{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:20:29Z","timestamp":1763036429631,"version":"3.40.3"},"reference-count":35,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2222,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30471562"],"award-info":[{"award-number":["30471562"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["BXJ0317"],"award-info":[{"award-number":["BXJ0317"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1038\/jid.2009.153","type":"journal-article","created":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T04:42:08Z","timestamp":1247892128000},"page":"2653-2660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Enhanced Proliferation and Activation of Peripheral Blood Mononuclear Cells in Patients with Psoriasis Vulgaris Mediated by Streptococcal Antigen with Bacterial DNA"],"prefix":"10.1016","volume":"129","author":[{"given":"Yi-Hua","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruo-Fei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ru","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2009.153_bb0010","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1126\/science.283.5406.1335","article-title":"Chlamydia infections and heart disease linked through antigenic mimicry","volume":"283","author":"Bachmaier","year":"1999","journal-title":"Science"},{"key":"10.1038\/jid.2009.153_bb0015","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s004030050455","article-title":"T lymphocytes reactive for group A streptococcal antigens in chronic plaque psoriatic lesions","volume":"291","author":"Baker","year":"1999","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/jid.2009.153_bb0020","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2133.1991.tb06036.x","article-title":"Altered cell-mediated immunity to group A haemolytic streptococcal antigens in chronic plaque psoriasis","volume":"125","author":"Baker","year":"1991","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2009.153_bb0025","doi-asserted-by":"crossref","first-page":"9237","DOI":"10.1073\/pnas.161293498","article-title":"Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition","volume":"98","author":"Bauer","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2009.153_bb0030","first-page":"145","article-title":"Bacterial CpG-DNA licenses TLR9","volume":"270","author":"Bauer","year":"2002","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1038\/jid.2009.153_bb0035","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nri1689","article-title":"Getting under the skin: the immunogenetics of psoriasis","volume":"5","author":"Bowcock","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1038\/jid.2009.153_bb0040","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1046\/j.1523-1747.2000.00919.x","article-title":"Skin CD4+ T cells produce interferon-gamma in vitro in response to streptococcal antigens in chronic plaque psoriasis","volume":"114","author":"Brown","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.153_bb0045","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/(SICI)1521-4141(200004)30:4<993::AID-IMMU993>3.0.CO;2-I","article-title":"Preferential stimulation of human lymphocytes by oligodeoxynucleotides that copy DNA CpG motifs present in virulent genes of group A streptococci","volume":"30","author":"Chatellier","year":"2000","journal-title":"Eur J Immunol"},{"key":"10.1038\/jid.2009.153_bb0050","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1182\/blood.V95.3.999.003k10_999_1006","article-title":"Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells","volume":"95","author":"Decker","year":"2000","journal-title":"Blood"},{"key":"10.1038\/jid.2009.153_bb0055","doi-asserted-by":"crossref","first-page":"7104","DOI":"10.4049\/jimmunol.176.11.7104","article-title":"Identical TCR beta-chain rearrangements in streptococcal angina and skin lesions of patients with psoriasis vulgaris","volume":"176","author":"Diluvio","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/jid.2009.153_bb0060","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/40166","article-title":"Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells","volume":"389","author":"Fuhlbrigge","year":"1997","journal-title":"Nature"},{"key":"10.1038\/jid.2009.153_bb0065","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/j.jaad.2005.10.057","article-title":"Innate and adaptive immunity and the pathophysiology of psoriasis","volume":"54","author":"Gaspari","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2009.153_bb0070","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.coi.2008.06.008","article-title":"Antimicrobial peptides and self-DNA in autoimmune skin inflammation","volume":"20","author":"Gilliet","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"10.1038\/jid.2009.153_bb0075","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(07)61128-3","article-title":"Pathogenesis and clinical features of psoriasis","volume":"370","author":"Griffiths","year":"2007","journal-title":"Lancet"},{"key":"10.1038\/jid.2009.153_bb0080","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-2133.1977.tb14130.x","article-title":"Lymphocyte activation by streptococcal antigens in psoriasis","volume":"97","author":"Gross","year":"1977","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2009.153_bb0085","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1046\/j.1365-2133.2003.05552.x","article-title":"Streptococcal throat infections and exacerbation of chronic plaque psoriasis: a prospective study","volume":"149","author":"Gudjonsson","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2009.153_bb0090","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A Toll-like receptor recognizes bacterial DNA","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"key":"10.1038\/jid.2009.153_bb0095","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.4049\/jimmunol.169.5.2781","article-title":"Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease","volume":"169","author":"Ichikawa","year":"2002","journal-title":"J Immunol"},{"key":"10.1038\/jid.2009.153_bb0100","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1146\/annurev.immunol.20.100301.064842","article-title":"CpG motifs in bacterial DNA and their immune effects","volume":"20","author":"Krieg","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/jid.2009.153_bb0105","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.4049\/jimmunol.181.7.4733","article-title":"Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis","volume":"181","author":"Kryczek","year":"2008","journal-title":"J Immunol"},{"key":"10.1038\/jid.2009.153_bb0110","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature06116","article-title":"Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide","volume":"449","author":"Lande","year":"2007","journal-title":"Nature"},{"key":"10.1038\/jid.2009.153_bb0115","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1084\/jem.20050500","article-title":"Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production","volume":"202","author":"Nestle","year":"2005","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2009.153_bb0120","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/01.cji.0000189028.18288.6f","article-title":"Antitumor effect of OK-432-derived DNA: one of the active constituents of OK-432, a streptococcal immunotherapeutic agent","volume":"29","author":"Oshikawa","year":"2006","journal-title":"J Immunother (1997)"},{"key":"10.1038\/jid.2009.153_bb0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0022-1759(00)00320-3","article-title":"Whole blood cultures to assess the immunostimulatory activities of CpG oligodeoxynucleotides","volume":"247","author":"Pichyangkul","year":"2001","journal-title":"J Immunol Methods"},{"key":"10.1038\/jid.2009.153_bb0130","first-page":"1934","article-title":"Specificity of antibodies to bacterial DNA in the sera of healthy human subjects and patients with systemic lupus erythematosus","volume":"26","author":"Pisetsky","year":"1999","journal-title":"J Rheumatol"},{"key":"10.1038\/jid.2009.153_bb0135","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1468-3083.2003.00720.x","article-title":"The role of T cells in psoriasis","volume":"17","author":"Prinz","year":"2003","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1038\/jid.2009.153_bb0140","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1172\/JCI26078","article-title":"Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis","volume":"116","author":"Prinz","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2009.153_bb0145","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1056\/NEJMra041320","article-title":"Psoriasis","volume":"352","author":"Schon","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2009.153_bb0150","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-2249.2001.01688.x","article-title":"The frequency of CLA+ CD8+ T cells in the blood of psoriasis patients correlates closely with the severity of their disease","volume":"126","author":"Sigmundsdottir","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1038\/jid.2009.153_bb0155","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/jid.2009.153_bb0160","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1468-3083.2006.01916.x","article-title":"The effect of methotrexate on the expression of cell adhesion molecules and activation molecule CD69 in psoriasis","volume":"21","author":"Torres-Alvarez","year":"2007","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1038\/jid.2009.153_bb0165","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/eji.200324032","article-title":"Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities","volume":"34","author":"Vollmer","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1038\/jid.2009.153_bb0170","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ni1497","article-title":"Development, cytokine profile and function of human interleukin 17-producing helper T cells","volume":"8","author":"Wilson","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2009.153_bb0175","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/MEG.0b013e32816e070b","article-title":"Pyoderma gangrenosum and exacerbation of psoriasis resulting from pegylated interferon alpha and ribavirin treatment of chronic hepatitis C","volume":"19","author":"Yurci","year":"2007","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1038\/jid.2009.153_bb0180","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature05505","article-title":"Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis","volume":"445","author":"Zheng","year":"2007","journal-title":"Nature"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15341191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15341191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T11:27:49Z","timestamp":1743938869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15341191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0022202X15341191"],"URL":"https:\/\/doi.org\/10.1038\/jid.2009.153","relation":{},"ISSN":["0022-202X"],"issn-type":[{"type":"print","value":"0022-202X"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced Proliferation and Activation of Peripheral Blood Mononuclear Cells in Patients with Psoriasis Vulgaris Mediated by Streptococcal Antigen with Bacterial DNA","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2009.153","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}