{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:20:15Z","timestamp":1791300015151,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1038\/jid.2011.349","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T04:48:36Z","timestamp":1320900516000},"page":"667-676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"P1","title":["Lymphatic Dysfunction Impairs Antigen-Specific Immunization, but Augments Tissue Swelling Following Contact with Allergens"],"prefix":"10.1016","volume":"132","author":[{"given":"Makoto","family":"Sugaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kuwano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiraku","family":"Suga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomitsu","family":"Miyagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanako","family":"Ohmatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Kadono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Okochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Blauvelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Tamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2011.349_bb0010","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.immuni.2008.08.013","article-title":"Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells","volume":"29","author":"Allenspach","year":"2008","journal-title":"Immunity"},{"key":"10.1038\/jid.2011.349_bb0015","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0145-2126(03)00256-X","article-title":"All three receptors for vascular endothelial growth factor (VEGF) are expressed on B-chronic lymphocytic leukemia (CLL) cells","volume":"28","author":"Bairey","year":"2004","journal-title":"Leuk Res"},{"key":"10.1038\/jid.2011.349_bb0020","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1083\/jcb.200501071","article-title":"Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity","volume":"169","author":"Bennett","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1038\/jid.2011.349_bb0025","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0002-9440(10)65285-6","article-title":"Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium","volume":"154","author":"Breiteneder-Geleff","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2011.349_bb0030","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/00000478-199005000-00005","article-title":"Primary malignant lymphoma arising in postmastectomy lymphedema. Another facet of the Stewart-Treves syndrome","volume":"14","author":"d\u2019Amore","year":"1990","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/jid.2011.349_bb0035","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1080\/10428190500051208","article-title":"De novo CD5-positive diffuse large B-cell lymphoma of the skin arising in chronic limb lymphedema","volume":"46","author":"Dargent","year":"2005","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/jid.2011.349_bb0040","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1093\/jnci\/89.24.1868","article-title":"Expression of human herpesvirus 8-encoded cyclin D in Kaposi's sarcoma spindle cells","volume":"89","author":"Davis","year":"1997","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/jid.2011.349_bb0045","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1073\/pnas.96.8.4546","article-title":"Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma","volume":"96","author":"Dupin","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2011.349_bb0050","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/1097-0142(19840901)54:5<943::AID-CNCR2820540534>3.0.CO;2-B","article-title":"Squamous carcinoma of the foot arising in association with longstanding verrucous hyperplasia in a patient with congenital lymphoedema","volume":"54","author":"Epstein","year":"1984","journal-title":"Cancer"},{"key":"10.1038\/jid.2011.349_bb0055","first-page":"H358","article-title":"Flow velocity of single lymphatic capillaries in human skin","volume":"270","author":"Fischer","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1038\/jid.2011.349_bb0060","first-page":"H89","article-title":"Peritoneal lymphatic uptake of fibrinogen and erythrocytes in the rat","volume":"244","author":"Flessner","year":"1983","journal-title":"Am J Physiol"},{"key":"10.1038\/jid.2011.349_bb0065","first-page":"951","article-title":"Squamous cell carcinoma in chronic lymphedema: case report and review of the literature","volume":"28","author":"Furukawa","year":"2002","journal-title":"Dermatol Surg"},{"key":"10.1038\/jid.2011.349_bb0070","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0002-9440(10)63986-7","article-title":"Differential and sequential expression of multiple chemokines during elicitation of allergic contact hypersensitivity","volume":"158","author":"Goebeler","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2011.349_bb0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0002-9440(10)63630-9","article-title":"Novel expression of vascular endothelial growth factor receptor (VEGFR)-3 and VEGF-C on corneal dendritic cells","volume":"163","author":"Hamrah","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2011.349_bb0080","doi-asserted-by":"crossref","first-page":"741","DOI":"10.4049\/jimmunol.167.2.741","article-title":"The dendritic cell populations of mouse lymph nodes","volume":"167","author":"Henri","year":"2001","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.349_bb0085","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/ng1383","article-title":"Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus","volume":"36","author":"Hong","year":"2004","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2011.349_bb0090","series-title":"Current Practice of Medicine","first-page":"68","article-title":"Eczemas - a classification and principles of therapy","author":"Hopkins","year":"1995"},{"key":"10.1038\/jid.2011.349_bb0095","first-page":"1599","article-title":"Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3","volume":"58","author":"Jussila","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2011.349_bb0100","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.immuni.2005.10.008","article-title":"Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity","volume":"23","author":"Kaplan","year":"2005","journal-title":"Immunity"},{"key":"10.1038\/jid.2011.349_bb0105","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1084\/jem.189.5.779","article-title":"Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity","volume":"189","author":"Kehren","year":"1999","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2011.349_bb0110","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.immuni.2005.04.004","article-title":"Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells","volume":"22","author":"Kissenpfennig","year":"2005","journal-title":"Immunity"},{"key":"10.1038\/jid.2011.349_bb0115","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1600-0536.2007.01230.x","article-title":"Cellular dynamics in the draining lymph nodes during sensitization and elicitation phases of contact hypersensitivity","volume":"57","author":"Larsen","year":"2007","journal-title":"Contact Dermatitis"},{"key":"10.1038\/jid.2011.349_bb0120","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1084\/jem.20080601","article-title":"Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection","volume":"206","author":"Lee","year":"2009","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2011.349_bb0125","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1084\/jem.166.6.1654","article-title":"Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies","volume":"166","author":"Macatonia","year":"1987","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2011.349_bb0130","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1084\/jem.129.1.81","article-title":"Studies on the sensitization of animals with simple chemical compounds. XI. The fate of labeled picryl chloride and dinitrochlorobenzene after sensitizing injections","volume":"29","author":"Macher","year":"1969","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2011.349_bb0135","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/jid.2010.25","article-title":"The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity","volume":"130","author":"Ogawa","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.349_bb0140","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.immuni.2004.06.014","article-title":"CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions","volume":"21","author":"Ohl","year":"2004","journal-title":"Immunity"},{"key":"10.1038\/jid.2011.349_bb0145","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1182\/blood.V91.10.3825","article-title":"Demonstration of Kaposi's sarcoma-associated herpes virus cyclin D homolog in cutaneous Kaposi's sarcoma by colorimetric in situ hybridization using a catalyzed signal amplification system","volume":"91","author":"Reed","year":"1998","journal-title":"Blood"},{"key":"10.1038\/jid.2011.349_bb0150","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.4049\/jimmunol.165.9.4910","article-title":"Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes","volume":"165","author":"Ruedl","year":"2000","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.349_bb0155","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1067\/mjd.2002.120909","article-title":"Lymphedema: an immunologically vulnerable site for development of neoplasms","volume":"47","author":"Ruocco","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2011.349_bb0160","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.4049\/jimmunol.162.5.2472","article-title":"Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes","volume":"162","author":"Saeki","year":"1999","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.349_bb0165","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1134\/S0006297907110041","article-title":"Gene expression for VEGF-A, VEGF-C, and their receptors in murine lymphocytes and macrophages","volume":"72","author":"Stepanova","year":"2007","journal-title":"Biochemistry (Mosc)"},{"key":"10.1038\/jid.2011.349_bb0170","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/1097-0142(194805)1:1<64::AID-CNCR2820010105>3.0.CO;2-W","article-title":"Lymphangiosarcoma in postmastectomy lymphoedema","volume":"1","author":"Stewart","year":"1948","journal-title":"Cancer"},{"key":"10.1038\/jid.2011.349_bb0175","doi-asserted-by":"crossref","first-page":"7665","DOI":"10.4049\/jimmunol.177.11.7665","article-title":"Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic Cell trafficking to lymph nodes","volume":"177","author":"Sugaya","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.349_bb0180","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1182\/blood-2004-08-3364","article-title":"Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter","volume":"105","author":"Sugaya","year":"2005","journal-title":"Blood"},{"key":"10.1038\/jid.2011.349_bb0185","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.4049\/jimmunol.0803661","article-title":"Blocking development of a CD8+ T cell response by targeting lymphatic recruitment of APC","volume":"182","author":"Teoh","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.349_bb0190","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.4049\/jimmunol.0900835","article-title":"Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment","volume":"183","author":"Tomei","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.349_bb0195","series-title":"Cell-Bound Antibodies","first-page":"51","article-title":"Implication of the cellular changes in lymph nodes during the development and inhibition of delayed hypersensitivity","author":"Turk","year":"1963"},{"key":"10.1038\/jid.2011.349_bb0200","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.4049\/jimmunol.165.12.6783","article-title":"CD4+ Th1 and CD8+ type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity","volume":"165","author":"Wang","year":"2000","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.349_bb0205","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2353\/ajpath.2007.061279","article-title":"CD19 expression in B cells is important for suppression of contact hypersensitivity","volume":"171","author":"Watanabe","year":"2007","journal-title":"Am J Pathol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15356517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15356517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T13:44:52Z","timestamp":1743947092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15356517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0022202X15356517"],"URL":"https:\/\/doi.org\/10.1038\/jid.2011.349","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13414977.14789078","asserted-by":"object"}]},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lymphatic Dysfunction Impairs Antigen-Specific Immunization, but Augments Tissue Swelling Following Contact with Allergens","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2011.349","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}