{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T19:42:47Z","timestamp":1781984567061,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1645,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1038\/jid.2011.11","type":"journal-article","created":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T11:53:08Z","timestamp":1297338788000},"page":"1216-1225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Radioprotective Effects of Bmi-1 Involve Epigenetic Silencing of Oxidase Genes and Enhanced DNA Repair in Normal Human Keratinocytes"],"prefix":"10.1016","volume":"131","author":[{"given":"Qinghua","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Eun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Hyuk","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"McBride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No-Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo K.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2011.11_bb0010","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1101\/gad.510809","article-title":"The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence","volume":"23","author":"Agger","year":"2009","journal-title":"Genes Dev"},{"key":"10.1038\/jid.2011.11_bb0015","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/cdd.2009.85","article-title":"Targeted depletion of Bmi-1 sensitizes tumor cells to p53-mediated apoptosis in response to radiation therapy","volume":"16","author":"Alajez","year":"2009","journal-title":"Cell Death Differ"},{"key":"10.1038\/jid.2011.11_bb0020","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1101\/gad.415507","article-title":"The polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells","volume":"21","author":"Bracken","year":"2007","journal-title":"Genes Dev"},{"key":"10.1038\/jid.2011.11_bb0025","doi-asserted-by":"crossref","first-page":"7691","DOI":"10.1038\/sj.onc.1207986","article-title":"Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks","volume":"23","author":"Buscemi","year":"2004","journal-title":"Oncogene"},{"key":"10.1038\/jid.2011.11_bb0030","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1615\/JEnvPathToxOncol.v23.i1.30","article-title":"Radiation-induced DNA damage: formation, measurement, and biochemical features","volume":"23","author":"Cadet","year":"2004","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"10.1038\/jid.2011.11_bb0035","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1021\/ar700245e","article-title":"Oxidatively generated damage to the guanine moiety of DNA: mechanistic aspects and formation in cells","volume":"41","author":"Cadet","year":"2008","journal-title":"Acc Chem Res"},{"key":"10.1038\/jid.2011.11_bb0040","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1158\/0008-5472.CAN-04-4065","article-title":"Oncogenic H-Ras up-regulates expression of Ku80 to protect cells from gamma-ray irradiation in NIH3T3 cells","volume":"65","author":"Chang","year":"2005","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2011.11_bb0045","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1523\/JNEUROSCI.5303-08.2009","article-title":"The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity","volume":"29","author":"Chatoo","year":"2009","journal-title":"J Neurosc"},{"key":"10.1038\/jid.2011.11_bb0050","doi-asserted-by":"crossref","first-page":"7742","DOI":"10.1158\/0008-5472.CAN-07-5882","article-title":"The polycomb gene product Bmi1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma","volume":"68","author":"Chiba","year":"2008","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2011.11_bb0055","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S1097-2765(01)00419-1","article-title":"Recombination at double-strand breaks and DNA ends: conserved mechanisms from phage to humans","volume":"8","author":"Cromie","year":"2001","journal-title":"Mol Cell"},{"key":"10.1038\/jid.2011.11_bb0060","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cell.2007.08.019","article-title":"The histone H3 lysin-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing","volume":"130","author":"De Santa","year":"2007","journal-title":"Cell"},{"key":"10.1038\/jid.2011.11_bb0065","doi-asserted-by":"crossref","first-page":"9043","DOI":"10.1074\/jbc.275.12.9043","article-title":"Inhibition of caspase-3-mediated poly(ADP-ribose) polymerase (PARP) apoptotic cleavage by human PARP autoantibodies and effect on cells undergoing apoptosis","volume":"275","author":"Decker","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2011.11_bb0070","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2011.11_bb0075","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1038\/nprot.2006.323","article-title":"Development of a highly reproducible three-dimensional organotypic model of the oral mucosa","volume":"1","author":"Dongari-Bagtzoglou","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1038\/jid.2011.11_bb0080","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1096\/fj.02-1104fje","article-title":"Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense","volume":"17","author":"Geiszt","year":"2003","journal-title":"FASEB J"},{"key":"10.1038\/jid.2011.11_bb0085","series-title":"Curr Protoc Cytom","article-title":"Stem cell identification and sorting using the Hoechst 33342 side population (SP)","author":"Goodell","year":"2005"},{"key":"10.1038\/jid.2011.11_bb0090","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1269\/jrr.07123","article-title":"Formation of clustered DNA damage after high-LET irradiation: a review","volume":"49","author":"Hada","year":"2008","journal-title":"J Radiat Res"},{"key":"10.1038\/jid.2011.11_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/B:BGEN.0000017682.96395.10","article-title":"Mechanisms of cellular senescence in human and mouse cells","volume":"5","author":"Itahana","year":"2004","journal-title":"Biogerontology"},{"key":"10.1038\/jid.2011.11_bb0100","doi-asserted-by":"crossref","first-page":"e1000506","DOI":"10.1371\/journal.pgen.1000506","article-title":"Genome-wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes","volume":"5","author":"Kallin","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1038\/jid.2011.11_bb0105","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1006\/excr.2000.4943","article-title":"In vitro replication and differentiation of normal human oral keratinocytes","volume":"258","author":"Kang","year":"2000","journal-title":"Exp Cell Res"},{"key":"10.1038\/jid.2011.11_bb0110","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/sj.bjc.6603529","article-title":"Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival","volume":"96","author":"Kang","year":"2007","journal-title":"Br J Cancer"},{"key":"10.1038\/jid.2011.11_bb0115","doi-asserted-by":"crossref","first-page":"555","DOI":"10.5483\/BMBRep.2008.41.8.555","article-title":"Cytosolic phospholipase A(2), lipoxygenase metabolites, and reactive oxygen species","volume":"41","author":"Kim","year":"2008","journal-title":"BMB Rep"},{"key":"10.1038\/jid.2011.11_bb0120","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.yexcr.2006.10.025","article-title":"Bmi-1 cooperates with human papillomavirus type 16 E6 to immortalize normal human oral keratinocytes","volume":"313","author":"Kim","year":"2007","journal-title":"Exp Cell Res"},{"key":"10.1038\/jid.2011.11_bb0125","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1126\/science.1149042","article-title":"Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination","volume":"318","author":"Lee","year":"2007","journal-title":"Science"},{"key":"10.1038\/jid.2011.11_bb0130","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature08040","article-title":"Bmi1 regulates mitochondrial function and the DNA damage response pathway","volume":"459","author":"Liu","year":"2009","journal-title":"Nature"},{"key":"10.1038\/jid.2011.11_bb0135","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.bbrc.2008.10.067","article-title":"NADPH oxidase-mediated generation of reactive oxygen species: A new mechanism for X-ray-induced HeLa cell death","volume":"377","author":"Liu","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/jid.2011.11_bb0140","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.molcel.2008.11.004","article-title":"Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms","volume":"32","author":"Margueron","year":"2008","journal-title":"Mol Cell"},{"key":"10.1038\/jid.2011.11_bb0145","first-page":"5414","article-title":"Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells","volume":"63","author":"Meng","year":"2003","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2011.11_bb0150","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0076-6879(05)09014-2","article-title":"Techniques for gamma-H2AX detection","volume":"409","author":"Nakamura","year":"2006","journal-title":"Methods Enzymol"},{"key":"10.1038\/jid.2011.11_bb0155","first-page":"31","article-title":"Protein kinase that regulate chromosome stability and their downstream targets","volume":"1","author":"Nojima","year":"2006","journal-title":"Genome Dyn"},{"key":"10.1038\/jid.2011.11_bb0160","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nature01587","article-title":"Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells","volume":"423","author":"Park","year":"2003","journal-title":"Nature"},{"key":"10.1038\/jid.2011.11_bb0165","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/jnci\/djj495","article-title":"The response of CD24 (-\/low)\/CD44+ breast cancer-initiating cells to radiation","volume":"98","author":"Phillips","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/jid.2011.11_bb0170","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1677\/erc.0.0060041","article-title":"Induction of cell death by radiotherapy","volume":"6","author":"Ross","year":"1999","journal-title":"Endocr Relat Cancer"},{"key":"10.1038\/jid.2011.11_bb0175","doi-asserted-by":"crossref","first-page":"12491","DOI":"10.1074\/jbc.C200093200","article-title":"ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation","volume":"277","author":"Saito","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2011.11_bb0180","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/ijc.2910190505","article-title":"Characterization of EBV-genome negative \u201cnull\u201d and \u201cT\u201d cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma","volume":"19","author":"Schneider","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1038\/jid.2011.11_bb0185","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tibs.2006.05.004","article-title":"The ATM-mediated DNA-damage response: taking shape","volume":"31","author":"Shiloh","year":"2006","journal-title":"Trends Biochem Sci"},{"key":"10.1038\/jid.2011.11_bb0190","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1158\/1078-0432.CCR-0669-3","article-title":"Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity","volume":"10","author":"Shin","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1038\/jid.2011.11_bb0195","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1667\/0033-7587(2001)155[0248:RISLGA]2.0.CO;2","article-title":"Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening","volume":"155","author":"Suzuki","year":"2001","journal-title":"Radiat Res"},{"key":"10.1038\/jid.2011.11_bb0200","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/sj.jid.5700960","article-title":"Nox1-based NADPH oxidase is the major source of UVA-induced reactive oxygen species in human keratinocytes","volume":"128","author":"Valencia","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.11_bb0205","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.molcel.2008.02.014","article-title":"Histone ubiquitination: triggering gene activity","volume":"29","author":"Weake","year":"2008","journal-title":"Mol Cell"},{"key":"10.1038\/jid.2011.11_bb0210","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.4161\/cc.7.19.6750","article-title":"Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation","volume":"7","author":"Zhao","year":"2008","journal-title":"Cell Cycle"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15353045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15353045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T17:38:55Z","timestamp":1743961135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15353045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0022202X15353045"],"URL":"https:\/\/doi.org\/10.1038\/jid.2011.11","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radioprotective Effects of Bmi-1 Involve Epigenetic Silencing of Oxidase Genes and Enhanced DNA Repair in Normal Human Keratinocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2011.11","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}