{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:38:26Z","timestamp":1790422706970,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2375,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1038\/jid.2008.391","type":"journal-article","created":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T11:01:59Z","timestamp":1230894119000},"page":"1388-1394","source":"Crossref","is-referenced-by-count":89,"title":["Elevated Dietary Magnesium Prevents Connective Tissue Mineralization in a Mouse Model of Pseudoxanthoma Elasticum (Abcc6\u2212\/\u2212)"],"prefix":"10.1016","volume":"129","author":[{"given":"Jennifer","family":"LaRusso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouni","family":"Uitto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2008.391_bb0010","first-page":"301","article-title":"The essentials of calcium, magnesium and phosphate metabolism: part I. Physiology","volume":"4","author":"Baker","year":"2002","journal-title":"Crit Care Resusc"},{"key":"10.1038\/jid.2008.391_bb0015","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00562741","article-title":"Scanning electron microscopic and X ray microanalysis study of the mineral deposits in pseudoxanthoma elasticum","volume":"259","author":"Calap","year":"1977","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/jid.2008.391_bb0020","first-page":"190","article-title":"The importance of magnesium in orthopedics. VI. The importance of magnesium in the treatment of ectopic calcification and ossification","volume":"56","author":"Ditmar","year":"1989","journal-title":"Acta Chir Orthop Traumatol Cech"},{"key":"10.1038\/jid.2008.391_bb0025","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1093\/jn\/133.9.2879","article-title":"Dietary magnesium intake in a national sample of US adults","volume":"133","author":"Ford","year":"2003","journal-title":"J Nutr"},{"key":"10.1038\/jid.2008.391_bb0030","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1373\/clinchem.2006.083675","article-title":"SPP1 promoter polymorphisms: identification of the first modifier gene for pseudoxanthoma elasticum","volume":"53","author":"Hendig","year":"2007","journal-title":"Clin Chem"},{"key":"10.1038\/jid.2008.391_bb0035","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/sj.jid.5700729","article-title":"Aberrant mineralization of connective tissues in a mouse model of pseudoxanthoma elasticum: systemic and local regulatory factors","volume":"127","author":"Jiang","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.391_bb0040","doi-asserted-by":"crossref","first-page":"8299","DOI":"10.1128\/MCB.25.18.8299-8310.2005","article-title":"Targeted ablation of the ABCC6 gene results in ectopic mineralization of connective tissues","volume":"25","author":"Klement","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1038\/jid.2008.391_bb0045","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1600-0625.2007.00645.x","article-title":"Ectopic mineralization of connective tissue in Abcc6\u2212\/\u2212 mice: effects of dietary modifications and a phosphate binder \u2013 a preliminary study","volume":"17","author":"LaRusso","year":"2007","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2008.391_bb0050","series-title":"J Invest Dermatol","article-title":"Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes","author":"Li","year":"2008"},{"key":"10.1038\/jid.2008.391_bb0055","series-title":"Am J Pathol","article-title":"Co-existent pseudoxanthoma elasticum and vitamin K-dependent coagulation factor deficiency: compound heterozygocity for mutations in the EECX gene","author":"Li","year":"2008"},{"key":"10.1038\/jid.2008.391_bb0060","series-title":"Exp Dermatol","article-title":"Pseudoxanthoma elasticum: clinical phenotypes, molecular genetics and putative pathomechanisms","author":"Li","year":"2009"},{"key":"10.1038\/jid.2008.391_bb0065","doi-asserted-by":"crossref","first-page":"820","DOI":"10.2169\/internalmedicine.31.820","article-title":"Hypomagnesemia with increased metabolism of parathyroid hormone and reduced responsiveness to calcitropic hormones","volume":"31","author":"Mori","year":"1992","journal-title":"Intern Med"},{"key":"10.1038\/jid.2008.391_bb0070","first-page":"1","article-title":"Pseudoxanthoma elasticum","volume":"6","author":"Neldner","year":"1988","journal-title":"Clin Dermatol"},{"key":"10.1038\/jid.2008.391_bb0075","series-title":"Connective Tissue and its Heritable Disorders: Molecular, Genetic and Medical Aspects","first-page":"561","article-title":"Pseudoxanthoma elasticum","author":"Neldner","year":"2002"},{"key":"10.1038\/jid.2008.391_bb0080","first-page":"1","article-title":"Pseudoxanthoma elasticum: genetic diagnostic markers","volume":"2","author":"Pfendner","year":"2008","journal-title":"Exp Opin Med Diagn"},{"key":"10.1038\/jid.2008.391_bb0085","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1136\/jmg.2007.051094","article-title":"Mutation detection in the ABCC6 gene and genotype-phenotype analysis in a large international case series affected by pseudoxanthoma elasticum","volume":"44","author":"Pfendner","year":"2007","journal-title":"J Med Genet"},{"key":"10.1038\/jid.2008.391_bb0090","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ajmg.1320190205","article-title":"Pseudoxanthoma elasticum: high calcium intake in early life correlates with severity","volume":"19","author":"Renie","year":"1984","journal-title":"Am J Med Genet"},{"key":"10.1038\/jid.2008.391_bb0095","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1007\/s00198-006-0104-3","article-title":"Reduction of dietary magnesium by only 50% in the rat disrupts bone and mineral metabolism","volume":"17","author":"Rude","year":"2006","journal-title":"Osteoporos Int"},{"key":"10.1038\/jid.2008.391_bb0100","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/jmg.2006.040972","article-title":"Polymorphisms in the xylosyltransferase genes cause higher serum XT-1 activity in patients with pseudoxanthoma elasticum (PXE) and are involved in a severe disease course","volume":"43","author":"Sch\u00f6n","year":"2006","journal-title":"J Med Genet"},{"key":"10.1038\/jid.2008.391_bb0105","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jaad.2004.11.066","article-title":"Oral phosphate binders in the treatment of pseudoxanthoma elasticum","volume":"53","author":"Sherer","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2008.391_bb0110","series-title":"Nonparametric Statistics for the Behavioral Sciences","first-page":"180","author":"Siegel","year":"1988"},{"key":"10.1038\/jid.2008.391_bb0115","first-page":"113","article-title":"Soft tissue calcification treated with local and oral magnesium therapy","volume":"3","author":"Steidl","year":"1990","journal-title":"Magnes Res"},{"key":"10.1038\/jid.2008.391_bb0120","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/sj.jid.5700610","article-title":"Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity","volume":"127","author":"Vanakker","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.391_bb0125","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1373\/clinchem.2007.088211","article-title":"Pseudoxanthoma elasticum: genetic variations in antioxidant genes are risk factors for early disease onset","volume":"53","author":"Zarbock","year":"2007","journal-title":"Clin Chem"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15343463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15343463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T19:26:35Z","timestamp":1558034795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15343463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0022202X15343463"],"URL":"https:\/\/doi.org\/10.1038\/jid.2008.391","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}