{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:06:01Z","timestamp":1791324361056,"version":"4.3.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2283,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1038\/jid.2009.27","type":"journal-article","created":{"date-parts":[[2009,3,12]],"date-time":"2009-03-12T16:08:38Z","timestamp":1236874118000},"page":"2202-2210","source":"Crossref","is-referenced-by-count":68,"title":["Rituximab Mediates a Strong Elevation of B-Cell-Activating Factor Associated with Increased Pathogen-Specific IgG but Not Autoantibodies in Pemphigus Vulgaris"],"prefix":"10.1016","volume":"129","author":[{"given":"Angela","family":"Nagel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Podstawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Eickmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Helge","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hertl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Eming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2009.27_bb0010","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1067\/mjd.2001.116339","article-title":"Intravenous immunoglobulin therapy in the treatment of patients with pemphigus vulgaris unresponsive to conventional immunosuppressive treatment","volume":"45","author":"Ahmed","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2009.27_bb0015","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1056\/NEJMoa062930","article-title":"Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin","volume":"355","author":"Ahmed","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2009.27_bb0020","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0923-1811(99)00016-X","article-title":"Autoimmunity against desmosomal cadherins in pemphigus","volume":"20","author":"Amagai","year":"1999","journal-title":"J Dermatol Sci"},{"key":"10.1038\/jid.2009.27_bb0025","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1365-2133.2006.07305.x","article-title":"Serum levels of BAFF are increased in bullous pemphigoid but not in pemphigus vulgaris","volume":"155","author":"Asashima","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2009.27_bb0030","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1172\/JCI18025","article-title":"BAFF selectively enhances the survival of plasmablasts generated from human memory B cells","volume":"112","author":"Avery","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2009.27_bb0035","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.smim.2006.04.006","article-title":"BAFF, APRIL and their receptors: structure, function and signaling","volume":"18","author":"Bossen","year":"2006","journal-title":"Semin Immunol"},{"key":"10.1038\/jid.2009.27_bb0040","doi-asserted-by":"crossref","first-page":"20878","DOI":"10.1073\/pnas.0709205105","article-title":"Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice","volume":"104","author":"Bouaziz","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2009.27_bb0045","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrd2085","article-title":"B cells move to centre stage: novel opportunities for autoimmune disease treatment","volume":"5","author":"Browning","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1038\/jid.2009.27_bb0050","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1002\/art.11181","article-title":"Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis","volume":"48","author":"Cambridge","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2009.27_bb0055","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/art.21650","article-title":"Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: relationships with B cell depletion, circulating antibodies, and clinical relapse","volume":"54","author":"Cambridge","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2009.27_bb0060","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1182\/blood-2006-01-0233","article-title":"Rituximab for steroid-refractory chronic graft-versus-host disease","volume":"108","author":"Cutler","year":"2006","journal-title":"Blood"},{"key":"10.1038\/jid.2009.27_bb0065","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrd1982","article-title":"An APRIL to remember: novel TNF ligands as therapeutic targets","volume":"5","author":"Dillon","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1038\/jid.2009.27_bb0070","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1084\/jem.192.7.953","article-title":"Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response","volume":"192","author":"Do","year":"2000","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2009.27_bb0075","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1517\/14712598.7.9.1287","article-title":"B-cell targeting: a novel approach to immune intervention today and tomorrow","volume":"7","author":"Dorner","year":"2007","journal-title":"Expert Opin Biol Ther"},{"key":"10.1038\/jid.2009.27_bb0080","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/08916930600972040","article-title":"Immunoadsorption in pemphigus","volume":"39","author":"Eming","year":"2006","journal-title":"Autoimmunity"},{"key":"10.1038\/jid.2009.27_bb0085","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1038\/jid.2008.172","article-title":"Rituximab exerts a dual effect in pemphigus vulgaris","volume":"128","author":"Eming","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.27_bb0090","series-title":"Biologics in General Medicine","first-page":"69","article-title":"Treating autoimmune bullous skin disorders with biologics","author":"Eming","year":"2007"},{"key":"10.1038\/jid.2009.27_bb0095","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000090659","article-title":"Prolonged clinical remission of patients with severe pemphigus upon rapid removal of desmoglein-reactive autoantibodies by immunoadsorption","volume":"212","author":"Eming","year":"2006","journal-title":"Dermatology"},{"key":"10.1038\/jid.2009.27_bb0100","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.4049\/jimmunol.178.5.2872","article-title":"IL-21 and BAFF\/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells","volume":"178","author":"Ettinger","year":"2007","journal-title":"J Immunol"},{"key":"10.1038\/jid.2009.27_bb0105","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/eji.200737557","article-title":"Levels of autoantibodies, unlike antibodies to all extrinsic antigen groups, fall following B cell depletion with Rituximab","volume":"38","author":"Ferraro","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1038\/jid.2009.27_bb0110","doi-asserted-by":"crossref","first-page":"817","DOI":"10.4049\/jimmunol.174.2.817","article-title":"Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy","volume":"174","author":"Gong","year":"2005","journal-title":"J Immunol"},{"key":"10.1038\/jid.2009.27_bb0115","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1056\/NEJMoa067752","article-title":"A single cycle of rituximab for the treatment of severe pemphigus","volume":"357","author":"Joly","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2009.27_bb0120","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1136\/ard.2006.060772","article-title":"Increase of B cell-activating factor of the TNF family (BAFF) after rituximab treatment: insights into a new regulating system of BAFF production","volume":"66","author":"Lavie","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1038\/jid.2009.27_bb0125","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10875-007-9082-2","article-title":"BAFF, a new target for intravenous immunoglobulin in autoimmunity and cancer","volume":"27","author":"Le Pottier","year":"2007","journal-title":"J Clin Immunol"},{"key":"10.1038\/jid.2009.27_bb0130","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S1074-7613(04)00079-2","article-title":"Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF","volume":"20","author":"Lesley","year":"2004","journal-title":"Immunity"},{"key":"10.1038\/jid.2009.27_bb0135","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/ni829","article-title":"DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL","volume":"3","author":"Litinskiy","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2009.27_bb0140","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.smim.2006.04.005","article-title":"The role of the BAFF\/APRIL system on T cell function","volume":"18","author":"Mackay","year":"2006","journal-title":"Semin Immunol"},{"key":"10.1038\/jid.2009.27_bb0145","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1146\/annurev.immunol.21.120601.141152","article-title":"BAFF AND APRIL: a tutorial on B cell survival","volume":"21","author":"Mackay","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/jid.2009.27_bb0150","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.coi.2007.04.008","article-title":"B cells and the BAFF\/APRIL axis: fast-forward on autoimmunity and signaling","volume":"19","author":"Mackay","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"10.1038\/jid.2009.27_bb0155","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.immunol.23.021704.115723","article-title":"Maintenance of serum antibody levels","volume":"23","author":"Manz","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/jid.2009.27_bb0160","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-0625.2006.00485.x","article-title":"Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases","volume":"16","author":"Matsushita","year":"2007","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2009.27_bb0165","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/art.21526","article-title":"Elevated serum BAFF levels in patients with systemic sclerosis: enhanced BAFF signaling in systemic sclerosis B lymphocytes","volume":"54","author":"Matsushita","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2009.27_bb0170","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jaad.2008.01.012","article-title":"Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus","volume":"58","author":"Murrell","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2009.27_bb0175","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1084\/jem.20031330","article-title":"BCMA is essential for the survival of long-lived bone marrow plasma cells","volume":"199","author":"O\u2019Connor","year":"2004","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2009.27_bb0180","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ceb.2004.07.006","article-title":"Desmosomes and disease: pemphigus and bullous impetigo","volume":"16","author":"Payne","year":"2004","journal-title":"Curr Opin Cell Biol"},{"key":"10.1038\/jid.2009.27_bb0185","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nri1886","article-title":"Competence and competition: the challenge of becoming a long-lived plasma cell","volume":"6","author":"Radbruch","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1038\/jid.2009.27_bb0190","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.coi.2005.04.005","article-title":"The role of APRIL and BAFF in lymphocyte activation","volume":"17","author":"Schneider","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"10.1038\/jid.2009.27_bb0195","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0165-2478(03)00050-6","article-title":"BAFF and the regulation of B cell survival","volume":"88","author":"Schneider","year":"2003","journal-title":"Immunol Lett"},{"key":"10.1038\/jid.2009.27_bb0200","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.jaad.2006.06.029","article-title":"High-dose intravenous immunoglobulins for the treatment of autoimmune mucocutaneous blistering diseases: evaluation of its use in 19 cases","volume":"56","author":"Segura","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2009.27_bb0205","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/ard.2006.057919","article-title":"Tolerance and efficacy of rituximab and changes in serum B cell biomarkers in patients with systemic complications of primary Sjogren's syndrome","volume":"66","author":"Seror","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1038\/jid.2009.27_bb0210","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/art.10947","article-title":"Rituximab therapy and autoimmune disorders: prospects for anti-B cell therapy","volume":"48","author":"Silverman","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2009.27_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2006.03.010","article-title":"B cell depletion therapy in systemic rheumatic diseases: different strokes for different folks?","volume":"121","author":"Stohl","year":"2006","journal-title":"Clin Immunol"},{"key":"10.1038\/jid.2009.27_bb0220","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.pharmthera.2006.06.002","article-title":"Targeting BAFF: immunomodulation for autoimmune diseases and lymphomas","volume":"112","author":"Sutherland","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1038\/jid.2009.27_bb0225","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1182\/blood.V76.9.1739.1739","article-title":"Identification and characterization of plasma cells in normal human bone marrow by high-resolution flow cytometry","volume":"76","author":"Terstappen","year":"1990","journal-title":"Blood"},{"key":"10.1038\/jid.2009.27_bb0230","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.immuni.2004.05.010","article-title":"Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches","volume":"20","author":"Thien","year":"2004","journal-title":"Immunity"},{"key":"10.1038\/jid.2009.27_bb0235","doi-asserted-by":"crossref","first-page":"R167","DOI":"10.1186\/ar2076","article-title":"Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis","volume":"8","author":"Vallerskog","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1038\/jid.2009.27_bb0240","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jdermsci.2006.12.008","article-title":"Increased serum levels of a proliferation-inducing ligand in patients with bullous pemphigoid","volume":"46","author":"Watanabe","year":"2007","journal-title":"J Dermatol Sci"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15344900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15344900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T18:46:43Z","timestamp":1589654803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15344900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0022202X15344900"],"URL":"https:\/\/doi.org\/10.1038\/jid.2009.27","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}