{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:44:38Z","timestamp":1792291478562,"version":"4.4.0"},"reference-count":167,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1038\/jid.2011.435","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T04:59:04Z","timestamp":1325825944000},"page":"949-963","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":271,"special_numbering":"P2","title":["Skin Barrier Disruption: A Requirement for Allergen Sensitization?"],"prefix":"10.1016","volume":"132","author":[{"given":"Anna","family":"De Benedetto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiharu","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2011.435_bb0010","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jaci.2006.04.046","article-title":"Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses","volume":"118","author":"Akei","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0015","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1038\/jid.2010.143","article-title":"Injury to the stratum corneum induces in vivo expression of human thymic stromal lymphopoietin in the epidermis","volume":"130","author":"Angelova-Fischer","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0020","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1084\/jem.20061675","article-title":"Interleukin 25 promotes the initiation of proallergic type 2 responses","volume":"204","author":"Angkasekwinai","year":"2007","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2011.435_bb0025","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1001\/archderm.1974.01630090016003","article-title":"IgE levels in sera of patients with pemphigus or bullous pemphigoid","volume":"110","author":"Arbesman","year":"1974","journal-title":"Arch Dermatol"},{"key":"10.1038\/jid.2011.435_bb0030","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.4049\/jimmunol.0903069","article-title":"Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis","volume":"184","author":"Blanchard","year":"2010","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.435_bb0035","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/jid.1959.158","article-title":"Penetration of anionic surfactants (surface active agents) into skin. I. Penetration of sodium laurate and sodium dodecyl sulfate into excised human skin","volume":"33","author":"Blank","year":"1959","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0040","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1398-9995.2007.01556.x","article-title":"Epicutaneous aeroallergen sensitization in atopic dermatitis infants - determining the role of epidermal barrier impairment","volume":"63","author":"Boralevi","year":"2008","journal-title":"Allergy"},{"key":"10.1038\/jid.2011.435_bb0045","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.1365-2230.1999.00459.x","article-title":"Polymorphic eruption of pregnancy and herpes gestationis: comparison of granulated cell proteins in tissue and serum","volume":"24","author":"Borrego","year":"1999","journal-title":"Clin Exp Dermatol"},{"key":"10.1038\/jid.2011.435_bb0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.0022-202X.2004.23587.x","article-title":"Cutaneous defense mechanisms by antimicrobial peptides","volume":"125","author":"Braff","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0055","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaad.2008.03.029","article-title":"Clinical detection of ichthyosis vulgaris in an atopic dermatitis clinic: implications for allergic respiratory disease and prognosis","volume":"59","author":"Bremmer","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2011.435_bb0060","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20082242","article-title":"Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome","volume":"206","author":"Briot","year":"2009","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2011.435_bb0065","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1038\/jid.2010.233","article-title":"Par2 inactivation inhibits early production of TSLP, but not cutaneous inflammation, in Netherton syndrome adult mouse model","volume":"130","author":"Briot","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0070","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jaci.2011.01.031","article-title":"Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy","volume":"127","author":"Brown","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0075","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jaci.2011.01.031","article-title":"Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy","volume":"127","author":"Brown","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0080","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jaci.2008.01.013","article-title":"Filaggrin null mutations and childhood atopic eczema: a population-based case-control study","volume":"121","author":"Brown","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0085","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/icb.2009.113","article-title":"Epithelium: the interplay between innate and Th2 immunity","volume":"88","author":"Bulek","year":"2010","journal-title":"Immunol Cell Biol"},{"key":"10.1038\/jid.2011.435_bb0090","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0190-9622(83)70073-3","article-title":"Bullous pemphigoid: a cause of peripheral blood eosinophilia","volume":"8","author":"Bushkell","year":"1983","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2011.435_bb0095","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/j.jaad.2008.06.014","article-title":"Ichthyosis prematurity syndrome: a well-defined congenital ichthyosis subtype","volume":"59","author":"Bygum","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2011.435_bb0100","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrm1619","article-title":"The cornified envelope: a model of cell death in the skin","volume":"6","author":"Candi","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1038\/jid.2011.435_bb0105","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1093\/hmg\/ddh273","article-title":"A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups","volume":"13","author":"Capon","year":"2004","journal-title":"Hum Mol Genet"},{"key":"10.1038\/jid.2011.435_bb0110","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/jid.1964.88","article-title":"Visualization of the cell layers of the stratum corneum","volume":"42","author":"Christophers","year":"1964","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0115","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/jid.1964.88","article-title":"Visualization of the cell layers of the stratum corneum","volume":"42","author":"Christophers","year":"1964","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0120","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/jid.2009.133","article-title":"Epidermal barrier dysfunction in atopic dermatitis","volume":"129","author":"Cork","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0125","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/276729a0","article-title":"Assembly of stratum corneum basic protein and keratin filaments in macrofibrils","volume":"276","author":"Dale","year":"1978","journal-title":"Nature"},{"key":"10.1038\/jid.2011.435_bb0130","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/jid.2008.259","article-title":"Atopic dermatitis: a disease caused by innate immune defects?","volume":"129","author":"De Benedetto","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0135","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/sj.jid.5701208","article-title":"Filaggrin expression in oral, nasal, and esophageal mucosa","volume":"128","author":"De Benedetto","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0140","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jaci.2010.10.018","article-title":"Tight junction defects in patients with atopic dermatitis","volume":"127","author":"De Benedetto","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0145","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s004030050259","article-title":"T-helper 2 involvement in the pathogenesis of bullous pemphigoid: role of soluble CD30 (sCD30)","volume":"289","author":"De Pita","year":"1997","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/jid.2011.435_bb0150","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1371\/journal.pbio.0060123","article-title":"Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity","volume":"6","author":"Demehri","year":"2008","journal-title":"PLoS Biol"},{"key":"10.1038\/jid.2011.435_bb0155","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1600-0536.2010.01769.x","article-title":"Standardized tape stripping prior to patch testing induces upregulation of Hsp90, Hsp70, IL-33, TNF-alpha and IL-8\/CXCL8 mRNA: new insights into the involvement of \u2018alarmins\u2019","volume":"63","author":"Dickel","year":"2010","journal-title":"Contact Dermatitis"},{"key":"10.1038\/jid.2011.435_bb0160","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/1523-1747.ep12472288","article-title":"Involucrin--structure and role in envelope assembly","volume":"100","author":"Eckert","year":"1993","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-4362.1981.tb05278.x","article-title":"Epidermal lipids, membranes, and keratinization","volume":"20","author":"Elias","year":"1981","journal-title":"Int J Dermatol"},{"key":"10.1038\/jid.2011.435_bb0170","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.0022-202X.2005.23668.x","article-title":"Stratum corneum defensive functions: an integrated view","volume":"125","author":"Elias","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0175","series-title":"Skin Barrier","author":"Elias","year":"2006"},{"key":"10.1038\/jid.2011.435_bb0180","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaci.2008.10.031","article-title":"IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response","volume":"123","author":"Eyerich","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0185","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1046\/j.1365-2133.2003.05265.x","article-title":"The role of T lymphocytes and cytokines in the pathogenesis of pemphigoid gestationis","volume":"148","author":"Fabbri","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2011.435_bb0190","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ng.358","article-title":"A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming","volume":"41","author":"Fallon","year":"2009","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2011.435_bb0195","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/205873929901200202","article-title":"A Th2-like cytokine response is involved in bullous pemphigoid. The role of IL-4 and IL-5 in the pathogenesis of the disease","volume":"12","author":"Feliciani","year":"1999","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1038\/jid.2011.435_bb0200","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0169-4758(92)90105-B","article-title":"Cytokines: making the right choice","volume":"8","author":"Finkelman","year":"1992","journal-title":"Parasitol Today"},{"key":"10.1038\/jid.2011.435_bb0205","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1111\/j.1365-2133.2010.10068.x","article-title":"Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age","volume":"163","author":"Flohr","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2011.435_bb0210","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1038\/jid.2010.74","article-title":"Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification?","volume":"130","author":"Fluhr","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0215","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S1074-7613(01)00243-6","article-title":"IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo","volume":"15","author":"Fort","year":"2001","journal-title":"Immunity"},{"key":"10.1038\/jid.2011.435_bb0220","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/BF00596151","article-title":"Ichthyosis linearis circumflexa Com\u00e8l with Trichorrhexis invaginata (Netherton's Syndrom): an ultrastructural study of the skin changes","volume":"245","author":"Frenk","year":"1972","journal-title":"Arch Dermatol Forsch"},{"key":"10.1038\/jid.2011.435_bb0225","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1083\/jcb.200110122","article-title":"Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice","volume":"156","author":"Furuse","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1038\/jid.2011.435_bb0230","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jaci.2009.07.034","article-title":"Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum","volume":"124","author":"Gao","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0235","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1001\/archderm.1967.01610050094016","article-title":"Exfoliative cytology of human horny layer. Methods of cell removal and microscopic techniques","volume":"96","author":"Goldschmidt","year":"1967","journal-title":"Arch Dermatol"},{"key":"10.1038\/jid.2011.435_bb0240","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1016\/j.ajpath.2011.01.053","article-title":"Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function","volume":"178","author":"Gruber","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2011.435_bb0245","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jaci.2007.12.1161","article-title":"Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity","volume":"121","author":"Gupta","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0250","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.4049\/jimmunol.181.10.7420","article-title":"Low expression of the IL-23\/Th17 pathway in atopic dermatitis compared to psoriasis","volume":"181","author":"Guttman-Yassky","year":"2008","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.435_bb0255","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jaci.2011.01.053","article-title":"Contrasting pathogenesis of atopic dermatitis and psoriasis--part I: clinical and pathologic concepts","volume":"127","author":"Guttman-Yassky","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0260","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.jaci.2011.01.054","article-title":"Contrasting pathogenesis of atopic dermatitis and psoriasis--part II: immune cell subsets and therapeutic concepts","volume":"127","author":"Guttman-Yassky","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0265","doi-asserted-by":"crossref","first-page":"345803","DOI":"10.1155\/2011\/345803","article-title":"Role of IL-17 and Th17 cells in liver diseases","volume":"2011","author":"Hammerich","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"10.1038\/jid.2011.435_bb0270","doi-asserted-by":"crossref","first-page":"161s","DOI":"10.1111\/1523-1747.ep12276359","article-title":"Immunopharmacology of the atopic diseases","volume":"85","author":"Hanifin","year":"1985","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0275","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/1523-1747.ep12292052","article-title":"Intercellular spaces of the human epidermis as demonstrated with lanthanum","volume":"57","author":"Hashimoto","year":"1971","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0280","doi-asserted-by":"crossref","first-page":"15817","DOI":"10.1073\/pnas.0706942104","article-title":"Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge","volume":"104","author":"He","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2011.435_bb0285","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s00439-005-0048-2","article-title":"Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR","volume":"118","author":"Helms","year":"2005","journal-title":"Hum Genet"},{"key":"10.1038\/jid.2011.435_bb0290","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1172\/JCI8624","article-title":"Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4","volume":"105","author":"Herrick","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2011.435_bb0295","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.4049\/jimmunol.170.5.2488","article-title":"IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen","volume":"170","author":"Herrick","year":"2003","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.435_bb0300","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.it.2007.04.007","article-title":"The epithelium takes centre stage in asthma and atopic dermatitis","volume":"28","author":"Holgate","year":"2007","journal-title":"Trends Immunol"},{"key":"10.1038\/jid.2011.435_bb0305","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2165\/00128071-200809010-00005","article-title":"Comparison of skin hydration evaluation sites and correlations among skin hydration, transepidermal water loss, SCORAD index, Nottingham Eczema Severity Score, and quality of life in patients with atopic dermatitis","volume":"9","author":"Hon","year":"2008","journal-title":"Am J Clin Dermatol"},{"key":"10.1038\/jid.2011.435_bb0310","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaci.2007.04.031","article-title":"Cytokine modulation of atopic dermatitis filaggrin skin expression","volume":"120","author":"Howell","year":"2007","journal-title":"J Allergy Clin lmmunol"},{"key":"10.1038\/jid.2011.435_bb0315","doi-asserted-by":"crossref","first-page":"e11944","DOI":"10.1371\/journal.pone.0011944","article-title":"IL-33 is produced by mast cells and regulates IgE-dependent inflammation","volume":"5","author":"Hsu","year":"2010","journal-title":"PLoS One"},{"key":"10.1038\/jid.2011.435_bb0320","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2340\/00015555-0329","article-title":"Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort","volume":"87","author":"Hubiche","year":"2007","journal-title":"Acta Derm Venereol"},{"key":"10.1038\/jid.2011.435_bb0325","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.4049\/jimmunol.180.4.2443","article-title":"IL-33, a potent inducer of adaptive immunity to intestinal nematodes","volume":"180","author":"Humphreys","year":"2008","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.435_bb0330","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/jid.2010.277","article-title":"IL-25 in atopic dermatitis: a possible link between inflammation and skin barrier dysfunction?","volume":"131","author":"Hvid","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0335","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/jid.2010.363","article-title":"Inflammatory peeling skin syndrome caused by a mutation in CDSN encoding corneodesmosin","volume":"131","author":"Israeli","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0340","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Janeway","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/jid.2011.435_bb0345","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1034\/j.1399-0039.1999.530203.x","article-title":"Linkage disequilibrium analysis of familial psoriasis: identification of multiple disease-associated MHC haplotypes","volume":"53","author":"Jenisch","year":"1999","journal-title":"Tissue Antigens"},{"key":"10.1038\/jid.2011.435_bb0350","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/jid.2008.106","article-title":"Animal models of atopic dermatitis","volume":"129","author":"Jin","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0355","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1398-9995.2010.02326.x","article-title":"Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema","volume":"65","author":"Jungersted","year":"2010","journal-title":"Allergy"},{"key":"10.1038\/jid.2011.435_bb0360","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1038\/jid.2008.29","article-title":"Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum","volume":"128","author":"Kezic","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0365","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jaci.2008.10.008","article-title":"Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA","volume":"123","author":"Kinoshita","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0370","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ajhg.2009.06.021","article-title":"Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome","volume":"85","author":"Klar","year":"2009","journal-title":"Am J Hum Genet"},{"key":"10.1038\/jid.2011.435_bb0375","series-title":"Skin Barrier","article-title":"A brief history of how the dead stratum corneum became alive","author":"Kligman","year":"2006"},{"key":"10.1038\/jid.2011.435_bb0380","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1468-2494.2011.00644.x","article-title":"Corneobiology and corneotherapy--a final chapter","volume":"33","author":"Kligman","year":"2011","journal-title":"Int J Cosmet Sci"},{"key":"10.1038\/jid.2011.435_bb0385","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1038\/jid.2008.111","article-title":"Possible pathogenic role of Th17 cells for atopic dermatitis","volume":"128","author":"Koga","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0390","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/(SICI)1521-4141(199803)28:03<769::AID-IMMU769>3.0.CO;2-H","article-title":"Percutaneous sensitization with allergens through barrier-disrupted skin elicits a Th2-dominant cytokine response","volume":"28","author":"Kondo","year":"1998","journal-title":"Eur J Immunol"},{"key":"10.1038\/jid.2011.435_bb0395","series-title":"J Invest Dermatol","article-title":"Skin microbiome: looking back to look forward","author":"Kong","year":"2011"},{"key":"10.1038\/jid.2011.435_bb0400","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.4049\/jimmunol.0900904","article-title":"Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2","volume":"183","author":"Kouzaki","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.435_bb0405","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1046\/j.1523-1747.2000.00083.x","article-title":"Evidence for the existence of a self-regulated enzymatic process within the human stratum corneum -an unexpected role for urocanic acid","volume":"115","author":"Krien","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0410","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1084\/jem.20091527","article-title":"External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers","volume":"206","author":"Kubo","year":"2009","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2011.435_bb0415","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.jaci.2004.12.1114","article-title":"SPINK5 polymorphism is associated with disease severity and food allergy in children with atopic dermatitis","volume":"115","author":"Kusunoki","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0420","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000301576","article-title":"Glucocorticoids inhibit double-stranded RNA-induced thymic stromal lymphopoietin release from keratinocytes in an atopic cytokine milieu more effectively than tacrolimus","volume":"153","author":"Le","year":"2010","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1038\/jid.2011.435_bb0425","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/j.1365-2133.2006.07191.x","article-title":"Transepidermal water loss, serum IgE and beta-endorphin as important and independent biological markers for development of itch intensity in atopic dermatitis","volume":"154","author":"Lee","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2011.435_bb0430","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/212628c0","article-title":"Induced \u201cshedding\u201d of the epidermal Langerhans's cells","volume":"212","author":"Lessard","year":"1966","journal-title":"Nature"},{"key":"10.1038\/jid.2011.435_bb0435","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/jid.1968.20","article-title":"The disappearance and regeneration of Langerhans cells following epidermal injury","volume":"50","author":"Lessard","year":"1968","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0440","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jaci.2011.06.041","article-title":"Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin\/OX40 ligand\/OX40 signaling pathways","volume":"128","author":"Li","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0445","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1167\/iovs.08-3074","article-title":"Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines","volume":"50","author":"Ma","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/jid.2011.435_bb0450","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1046\/j.1523-1747.2003.12359.x","article-title":"Barrier function of the skin: \u201cla raison d\u2019etre\u201d of the epidermis","volume":"121","author":"Madison","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0455","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/jid.1958.71","article-title":"Studies on the percutaneous absorption of C14 labeled steroids by use of the gas-flow cell","volume":"31","author":"Malkinson","year":"1958","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0460","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1365-2133.1994.tb13109.x","article-title":"Epidermolysis bullosa pruriginosa: dystrophic epidermolysis bullosa with distinctive clinicopathological features","volume":"130","author":"McGrath","year":"1994","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2011.435_bb0465","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1046\/j.1523-1747.1999.00614.x","article-title":"Allelic heterogeneity of dominant and recessive COL7A1 mutations underlying epidermolysis bullosa pruriginosa","volume":"112","author":"Mellerio","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0470","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000211511","article-title":"Morphologic basis for a pore-pathway in mammalian stratum corneum","volume":"10","author":"Menon","year":"1997","journal-title":"Skin Pharmacol"},{"key":"10.1038\/jid.2011.435_bb0475","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nri2455","article-title":"Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells","volume":"8","author":"Merad","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1038\/jid.2011.435_bb0480","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.jaci.2010.09.015","article-title":"Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus","volume":"126","author":"Miajlovic","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0485","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1242\/jcs.03280","article-title":"Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4","volume":"119","author":"Milger","year":"2006","journal-title":"J Cell Sci"},{"key":"10.1038\/jid.2011.435_bb0490","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/jid.1957.112","article-title":"Location of the superficial epithelial barrier to skin penetration","volume":"29","author":"Monash","year":"1957","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0495","doi-asserted-by":"crossref","first-page":"15912","DOI":"10.1074\/jbc.M701779200","article-title":"Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4\/Fatp4 mutant mice","volume":"282","author":"Moulson","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2011.435_bb0500","doi-asserted-by":"crossref","first-page":"e3331","DOI":"10.1371\/journal.pone.0003331","article-title":"The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel \u2018alarmin\u2019?","volume":"3","author":"Moussion","year":"2008","journal-title":"PLoS One"},{"key":"10.1038\/jid.2011.435_bb0505","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.clim.2009.11.006","article-title":"Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3","volume":"134","author":"Nagel","year":"2010","journal-title":"Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0510","series-title":"J Invest Dermatol","article-title":"Antimicrobial peptides: old molecules with new ideas","author":"Nakatsuji","year":"2011"},{"key":"10.1038\/jid.2011.435_bb0515","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/jid.2008.280","article-title":"Clinical severity correlates with impaired barrier in filaggrin-related eczema","volume":"129","author":"Nemoto-Hasebe","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0520","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0190-9622(94)70059-1","article-title":"Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin","volume":"30","author":"Nickoloff","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2011.435_bb0525","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/00000372-199306000-00005","article-title":"Recessive ichthyosis congenita type IV","volume":"15","author":"Niemi","year":"1993","journal-title":"Am J Dermatopathol"},{"key":"10.1038\/jid.2011.435_bb0530","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/1523-1747.ep12319282","article-title":"Altered permeability and disordered cutaneous immunoregulatory function in mice with acute barrier disruption","volume":"109","author":"Nishijima","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0535","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jaci.2009.12.934","article-title":"Atopic dermatitis keratinocytes exhibit normal T(H)17 cytokine responses","volume":"125","author":"Nograles","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0540","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.jaci.2009.03.041","article-title":"IL-22-producing \u201cT22\u201d T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells","volume":"123","author":"Nograles","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0545","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11882-004-0069-2","article-title":"Immunoglobulin E-bearing antigen-presenting cells in atopic dermatitis","volume":"4","author":"Novak","year":"2004","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1038\/jid.2011.435_bb0550","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/j.1365-2222.2010.03522.x","article-title":"The role of filaggrin in the atopic diathesis","volume":"40","author":"O\u2019Regan","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1038\/jid.2011.435_bb0555","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.jaci.2010.04.038","article-title":"Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes","volume":"126","author":"O\u2019Regan","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0560","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4168\/aair.2011.3.2.81","article-title":"IL-33 and airway inflammation","volume":"3","author":"Oboki","year":"2011","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1038\/jid.2011.435_bb0565","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ajhg.2010.07.005","article-title":"Loss of corneodesmosin leads to severe skin barrier defect, pruritus, and atopy: unraveling the peeling skin disease","volume":"87","author":"Oji","year":"2010","journal-title":"Am J Hum Genet"},{"key":"10.1038\/jid.2011.435_bb0570","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1365-2133.2008.08999.x","article-title":"Ichthyosis vulgaris: novel FLG mutations in the German population and high presence of CD1a+ cells in the epidermis of the atopic subgroup","volume":"160","author":"Oji","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2011.435_bb0575","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.tibs.2009.08.001","article-title":"The emerging roles of serine protease cascades in the epidermis","volume":"34","author":"Ovaere","year":"2009","journal-title":"Trends Biochem Sci"},{"key":"10.1038\/jid.2011.435_bb0580","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jaci.2009.05.042","article-title":"Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen","volume":"124","author":"Oyoshi","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0585","doi-asserted-by":"crossref","first-page":"6317","DOI":"10.4049\/jimmunol.180.9.6317","article-title":"TLR2-mediated activation of neutrophils in response to German cockroach frass","volume":"180","author":"Page","year":"2008","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.435_bb0590","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1767","article-title":"Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis","volume":"38","author":"Palmer","year":"2006","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2011.435_bb0595","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nri2735","article-title":"How are T(H)2-type immune responses initiated and amplified?","volume":"10","author":"Paul","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1038\/jid.2011.435_bb0600","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1046\/j.1523-1747.2000.00178.x","article-title":"Loss of normal profilaggrin and filaggrin in flaky tail (ft\/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris","volume":"115","author":"Presland","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0605","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","article-title":"The skin: an indispensable barrier","volume":"17","author":"Proksch","year":"2008","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2011.435_bb0610","doi-asserted-by":"crossref","first-page":"9773","DOI":"10.1073\/pnas.0901206106","article-title":"The cytokine interleukin-33 mediates anaphylactic shock","volume":"106","author":"Pushparaj","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2011.435_bb0615","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/j.1523-1747.2005.23726.x","article-title":"Stratum corneum moisturization at the molecular level: an update in relation to the dry skin cycle","volume":"124","author":"Rawlings","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0620","series-title":"Physiology and Biochemistry of Skin","author":"Rothman","year":"1954"},{"key":"10.1038\/jid.2011.435_bb0625","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev.ph.06.030144.001211","article-title":"The physiology of the skin","volume":"6","author":"Rothman","year":"1944","journal-title":"Annu Rev Physiol"},{"key":"10.1038\/jid.2011.435_bb0630","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/j.1440-1843.2007.01175.x","article-title":"Pollen proteolytic enzymes degrade tight junctions","volume":"12","author":"Runswick","year":"2007","journal-title":"Respirology"},{"key":"10.1038\/jid.2011.435_bb0635","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1242\/jcs.033969","article-title":"Filaggrin in the frontline: role in skin barrier function and disease","volume":"122","author":"Sandilands","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1038\/jid.2011.435_bb0640","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1152\/physrev.1971.51.4.702","article-title":"Permeability of the skin","volume":"51","author":"Scheuplein","year":"1971","journal-title":"Physiol Rev"},{"key":"10.1038\/jid.2011.435_bb0645","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/ni.1919","article-title":"Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel","volume":"11","author":"Schmidt","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2011.435_bb0650","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity"},{"key":"10.1038\/jid.2011.435_bb0655","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1111\/j.1398-9995.2009.02080.x","article-title":"Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure","volume":"64","author":"Schuttelaar","year":"2009","journal-title":"Allergy"},{"key":"10.1038\/jid.2011.435_bb0660","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0012-1606(86)90230-7","article-title":"Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment","volume":"115","author":"Scott","year":"1986","journal-title":"Dev Biol"},{"key":"10.1038\/jid.2011.435_bb0665","first-page":"3186","article-title":"IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation","volume":"184","author":"Sehra","year":"2010","journal-title":"J lmmunol"},{"key":"10.1038\/jid.2011.435_bb0670","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00011-009-0088-5","article-title":"IL-33 synergizes with IgE-dependent and IgE-independent agents to promote mast cell and basophil activation","volume":"59","author":"Silver","year":"2010","journal-title":"Inflamm Res"},{"key":"10.1038\/jid.2011.435_bb0675","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ng1743","article-title":"Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris","volume":"38","author":"Smith","year":"2006","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2011.435_bb0680","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1756-0500-4-90","article-title":"FATP4 missense and nonsense mutations cause similar features in Ichthyosis Prematurity Syndrome","volume":"4","author":"Sobol","year":"2011","journal-title":"BMC Res Notes"},{"key":"10.1038\/jid.2011.435_bb0685","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ni805","article-title":"Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP","volume":"3","author":"Soumelis","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2011.435_bb0690","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.anai.2009.10.002","article-title":"From atopic dermatitis to asthma: the atopic march","volume":"105","author":"Spergel","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1038\/jid.2011.435_bb0695","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1172\/JCI1647","article-title":"Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice","volume":"101","author":"Spergel","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2011.435_bb0700","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1084\/jem.155.3.863","article-title":"Depletion of epidermal langerhans cells and Ia immunogenicity from tape-stripped mouse skin","volume":"155","author":"Streilein","year":"1982","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2011.435_bb0705","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2567.2006.02401.x","article-title":"Epicutaneous immunization converts subsequent and established antigen-specific T helper type 1 (Th1) to Th2-type responses","volume":"119","author":"Strid","year":"2006","journal-title":"Immunology"},{"key":"10.1038\/jid.2011.435_bb0710","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1002\/eji.200425196","article-title":"Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response","volume":"34","author":"Strid","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1038\/jid.2011.435_bb0715","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1365-2222.2005.02260.x","article-title":"Epicutaneous exposure to peanut protein prevents oral tolerance and enhances allergic sensitization","volume":"35","author":"Strid","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1038\/jid.2011.435_bb0720","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.jaci.2010.12.1124","article-title":"Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities","volume":"127","author":"Suarez-Farinas","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0725","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/1523-1747.ep12470383","article-title":"Evidence that the corneocyte has a chemically bound lipid envelope","volume":"88","author":"Swartzendruber","year":"1987","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0730","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1398-9995.2005.00958.x","article-title":"Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells","volume":"61","author":"Tai","year":"2006","journal-title":"Allergy"},{"key":"10.1038\/jid.2011.435_bb0735","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2332\/allergolint.10-RAI-0273","article-title":"Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases","volume":"60","author":"Takai","year":"2011","journal-title":"Allergol Int"},{"key":"10.1038\/jid.2011.435_bb0740","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature07548","article-title":"Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein","volume":"457","author":"Trompette","year":"2009","journal-title":"Nature"},{"key":"10.1038\/jid.2011.435_bb0745","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0955-0674(02)00362-9","article-title":"Claudin-based barrier in simple and stratified cellular sheets","volume":"14","author":"Tsukita","year":"2002","journal-title":"Curr Opin Cell Biol"},{"key":"10.1038\/jid.2011.435_bb0750","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/35067088","article-title":"Multifunctional strands in tight junctions","volume":"2","author":"Tsukita","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1038\/jid.2011.435_bb0755","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1242\/dev.129.7.1775","article-title":"Permeability barrier dysfunction in transgenic mice overexpressing claudin 6","volume":"129","author":"Turksen","year":"2002","journal-title":"Development"},{"key":"10.1038\/jid.2011.435_bb0760","doi-asserted-by":"crossref","first-page":"b2433","DOI":"10.1136\/bmj.b2433","article-title":"Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis","volume":"339","author":"van den Oord","year":"2009","journal-title":"BMJ"},{"key":"10.1038\/jid.2011.435_bb0765","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jaci.2010.09.002","article-title":"Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway","volume":"126","author":"Vu","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0770","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/ng728","article-title":"Gene polymorphism in Netherton and common atopic disease","volume":"29","author":"Walley","year":"2001","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2011.435_bb0775","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1172\/JCI5844","article-title":"Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions","volume":"104","author":"Wan","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2011.435_bb0780","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.4049\/jimmunol.156.11.4079","article-title":"Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice","volume":"156","author":"Wang","year":"1996","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.435_bb0785","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1084\/jem.20070406","article-title":"IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells","volume":"204","author":"Wang","year":"2007","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2011.435_bb0790","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1046\/j.1523-1747.1999.00774.x","article-title":"Water disrupts stratum corneum lipid lamellae: damage is similar to surfactants","volume":"113","author":"Warner","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.435_bb0795","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jaci.2006.05.004","article-title":"Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations","volume":"118","author":"Weidinger","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0800","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.jaci.2008.02.014","article-title":"Filaggrin mutations, atopic eczema, hay fever, and asthma in children","volume":"121","author":"Weidinger","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0805","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1136\/bmj.2.5528.1504","article-title":"Ichthyosis","volume":"2","author":"Wells","year":"1966","journal-title":"Br Med J"},{"key":"10.1038\/jid.2011.435_bb0810","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ni1497","article-title":"Development, cytokine profile and function of human interleukin 17-producing helper T cells","volume":"8","author":"Wilson","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2011.435_bb0815","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1172\/JCI115884","article-title":"Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice","volume":"90","author":"Wood","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2011.435_bb0820","first-page":"308","article-title":"Epidermolysis bullosa pruriginosa (McGrath) successfully controlled by oral cyclosporin","volume":"137","author":"Yamasaki","year":"1997","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2011.435_bb0825","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.jaci.2006.08.030","article-title":"Lack of filaggrin expression in the human bronchial mucosa","volume":"118","author":"Ying","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.435_bb0830","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1073\/pnas.0812668106","article-title":"Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma","volume":"106","author":"Zhang","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2011.435_bb0835","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ni.1852","article-title":"Sensing the outside world: TSLP regulates barrier immunity","volume":"11","author":"Ziegler","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2011.435_bb0840","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1038\/sj.jid.5700882","article-title":"Langerhans cells and lymph node dendritic cells express the tight junction component claudin-1","volume":"127","author":"Zimmerli","year":"2007","journal-title":"J Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15356050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15356050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T12:07:58Z","timestamp":1743941278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15356050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":167,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0022202X15356050"],"URL":"https:\/\/doi.org\/10.1038\/jid.2011.435","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Skin Barrier Disruption: A Requirement for Allergen Sensitization?","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2011.435","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}