{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:06:43Z","timestamp":1766268403815},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2526,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1038\/jid.2008.204","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T10:16:07Z","timestamp":1216289767000},"page":"89-98","source":"Crossref","is-referenced-by-count":24,"title":["Dominance of Nonmalignant T-Cell Clones and Distortion of the TCR Repertoire in the Peripheral Blood of Patients with Cutaneous CD30+ Lymphoproliferative Disorders"],"prefix":"10.1016","volume":"129","author":[{"given":"Daniel","family":"Humme","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansgar","family":"Lukowsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Steinhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Walden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram","family":"Sterry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chalid","family":"Assaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2008.204_bb0010","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1158\/1078-0432.CCR-05-1818","article-title":"Alterations in the T-cell receptor variable beta gene-restricted profile of CD8+ T lymphocytes in the peripheral circulation of patients with squamous cell carcinoma of the head and neck","volume":"15","author":"Albers","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1038\/jid.2008.204_bb0015","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1002\/1097-0142(19930315)71:6<2097::AID-CNCR2820710626>3.0.CO;2-7","article-title":"Primary cutaneous CD30-positive large cell lymphoma: definition of a new type of cutaneous lymphoma with a favorable prognosis. A European Multicenter Study of 47 patients","volume":"71","author":"Beljaards","year":"1993","journal-title":"Cancer"},{"key":"10.1038\/jid.2008.204_bb0020","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/1523-1747.ep12345532","article-title":"The dominant T-cell clone is present in multiple regressing skin lesions and associated T-cell lymphomas of patients with lymphomatoide papulosis","volume":"106","author":"Chott","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.204_bb0025","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1056\/NEJM199204233261704","article-title":"Hodgkin's disease, lymphomatoid papulosis, and cutaneous T-cell lymphoma derived from a common T-cell clone","volume":"326","author":"Davis","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2008.204_bb0030","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1182\/blood.V92.9.3376","article-title":"Prognostic significance of a polymerase chain reaction-detectable dominant T-lymphocyte clone in cutaneous lesions of patients with mycosis fungoides","volume":"92","author":"Delfau-Larue","year":"1998","journal-title":"Blood"},{"key":"10.1038\/jid.2008.204_bb0035","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1177\/107327480701400205","article-title":"Need for an improved molecular\/genetic classification for CD30+ lymphomas involving the skin","volume":"14","author":"Droc","year":"2007","journal-title":"Cancer Control"},{"key":"10.1038\/jid.2008.204_bb0040","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0190-9622(94)70019-2","article-title":"Lymphomatoid papulosis: a clinical and histopathologic review of 53 cases with leukocyte immunophenotyping, DNA flow cytometry, and T-cell receptor gene rearrangement studies","volume":"30","author":"EI Azhary","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2008.204_bb0045","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/j.0022-202X.2004.22304.x","article-title":"The cell infiltrate in lymphomatoid papulosis comprises a mixture of polyclonal large atypical cells (CD30-positive) and smaller monoclonal T cells (CD30-negative)","volume":"122","author":"Gellrich","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.204_bb0050","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1600-0560.2006.00560.x","article-title":"Detection of clonal rearrangement of T-cell receptor genes in the diagnosis of primary cutaneous CD30+ lymphoproliferative disorders","volume":"33","author":"Greisser","year":"2006","journal-title":"J Cutan Pathol"},{"key":"10.1038\/jid.2008.204_bb0055","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1182\/blood.V100.6.2168","article-title":"A prospective study on the evolution of the T-cell repertoire in patients with Sezary syndrome treated by extracorporeal photopheresis","volume":"100","author":"Ingen-Housz-Oro","year":"2002","journal-title":"Blood"},{"key":"10.1038\/jid.2008.204_bb0060","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.0303-6987.2006.00507.x","article-title":"Pathobiology of CD30+ cutaneous T-cell lymphomas","volume":"33","author":"Kadin","year":"2006","journal-title":"J Cutan Pathol"},{"key":"10.1038\/jid.2008.204_bb0065","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-2133.1991.tb00627.x","article-title":"Lymphomatoid papulosis followed by large cell lymphoma: immunophenotypical and genotypical analysis","volume":"124","author":"Kaudewitz","year":"1991","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2008.204_bb0070","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/0190-9622(90)70141-4","article-title":"Hodgkin's disease followed by lymphomatoid papulosis. Immunophenotypic evidence for a close relationship between lymphomatoid papulosis and Hodgkin's disease","volume":"22","author":"Kaudewitz","year":"1990","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2008.204_bb0075","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.mad.2006.01.011","article-title":"Human cytomegalovirus infection and T cell immunosenescence: a mini review","volume":"127","author":"Koch","year":"2006","journal-title":"Mech Ageing Dev"},{"key":"10.1038\/jid.2008.204_bb0080","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1006\/clim.1998.4638","article-title":"Role of cytomegalovirus in the T cell changes seen in elderly individuals","volume":"90","author":"Looney","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1038\/jid.2008.204_bb0085","first-page":"303","article-title":"Clonality analysis by T-cell receptor \u03b3 PCR and high- resolution electrophoresis in the diagnosis of cutaneous T-cell lymphoma (CTCL)","volume":"218","author":"Lukowsky","year":"2003","journal-title":"Methods Mol Biol"},{"key":"10.1038\/jid.2008.204_bb0090","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1001\/archderm.1968.01610070029004","article-title":"Lymphomatoid papulosis. A continuing self-healing eruption, clinically benign\u2014histologically malignant","volume":"97","author":"Macaulay","year":"1968","journal-title":"Arch Dermatol"},{"key":"10.1038\/jid.2008.204_bb0095","first-page":"173","article-title":"A simplified method of detection of clonal rearrangements of the T-cell receptor-\u03b3 chain gene","volume":"1","author":"McCarthy","year":"1992","journal-title":"Diagn Mol Pathol"},{"key":"10.1038\/jid.2008.204_bb0100","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/00019606-200309000-00005","article-title":"Peripheral blood T-cell clonality in mycosis fungoides and non-lymphoma controls","volume":"12","author":"Muche","year":"2003","journal-title":"Diagn Mol Pathol"},{"key":"10.1038\/jid.2008.204_bb0105","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1182\/blood-2005-10-4239","article-title":"Significance of circulating T-cell clones in S\u00e9zary syndrome","volume":"107","author":"Ortonne","year":"2006","journal-title":"Blood"},{"key":"10.1038\/jid.2008.204_bb0110","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1073\/pnas.90.9.4319","article-title":"The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments","volume":"90","author":"Pannetier","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2008.204_bb0115","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1200\/JCO.1995.13.6.1343","article-title":"CD30\/Ki-1-positive lymphoproliferative disorders of the skin-clinicopathologic correlation and statistical analysis of 86 cases: a multicentric study from the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Project Group","volume":"13","author":"Paulli","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1038\/jid.2008.204_bb0120","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1084\/jem.179.2.609","article-title":"Clonal Population of T cells in normal elderly humans: the T cell equivalent to \u201cbenign monoclonal gammopathy\u201d","volume":"179","author":"Posnett","year":"1994","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2008.204_bb0125","volume":"vol. 3","author":"Sambrook","year":"1989"},{"key":"10.1038\/jid.2008.204_bb0130","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/elps.1150190507","article-title":"Detection of clonal T cells in cutaneous T cell lymphoma by polymerase chain reaction: comparison of mutation detection enhancement-polyacrylamide gel electrophoresis, temperature gradient gel electrophoresis and fragment analysis of sequencing gels","volume":"19","author":"Scheller","year":"1998","journal-title":"Electrophoresis"},{"key":"10.1038\/jid.2008.204_bb0135","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.4049\/jimmunol.158.9.4493","article-title":"Expanded CD4+ and CD8+ T cell clones in elderly humans","volume":"158","author":"Schwab","year":"1997","journal-title":"J Immunol"},{"key":"10.1038\/jid.2008.204_bb0140","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jaad.2005.01.014","article-title":"T-cell clonality of peripheral blood lymphocytes in patients with lymphomatoid papulosis","volume":"53","author":"Schultz","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2008.204_bb0145","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1182\/blood-2001-12-0199","article-title":"Single-cell analyses of CD 30+ cells in lymphomatoid papulosis demonstrates a common clonal T-cell origin","volume":"100","author":"Steinhoff","year":"2002","journal-title":"Blood"},{"key":"10.1038\/jid.2008.204_bb0150","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.molmed.2007.01.005","article-title":"Immune remodelling: lesson from repertoire alterations during chronological aging and in immune-mediated disease","volume":"13","author":"Vallejo","year":"2007","journal-title":"Trends Mol Med"},{"key":"10.1038\/jid.2008.204_bb0155","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/1097-0320(20000801)40:4<336::AID-CYTO9>3.0.CO;2-0","article-title":"Flow cytometric analysis of the Vbeta repertoire in healthy controls","volume":"40","author":"van den Beemd","year":"2000","journal-title":"Cytometry"},{"key":"10.1038\/jid.2008.204_bb0160","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardisation of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 concerted action BMH4-CT98-3936","volume":"17","author":"van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"10.1038\/jid.2008.204_bb0165","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1097\/00000478-199810000-00004","article-title":"Statistical evaluation of diagnostic and prognostic features of CD30+ cutaneous lymphoproliferative disorders: a clinicopathologic study of 65 cases","volume":"22","author":"Vergier","year":"1898","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/jid.2008.204_bb0170","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1056\/NEJM198608213150802","article-title":"Clonal T-cell populations in lymphomatoid papulosis. Evidence of a lymphoproliferative origin for a clinically benign disease","volume":"315","author":"Weiss","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2008.204_bb0175","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/1523-1747.ep12471773","article-title":"Analysis of \u03b2, \u03b3, and \u03b4 Tcell receptor genes in lymphomatoid papulosis: cellular basis of two distinct histologic subsets","volume":"96","author":"Whittaker","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.204_bb0180","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1182\/blood-2004-09-3502","article-title":"WHO-EORTC classification for cutaneous lymphomas","volume":"105","author":"Willemze","year":"2005","journal-title":"Blood"},{"key":"10.1038\/jid.2008.204_bb0185","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/1523-1747.ep12312548","article-title":"Lymphomatoid papulosis and associated cutaneous lymphoproliferative disorders exhibit a common clonal origin","volume":"105","author":"Wood","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.204_bb0190","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1182\/blood-2003-04-1044","article-title":"Profound loss of T-cell receptor complexity in cutaneous T-cell lymphoma","volume":"102","author":"Yawalkar","year":"2003","journal-title":"Blood"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1534080X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1534080X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T06:12:54Z","timestamp":1684476774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X1534080X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0022202X1534080X"],"URL":"https:\/\/doi.org\/10.1038\/jid.2008.204","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}