{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:08:43Z","timestamp":1793916523705,"version":"4.8.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2679,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1038\/jid.2008.45","type":"journal-article","created":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T11:32:07Z","timestamp":1205407927000},"page":"2041-2048","source":"Crossref","is-referenced-by-count":101,"title":["HSP70i Accelerates Depigmentation in a Mouse Model of Autoimmune Vitiligo"],"prefix":"10.1016","volume":"128","author":[{"given":"Cecele J.","family":"Denman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"McCracken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidhya","family":"Hariharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Klarquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kepa","family":"Oyarbide-Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Guevara-Pati\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Caroline Le Poole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2008.45_bb0010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/157339506778018514","article-title":"Initiation of the immune response by extracellular Hsp72: chaperokine activity of Hsp72","volume":"2","author":"Asea","year":"2006","journal-title":"Curr Immunol Rev"},{"key":"10.1038\/jid.2008.45_bb0015","first-page":"277","article-title":"Trigger factors in childhood psoriasis and vitiligo","volume":"28","author":"Barisi\u0107-Drusko","year":"2004","journal-title":"Coll Antropol"},{"key":"10.1038\/jid.2008.45_bb0020","doi-asserted-by":"crossref","first-page":"31688","DOI":"10.1074\/jbc.M704129200","article-title":"Human heat shock protein 70 enhances tumor antigen presentation through complex formation and intracellular antigen delivery without innate immune signaling","volume":"282","author":"Bendz","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2008.45_bb0025","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/carcin\/bgl152","article-title":"Hsp70 protects against UVB induced apoptosis by preventing release of cathepsins and cytochrome c in human melanocytes","volume":"28","author":"Bivik","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1038\/jid.2008.45_bb0030","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1600-0749.2004.00130.x","article-title":"On the etiology of contact\/occupational vitiligo","volume":"17","author":"Boissy","year":"2004","journal-title":"Pigment Cell Res"},{"key":"10.1038\/jid.2008.45_bb0035","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S1471-4906(00)01844-5","article-title":"A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo","volume":"22","author":"Das","year":"2001","journal-title":"Trends Immunol"},{"key":"10.1038\/jid.2008.45_bb0040","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nm1363","article-title":"Autoimmunity and tumor immunity induced by immune responses to mutations in self","volume":"12","author":"Engelhorn","year":"2006","journal-title":"Nat Med"},{"key":"10.1038\/jid.2008.45_bb0045","doi-asserted-by":"crossref","first-page":"5238","DOI":"10.1158\/0008-5472.CAN-04-3804","article-title":"Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells","volume":"65","author":"Gastpar","year":"2005","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2008.45_bb0050","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1002\/eji.200535050","article-title":"The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells","volume":"35","author":"Haug","year":"2005","journal-title":"Eur J Immunol"},{"key":"10.1038\/jid.2008.45_bb0055","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00403-006-0668-y","article-title":"Induction of cellular immunity against hair follicle melanocyte causes alopecia","volume":"298","author":"Hedstrand","year":"2006","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/jid.2008.45_bb0060","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.0022-202X.2005.23653.x","article-title":"4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo","volume":"124","author":"Kroll","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.45_bb0065","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1158\/0008-5472.CAN-03-3227","article-title":"Vaccination-induced autoimmune vitiligo is a consequence of secondary trauma to the skin","volume":"64","author":"Lane","year":"2004","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2008.45_bb0070","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.4049\/jimmunol.176.8.4600","article-title":"Insufficient APC capacities of dendritic cells in gene gun-mediated DNA vaccination","volume":"176","author":"Lauterbach","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/jid.2008.45_bb0075","first-page":"227","article-title":"Autoimmune etiology of generalized vitiligo","volume":"10","author":"Le Poole","year":"2008"},{"key":"10.1038\/jid.2008.45_bb0080","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/1523-1747.ep12476645","article-title":"Presence or absence of melanocytes in vitiligo lesions: an immunohistochemical investigation","volume":"100","author":"Le Poole","year":"1993","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.45_bb0085","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1006\/excr.1993.1102","article-title":"Phagocytosis by normal human melanocytes in vitro","volume":"205","author":"Le Poole","year":"1993","journal-title":"Exp Cell Res"},{"key":"10.1038\/jid.2008.45_bb0090","doi-asserted-by":"crossref","first-page":"7849","DOI":"10.4049\/jimmunol.177.11.7849","article-title":"Heat shock protein 70 is secreted from tumor cells by a nonclassical pathway involving lysosomal endosomes","volume":"177","author":"Mambula","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/jid.2008.45_bb0095","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ymeth.2007.06.009","article-title":"Mechanisms for Hsp70 secretion: crossing membranes without a leader","volume":"43","author":"Mambula","year":"2007","journal-title":"Methods"},{"key":"10.1038\/jid.2008.45_bb0100","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/3-540-29717-0_12","article-title":"Heat shock proteins in immunity","volume":"172","author":"Multhoff","year":"2006","journal-title":"Handb Exp Pharmacol"},{"key":"10.1038\/jid.2008.45_bb0105","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1600-0749.2007.00408.x","article-title":"Neurogenic dysregulation, oxidative stress, autoimmunity, and melanocytorrhagy in vitiligo: can they be interconnected?","volume":"20","author":"Namazi","year":"2007","journal-title":"Pigment Cell Res"},{"key":"10.1038\/jid.2008.45_bb0110","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0190-9622(83)70182-9","article-title":"Vitiligo in patients with metastatic melanoma: a good prognostic sign","volume":"9","author":"Nordlund","year":"1983","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2008.45_bb0115","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1046\/j.1523-1747.1998.00411.x","article-title":"Anti-tyrosinase-related protein-2 immune response in vitiligo patients and melanoma patients receiving active-specific immunotherapy","volume":"111","author":"Okamoto","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2008.45_bb0120","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1084\/jem.188.6.1203","article-title":"High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo","volume":"188","author":"Ogg","year":"1998","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2008.45_bb0125","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1073\/pnas.96.6.2982","article-title":"Vaccination with a recombinant vaccinia virus encoding a \u201cself\u201d antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes","volume":"96","author":"Overwijk","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2008.45_bb0130","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.4049\/jimmunol.178.3.1671","article-title":"Stimulation of cell surface CCR5 and CD40 molecules by their ligands or by HSP70 up-regulates APOBEC3G expression in CD4(+) T cells and dendritic cells","volume":"178","author":"Pido-Lopez","year":"2007","journal-title":"J Immunol"},{"key":"10.1038\/jid.2008.45_bb0135","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.4049\/jimmunol.177.6.4168","article-title":"Killing of normal melanocytes, combined with heat shock protein 70 and CD40L expression, cures large established melanomas","volume":"177","author":"Sanchez-Perez","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/jid.2008.45_bb0140","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1600-0749.2007.00384.x","article-title":"The genetics of generalized vitiligo and associated autoimmune diseases","volume":"20","author":"Spritz","year":"2007","journal-title":"Pigment Cell Res"},{"key":"10.1038\/jid.2008.45_bb0145","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/(SICI)1097-0215(20000401)86:1<89::AID-IJC14>3.0.CO;2-I","article-title":"Genetic immunization of mice with human tyrosinase-related protein 2: implications for the immunotherapy of melanoma","volume":"86","author":"Steitz","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1038\/jid.2008.45_bb0150","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1379\/1466-1268(1996)001<0023:AHSGTT>2.3.CO;2","article-title":"A hitchhiker's guide to the human Hsp70 family","volume":"1","author":"Tavaria","year":"1996","journal-title":"Cell Stress Chaperones"},{"key":"10.1038\/jid.2008.45_bb0155","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1016\/S0264-410X(03)00275-5","article-title":"Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe","volume":"21","author":"Trimble","year":"2003","journal-title":"Vaccine"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15340008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15340008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T02:40:40Z","timestamp":1557369640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15340008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0022202X15340008"],"URL":"https:\/\/doi.org\/10.1038\/jid.2008.45","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}