{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:33:07Z","timestamp":1772134387269,"version":"3.50.1"},"reference-count":135,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2314,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1038\/jid.2009.8","type":"journal-article","created":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T10:41:28Z","timestamp":1235040088000},"page":"1868-1877","source":"Crossref","is-referenced-by-count":56,"title":["Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne"],"prefix":"10.1016","volume":"129","author":[{"given":"Bodo C.","family":"Melnik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos C.","family":"Zouboulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2009.8_bb0010","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.0022-202X.2004.23307.x","article-title":"Cytochrome P450: a target for drug development for skin disease","volume":"123","author":"Ahmad","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0015","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1042\/BJ20071594","article-title":"Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling","volume":"413","author":"Ahmed","year":"2008","journal-title":"Biochem J"},{"key":"10.1038\/jid.2009.8_bb0020","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/S0002-9440(10)63574-2","article-title":"Hedgehog signaling regulates sebaceous gland development","volume":"163","author":"Allen","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2009.8_bb0025","first-page":"33","article-title":"Evaluation of the anti-comedo effect of azelaic acid using the technique of horny layer biopsy and scanning electron microscopy","volume":"125","author":"Angius","year":"1990","journal-title":"G Ital Dermatol Venereol"},{"key":"10.1038\/jid.2009.8_bb0030","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1365-2133.1992.tb14870.x","article-title":"Interleukin 1 immunoreactivity in sebaceous glands","volume":"127","author":"Anttila","year":"1992","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2009.8_bb0035","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1096\/fj.05-3934fje","article-title":"Endocytotic pathways and biological effects induced by UVB-dependent or ligand-dependent activation of the keratinocyte growth factor receptor","volume":"20","author":"Belleudi","year":"2006","journal-title":"FASEB J"},{"key":"10.1038\/jid.2009.8_bb0040","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1111\/j.1600-0854.2007.00651.x","article-title":"Keratinocyte growth factor receptor ligands target the receptor to different intracellular pathways","volume":"8","author":"Belleudi","year":"2007","journal-title":"Traffic"},{"key":"10.1038\/jid.2009.8_bb0045","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1525-1470.2005.00141.x","article-title":"Successful acne management in Apert syndrome twins","volume":"22","author":"Benjamin","year":"2005","journal-title":"Pediatr Dermatol"},{"key":"10.1038\/jid.2009.8_bb0050","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1600-0625.1995.tb00057.x","article-title":"Messenger RNAs for the multifunctional cytokines interleukin-1alpha, interleukin-1beta, and tumor necrosis factor-alpha are present in adnexal tissues and in dermis of normal human skin","volume":"4","author":"Boehm","year":"1995","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2009.8_bb0055","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1046\/j.0022-202x.2001.01704.x","article-title":"Evidence for expression of melanocortin-1 receptor in human sebocytes in vitro and in situ","volume":"118","author":"B\u00f6hm","year":"2002","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0060","first-page":"1158","article-title":"Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients","volume":"1995","author":"Boudou","year":"1995","journal-title":"J Clin Endocr Metab"},{"key":"10.1038\/jid.2009.8_bb0065","first-page":"496","article-title":"Pronounced and early acne in Apert's syndrome: a case successfully treated with oral isotretinoin","volume":"12","author":"Campanati","year":"2002","journal-title":"Eur J Dermatol"},{"key":"10.1038\/jid.2009.8_bb0070","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1194\/jlr.M500154-JLR200","article-title":"KGF induces lipogenic genes through a PI3K and JNK\/SREBP-1 pathway in H292 cells","volume":"46","author":"Chang","year":"2005","journal-title":"J Lipid Res"},{"key":"10.1038\/jid.2009.8_bb0075","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0092-8674(00)80467-5","article-title":"Exocrine gland dysfuction in MC5R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides","volume":"91","author":"Chen","year":"1997","journal-title":"Cell"},{"key":"10.1038\/jid.2009.8_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.1998.9103","article-title":"Essential role for sonic hedgehog during hair follicle morphogenesis","volume":"205","author":"Chiang","year":"1999","journal-title":"Dev Biol"},{"key":"10.1038\/jid.2009.8_bb0085","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/sj.jid.5701188","article-title":"Propionibacterium acnes stimulates pro-matrix metalloproteinase-2 expression through tumor necrosis factor-\u03b1 in human dermal fibroblasts","volume":"128","author":"Choi","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0090","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/09546630305549","article-title":"Acne in Apert's syndrome: treatment with isotretinoin","volume":"14","author":"Cuerda","year":"2003","journal-title":"J Dermatol Treat"},{"key":"10.1038\/jid.2009.8_bb0095","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1210\/edrv-8-3-338","article-title":"The endocrinology and developmental biology of the prostate","volume":"8","author":"Cunha","year":"1987","journal-title":"Endo Rev"},{"key":"10.1038\/jid.2009.8_bb0100","first-page":"145","article-title":"Keratinocyte growth factor is an important endogeneous mediator of hair follicle growth development, and differentiation. Normalization of the nu\/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia","volume":"147","author":"Danilenko","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2009.8_bb0105","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.det.2007.06.017","article-title":"Keratinocyte growth factor receptors","volume":"25","author":"De Giorgi","year":"2007","journal-title":"Dermatol Clin"},{"key":"10.1038\/jid.2009.8_bb0110","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1242\/dev.127.3.483","article-title":"An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis","volume":"127","author":"De Moerlooze","year":"2000","journal-title":"Development"},{"key":"10.1038\/jid.2009.8_bb0115","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/1523-1747.ep12277353","article-title":"Effects of azelaic acid on proliferation and ultrastructure of mouse keratinocytes in vitro","volume":"93","author":"Detmar","year":"1989","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.gene.2003.09.004","article-title":"Functional analysis of the human Sprouty2 gene promoter","volume":"322","author":"Ding","year":"2003","journal-title":"Gene"},{"key":"10.1038\/jid.2009.8_bb0125","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/jcp.21078","article-title":"Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF\u03b21 signaling and EGF as well FGF receptor tyrosine kinase \u2013 ERK pathways in mesenchymal cells","volume":"212","author":"Ding","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1038\/jid.2009.8_bb0130","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1046\/j.1365-2230.1999.00533.x","article-title":"Isotretinoin therapy for antibiotic-refractory acne in Apert's syndrome","volume":"24","author":"Downs","year":"1999","journal-title":"Clin Exp Dermatol"},{"key":"10.1038\/jid.2009.8_bb0135","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1006\/bbrc.1999.0502","article-title":"Optimization of treatment conditions for studying the anticancer effects of retinoids using pancreatic adenocarcinoma as a model","volume":"257","author":"El-Metwally","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/jid.2009.8_bb0140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cytogfr.2005.01.001","article-title":"Cellular signaling by fibroblast growth factor receptors","volume":"16","author":"Eswarakumar","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1038\/jid.2009.8_bb0145","first-page":"481","article-title":"Klinische und experimentelle Untersuchungen \u00fcber die Wirkung von Benzoylperoxid in der Behandlung der Akne","volume":"29","author":"Fanta","year":"1978","journal-title":"Hautarzt"},{"key":"10.1038\/jid.2009.8_bb0150","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.0022-202X.2005.23686.x","article-title":"Towards dissecting the pathogenesis of retinoid-induced hair loss: all-trans retinoic acid induces premature hair follicle regression (catagen) by upregulation of transforming growth factor-beta2 in the dermal papilla","volume":"124","author":"Foitzik","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0155","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1046\/j.1523-1747.2001.01327.x","article-title":"Keratins and the keratinocyte activation cycle","volume":"116","author":"Freedberg","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0160","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1365-2133.1985.tb02419.x","article-title":"Azelaic acid and sebum excretion rate","volume":"113","author":"Gassm\u00fcller","year":"1985","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2009.8_bb0165","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1210\/endo-122-3-1159","article-title":"5\u03b1-Dihydrotestosterone formation is necessary for embryogenesis of the rat prostate","volume":"122","author":"George","year":"1988","journal-title":"Endocrinology"},{"key":"10.1038\/jid.2009.8_bb0170","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1046\/j.1525-1470.2003.20517.x","article-title":"Isotretinoin treatment of acne in a patient with Apert syndrome","volume":"20","author":"Gilaberte","year":"2003","journal-title":"Pediatr Dermatol"},{"key":"10.1038\/jid.2009.8_bb0175","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1091\/mbc.1.1.87","article-title":"Retinoic acid induces transforming growth factor-\u03b22 in cultured keratinocytes and mouse epidermis","volume":"1","author":"Glick","year":"1989","journal-title":"Cell Regulation"},{"key":"10.1038\/jid.2009.8_bb0180","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00416928","article-title":"Cytokinetic studies on the sebosuppressive effect of drugs using the example of benzoyl peroxide","volume":"167","author":"Gloor","year":"1980","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/jid.2009.8_bb0185","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1002\/1529-0131(200009)43:9<1916::AID-ANR2>3.0.CO;2-I","article-title":"The role of the chondrocyte in osteoarthritis","volume":"43","author":"Goldring","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2009.8_bb0190","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0190-9622(82)70066-0","article-title":"Comparative effect of isotretinoin and etretinate on acne and sebaceous gland secretion","volume":"6","author":"Goldstein","year":"1982","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2009.8_bb0195","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1067\/mjd.2003.618","article-title":"Management of acne. A report from a global alliance to improve outcomes in acne. Antimicrobial therapy","volume":"49","author":"Gollnick","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2009.8_bb0200","first-page":"452","article-title":"Effects of azelaic acid on filaggrin, other cytokeratins and on the ultrastructure of human keratinocytes in vivo","volume":"89","author":"Gollnick","year":"1987","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0205","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1046\/j.1439-0353.2004.04731.x","article-title":"Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies","volume":"2","author":"Gollnick","year":"2004","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1038\/jid.2009.8_bb0210","first-page":"5386","article-title":"Regulation of Gli activity by all-trans retinoic acid in mouse keratinocytes","volume":"60","author":"Goyette","year":"2000","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2009.8_bb0215","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/sj.emboj.7601583","article-title":"The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development","volume":"26","author":"Grose","year":"2007","journal-title":"EMBO J"},{"key":"10.1038\/jid.2009.8_bb0220","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/1523-1747.ep12329907","article-title":"Modeling acne in vitro","volume":"106","author":"Guy","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0225","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1128\/MCB.18.7.3966","article-title":"Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation","volume":"18","author":"Hadari","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1038\/jid.2009.8_bb0230","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1677\/joe.1.06862","article-title":"Region-specific expression of androgen and growth factor pathway genes in the rat epididymis and the effects of dual 5\u03b1-reductase inhibition","volume":"190","author":"Henderson","year":"2006","journal-title":"J Endocrinol"},{"key":"10.1038\/jid.2009.8_bb0235","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jaad.2005.01.007","article-title":"Resolution of acne following therapy with an oral contraceptive in a patient with Apert syndrome","volume":"53","author":"Hsieh","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2009.8_bb0240","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2133.1996.tb07609.x","article-title":"Keratin expression in pilosebaceous epithelia in truncal skin of acne patients","volume":"134","author":"Hughes","year":"1996","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2009.8_bb0245","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1046\/j.1365-2133.1998.02451.x","article-title":"All-trans retinoic acid comprises desmosome expression in human epidermis","volume":"139","author":"Humphries","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2009.8_bb0250","first-page":"524","article-title":"The androgen control of sebum production. Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity","volume":"76","author":"Imperato-McGinley","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1038\/jid.2009.8_bb0255","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/1523-1747.ep12460324","article-title":"Proinflammatory levels of interleukin 1 alpha-like bioactivity are present in the majority of open comedones in acne vulgaris","volume":"98","author":"Ingham","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0260","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1046\/j.1523-1747.2003.12321.x","article-title":"Inflammatory events are involved in acne lesion initiation","volume":"121","author":"Jeremy","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0265","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S0140-6736(80)92273-4","article-title":"13-cis retinoic acid and acne","volume":"2","author":"Jones","year":"1980","journal-title":"Lancet"},{"key":"10.1038\/jid.2009.8_bb0270","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1001\/archderm.1974.01630020028006","article-title":"A human model of coal tar acne","volume":"109","author":"Kaidbey","year":"1974","journal-title":"Arch Dermatol"},{"key":"10.1038\/jid.2009.8_bb0275","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0190-9622(97)70049-5","article-title":"The treatment of acne with topical retinoids: one man's opinions","volume":"36","author":"Kligman","year":"1997","journal-title":"J Am Acad Dermatol Suppl"},{"key":"10.1038\/jid.2009.8_bb0280","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0092-8674(00)80252-4","article-title":"A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras\/MAPK signaling pathway","volume":"89","author":"Kouhara","year":"1997","journal-title":"Cell"},{"key":"10.1038\/jid.2009.8_bb0285","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/1523-1747.ep12477026","article-title":"Monoclonal antibody labeling for cytokeratins and filaggrin in the human pilosebaceous unit of normal, seborrhoeic and acne skin","volume":"91","author":"Kurokawa","year":"1988","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0290","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF00406424","article-title":"Inhibitory effects of 13cis-retinoic acid on human sebaceous glands","volume":"269","author":"Landthaler","year":"1980","journal-title":"Arch Derm Res"},{"key":"10.1038\/jid.2009.8_bb0295","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1242\/dev.02765","article-title":"Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis","volume":"134","author":"Lin","year":"2007","journal-title":"Development"},{"key":"10.1038\/jid.2009.8_bb0300","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1359\/jbmr.2001.16.4.705","article-title":"Increased expression of protein kinase C\u03b1, interleukin-1\u03b1, and RhoA guanosine 5\u2032-triphosphatase in osteoblasts expressing the Ser252Trp fibroblast growth factor 2 Apert mutation: identification by analysis of complementary DNA microarray","volume":"16","author":"Lomri","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10.1038\/jid.2009.8_bb0305","doi-asserted-by":"crossref","first-page":"21052","DOI":"10.1074\/jbc.M601559200","article-title":"Control of fibroblast growth factor (FGF)7- and FGF1-induced mitogenesis and downstream signaling by distinct heparin octasaccaride motifs","volume":"281","author":"Luo","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2009.8_bb0310","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0012-1606(02)00031-3","article-title":"Hormonal, cellular, and molecular control of prostatic development","volume":"253","author":"Marker","year":"2003","journal-title":"Dev Biol"},{"key":"10.1038\/jid.2009.8_bb0315","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0925-4773(96)00495-9","article-title":"A novel MAP kinase phosphatase is localized in the branchial arm region and tail tip of Xenopus embryos and is inducible by retinoic acid","volume":"55","author":"Mason","year":"1996","journal-title":"Mech Dev"},{"key":"10.1038\/jid.2009.8_bb0320","first-page":"20","article-title":"Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin \u2013 an in vivo and in vitro study","volume":"143","author":"Mayer-da-Silva","year":"1989","journal-title":"Acta Derm Venereol (Stockh) Suppl"},{"key":"10.1038\/jid.2009.8_bb0325","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1610-0387.2008.06822.x","article-title":"FGFR2 signalling and the pathogenesis of acne","volume":"6","author":"Melnik","year":"2008","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1038\/jid.2009.8_bb0330","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/j.1365-2133.2008.08559.x","article-title":"Unilateral segmental acneiform naevus: a model disorder towards understanding fibroblast growth factor receptor 2 function in acne?","volume":"158","author":"Melnik","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2009.8_bb0335","first-page":"68","article-title":"The rabbit ear microcomedo prevention assay. A new model to evaluate antiacne agents","volume":"Vol. 3","author":"Mezick","year":"1987"},{"key":"10.1038\/jid.2009.8_bb0340","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1128\/MCB.16.3.977","article-title":"Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction","volume":"16","author":"Mohammadi","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1038\/jid.2009.8_bb0345","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1534-5807(04)00026-7","article-title":"Regulation of segmental patterning by retinoic acid signaling during Xenopus somitogenesis","volume":"6","author":"Moreno","year":"2004","journal-title":"Dev Cell"},{"key":"10.1038\/jid.2009.8_bb0350","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1074\/jbc.M310206200","article-title":"Identification of genetic pathways activated by the androgen receptor during the induction of proliferation in the ventral prostate gland","volume":"279","author":"Natermet","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2009.8_bb0355","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2133.1983.tb03990.x","article-title":"Beneficial effect of 15% azelaic acid cr\u00e8me on acne vulgaris","volume":"109","author":"Nazzaro-Porro","year":"1983","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2009.8_bb0360","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1038\/sj.jid.5700289","article-title":"13-cis retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes","volume":"126","author":"Nelson","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0365","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1346-8138.1996.tb03993.x","article-title":"An ultrastructural study of the retention hyperkeratosis of experimentally induced comedones in rabbits: the effect of three comedolytics","volume":"23","author":"Oh","year":"1996","journal-title":"J Dermatol"},{"key":"10.1038\/jid.2009.8_bb0370","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1128\/MCB.20.3.979-989.2000","article-title":"FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors","volume":"20","author":"Ong","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1038\/jid.2009.8_bb0375","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/bbrc.1997.7272","article-title":"SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells","volume":"238","author":"Ong","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/jid.2009.8_bb0380","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1006\/dbio.1993.1205","article-title":"Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2)","volume":"158","author":"Orr-Urtreger","year":"1993","journal-title":"Dev Biol"},{"key":"10.1038\/jid.2009.8_bb0385","series-title":"Williams Textbook of Endocrinology","first-page":"517","article-title":"The adrenal cortex","author":"Orth","year":"1998"},{"key":"10.1038\/jid.2009.8_bb0390","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.0022-202X.2005.23848.x","article-title":"Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin","volume":"125","author":"Papakonstantinou","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0395","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000017855","article-title":"Polymorphisms in the human cytochrome P-450 1A1 gene (CYP1A1) as a factor for developing acne","volume":"196","author":"Paraskevaidis","year":"1998","journal-title":"Dermatology"},{"key":"10.1038\/jid.2009.8_bb0400","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1525-1470.1992.tb00352.x","article-title":"Isotretinoin for acne in Apert syndrome","volume":"9","author":"Parker","year":"1992","journal-title":"Pediatr Dermatol"},{"key":"10.1038\/jid.2009.8_bb0405","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/sj.jid.5701098","article-title":"All-trans retinoic acid-induced hyalorunan production and hyperplasia are partly mediated by EGFR signaling in epidermal keratinocytes","volume":"128","author":"Pasonen-Sepp\u00e4nen","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0410","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0006-2952(84)90376-9","article-title":"Antimitochondrial effect of staturated medium chain length (C8-C13) dicarboxylic acids","volume":"33","author":"Passi","year":"1984","journal-title":"Biochem Pharmacol"},{"key":"10.1038\/jid.2009.8_bb0415","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000246655","article-title":"Digital image analysis of microcomedones","volume":"190","author":"Pi\u00e9rad","year":"1995","journal-title":"Dermatology"},{"key":"10.1038\/jid.2009.8_bb0420","first-page":"128","article-title":"Autoradiographische Untersuchungen an Epidermis und Adnexen nach Vitamin A S\u00e4ure-Behandlung","volume":"23","author":"Plewig","year":"1972","journal-title":"Hautarzt"},{"key":"10.1038\/jid.2009.8_bb0425","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/BF00595286","article-title":"Cellular dynamics of comedo formation in acne vulgaris","volume":"242","author":"Plewig","year":"1971","journal-title":"Arch Dermatol Forsch"},{"key":"10.1038\/jid.2009.8_bb0430","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/jid.1969.4","article-title":"Sebaceous gland response in man to the administration of testosterone, delta-4-androstendione, and dehydroisoandrosterone","volume":"52","author":"Pochi","year":"1969","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0435","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1677\/erc.0.0070165","article-title":"Fibroblast growth factors, their receptors and signaling","volume":"7","author":"Powers","year":"2000","journal-title":"Endocr Relat Cancer"},{"key":"10.1038\/jid.2009.8_bb0440","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1210\/en.2006-1113","article-title":"Androgen regulation of prostate morphoregulatory gene expression: Fgf10-dependent and -independent pathways","volume":"148","author":"Pu","year":"2007","journal-title":"Endocrinology"},{"key":"10.1038\/jid.2009.8_bb0445","first-page":"257","article-title":"Kinisch-experimentelle Untersuchungen zum Wirkungsmechanismus von Benzoylperoxid","volume":"33","author":"Puschmann","year":"1982","journal-title":"Hautarzt"},{"key":"10.1038\/jid.2009.8_bb0450","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1172\/JCI20384","article-title":"Disruption of Fgf10\/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate","volume":"113","author":"Rice","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2009.8_bb0455","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1242\/jcs.95.1.125","article-title":"Organ maintenance of human sebaceous glands: in vitro effects of 13-cis retinoic acid and testosterone","volume":"95","author":"Ridden","year":"1990","journal-title":"J Cell Sci"},{"key":"10.1038\/jid.2009.8_bb0460","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/sj.jid.5700202","article-title":"Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo","volume":"126","author":"Ritti\u00e9","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0465","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0026-895X(25)08899-6","article-title":"Role of isozymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal","volume":"41","author":"Roberts","year":"1992","journal-title":"Mol Pharmacol"},{"key":"10.1038\/jid.2009.8_bb0470","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0190-9622(89)70190-0","article-title":"Successful treatment of the acne of Apert's syndrome with isotretinoin","volume":"21","author":"Robinson","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2009.8_bb0475","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1034\/j.1600-0625.2003.00014.x","article-title":"Involvement of the SREBP pathway in the mode of action of androgens in sebaceous glands in vivo","volume":"12","author":"Rosignoli","year":"2003","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2009.8_bb0480","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/1523-1747.ep12261252","article-title":"Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin \u2013 a possible pathogenic factor in acne","volume":"56","author":"Sansone","year":"1971","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0485","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0092-8674(00)00114-8","article-title":"Cell signaling by receptor tyrosine kinases","volume":"103","author":"Schlessinger","year":"2000","journal-title":"Cell"},{"key":"10.1038\/jid.2009.8_bb0490","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S1097-2765(00)00073-3","article-title":"Crystal structure of a ternary FGF-FGFR-heparin complex reveal a dual role for heparin in FGFR binding and dimerization","volume":"6","author":"Schlessinger","year":"2000","journal-title":"Mol Cell"},{"key":"10.1038\/jid.2009.8_bb0495","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1055\/s-2007-961813","article-title":"All-trans-retinoic acid and 13-cis-retinoic acid: pharmacokinetics and biological activity in different cell culture models of human keratinocytes","volume":"39","author":"Schroeder","year":"2007","journal-title":"Horm Metab Res"},{"key":"10.1038\/jid.2009.8_bb0500","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.cell.2007.02.050","article-title":"Dual transcriptional activities underlie opposing effects of retinoic acid on cell survival","volume":"129","author":"Schug","year":"2007","journal-title":"Cell"},{"key":"10.1038\/jid.2009.8_bb0505","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1210\/jcem-38-1-113","article-title":"Testosterone formation and metabolism during male sexual differentiation in the human embryo","volume":"38","author":"Siiteri","year":"1974","journal-title":"J Clin Endocrinal Metab"},{"key":"10.1038\/jid.2009.8_bb0510","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1476-4598-6-82","article-title":"On the role of transforming growth factor-\u03b2 in the growth inhibitory effects of retinoic acid in human pancreatic cancer cells","volume":"6","author":"Singh","year":"2007","journal-title":"Mol Cancer"},{"key":"10.1038\/jid.2009.8_bb0515","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/sj.jid.5701155","article-title":"IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase\/Akt pathway","volume":"128","author":"Smith","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0520","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1242\/dev.01690","article-title":"FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis","volume":"132","author":"Steinberg","year":"2005","journal-title":"Development"},{"key":"10.1038\/jid.2009.8_bb0525","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0960-9822(98)70443-9","article-title":"Sonic hedgehog signaling is essential for hair development","volume":"8","author":"St-Jacques","year":"1998","journal-title":"Curr Biol"},{"key":"10.1038\/jid.2009.8_bb0530","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/1523-1747.ep12519851","article-title":"The effect of marked inhibition of sebum production with 13cis-retinoic acid on the skin surface lipid composition","volume":"74","author":"Strauss","year":"1980","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0535","doi-asserted-by":"crossref","first-page":"5114","DOI":"10.1128\/MCB.22.14.5114-5127.2002","article-title":"Selective cooperation between fatty acid binding proteins and peroxisome proliferator- activated receptors in regulating transcription","volume":"22","author":"Tan","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1038\/jid.2009.8_bb0540","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/1523-1747.ep12317162","article-title":"Activity of the type 1 5\u03b1-reductase exhibits regional differences in isolated sebaceous glands and whole skin","volume":"105","author":"Thiboutot","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0545","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000017863","article-title":"Activity of 5-alpha-reductase and 17-beta- hydroxysteroid dehydrogenase in the infrainfundibulum of subjects with and without acne vulgaris","volume":"196","author":"Thiboutot","year":"1998","journal-title":"Dermatology"},{"key":"10.1038\/jid.2009.8_bb0550","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1365-2133.2001.04276.x","article-title":"Lipid analysis of follicular casts from cyanoacrylate strips as a new method for studying therapeutic effects of antiacne agents","volume":"145","author":"Thielitz","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2009.8_bb0555","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/sj.jid.5700439","article-title":"Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenic steps in acne initiation","volume":"127","author":"Thielitz","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0560","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1677\/joe.0.0710279","article-title":"Effect of alpha-melanocyte-stimulating hormone and testosterone on cutaneous and modified sebaceous glands in the rat","volume":"71","author":"Thody","year":"1976","journal-title":"J Endocrinol"},{"key":"10.1038\/jid.2009.8_bb0565","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1677\/joe.0.0640503","article-title":"Control of sebaceous gland function in the rat by alpha-melanocyte-stimulating hormone","volume":"64","author":"Thody","year":"1975","journal-title":"J Endocrinol"},{"key":"10.1038\/jid.2009.8_bb0570","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/1523-1747.ep12873985","article-title":"Trans retinoic acid enhances growth response epidermal keratinocytes to epidermal growth factor and transforming growth factor beta","volume":"94","author":"Tong","year":"1990","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0575","first-page":"14","article-title":"Pharmocology and toxicology of azelaic acid","volume":"143","author":"T\u00f6pert","year":"1989","journal-title":"Acta Derm Venereol (Stockh) Suppl"},{"key":"10.1038\/jid.2009.8_bb0580","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/sj.jid.5700213","article-title":"Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling","volume":"126","author":"Trivedi","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0585","doi-asserted-by":"crossref","first-page":"pe17","DOI":"10.1126\/stke.2282004pe17","article-title":"Promotion and attenuation of FGF signaling through the Ras-MAPK pathway","volume":"2004","author":"Tsang","year":"2004","journal-title":"Sci STKE"},{"key":"10.1038\/jid.2009.8_bb0590","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1523-1747.2000.00066.x","article-title":"13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerizations to all-trans retinoic acid and binding to retinoid acid receptors","volume":"115","author":"Tsukada","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0595","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2165\/00003088-199120010-00005","article-title":"Pharmacokinetic interactions between theophylline and other medications (Part I)","volume":"20","author":"Upton","year":"1991","journal-title":"Clin Pharmacokinet"},{"key":"10.1038\/jid.2009.8_bb0600","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1016\/j.bmc.2007.01.026","article-title":"Synthesis and in vitro evaluation of targeted tetracycline derivatives: effects on inhibition of matrix metalloproteinases","volume":"15","author":"Vidal","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"10.1038\/jid.2009.8_bb0605","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0190-9622(98)70443-8","article-title":"Topical tretinoin in acne therapy","volume":"39","author":"Webster","year":"1998","journal-title":"J Am Acad Dermatol Suppl"},{"key":"10.1038\/jid.2009.8_bb0610","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF02353475","article-title":"Cytochrome P450A (CYP3A) metabolism: prediction of in vivo activity in humans","volume":"24","author":"Wilkinson","year":"1996","journal-title":"J Pharamcokinet Biopharm"},{"key":"10.1038\/jid.2009.8_bb0615","first-page":"289","article-title":"Untersuchungen zur Wirkung von Benzoylperoxid auf die Talgdr\u00fcsensekretion","volume":"169","author":"Wirth","year":"1983","journal-title":"Dermatol Monatsschr"},{"key":"10.1038\/jid.2009.8_bb0620","doi-asserted-by":"crossref","first-page":"6684","DOI":"10.1073\/pnas.052138899","article-title":"FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl","volume":"99","author":"Wong","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2009.8_bb0625","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1073\/pnas.0436500100","article-title":"Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors","volume":"100","author":"Yeh","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2009.8_bb0630","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1074\/jbc.M108368200","article-title":"Sprouty2 inhibits the Ras\/MAP kinase pathway by inhibiting the activation of Raf","volume":"277","author":"Yusoff","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2009.8_bb0635","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1749-6632.2003.tb03175.x","article-title":"Proopiomelanocortin peptides and sebogenesis","volume":"994","author":"Zhang","year":"2003","journal-title":"Ann NY Acad Sci"},{"key":"10.1038\/jid.2009.8_bb0640","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.peptides.2005.05.030","article-title":"Melanocortin-5 receptor: a marker of human sebocyte differentiation","volume":"27","author":"Zhang","year":"2006","journal-title":"Peptides"},{"key":"10.1038\/jid.2009.8_bb0645","first-page":"225","article-title":"Transcriptional control of epidermal growth factor receptor by retinoic acid","volume":"3","author":"Zheng","year":"1992","journal-title":"Cell Growth Differ"},{"key":"10.1038\/jid.2009.8_bb0650","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1610-0387.2003.03011.x","article-title":"Treatment of acne with antiandrogens \u2013 an evidence-based review","volume":"1","author":"Zouboulis","year":"2003","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1038\/jid.2009.8_bb0655","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1600-0625.2008.00725.x","article-title":"Frontiers in sebaceous gland biology and pathology","volume":"17","author":"Zouboulis","year":"2008","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2009.8_bb0660","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.0906-6705.2005.0285a.x","article-title":"What is the pathogenesis of acne?","volume":"14","author":"Zouboulis","year":"2005","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2009.8_bb0665","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/1523-1747.ep12471782","article-title":"Effects of 13-cis-retinoic acid, all-trans-retinoic acid, and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro","volume":"96","author":"Zouboulis","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2009.8_bb0670","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1046\/j.1523-1747.1999.00771.x","article-title":"Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)","volume":"113","author":"Zouboulis","year":"1999","journal-title":"J Invest Dematol"},{"key":"10.1038\/jid.2009.8_bb0675","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000017861","article-title":"The human sebocyte culture model provides new insights into development and management of seborrhoea and acne","volume":"196","author":"Zouboulis","year":"1998","journal-title":"Dermatology"},{"key":"10.1038\/jid.2009.8_bb0680","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000210927","article-title":"Culture of human sebocytes and markers of sebocytic differentiation in vitro","volume":"4","author":"Zouboulis","year":"1991","journal-title":"Skin Pharmacol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15344390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15344390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:35:15Z","timestamp":1738942515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15344390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":135,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0022202X15344390"],"URL":"https:\/\/doi.org\/10.1038\/jid.2009.8","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1161959.622399","asserted-by":"object"}]},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}