{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:55:12Z","timestamp":1772801712463,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1523,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1038\/jid.2011.152","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T11:33:34Z","timestamp":1309433614000},"page":"2040-2048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Inhibition of Contact Sensitivity by Farnesylthiosalicylic Acid-Amide, a Potential Rap1 Inhibitor"],"prefix":"10.1016","volume":"131","author":[{"given":"Adam","family":"Mor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roni","family":"Haklai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofer","family":"Ben-Moshe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoseph A.","family":"Mekori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoel","family":"Kloog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2011.152_bb0010","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/icb.2009.32","article-title":"Leukocyte adhesion deficiency syndrome: a controversy solved","volume":"87","author":"Abram","year":"2009","journal-title":"Immunol Cell Biol"},{"key":"10.1038\/jid.2011.152_bb0015","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1158\/1078-0432.CCR-06-0792","article-title":"The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1","volume":"12","author":"Barkan","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1038\/jid.2011.152_bb0020","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1001\/archderm.1989.01670140128025","article-title":"Contact allergic dermatitis","volume":"125","author":"Bergstresser","year":"1989","journal-title":"Arch Dermatol"},{"key":"10.1038\/jid.2011.152_bb0025","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.molcel.2006.01.012","article-title":"PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis","volume":"21","author":"Bivona","year":"2006","journal-title":"Mol Cell"},{"key":"10.1038\/jid.2011.152_bb0030","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ymeth.2005.05.022","article-title":"Analysis of Ras and Rap activation in living cells using fluorescent Ras binding domains","volume":"37","author":"Bivona","year":"2005","journal-title":"Methods"},{"key":"10.1038\/jid.2011.152_bb0035","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1083\/jcb.200311093","article-title":"Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion","volume":"164","author":"Bivona","year":"2004","journal-title":"J Cell Biol"},{"key":"10.1038\/jid.2011.152_bb0040","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1074-7613(04)00080-9","article-title":"Immune sensitization in the skin is by antigen-independent effects of IgE","volume":"20","author":"Bryce","year":"2004","journal-title":"Immunity"},{"key":"10.1038\/jid.2011.152_bb0045","doi-asserted-by":"crossref","first-page":"8409","DOI":"10.1128\/MCB.20.22.8409-8419.2000","article-title":"CD28 and the tyrosine kinase Lck stimulate mitogen activated protein kinase activity in T cells via inhibition of the small G protein Rap1","volume":"20","author":"Carey","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1038\/jid.2011.152_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0536.2007.01232.x","article-title":"Patients with multiple contact allergies: a review","volume":"58","author":"Carlsen","year":"2008","journal-title":"Contact Dermatitis"},{"key":"10.1038\/jid.2011.152_bb0055","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.4049\/jimmunol.131.6.2682","article-title":"Desensitization of contact allergy to DNFB in mice","volume":"131","author":"Claman","year":"1983","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.152_bb0060","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1128\/MCB.25.10.4117-4128.2005","article-title":"Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4","volume":"25","author":"Dillon","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1038\/jid.2011.152_bb0065","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0167-4889(99)00144-5","article-title":"Targeting of K-Ras 4B by S-trans, trans-farnesyl thiosalicylic acid","volume":"1452","author":"Elad","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/jid.2011.152_bb0070","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/01.ATV.0000112021.98971.f0","article-title":"Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor","volume":"24","author":"George","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1038\/jid.2011.152_bb0075","doi-asserted-by":"crossref","first-page":"11709","DOI":"10.1158\/0008-5472.CAN-06-1878","article-title":"A Ras inhibitor tilts the balance between Rac and Rho and blocks phosphatidylinositol 3-kinase-dependent glioblastoma cell migration","volume":"66","author":"Goldberg","year":"2006","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2011.152_bb0080","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1158\/1535-7163.MCT-08-0488","article-title":"Salirasib (farnesyl thiosalicylic acid) for brain tumor treatment: a convection-enhanced drug delivery study in rats","volume":"7","author":"Goldberg","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"10.1038\/jid.2011.152_bb0085","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1021\/jm801165r","article-title":"New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models","volume":"52","author":"Goldberg","year":"2009","journal-title":"J Med Chem"},{"key":"10.1038\/jid.2011.152_bb0090","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00280-007-0451-6","article-title":"Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice","volume":"61","author":"Haklai","year":"2008","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1038\/jid.2011.152_bb0095","doi-asserted-by":"crossref","first-page":"14019","DOI":"10.1073\/pnas.96.24.14019","article-title":"Novel Ras antagonist blocks human melanoma growth","volume":"96","author":"Jansen","year":"1999","journal-title":"Proc Natl Acad Sci"},{"key":"10.1038\/jid.2011.152_bb0100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jneuroim.2005.07.008","article-title":"Inhibition of Ras attenuates the course of experimental autoimmune neuritis","volume":"168","author":"Kafri","year":"2005","journal-title":"J Neuroimmunol"},{"key":"10.1038\/jid.2011.152_bb0105","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1046\/j.1365-2249.2001.01674.x","article-title":"Treatment of MRL\/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS)","volume":"126","author":"Katzav","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1038\/jid.2011.152_bb0110","doi-asserted-by":"crossref","first-page":"22263","DOI":"10.1074\/jbc.270.38.22263","article-title":"Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid","volume":"270","author":"Marom","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2011.152_bb0115","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-065X.2007.00538.x","article-title":"Small GTPases and LFA-1 reciprocally modulate adhesion and signaling","volume":"218","author":"Mor","year":"2007","journal-title":"Immunol Rev"},{"key":"10.1038\/jid.2011.152_bb0120","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/ncb1592","article-title":"The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2","volume":"9","author":"Mor","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1038\/jid.2011.152_bb0125","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1128\/MCB.00366-09","article-title":"Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane","volume":"29","author":"Mor","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1038\/jid.2011.152_bb0130","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.carpath.2008.10.009","article-title":"The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat","volume":"19","author":"Pando","year":"2010","journal-title":"Cardiovasc Pathol"},{"key":"10.1038\/jid.2011.152_bb0135","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/j.bcp.2009.02.010","article-title":"Ras inhibition attenuates myocardial ischemia-reperfusion injury","volume":"77","author":"Pando","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"10.1038\/jid.2011.152_bb0140","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-065X.2007.00530.x","article-title":"Signaling by small GTP in the immune system","volume":"218","author":"Scheele","year":"2007","journal-title":"Immunol Rev"},{"key":"10.1038\/jid.2011.152_bb0145","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1600-0536.2007.01220.x","article-title":"The epidemiology of contact allergy in the general population\u2212prevalence and main findings","volume":"57","author":"Thyssen","year":"2007","journal-title":"Contact Dermatitis"},{"key":"10.1038\/jid.2011.152_bb0150","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1038\/sj.onc.1202602","article-title":"A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice","volume":"18","author":"Weisz","year":"1999","journal-title":"Oncogene"},{"key":"10.1038\/jid.2011.152_bb0155","first-page":"1428","article-title":"Farnesyltransferase inhibitors as anticancer agents: current status","volume":"4","author":"Zhu","year":"2003","journal-title":"Curr Opin Investig Drugs"},{"key":"10.1038\/jid.2011.152_bb0160","first-page":"449","article-title":"Differential inhibition of contact sensitivity by suppressor T cells and suppressor factor induced by combined treatment with dinitrobenzenesulphonate and dinitrofluorobenzene","volume":"45","author":"Zimber","year":"1982","journal-title":"Immunology"},{"key":"10.1038\/jid.2011.152_bb0165","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1158\/1535-7163.MCT-06-0706","article-title":"Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid)","volume":"6","author":"Zundelevich","year":"2007","journal-title":"Mol Cancer Ther"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15350466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15350466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T11:53:35Z","timestamp":1743940415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15350466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0022202X15350466"],"URL":"https:\/\/doi.org\/10.1038\/jid.2011.152","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of Contact Sensitivity by Farnesylthiosalicylic Acid-Amide, a Potential Rap1 Inhibitor","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2011.152","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}