{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:10:08Z","timestamp":1777461008622,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1310,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1038\/jid.2011.466","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T13:29:17Z","timestamp":1328189357000},"page":"1409-1415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Identification of Quantitative Trait Loci in Experimental Epidermolysis Bullosa Acquisita"],"prefix":"10.1016","volume":"132","author":[{"given":"Ralf J.","family":"Ludwig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susen","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia d C.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Recke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enno","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlef","family":"Zillikens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleh M.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2011.466_bb0010","doi-asserted-by":"crossref","first-page":"e1000361","DOI":"10.1371\/journal.ppat.1000361","article-title":"Caspase-7 activation by the Nlrc4\/Ipaf inflammasome restricts Legionella pneumophila infection","volume":"5","author":"Akhter","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1038\/jid.2011.466_bb0015","series-title":"Dermatology","first-page":"417","article-title":"Pemphigus","author":"Amagai","year":"2008"},{"key":"10.1038\/jid.2011.466_bb0020","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(91)90360-B","article-title":"Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion","volume":"67","author":"Amagai","year":"1991","journal-title":"Cell"},{"key":"10.1038\/jid.2011.466_bb0025","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/art.27272","article-title":"Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status","volume":"62","author":"Bang","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2011.466_bb0030","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0625.2009.00948.x","article-title":"Animal models for autoimmune bullous dermatoses","volume":"19","author":"Bieber","year":"2010","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2011.466_bb0035","series-title":"Dermatology","first-page":"431","article-title":"Pemphigoid group","author":"Borradori","year":"2008"},{"key":"10.1038\/jid.2011.466_bb0040","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1046\/j.1365-2230.2003.01419.x","article-title":"Comparison of immunofluorescence microscopy, immunoblotting and enzyme-linked immunosorbent assay methods in the laboratory diagnosis of bullous pemphigoid","volume":"28","author":"Chan","year":"2003","journal-title":"Clin Exp Dermatol"},{"key":"10.1038\/jid.2011.466_bb0045","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2133.2005.06938.x","article-title":"Cytokine gene polymorphisms in bullous pemphigoid in a Chinese population","volume":"154","author":"Chang","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2011.466_bb0050","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/path.2157","article-title":"NADPH oxidase is required for neutrophil-dependent autoantibody-induced tissue damage","volume":"212","author":"Chiriac","year":"2007","journal-title":"J Pathol"},{"key":"10.1038\/jid.2011.466_bb0055","doi-asserted-by":"crossref","first-page":"8569","DOI":"10.1073\/pnas.93.16.8569","article-title":"A common major histocompatibility complex class II allele HLA-DQB1* 0301 is present in clinical variants of pemphigoid","volume":"93","author":"Delgado","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2011.466_bb0060","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1172\/JCI114812","article-title":"Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome","volume":"86","author":"Diaz","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2011.466_bb0065","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1534\/genetics.109.113183","article-title":"Bayesian quantitative trait locus mapping using inferred haplotypes","volume":"184","author":"Durrant","year":"2010","journal-title":"Genetics"},{"key":"10.1038\/jid.2011.466_bb0070","doi-asserted-by":"crossref","first-page":"e1000024","DOI":"10.1371\/journal.pgen.1000024","article-title":"Defining the role of the MHC in autoimmunity: a review and pooled analysis","volume":"4","author":"Fernando","year":"2008","journal-title":"PLoS Genet"},{"key":"10.1038\/jid.2011.466_bb0075","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/ng.553","article-title":"Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)","volume":"42","author":"Franke","year":"2010","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2011.466_bb0080","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/1523-1747.ep12470317","article-title":"Increased frequency of HLA-DR2 in patients with autoantibodies to epidermolysis bullosa acquisita antigen: evidence that the expression of autoimmunity to type VII collagen is HLA class II allele associated","volume":"91","author":"Gammon","year":"1988","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.466_bb0085","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1093\/rheumatology\/kem096","article-title":"Caspase 7 influences susceptibility to rheumatoid arthritis","volume":"46","author":"Garcia-Lozano","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"10.1038\/jid.2011.466_bb0090","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.immuni.2007.06.008","article-title":"Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis","volume":"27","author":"Green","year":"2007","journal-title":"Immunity"},{"key":"10.1038\/jid.2011.466_bb0095","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jaad.2009.09.010","article-title":"The role of Fc gamma receptors polymorphisms in bullous pemphigoid","volume":"63","author":"Guilabert","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2011.466_bb0100","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/ng.472","article-title":"Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus","volume":"41","author":"Han","year":"2009","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2011.466_bb0105","doi-asserted-by":"crossref","first-page":"8095","DOI":"10.4049\/jimmunol.177.11.8095","article-title":"Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4","volume":"177","author":"Hilliard","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.466_bb0110","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/path.2857","article-title":"Autoantibody-induced intestinal inflammation and weight loss in experimental epidermolysis bullosa acquisita","volume":"224","author":"Ishii","year":"2011","journal-title":"J Pathol"},{"key":"10.1038\/jid.2011.466_bb0115","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/j.1365-2133.2010.09680.x","article-title":"Clearance rates of circulating and tissue-bound autoantibodies to type VII collagen in experimental epidermolysis bullosa acquisita","volume":"162","author":"Kasperkiewicz","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2011.466_bb0120","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1182\/blood-2010-10-314609","article-title":"Heat shock protein 90 inhibition in autoimmunity to type VII collagen: evidence that non-malignant plasma cells are not therapeutic targets","volume":"117","author":"Kasperkiewicz","year":"2011","journal-title":"Blood"},{"key":"10.1038\/jid.2011.466_bb0125","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF01893018","article-title":"Initiation of complement activation","volume":"7","author":"Lachmann","year":"1984","journal-title":"Springer Semin Immunopathol"},{"key":"10.1038\/jid.2011.466_bb0130","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.humimm.2005.09.003","article-title":"Disease relevant HLA class II alleles isolated by genotypic, haplotypic, and sequence analysis in North American Caucasians with pemphigus vulgaris","volume":"67","author":"Lee","year":"2006","journal-title":"Hum Immunol"},{"key":"10.1038\/jid.2011.466_bb0135","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/jid.2010.248","article-title":"Generation of antibodies of distinct subclasses and specificity is linked to H2s in an active mouse model of epidermolysis bullosa acquisita","volume":"131","author":"Ludwig","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.466_bb0140","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1172\/JCI200421055","article-title":"A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice","volume":"114","author":"Marietta","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2011.466_bb0145","doi-asserted-by":"crossref","first-page":"6514","DOI":"10.4049\/jimmunol.178.10.6514","article-title":"The alternative pathway in complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita","volume":"178","author":"Mihai","year":"2007","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.466_bb0150","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1034\/j.1399-0039.1999.540402.x","article-title":"HLA-DRB1 polymorphisms and autoimmune responses to desmogleins in Japanese patients with pemphigus","volume":"54","author":"Miyagawa","year":"1999","journal-title":"Tissue Antigens"},{"key":"10.1038\/jid.2011.466_bb0155","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1365-2133.2002.04564.x","article-title":"Genotyping for HLA-A, B and C alleles in Japanese patients with pemphigus: prevalence of Asian alleles of the HLA-B15 family","volume":"146","author":"Miyagawa","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2011.466_bb0160","doi-asserted-by":"crossref","first-page":"12640","DOI":"10.1073\/pnas.230304397","article-title":"A method for fine mapping quantitative trait loci in outbred animal stocks","volume":"97","author":"Mott","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2011.466_bb0165","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1471-2105-11-S12-S5","article-title":"Community-driven computational biology with Debian Linux","volume":"11","author":"M\u00f6ller","year":"2010","journal-title":"BMC Bioinform"},{"key":"10.1038\/jid.2011.466_bb0170","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.0022-202X.2005.23681.x","article-title":"Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: results from an Italian case-control study","volume":"125","author":"Naldi","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.466_bb0175","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1346-8138.2000.tb02141.x","article-title":"Polymorphisms of HLA-DR and -DQ genes in Japanese patients with bullous pemphigoid","volume":"27","author":"Okazaki","year":"2000","journal-title":"J Dermatol"},{"key":"10.1038\/jid.2011.466_bb0180","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0140-6736(79)91493-4","article-title":"HLA-DRW4 in 91% of Jewish pemphigus vulgaris patients","volume":"2","author":"Park","year":"1979","journal-title":"Lancet"},{"key":"10.1038\/jid.2011.466_bb0185","first-page":"127","article-title":"Role of immunofluorescence microscopy in dermatology","volume":"146","author":"Pohla-Gubo","year":"2011","journal-title":"G Ital Dermatol Venereol"},{"key":"10.1038\/jid.2011.466_bb0190","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1399-0039.2007.00826.x","article-title":"HLA-DRB1*0402 haplotypes without DQB1*0302 in Venezuelan patients with pemphigus vulgaris","volume":"69","author":"Saenz-Cantele","year":"2007","journal-title":"Tissue Antigens"},{"key":"10.1038\/jid.2011.466_bb0195","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1084\/jem.20011299","article-title":"Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis","volume":"195","author":"Sardy","year":"2002","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2011.466_bb0200","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-2133.2007.08388.x","article-title":"Binding of avian IgY to type VII collagen does not activate complement and leuckocytes fail to induce subepidermal blistering in mice","volume":"158","author":"Sesarman","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2011.466_bb0205","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10875-008-9244-x","article-title":"HLA class II (DRB, DQA1 and DQB1) allele and haplotype frequencies in the patients with pemphigus vulgaris","volume":"29","author":"Shams","year":"2009","journal-title":"J Clin Immunol"},{"key":"10.1038\/jid.2011.466_bb0210","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/path.1674","article-title":"Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid","volume":"204","author":"Shimanovich","year":"2004","journal-title":"J Pathol"},{"key":"10.1038\/jid.2011.466_bb0215","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.4049\/jimmunol.177.5.3461","article-title":"Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice","volume":"177","author":"Sitaru","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.466_bb0220","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0002-9440(10)64182-X","article-title":"Autoantibodies to type VII collagen mediate Fc gamma-dependent neutrophil activation and induce dermal-epidermal separation in cryosections of human skin","volume":"161","author":"Sitaru","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2011.466_bb0225","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1172\/JCI200521386","article-title":"Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen","volume":"115","author":"Sitaru","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2011.466_bb0230","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1399-0039.1997.tb02706.x","article-title":"Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (alpha 1*0501, beta 1*02) or the HLA-DQ (alpha 1*03, beta 1*0302) heterodimers","volume":"49","author":"Spurkland","year":"1997","journal-title":"Tissue Antigens"},{"key":"10.1038\/jid.2011.466_bb0235","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/0092-8674(81)90115-X","article-title":"Characterization of bullous pemphigoid antigen: a unique basement membrane protein of stratified squamous epithelia","volume":"24","author":"Stanley","year":"1981","journal-title":"Cell"},{"key":"10.1038\/jid.2011.466_bb0240","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1172\/JCI113803","article-title":"Isolation of complementary DNA for bullous pemphigoid antigen by use of patients\u2019 autoantibodies","volume":"82","author":"Stanley","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2011.466_bb0245","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.1073\/pnas.84.18.6542","article-title":"Detection of disease-specific restriction fragment length polymorphisms in pemphigus vulgaris linked to the DQw1 and DQw3 alleles of the HLA-D region","volume":"84","author":"Szafer","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2011.466_bb0250","first-page":"1912","article-title":"Genetic and expression analysis of CASP7 gene in a European Caucasian population with rheumatoid arthritis","volume":"35","author":"Teixeira","year":"2008","journal-title":"J Rheumatol"},{"key":"10.1038\/jid.2011.466_bb0255","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00403-007-0755-8","article-title":"Relevance of the low-affinity type of the Fcgamma-receptor IIIa-polymorphism in bullous pemphigoid","volume":"299","author":"Weisenseel","year":"2007","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/jid.2011.466_bb0260","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1172\/JCI113373","article-title":"Epidermolysis bullosa acquisita antigen is the globular carboxyl terminus of type VII procollagen","volume":"81","author":"Woodley","year":"1988","journal-title":"J Clin Invest"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15357456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15357456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T17:54:07Z","timestamp":1743962047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15357456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0022202X15357456"],"URL":"https:\/\/doi.org\/10.1038\/jid.2011.466","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of Quantitative Trait Loci in Experimental Epidermolysis Bullosa Acquisita","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2011.466","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}