{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:34:13Z","timestamp":1771871653007,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1038\/jid.2011.400","type":"journal-article","created":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T10:15:22Z","timestamp":1326363322000},"page":"829-834","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"P2","title":["Old and New: Recent Innovations in Vaccine Biology and Skin T Cells"],"prefix":"10.1016","volume":"132","author":[{"given":"Thomas S.","family":"Kupper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2011.400_bb0010","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S1473-3099(10)70157-2","article-title":"Needle-free influenza vaccination","volume":"10","author":"Amorij","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"10.1038\/jid.2011.400_bb0015","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/eji.201041377","article-title":"Memory T cells as an occupying force","volume":"41","author":"Bevan","year":"2011","journal-title":"Eur J Immunol"},{"key":"10.1038\/jid.2011.400_bb0020","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/archpedi.1993.02160310074022","article-title":"Edward Jenner (1749\u20131823). The history and effects of smallpox, inoculation, and vaccination","volume":"147","author":"Bloch","year":"1993","journal-title":"Am J Dis Children (1960)"},{"key":"10.1038\/jid.2011.400_bb0025","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S1359-6446(01)02081-5","article-title":"The past, present and future of HIV-vaccine development: a critical view","volume":"7","author":"Bojak","year":"2002","journal-title":"Drug Discovery Today"},{"issue":"Suppl 1","key":"10.1038\/jid.2011.400_bb0030","doi-asserted-by":"crossref","first-page":"s6","DOI":"10.1136\/bmj.39021.640255.94","article-title":"Antibiotics: the epitome of a wonder drug","volume":"334","author":"Bud","year":"2007","journal-title":"Br Med J (Clinical Research ed)"},{"key":"10.1038\/jid.2011.400_bb0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0065-2776(08)60022-X","article-title":"Lymphocyte trafficking and regional immunity","volume":"72","author":"Butcher","year":"1999","journal-title":"Adv Immunol"},{"key":"10.1038\/jid.2011.400_bb0040","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/INF.0b013e318227759a","article-title":"Smallpox variolation during the revolutionary war","volume":"30","author":"Cantey","year":"2011","journal-title":"Pediatr Infect Dis J"},{"key":"10.1038\/jid.2011.400_bb0045","doi-asserted-by":"crossref","first-page":"R437","DOI":"10.1016\/j.cub.2009.04.001","article-title":"The natural history of antibiotics","volume":"19","author":"Clardy","year":"2009","journal-title":"Curr Biol"},{"key":"10.1038\/jid.2011.400_bb0050","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/jid.2009.247","article-title":"Skin resident T cells: the ups and downs of on site immunity","volume":"130","author":"Clark","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.400_bb0055","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.4049\/jimmunol.176.7.4431","article-title":"The vast majority of CLA+ T cells are resident in normal skin","volume":"176","author":"Clark","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.400_bb0060","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/sj.jid.5700199","article-title":"A novel method for the isolation of skin resident T cells from normal and diseased human skin","volume":"126","author":"Clark","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.400_bb0065","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/jama.2009.143","article-title":"Penicillin treatment of syphilis: clearing away the shadow on the land","volume":"301","author":"Douglas","year":"2009","journal-title":"JAMA"},{"key":"10.1038\/jid.2011.400_bb0070","doi-asserted-by":"crossref","first-page":"475","DOI":"10.12968\/hmed.2009.70.8.43543","article-title":"The last year before the dawn of antibiotics","volume":"70","author":"Ellis","year":"2009","journal-title":"Br J Hosp Med (Lond)"},{"key":"10.1038\/jid.2011.400_bb0075","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0022-2143(03)00102-1","article-title":"Smallpox in history: the birth, death, and impact of a dread disease","volume":"142","author":"Eyler","year":"2003","journal-title":"J Lab Clin Med"},{"key":"10.1038\/jid.2011.400_bb0080","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/ni.1718","article-title":"Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus","volume":"10","author":"Gebhardt","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2011.400_bb0085","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.1016\/j.vaccine.2011.06.085","article-title":"Human immunodeficiency virus (HIV) immunopathogenesis and vaccine development: a review","volume":"29","author":"Girard","year":"2011","journal-title":"Vaccine"},{"key":"10.1038\/jid.2011.400_bb0090","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1171700","article-title":"Topographical and temporal diversity of the human skin microbiome","volume":"324","author":"Grice","year":"2009","journal-title":"Science (New York, NY)"},{"key":"10.1038\/jid.2011.400_bb0095","series-title":"J Invest Dermatol","article-title":"The epidermis as an adjuvant","author":"Gutowska-Owsiak","year":"2012"},{"key":"10.1038\/jid.2011.400_bb0100","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S1201-9712(98)90096-0","article-title":"The myth of the medical breakthrough: smallpox, vaccination, and Jenner reconsidered","volume":"3","author":"Gross","year":"1998","journal-title":"Int J Infect Dis"},{"key":"10.1038\/jid.2011.400_bb0105","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature10003","article-title":"Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine","volume":"473","author":"Hansen","year":"2011","journal-title":"Nature"},{"key":"10.1038\/jid.2011.400_bb0110","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/S0264-410X(99)00434-X","article-title":"Vaccines in historic evolution and perspective: a narrative of vaccine discoveries","volume":"18","author":"Hilleman","year":"2000","journal-title":"Vaccine"},{"key":"10.1038\/jid.2011.400_bb0115","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.it.2010.08.006","article-title":"In vivo function of Langerhans cells and dermal dendritic cells","volume":"31","author":"Kaplan","year":"2010","journal-title":"Trends Immunol"},{"key":"10.1038\/jid.2011.400_bb0120","first-page":"175","article-title":"Immunogenicity assays and surrogate markers to predict vaccine efficacy","volume":"95","author":"Kayhty","year":"1998","journal-title":"Dev Biol"},{"key":"10.1038\/jid.2011.400_bb0125","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2165\/00003495-200363100-00006","article-title":"Recombinant hepatitis B vaccine (Engerix-B): a review of its immunogenicity and protective efficacy against hepatitis B","volume":"63","author":"Keating","year":"2003","journal-title":"Drugs"},{"key":"10.1038\/jid.2011.400_bb0130","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1586\/14760584.8.1.13","article-title":"IMVAMUNE: modified VACV Ankara strain as an attenuated smallpox vaccine","volume":"8","author":"Kennedy","year":"2009","journal-title":"Expert Review of Vaccines"},{"key":"10.1038\/jid.2011.400_bb0135","doi-asserted-by":"crossref","first-page":"656","DOI":"10.4269\/ajtmh.1975.24.656","article-title":"Smallpox vaccination revisited. Some observations on the biology of VACV","volume":"24","author":"Koplan","year":"1975","journal-title":"Am J Tropical Med Hygiene"},{"key":"10.1038\/jid.2011.400_bb0140","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nri1310","article-title":"Immune surveillance in the skin: mechanisms and clinical consequences","volume":"4","author":"Kupper","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1038\/jid.2011.400_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1523-1747.2004.23554.x","article-title":"Changing paradigms in cutaneous immunology: adapting with dendritic cells","volume":"124","author":"Larregina","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.400_bb0150","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S1359-6446(04)03170-8","article-title":"Ultrasound and transdermal drug delivery","volume":"9","author":"Lavon","year":"2004","journal-title":"Drug Discovery Today"},{"key":"10.1038\/jid.2011.400_bb0155","doi-asserted-by":"crossref","first-page":"f511","DOI":"10.1016\/j.immuni.2006.06.019","article-title":"Dynamic programming of CD8+ T cell trafficking after live viral immunization","volume":"25","author":"Liu","year":"2006","journal-title":"Immunity"},{"key":"10.1038\/jid.2011.400_bb0160","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nm.2078","article-title":"Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity","volume":"16","author":"Liu","year":"2010","journal-title":"Nat Med"},{"key":"10.1038\/jid.2011.400_bb0165","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nm0598supp-515","article-title":"Vaccine developments","volume":"4","author":"Liu","year":"1998","journal-title":"Nat Med"},{"key":"10.1038\/jid.2011.400_bb0170","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1084\/jem.20090858","article-title":"Dynamic T cell migration program provides resident memory within intestinal epithelium","volume":"207","author":"Masopust","year":"2010","journal-title":"J Exper Med"},{"key":"10.1038\/jid.2011.400_bb0175","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1164\/rccm.200411-1603OE","article-title":"The diagnosis and therapy of tuberculosis during the past 100 years","volume":"171","author":"Mitchison","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1038\/jid.2011.400_bb0180","series-title":"J Invest Dermatol","article-title":"Innate immunity: ignored for decades, but not forgotten","author":"Modlin","year":"2011"},{"key":"10.1038\/jid.2011.400_bb0185","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1084\/jem.20072290","article-title":"Yellow fever and Max Theiler: the only Nobel Prize for a virus vaccine","volume":"204","author":"Norrby","year":"2007","journal-title":"J Exper Med"},{"key":"10.1038\/jid.2011.400_bb0190","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.jaci.2006.09.037","article-title":"Smallpox vaccines: past, present, and future","volume":"118","author":"Parrino","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.400_bb0195","first-page":"1053","article-title":"A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites","volume":"136","author":"Picker","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2011.400_bb0200","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.4049\/jimmunol.150.3.1122","article-title":"Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells","volume":"150","author":"Picker","year":"1993","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.400_bb0205","doi-asserted-by":"crossref","first-page":"e16245","DOI":"10.1371\/journal.pone.0016245","article-title":"Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity","volume":"6","author":"Purwar","year":"2011","journal-title":"PLoS One"},{"key":"10.1038\/jid.2011.400_bb0210","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/00006454-199902000-00002","article-title":"Smallpox: a history of its rise and fall","volume":"18","author":"Radetsky","year":"1999","journal-title":"Pediatr Infect Dis J"},{"key":"10.1038\/jid.2011.400_bb0215","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/eji.1830240132","article-title":"Skin disease-related T cells bind to endothelial selectins: expression of cutaneous lymphocyte antigen (CLA) predicts E-selectin but not P-selectin binding","volume":"24","author":"Rossiter","year":"1994","journal-title":"Eur J Immunol"},{"key":"10.1038\/jid.2011.400_bb0220","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ni.2029","article-title":"Regional and mucosal memory T cells","volume":"12","author":"Sheridan","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2011.400_bb0225","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jinf.2005.07.021","article-title":"The history of the smallpox vaccine","volume":"52","author":"Stewart","year":"2006","journal-title":"J Infect"},{"key":"10.1038\/jid.2011.400_bb0230","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nm.2182","article-title":"Dissolving polymer microneedle patches for influenza vaccination","volume":"16","author":"Sullivan","year":"2010","journal-title":"Nat Med"},{"key":"10.1038\/jid.2011.400_bb0235","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nbt0409-344","article-title":"Getting to the core of the gut microbiome","volume":"27","author":"Tschop","year":"2009","journal-title":"Nat Biotechnol"},{"key":"10.1038\/jid.2011.400_bb0240","doi-asserted-by":"crossref","first-page":"17872","DOI":"10.1073\/pnas.1010201107","article-title":"Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence","volume":"107","author":"Wakim","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2011.400_bb0245","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/01.all.0000136758.66442.28","article-title":"Smallpox, vaccination and adverse reactions to smallpox vaccine","volume":"4","author":"Wollenberg","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.400_bb0250","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/jid.2008.225","article-title":"Resident and \u201cinflammatory\u201d dendritic cells in human skin","volume":"129","author":"Zaba","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.400_bb0255","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1084\/jem.20061792","article-title":"Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation","volume":"204","author":"Zhu","year":"2007","journal-title":"J Exper Med"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15356578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15356578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T17:45:17Z","timestamp":1743961517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15356578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0022202X15356578"],"URL":"https:\/\/doi.org\/10.1038\/jid.2011.400","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Old and New: Recent Innovations in Vaccine Biology and Skin T Cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2011.400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}