{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:33:54Z","timestamp":1791401634644,"version":"4.3.3"},"reference-count":29,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1827,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1038\/jid.2010.208","type":"journal-article","created":{"date-parts":[[2010,7,15]],"date-time":"2010-07-15T09:03:29Z","timestamp":1279184609000},"page":"2743-2751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Absence of CCR4 Exacerbates Skin Inflammation in an Oxazolone-Induced Contact Hypersensitivity Model"],"prefix":"10.1016","volume":"130","author":[{"given":"Sari","family":"Lehtim\u00e4ki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Tillander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Puustinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sampsa","family":"Matikainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"Nyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna","family":"Fyhrquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terhi","family":"Savinko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja-Leena","family":"Majuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Alenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Lauerma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2010.208_bb0010","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/jid.2008.358","article-title":"PS3, a semisynthetic beta-1,3-glucan sulfate, diminishes contact hypersensitivity responses through inhibition of L- and P-selectin functions","volume":"129","author":"Alban","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2010.208_bb0015","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4049\/jimmunol.166.1.103","article-title":"C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential","volume":"166","author":"Andrew","year":"2001","journal-title":"J Immunol"},{"key":"10.1038\/jid.2010.208_bb0020","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.4049\/jimmunol.178.8.4891","article-title":"Human peripheral blood T regulatory cells (Tregs), functionally primed CCR4+ Tregs and unprimed CCR4- Tregs, regulate effector T cells using FasL","volume":"178","author":"Baatar","year":"2007","journal-title":"J Immunol"},{"key":"10.1038\/jid.2010.208_bb0025","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1084\/jem.20041059","article-title":"A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations","volume":"201","author":"Baekkevold","year":"2005","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2010.208_bb0030","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.4049\/jimmunol.178.6.3358","article-title":"Cutting Edge: Chemokine receptor CCR4 is necessary for antigen-driven cutaneous accumulation of CD4 T cells under physiological conditions","volume":"178","author":"Campbell","year":"2007","journal-title":"J Immunol"},{"key":"10.1038\/jid.2010.208_bb0035","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1182\/blood.V93.2.580","article-title":"Selective requirements for leukocyte adhesion molecules in models of acute and chronic cutaneous inflammation: participation of E- and P- but not L-selectin","volume":"93","author":"Catalina","year":"1999","journal-title":"Blood"},{"key":"10.1038\/jid.2010.208_bb0040","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/ACI.0b013e3283079ea4","article-title":"T regulatory cells in contact hypersensitivity","volume":"8","author":"Cavani","year":"2008","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1038\/jid.2010.208_bb0045","first-page":"551","article-title":"Inducible interleukin-4-secreting cells provoked in mice during chemical sensitization","volume":"81","author":"Dearman","year":"1994","journal-title":"Immunology"},{"key":"10.1038\/jid.2010.208_bb0050","doi-asserted-by":"crossref","first-page":"7487","DOI":"10.4049\/jimmunol.174.12.7487","article-title":"Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis","volume":"174","author":"Denning","year":"2005","journal-title":"J Immunol"},{"key":"10.1038\/jid.2010.208_bb0055","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1084\/jem.20072689","article-title":"Ticks produce highly selective chemokine binding proteins with antiinflammatory activity","volume":"205","author":"Deruaz","year":"2008","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2010.208_bb0060","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.2353\/ajpath.2007.060747","article-title":"Phase-dependent roles of E-selectin during chronic contact hypersensitivity responses","volume":"170","author":"Fujita","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2010.208_bb0065","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1084\/jem.185.9.1595","article-title":"Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells","volume":"185","author":"Godiska","year":"1997","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2010.208_bb0070","doi-asserted-by":"crossref","first-page":"6860","DOI":"10.4049\/jimmunol.163.12.6860","article-title":"Endothelial cell E- and P-selectin up-regulation in murine contact sensitivity is prolonged by distinct mechanisms occurring in sequence","volume":"163","author":"Harari","year":"1999","journal-title":"J Immunol"},{"key":"10.1038\/jid.2010.208_bb0075","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/eji.200323658","article-title":"Skin-versus gut-skewed homing receptor expression and intrinsic CCR4 expression on human peripheral blood CD4+CD25+ suppressor T cells","volume":"33","author":"Iellem","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1038\/jid.2010.208_bb0080","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1084\/jem.194.6.847","article-title":"Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells","volume":"194","author":"Iellem","year":"2001","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2010.208_bb0085","doi-asserted-by":"crossref","first-page":"15036","DOI":"10.1074\/jbc.272.23.15036","article-title":"The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4","volume":"272","author":"Imai","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2010.208_bb0090","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1074\/jbc.273.3.1764","article-title":"Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4","volume":"273","author":"Imai","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2010.208_bb0095","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/intimm\/11.1.81","article-title":"Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine","volume":"11","author":"Imai","year":"1999","journal-title":"Int Immunol"},{"key":"10.1038\/jid.2010.208_bb0100","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1002\/eji.200838397","article-title":"Insights into Langerhans cell function from Langerhans cell ablation models","volume":"38","author":"Kaplan","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1038\/jid.2010.208_bb0105","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1089\/jir.2006.0064","article-title":"Expression of chemokine receptor CCR4 and its ligands (CCL17 and CCL22) in murine contact hypersensitivity","volume":"27","author":"Kusumoto","year":"2007","journal-title":"J Interferon Cytokine Res"},{"key":"10.1038\/jid.2010.208_bb0110","doi-asserted-by":"crossref","first-page":"272","DOI":"10.2340\/0001555575272275","article-title":"Topical cis-urocanic acid suppresses both induction and elicitation of contact hypersensitivity in BALB\/C mice","volume":"75","author":"Lauerma","year":"1995","journal-title":"Acta Derm Venereol"},{"key":"10.1038\/jid.2010.208_bb0115","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1600-0625.2007.00630.x","article-title":"CCR4 and CCR10 ligands play additive roles in mouse contact hypersensitivity","volume":"17","author":"Mirshahpanah","year":"2008","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2010.208_bb0120","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1084\/jem.194.10.1541","article-title":"CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin","volume":"194","author":"Reiss","year":"2001","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2010.208_bb0125","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1002\/eji.200636207","article-title":"CD4+ CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue","volume":"36","author":"Ring","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1038\/jid.2010.208_bb0130","first-page":"131","article-title":"The role of CD4+ and CD8+ T cells in contact hypersensitivity and allergic contact dermatitis","volume":"14","author":"Saint-Mezard","year":"2004","journal-title":"Eur J Dermatol"},{"key":"10.1038\/jid.2010.208_bb0135","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1084\/jem.20070081","article-title":"Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease","volume":"204","author":"Sather","year":"2007","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2010.208_bb0140","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1152\/physrev.1999.79.1.181","article-title":"Mechanisms that regulate the function of the selectins and their ligands","volume":"79","author":"Vestweber","year":"1999","journal-title":"Physiol Rev"},{"key":"10.1038\/jid.2010.208_bb0145","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nri2343","article-title":"How regulatory T cells work","volume":"8","author":"Vignali","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1038\/jid.2010.208_bb0150","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1084\/jem.20062076","article-title":"CCR4-dependent regulatory T cell function in inflammatory bowel disease","volume":"204","author":"Yuan","year":"2007","journal-title":"J Exp Med"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15346285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15346285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T11:42:17Z","timestamp":1743939737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15346285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0022202X15346285"],"URL":"https:\/\/doi.org\/10.1038\/jid.2010.208","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Absence of CCR4 Exacerbates Skin Inflammation in an Oxazolone-Induced Contact Hypersensitivity Model","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2010.208","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}