{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:11:46Z","timestamp":1785600706612,"version":"3.56.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2495,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1038\/jid.2008.258","type":"journal-article","created":{"date-parts":[[2008,9,4]],"date-time":"2008-09-04T10:03:29Z","timestamp":1220522609000},"page":"329-339","source":"Crossref","is-referenced-by-count":81,"title":["Transient Receptor Potential Vanilloid-1 Signaling as a Regulator of Human Sebocyte Biology"],"prefix":"10.1016","volume":"129","author":[{"given":"Bal\u00e1zs I.","family":"T\u00f3th","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"G\u00e9czy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Griger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik\u00f3","family":"D\u00f3zsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Seltmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos C.","family":"Zouboulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Paus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"B\u00edr\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2008.258_bb0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00109-005-0715-8","article-title":"Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands","volume":"84","author":"Alestas","year":"2006","journal-title":"J Mol Med"},{"key":"10.1038\/jid.2008.258_bb0015","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.med.53.082901.104018","article-title":"The mechanisms of action of PPARs","volume":"53","author":"Berger","year":"2002","journal-title":"Annu Rev Med"},{"key":"10.1038\/jid.2008.258_bb0020","series-title":"Capsaicin in the Study of Pain","first-page":"27","article-title":"Cellular mechanisms of the action of capsaicin","author":"Bevan","year":"1993"},{"key":"10.1038\/jid.2008.258_bb0025","doi-asserted-by":"crossref","first-page":"13396","DOI":"10.1073\/pnas.231243698","article-title":"Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells","volume":"98","author":"Birder","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2008.258_bb0030","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1038\/sj.jid.5700321","article-title":"Hair cycle control by vanilloid receptor-1 (TRPV1): evidence from TRPV1 knockout mice","volume":"126","author":"B\u00edr\u00f3","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.258_bb0035","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.0906-6705.2005.0321a.x","article-title":"How best to fight that nasty itch\u2014from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches","volume":"14","author":"Bir\u00f3","year":"2005","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2008.258_bb0040","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1182\/blood.V91.4.1332","article-title":"Characterization of functional vanilloid receptors expressed by mast cells","volume":"91","author":"B\u00edr\u00f3","year":"1998","journal-title":"Blood"},{"key":"10.1038\/jid.2008.258_bb0045","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0002-9440(10)62320-6","article-title":"A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1\/TRPV1) signaling in human hair growth control","volume":"166","author":"Bod\u00f3","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2008.258_bb0050","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.0022-202X.2004.23209.x","article-title":"Vanilloid receptor-1 (VR1) is widely expressed on various epithelial and mesenchymal cell types of human skin","volume":"123","author":"Bod\u00f3","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.258_bb0055","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin-receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1038\/jid.2008.258_bb0060","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/83336","article-title":"PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation","volume":"7","author":"Chawla","year":"2001","journal-title":"Nat Med"},{"key":"10.1038\/jid.2008.258_bb0065","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1523-1747.2003.12411.x","article-title":"Expression of peroxisome proliferator-activated receptor and CCAAT\/enhancer binding protein transcription factors in cultured human sebocytes","volume":"121","author":"Chen","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.258_bb0070","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1006\/bbrc.2001.5299","article-title":"Immunoreactivity of VR1 on epidermal keratinocyte of human skin","volume":"285","author":"Denda","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/jid.2008.258_bb0075","first-page":"649","article-title":"Peroxisome proliferator-activated receptors: nuclear control of metabolism","volume":"20","author":"Desvergne","year":"1999","journal-title":"Endocr Rev"},{"key":"10.1038\/jid.2008.258_bb0080","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/384039a0","article-title":"The PPARalpha-leukotriene B4 pathway to inflammation control","volume":"384","author":"Devchand","year":"1996","journal-title":"Nature"},{"key":"10.1038\/jid.2008.258_bb0085","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0959-4388(02)00340-9","article-title":"Endovanilloid signaling in pain","volume":"12","author":"Di Marzo","year":"2002","journal-title":"Curr Opin Neurobiol"},{"key":"10.1038\/jid.2008.258_bb0090","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/1523-1747.ep12465246","article-title":"Characterization of human sebaceous cells in vitro","volume":"96","author":"Doran","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.258_bb0095","series-title":"Neurogenic Inflammation","first-page":"324","author":"Geppetti","year":"1996"},{"key":"10.1038\/jid.2008.258_bb0100","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1038\/jid.2008.258_bb0105","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1152\/physrev.1998.78.3.783","article-title":"Understanding adipocyte differentiation","volume":"78","author":"Gregoire","year":"1998","journal-title":"Physiol Rev"},{"key":"10.1038\/jid.2008.258_bb0110","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00109-007-0209-y","article-title":"Protein kinase C-beta and -delta isoenzymes promote arachidonic acid production and proliferation of MonoMac-6 cells","volume":"85","author":"Griger","year":"2007","journal-title":"J Mol Med"},{"key":"10.1038\/jid.2008.258_bb0115","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0031-6997(25)06664-5","article-title":"Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons","volume":"43","author":"Holzer","year":"1991","journal-title":"Pharmacol Rev"},{"key":"10.1038\/jid.2008.258_bb0120","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1073\/pnas.97.11.6155","article-title":"Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances","volume":"97","author":"Hwang","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2008.258_bb0125","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1006\/bbrc.2002.6393","article-title":"Functional vanilloid receptors in cultured normal human epidermal keratinocytes","volume":"291","author":"Inoue","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/jid.2008.258_bb0130","first-page":"53","article-title":"Role of the nerve terminals in the mechanism of inflammatory reactions","volume":"7","author":"Jancs\u00f3","year":"1960","journal-title":"Bull Millard Fillmore Hosp"},{"key":"10.1038\/jid.2008.258_bb0135","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1073\/pnas.90.6.2160","article-title":"Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers","volume":"90","author":"Keller","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2008.258_bb0140","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/35013000","article-title":"Roles of PPARs in health and disease","volume":"405","author":"Kersten","year":"2000","journal-title":"Nature"},{"key":"10.1038\/jid.2008.258_bb0145","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.eururo.2004.08.007","article-title":"Immunohistochemical evidence of vanilloid receptor 1 in normal human urinary bladder","volume":"46","author":"Lazzeri","year":"2004","journal-title":"Eur Urol"},{"key":"10.1038\/jid.2008.258_bb0150","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1038\/sj.jid.5700880","article-title":"Transient receptor potential vanilloid-1 mediates heat-shock-induced matrix metalloproteinase-1 expression in human epidermal keratinocytes","volume":"127","author":"Li","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.258_bb0155","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/mnfr.200500097","article-title":"Roles for lipid-activated transcription factors in atherosclerosis","volume":"49","author":"Nagy","year":"2005","journal-title":"Mol Nutr Food Res"},{"key":"10.1038\/jid.2008.258_bb0160","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0022-5347(05)64910-5","article-title":"Topography of the vanilloid receptor in the human bladder: more than just the nerve fibers","volume":"168","author":"Ost","year":"2002","journal-title":"J Urol"},{"key":"10.1038\/jid.2008.258_bb0165","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1172\/JCI28553","article-title":"Frontiers in pruritus research: scratching the brain for more effective itch therapy","volume":"116","author":"Paus","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2008.258_bb0170","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0022-202X(89)90194-2","article-title":"Relationship of sebaceous cell stage to growth in culture","volume":"92","author":"Rosenfield","year":"1989","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.258_bb0175","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1046\/j.1523-1747.1999.00487.x","article-title":"Rat preputial sebocyte differentiation involves peroxisome proliferator-activated receptors","volume":"112","author":"Rosenfield","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.258_bb0180","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1046\/j.0022-202x.2001.01516.x","article-title":"Epidermal growth factor and 1alpha,25-dihydroxyvitamin D3 suppress lipogenesis in hamster sebaceous gland cells in vitro","volume":"117","author":"Sato","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.258_bb0185","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1124\/jpet.102.040675","article-title":"Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes","volume":"304","author":"Southall","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/jid.2008.258_bb0190","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.0906-6705.2004.0178.x","article-title":"Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures","volume":"13","author":"St\u00e4nder","year":"2004","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2008.258_bb0195","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1038\/sj.jid.5700231","article-title":"Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus","volume":"126","author":"Steinhoff","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.258_bb0200","first-page":"151","article-title":"Mitochondria as regulators of apoptosis: doubt no more","volume":"1366","author":"Susin","year":"1998","journal-title":"Biochem Biophys Acta"},{"key":"10.1038\/jid.2008.258_bb0205","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0031-6997(24)01403-0","article-title":"Vanilloid (capsaicin) receptors and mechanisms","volume":"51","author":"Sz\u00e1ll\u00e1si","year":"1999","journal-title":"Pharmacol Rev"},{"key":"10.1038\/jid.2008.258_bb0210","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1182\/blood-2007-06-096222","article-title":"PPAR{gamma} regulates the function of human dendritic cells primarily by altering lipid metabolism","volume":"110","author":"Szatmari","year":"2007","journal-title":"Blood"},{"key":"10.1038\/jid.2008.258_bb0215","first-page":"251","article-title":"A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain","volume":"73","author":"Szolcs\u00e1nyi","year":"1977","journal-title":"J Physiol (Paris)"},{"key":"10.1038\/jid.2008.258_bb0220","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1152\/physrev.1989.69.2.383","article-title":"Control and function of sebaceous glands","volume":"69","author":"Thody","year":"1989","journal-title":"Physiol Rev"},{"key":"10.1038\/jid.2008.258_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0896-6273(00)80564-4","article-title":"The cloned capsaicin receptor integrates multiple pain-producing stimuli","volume":"21","author":"Tominaga","year":"1998","journal-title":"Neuron"},{"key":"10.1038\/jid.2008.258_bb0230","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s007950100002","article-title":"Pathogenesis of acne","volume":"34","author":"Toyoda","year":"2001","journal-title":"Med Electron Microsc"},{"key":"10.1038\/jid.2008.258_bb0235","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1038\/sj.jid.5700336","article-title":"Peroxisome proliferator-activated receptors increase human sebum production","volume":"126","author":"Trivedi","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.258_bb0240","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1124\/mol.59.1.9","article-title":"Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist","volume":"59","author":"Wahl","year":"2001","journal-title":"Mol Pharmacol"},{"key":"10.1038\/jid.2008.258_bb0245","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1523-1747.2003.12029.x","article-title":"Differentiation and apoptosis in human immortalized sebocytes","volume":"120","author":"Wr\u00f3bel","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.258_bb0250","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/sj.jid.5700028","article-title":"Involvement of PPARgamma in oxidative stress-mediated prostaglandin E(2) production in SZ95 human sebaceous gland cells","volume":"126","author":"Zhang","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.258_bb0255","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.clindermatol.2004.03.004","article-title":"Acne and sebaceous gland function","volume":"22","author":"Zouboulis","year":"2004","journal-title":"Clin Dermatol"},{"issue":"Suppl 4","key":"10.1038\/jid.2008.258_bb0260","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1600-0625.2004.00254.x","article-title":"Neuroendocrine regulation of sebocytes\u2014a pathogenetic link between stress and acne","volume":"13","author":"Zouboulis","year":"2004","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2008.258_bb0265","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.0906-6705.2005.0285a.x","article-title":"What is the pathogenesis of acne?","volume":"14","author":"Zouboulis","year":"2005","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2008.258_bb0270","doi-asserted-by":"crossref","first-page":"7148","DOI":"10.1073\/pnas.102180999","article-title":"Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes","volume":"99","author":"Zouboulis","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2008.258_bb0275","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1046\/j.1523-1747.1999.00771.x","article-title":"Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)","volume":"113","author":"Zouboulis","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.258_bb0280","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000017861","article-title":"The human sebocyte culture model provides new insights into development and management of seborrhoea and acne","volume":"196","author":"Zouboulis","year":"1998","journal-title":"Dermatology"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15342093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15342093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T20:37:40Z","timestamp":1738355860000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15342093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0022202X15342093"],"URL":"https:\/\/doi.org\/10.1038\/jid.2008.258","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}