500","volume":"47","author":"D Sander","year":"1996","unstructured":"Sander D, Klingelh\u00f6fer J . Diurnal systolic blood pressure variability is the strongest predictor of early carotid atherosclerosis. Neurology 1996; 47: 500\u2013507.","journal-title":"Neurology"},{"key":"BFjhh2013106_CR26","first-page":"333","volume":"1","author":"R Asma","year":"1996","unstructured":"Asma R, Scuteri A, Topouchian J, Brisac AM, Maldonado J, Cloarec L et al. Arterial distensibility and circadian blood pressure variability. Blood Press Monit 1996; 1: 333\u2013338.","journal-title":"Blood Press Monit"},{"key":"BFjhh2013106_CR27","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jash.2011.03.001","volume":"5","author":"M Nagai","year":"2011","unstructured":"Nagai M, Hoshide S, Ishikawa J, Shimada K, Kario K . Visit-to-visit blood pressure variations: new independent determinants for carotid artery measures in the elderly at high risk of cardiovascular disease. J Am Soc Hypertens 2011; 5: 184\u2013192.","journal-title":"J Am Soc Hypertens"},{"key":"BFjhh2013106_CR28","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1161\/HYPERTENSIONAHA.112.197491","volume":"60","author":"G Schillaci","year":"2012","unstructured":"Schillaci G, Bilo G, Pucci G, Laurent S, Macquin-Mavier I, Boutouyrie P et al. Relationship between short-term blood pressure variability and large-artery stiffness in human hypertension. Hypertension 2012; 60: 369\u2013377.","journal-title":"Hypertension"},{"key":"BFjhh2013106_CR29","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1097\/HJH.0b013e328172dc2e","volume":"25","author":"Y Shintani","year":"2007","unstructured":"Shintani Y, Kikuya M, Hara A, Ohkubo T, Metoki H, Asayama K et al. Ambulatory blood pressure, blood pressure variability and the prevalence of carotid artery alteration: the Ohasama study. J Hypertens 2007; 25: 1704\u20131710.","journal-title":"J Hypertens"},{"key":"BFjhh2013106_CR30","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/hr.2012.177","volume":"36","author":"M Fukui","year":"2013","unstructured":"Fukui M, Ushigome E, Tanaka M, Hamaguchi M, Tanaka T, Atsuta H et al. Home blood pressure variability on one occasion is a novel factor associated with arterial stiffness in patients with type 2 diabetes. Hypertens Res 2013; 36: 219\u2013225.","journal-title":"Hypertens Res"},{"key":"BFjhh2013106_CR31","doi-asserted-by":"publisher","first-page":"H284","DOI":"10.1152\/ajpheart.2001.281.1.H284","volume":"281","author":"KD Monahan","year":"2001","unstructured":"Monahan KD, Dinenno FA, Seals DR, Clevenger CM, DeSouza CA, Tanaka H . Age-associated changes in cardiovagal baroreflex sensitivity are related to central arterial compliance. Am J Physiol Heart Circ Physiol 2001; 281: H284\u2013H289.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFjhh2013106_CR32","first-page":"H1139","volume":"271","author":"I Bonyhay","year":"1996","unstructured":"Bonyhay I, Jokkel G, Kollai M . Relation between baroreflex sensitivity and carotid artery elasticity in healthy humans. Am J Physiol 1996; 271: H1139\u2013H1144.","journal-title":"Am J Physiol"},{"key":"BFjhh2013106_CR33","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1161\/HYPERTENSIONAHA.111.176560","volume":"59","author":"Y Okada","year":"2012","unstructured":"Okada Y, Galbreath M, Shibata S, Jarvis SS, VanGundy TB, Meier RL et al. Relationship between sympathetic baroreflex sensitivity and arterial stiffness in elderly men and women. Hypertension 2012; 59: 98\u2013104.","journal-title":"Hypertension"},{"key":"BFjhh2013106_CR34","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1097\/HJH.0b013e32811d6a07","volume":"25","author":"FUS Mattace-Raso","year":"2007","unstructured":"Mattace-Raso FUS, van den Meiracker AH, Bos WJ, van der Cammen TJM, Westerhof BE, Elias-Smale S et al. Arterial stiffeness, cardiovagal baroreflex sensitivity and postural blood pressure changes in older adults: The Rotterdam Study. J Hypertens 2007; 25: 1421\u20131426.","journal-title":"J Hypertens"},{"key":"BFjhh2013106_CR35","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1161\/01.HYP.34.2.201","volume":"34","author":"D Liao","year":"1994","unstructured":"Liao D, Arnett DK, Tyroler HA, Riley WA, Chambless LE, Szklo M et al. Arterial stiffness and the development of hypertension. The ARIC study. Hypertension 1994; 34: 201\u2013206.","journal-title":"Hypertension"},{"key":"BFjhh2013106_CR36","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1751-7176.2011.00581.x","volume":"14","author":"P Muntner","year":"2012","unstructured":"Muntner P, Levitan EB, Reynolds K, Mann DM, Tonelli M, Oparil S et al. Within-visit variability of blood pressure and all-cause and cardiovascular mortality among US adults. J Clin Hypertens (Greenwich) 2012; 14: 165\u2013171.","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"BFjhh2013106_CR37","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1161\/HYPERTENSIONAHA.112.202143","volume":"60","author":"R Schutte","year":"2012","unstructured":"Schutte R, Thijs L, Liu YP, Asayama K, Jin Y, Odili A et al. Within-subject blood pressure level\u2014not variability\u2014predicts fatal and nonfatal outcomes in a general population. Hypertension 2012; 60: 1138\u20131147.","journal-title":"Hypertension"}],"container-title":["Journal of Human Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jhh2013106.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jhh2013106","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jhh2013106.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T16:46:38Z","timestamp":1647535598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jhh2013106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,24]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["BFjhh2013106"],"URL":"https:\/\/doi.org\/10.1038\/jhh.2013.106","relation":{},"ISSN":["0950-9240","1476-5527"],"issn-type":[{"value":"0950-9240","type":"print"},{"value":"1476-5527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,24]]},"assertion":[{"value":"12 August 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}