{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:37:27Z","timestamp":1791286647835,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Hypertens"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1038\/jhh.2015.98","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T09:22:04Z","timestamp":1444296124000},"page":"374-378","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["ARMC5 mutation analysis in patients with primary aldosteronism and bilateral adrenal lesions"],"prefix":"10.1038","volume":"30","author":[{"given":"P","family":"Mulatero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Schiavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T A","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Monticone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Barbon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Opocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Fallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,8]]},"reference":[{"key":"BFjhh201598_CR1","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1210\/jc.2003-031337","volume":"89","author":"P Mulatero","year":"2004","unstructured":"Mulatero P, Stowasser M, Loh KC, Fardella CE, Gordon RD, Mosso L et al. Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents. J Clin Endocrinol Metab 2004; 89: 1045\u20131050.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFjhh201598_CR2","doi-asserted-by":"publisher","first-page":"3266","DOI":"10.1210\/jc.2008-0104","volume":"93","author":"JW Funder","year":"2008","unstructured":"Funder JW, Carey RM, Fardella C, Gomez-Sanchez CE, Mantero F, Stowasser M et al. Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2008; 93: 3266\u20133281.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFjhh201598_CR3","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/S2213-8587(14)70069-5","volume":"3","author":"S Monticone","year":"2015","unstructured":"Monticone S, Viola A, Rossato D, Veglio F, Reincke M, Gomez-Sanchez C et al. Adrenal vein sampling in primary aldosteronism: towards a standardised protocol. Lancet Diabetes Endocrinol 2015; 3: 296\u2013303.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"BFjhh201598_CR4","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1126\/science.1198785","volume":"331","author":"M Choi","year":"2011","unstructured":"Choi M, Scholl UI, Yue P, Bj\u00f6rklund P, Zhao B, Nelson-Williams C et al. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science 2011; 331: 768\u2013772.","journal-title":"Science"},{"key":"BFjhh201598_CR5","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/ng.2550","volume":"45","author":"F Beuschlein","year":"2013","unstructured":"Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD et al. Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet 2013; 45: 440\u2013444 444e1-2.","journal-title":"Nat Genet"},{"key":"BFjhh201598_CR6","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/ng.2695","volume":"45","author":"UI Scholl","year":"2013","unstructured":"Scholl UI, Goh G, St\u00f6lting G, de Oliveira RC, Choi M, Overton JD et al. Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism. Nat Genet 2013; 45: 1050\u20131054.","journal-title":"Nat Genet"},{"key":"BFjhh201598_CR7","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/ng.2716","volume":"45","author":"EA Azizan","year":"2013","unstructured":"Azizan EA, Poulsen H, Tuluc P, Zhou J, Clausen MV, Lieb A et al. Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet 2013; 45: 1055\u20131060.","journal-title":"Nat Genet"},{"key":"BFjhh201598_CR8","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.mce.2014.09.015","volume":"399","author":"S Monticone","year":"2015","unstructured":"Monticone S, Else T, Mulatero P, Williams TA, Rainey WE . Understanding primary aldosteronism: impact of next generation sequencing and expression profiling. Mol Cell Endocrinol 2015; 399: 311\u2013320.","journal-title":"Mol Cell Endocrinol"},{"key":"BFjhh201598_CR9","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nrendo.2012.230","volume":"9","author":"P Mulatero","year":"2013","unstructured":"Mulatero P, Monticone S, Rainey WE, Veglio F, Williams TA . Role of KCNJ5 in familial and sporadic primary aldosteronism. Nat Rev Endocrinol 2013; 9: 104\u2013112.","journal-title":"Nat Rev Endocrinol"},{"key":"BFjhh201598_CR10","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1097\/HJH.0b013e3283028352","volume":"26","author":"N Sukor","year":"2008","unstructured":"Sukor N, Mulatero P, Gordon RD, So A, Duffy D, Bertello C et al. Further evidence for linkage of familial hyperaldosteronism type II at chromosome 7p22 in Italian as well as Australian and South American families. J Hypertens 2008; 26: 1577\u20131582.","journal-title":"J Hypertens"},{"key":"BFjhh201598_CR11","doi-asserted-by":"publisher","first-page":"e06315","DOI":"10.7554\/eLife.06315","volume":"4","author":"UI Scholl","year":"2015","unstructured":"Scholl UI, St\u00f6lting G, Nelson-Williams C, Vichot AA, Choi M, Loring E et al. Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism. Elife 2015; 4: e06315.","journal-title":"Elife"},{"key":"BFjhh201598_CR12","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1056\/NEJMoa1304603","volume":"369","author":"G Assi\u00e9","year":"2013","unstructured":"Assi\u00e9 G, Lib\u00e9 R, Espiard S, Rizk-Rabin M, Guimier A, Luscap W et al. ARMC5 mutations in macronodular adrenal hyperplasia with Cushing's syndrome. N Engl J Med 2013; 369: 2105\u20132114.","journal-title":"N Engl J Med"},{"key":"BFjhh201598_CR13","doi-asserted-by":"publisher","first-page":"E1113","DOI":"10.1210\/jc.2013-4280","volume":"99","author":"FR Faucz","year":"2014","unstructured":"Faucz FR, Zilbermint M, Lodish MB, Szarek E, Trivellin G, Sinaii N et al. Macronodular adrenal hyperplasia due to mutations in an armadillo repeat containing 5 (ARMC5) gene: a clinical and genetic investigation. J Clin Endocrinol Metab 2014; 99: E1113\u2013E1119.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFjhh201598_CR14","doi-asserted-by":"publisher","first-page":"E900","DOI":"10.1210\/jc.2014-4167","volume":"100","author":"M Zilbermint","year":"2015","unstructured":"Zilbermint M, Xekouki P, Faucz FR, Berthon A, Gkourogianni A, Helene Schernthaner-Reiter M et al. Primary aldosteronism and ARMC5 variants. J Clin Endocrinol Metab 2015; 100: E900\u2013E909.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFjhh201598_CR15","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1161\/HYPERTENSIONAHA.113.01733","volume":"63","author":"TA Williams","year":"2014","unstructured":"Williams TA, Monticone S, Schack VR, Stindl J, Burrello J, Buffolo F et al. Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas. Hypertension 2014; 63: 188\u2013195.","journal-title":"Hypertension"},{"key":"BFjhh201598_CR16","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1097\/HJH.0b013e32834937f3","volume":"29","author":"F Fallo","year":"2011","unstructured":"Fallo F, Bertello C, Tizzani D, Fassina A, Boulkroun S, Sonino N et al. Concurrent primary aldosteronism and subclinical cortisol hypersecretion: a prospective study. J Hypertens 2011; 29: 1773\u20131777.","journal-title":"J Hypertens"},{"key":"BFjhh201598_CR17","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1161\/HYPERTENSIONAHA.114.03419","volume":"64","author":"FL Fernandes-Rosa","year":"2014","unstructured":"Fernandes-Rosa FL, Williams TA, Riester A, Steichen O, Beuschlein F, Boulkroun S et al. Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma. Hypertension 2014; 64: 354\u2013361.","journal-title":"Hypertension"},{"key":"BFjhh201598_CR18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/(SICI)1098-1004(200001)15:1<7::AID-HUMU4>3.0.CO;2-N","volume":"15","author":"JT den Dunnen","year":"2000","unstructured":"den Dunnen JT, Antonarakis SE . Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion. Hum Mutat 2000; 15: 7\u201312.","journal-title":"Hum Mutat"},{"key":"BFjhh201598_CR19","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1161\/HYPERTENSIONAHA.111.175083","volume":"58","author":"P Mulatero","year":"2011","unstructured":"Mulatero P, Tizzani D, Viola A, Bertello C, Monticone S, Mengozzi G et al. Prevalence and characteristics of familial hyperaldosteronism: the PATOGEN study (Primary Aldosteronism in TOrino-GENetic forms). Hypertension 2011; 58: 797\u2013803.","journal-title":"Hypertension"},{"key":"BFjhh201598_CR20","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","volume":"285","author":"National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults","year":"2001","unstructured":"National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486\u20132497.","journal-title":"JAMA"},{"key":"BFjhh201598_CR21","doi-asserted-by":"publisher","first-page":"E1567","DOI":"10.1210\/jc.2011-3132","volume":"97","author":"S Monticone","year":"2012","unstructured":"Monticone S, Hattangady NG, Nishimoto K, Mantero F, Rubin B, Cicala MV et al. Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells. J Clin Endocrinol Metab 2012; 97: E1567\u2013E1572.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFjhh201598_CR22","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1210\/en.2011-1733","volume":"153","author":"K Oki","year":"2012","unstructured":"Oki K, Plonczynski MW, Lam ML, Gomez-Sanchez EP, Gomez-Sanchez CE . Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis. Endocrinology 2012; 153: 1774\u20131782.","journal-title":"Endocrinology"},{"key":"BFjhh201598_CR23","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1210\/jc.2014-1062","volume":"99","author":"CE Gomez-Sanchez","year":"2014","unstructured":"Gomez-Sanchez CE . Channels and pumps in aldosterone-producing adenomas. J Clin Endocrinol Metab 2014; 99: 1152\u20131156.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFjhh201598_CR24","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.mce.2014.12.004","volume":"408","author":"CE Gomez-Sanchez","year":"2015","unstructured":"Gomez-Sanchez CE, Kuppusamy M, Gomez-Sanchez EP . Somatic mutations of the ATP1A1 gene and aldosterone-producing adenomas. Mol Cell Endocrinol 2015; 408: 213\u2013219.","journal-title":"Mol Cell Endocrinol"},{"key":"BFjhh201598_CR25","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1161\/HYPERTENSIONAHA.110.150318","volume":"55","author":"TA Williams","year":"2010","unstructured":"Williams TA, Monticone S, Morello F, Liew CC, Mengozzi G, Pilon C et al. Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro. Hypertension 2010; 55: 1468\u20131475.","journal-title":"Hypertension"},{"key":"BFjhh201598_CR26","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.mce.2003.10.025","volume":"217","author":"JM Connell","year":"2004","unstructured":"Connell JM, Fraser R, MacKenzie SM, Friel EC, Ingram MC, Holloway CD et al. The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation. Mol Cell Endocrinol 2004; 217: 243\u2013247.","journal-title":"Mol Cell Endocrinol"},{"key":"BFjhh201598_CR27","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1161\/01.HYP.35.3.694","volume":"35","author":"P Mulatero","year":"2000","unstructured":"Mulatero P, Schiavone D, Fallo F, Rabbia F, Pilon C, Chiandussi L et al. CYP11B2 gene polymorphisms in idiopathic hyperaldosteronism. Hypertension 2000; 35: 694\u2013698.","journal-title":"Hypertension"},{"key":"BFjhh201598_CR28","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1161\/CIRCRESAHA.111.262931","volume":"111","author":"F McManus","year":"2012","unstructured":"McManus F, Sands W, Diver L, MacKenzie SM, Fraser R, Davies E et al. APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans. Circ Res 2012; 111: 212\u2013219.","journal-title":"Circ Res"},{"key":"BFjhh201598_CR29","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.tcb.2010.05.003","volume":"20","author":"R Tewari","year":"2010","unstructured":"Tewari R, Bailes E, Bunting KA, Coates JC . Armadillo-repeat protein functions: questions for little creatures. Trends Cell Biol 2010; 20: 470\u2013481.","journal-title":"Trends Cell Biol"},{"key":"BFjhh201598_CR30","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1093\/hmg\/ddt484","volume":"23","author":"A Berthon","year":"2014","unstructured":"Berthon A, Drelon C, Ragazzon B, Boulkroun S, Tissier F, Amar L et al. WNT\/\u03b2-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production. Hum Mol Genet 2014; 23: 889\u2013905.","journal-title":"Hum Mol Genet"},{"key":"BFjhh201598_CR31","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1210\/jc.2005-1733","volume":"91","author":"F Fallo","year":"2006","unstructured":"Fallo F, Veglio F, Bertello C, Sonino N, Della Mea P, Ermani M et al. Prevalence and characteristics of the metabolic syndrome in primary aldosteronism. J Clin Endocrinol Metab 2006; 91: 454\u2013459.","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Human Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jhh201598.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jhh201598","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jhh201598.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T20:04:24Z","timestamp":1647547464000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jhh201598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,8]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["BFjhh201598"],"URL":"https:\/\/doi.org\/10.1038\/jhh.2015.98","relation":{},"ISSN":["0950-9240","1476-5527"],"issn-type":[{"value":"0950-9240","type":"print"},{"value":"1476-5527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,8]]},"assertion":[{"value":"23 June 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}