{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:53:01Z","timestamp":1790682781395,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2679,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1038\/jid.2008.30","type":"journal-article","created":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T09:08:06Z","timestamp":1204794486000},"page":"2003-2012","source":"Crossref","is-referenced-by-count":71,"title":["Phospho-ERK Staining Is a Poor Indicator of the Mutational Status of BRAF and NRAS in Human Melanoma"],"prefix":"10.1016","volume":"128","author":[{"given":"Roland","family":"Houben","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia S.","family":"Vetter-Kauczok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Ortmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf R.","family":"Rapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva B.","family":"Broecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen C.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2008.30_bb0010","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1016\/j.febslet.2005.03.024","article-title":"Second nature: biological functions of the Raf-1 \u201ckinase\u201d","volume":"579","author":"Baccarini","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1038\/jid.2008.30_bb0015","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/cncr.22273","article-title":"Molecularly targeted therapy for melanoma: current reality and future options","volume":"107","author":"Becker","year":"2006","journal-title":"Cancer"},{"key":"10.1038\/jid.2008.30_bb0020","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.tem.2006.07.008","article-title":"Seven-transmembrane receptor signalling and ERK compartmentalization","volume":"17","author":"Caunt","year":"2006","journal-title":"Trends Endocrinol Metab"},{"key":"10.1038\/jid.2008.30_bb0025","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1021\/cr000241p","article-title":"MAP kinases","volume":"101","author":"Chen","year":"2001","journal-title":"Chem Rev"},{"key":"10.1038\/jid.2008.30_bb0030","first-page":"3728","article-title":"Mitogen-activated protein kinase activation is an early event in melanoma progression","volume":"8","author":"Cohen","year":"2002","journal-title":"Clin Cancer Res"},{"key":"10.1038\/jid.2008.30_bb0035","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nature00766","article-title":"Mutations of the BRAF gene in human cancer","volume":"417","author":"Davies","year":"2002","journal-title":"Nature"},{"key":"10.1038\/jid.2008.30_bb0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0003-9861(02)00244-8","article-title":"Untying the regulation of the Raf-1 kinase","volume":"404","author":"Dhillon","year":"2002","journal-title":"Arch Biochem Biophys"},{"key":"10.1038\/jid.2008.30_bb0045","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1128\/MCB.23.6.1983-1993.2003","article-title":"A Raf-1 mutant that dissociates MEK\/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation","volume":"23","author":"Dhillon","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1038\/jid.2008.30_bb0050","doi-asserted-by":"crossref","first-page":"9483","DOI":"10.1158\/0008-5472.CAN-05-4227","article-title":"In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling","volume":"66","author":"Dumaz","year":"2006","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2008.30_bb0055","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/sj.bjc.6603291","article-title":"Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis","volume":"95","author":"Eisen","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1038\/jid.2008.30_bb0060","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1038\/sj.onc.1209419","article-title":"Regulation of iNOS by the p44\/42 mitogen-activated protein kinase pathway in human melanoma","volume":"25","author":"Ellerhorst","year":"2006","journal-title":"Oncogene"},{"key":"10.1038\/jid.2008.30_bb0065","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/jnci\/95.12.878","article-title":"Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis","volume":"95","author":"Fu","year":"2003","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/jid.2008.30_bb0070","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.molcel.2005.10.022","article-title":"Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization","volume":"20","author":"Garnett","year":"2005","journal-title":"Mol Cell"},{"key":"10.1038\/jid.2008.30_bb0075","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1515\/BC.2005.025","article-title":"Oncogenic Ras in tumour progression and metastasis","volume":"386","author":"Giehl","year":"2005","journal-title":"Biol Chem"},{"key":"10.1038\/jid.2008.30_bb0080","doi-asserted-by":"crossref","first-page":"7392","DOI":"10.1158\/1078-0432.CCR-05-0283","article-title":"Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis","volume":"11","author":"Hagan","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1038\/jid.2008.30_bb0085","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0014-4827(03)00037-5","article-title":"Examining the mechanism of Erk nuclear translocation using green fluorescent protein","volume":"285","author":"Horgan","year":"2003","journal-title":"Exp Cell Res"},{"key":"10.1038\/jid.2008.30_bb0090","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1477-3163-3-6","article-title":"Constitutive activation of the Ras\u2013Raf signaling pathway in metastatic melanoma is associated with poor prognosis","volume":"3","author":"Houben","year":"2004","journal-title":"J Carcinog"},{"key":"10.1038\/jid.2008.30_bb0095","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/sj.jid.5700170","article-title":"Absence of classical MAP kinase pathway signalling in Merkel cell carcinoma","volume":"126","author":"Houben","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.30_bb0100","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1124\/mol.58.4.659","article-title":"Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling","volume":"58","author":"Houslay","year":"2000","journal-title":"Mol Pharmacol"},{"key":"10.1038\/jid.2008.30_bb0105","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0959-437X(01)00260-X","article-title":"Anchorage-dependent ERK signaling\u2014mechanisms and consequences","volume":"12","author":"Howe","year":"2002","journal-title":"Curr Opin Genet Dev"},{"key":"10.1038\/jid.2008.30_bb0110","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1042\/bst0320443","article-title":"Integrin regulation of cell signalling and motility","volume":"32","author":"Juliano","year":"2004","journal-title":"Biochem Soc Trans"},{"key":"10.1038\/jid.2008.30_bb0115","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s00412-005-0341-9","article-title":"Control of MAP kinase signaling to the nucleus","volume":"114","author":"Kondoh","year":"2005","journal-title":"Chromosoma"},{"key":"10.1038\/jid.2008.30_bb0120","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0065-230X(08)60765-4","article-title":"Signal transduction through MAP kinase cascades","volume":"74","author":"Lewis","year":"1998","journal-title":"Adv Cancer Res"},{"key":"10.1038\/jid.2008.30_bb0125","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1038\/sj.jid.5700870","article-title":"ERK1\/2 is highly phosphorylated in melanoma metastases and protects melanoma cells from cisplatin-mediated apoptosis","volume":"127","author":"Mirmohammadsadegh","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.30_bb0130","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1349-7006.2007.00445.x","article-title":"Activation of ERK1\/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis","volume":"98","author":"Mizumoto","year":"2007","journal-title":"Cancer Sci"},{"key":"10.1038\/jid.2008.30_bb0135","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/ijc.21466","article-title":"Subcellular localization, modification and protein complex formation of the cdk-inhibitor p16 in Rb-functional and Rb-inactivated tumor cells","volume":"118","author":"Nilsson","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1038\/jid.2008.30_bb0140","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0065-230X(04)91005-6","article-title":"Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis","volume":"91","author":"Odabaei","year":"2004","journal-title":"Adv Cancer Res"},{"key":"10.1038\/jid.2008.30_bb0145","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1038\/sj.onc.1208435","article-title":"RKIP downregulates B-Raf kinase activity in melanoma cancer cells","volume":"24","author":"Park","year":"2005","journal-title":"Oncogene"},{"key":"10.1038\/jid.2008.30_bb0150","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2005.12.022","article-title":"BuCy RAFs drive cells into MEK addiction","volume":"9","author":"Rapp","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1038\/jid.2008.30_bb0155","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1042\/BST0340833","article-title":"The role of scaffold proteins in MEK\/ERK signalling","volume":"34","author":"Sacks","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"10.1038\/jid.2008.30_bb0160","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0079-6107(98)00052-2","article-title":"Signaling through focal adhesion kinase","volume":"71","author":"Schlaepfer","year":"1999","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1038\/jid.2008.30_bb0165","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1158\/0008-5472.CAN-03-3861","article-title":"Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell lines","volume":"64","author":"Schuierer","year":"2004","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2008.30_bb0170","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1083\/jcb.200212141","article-title":"PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation","volume":"162","author":"Slack-Davis","year":"2003","journal-title":"J Cell Biol"},{"key":"10.1038\/jid.2008.30_bb0175","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature04304","article-title":"BRAF mutation predicts sensitivity to MEK inhibition","volume":"439","author":"Solit","year":"2006","journal-title":"Nature"},{"key":"10.1038\/jid.2008.30_bb0180","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1529-8019.2005.00052.x","article-title":"Cutaneous melanoma: available therapy for metastatic disease","volume":"19","author":"Tarhini","year":"2006","journal-title":"Dermatol Ther"},{"key":"10.1038\/jid.2008.30_bb0185","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/sj.jid.5700011","article-title":"Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi","volume":"126","author":"Uribe","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.30_bb0190","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0092-8674(04)00215-6","article-title":"Mechanism of activation of the RAF\u2013ERK signaling pathway by oncogenic mutations of B-RAF","volume":"116","author":"Wan","year":"2004","journal-title":"Cell"},{"key":"10.1038\/jid.2008.30_bb0195","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11010-005-9089-z","article-title":"ERK regulation upon contact inhibition in fibroblasts","volume":"286","author":"Wayne","year":"2006","journal-title":"Mol Cell Biochem"},{"key":"10.1038\/jid.2008.30_bb0200","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/43686","article-title":"Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP","volume":"401","author":"Yeung","year":"1999","journal-title":"Nature"},{"key":"10.1038\/jid.2008.30_bb0205","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1007\/s00018-006-6005-y","article-title":"Back to the roots: the remarkable RAF oncogene story","volume":"63","author":"Zebisch","year":"2006","journal-title":"Cell Mol Life Sci"},{"key":"10.1038\/jid.2008.30_bb0210","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1136\/jcp.2005.025957","article-title":"Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma","volume":"58","author":"Zhuang","year":"2005","journal-title":"J Clin Pathol"},{"key":"10.1038\/jid.2008.30_bb0215","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1440-1827.2007.02050.x","article-title":"Lack of association between BRAF V600E mutation and mitogen-activated protein kinase activation in papillary thyroid carcinoma","volume":"57","author":"Zuo","year":"2007","journal-title":"Pathol Int"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15339725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15339725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T14:44:48Z","timestamp":1557326688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15339725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0022202X15339725"],"URL":"https:\/\/doi.org\/10.1038\/jid.2008.30","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}