{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:00:28Z","timestamp":1790528428772,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1615,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1038\/jid.2011.73","type":"journal-article","created":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T10:49:19Z","timestamp":1300963759000},"page":"1513-1520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["IL-21 Reduces Immediate Hypersensitivity Reactions in Mouse Skin by Suppressing Mast Cell Activation or IgE Production"],"prefix":"10.1016","volume":"131","author":[{"given":"Risa","family":"Tamagawa-Mineoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunao","family":"Kishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osam","family":"Mazda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norito","family":"Katoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2011.73_bb0010","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1182\/blood-2003-03-0669","article-title":"Interleukin-21 inhibits dendritic cell activation and maturation","volume":"102","author":"Brandt","year":"2003","journal-title":"Blood"},{"key":"10.1038\/jid.2011.73_bb0015","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cytogfr.2007.04.003","article-title":"Interleukin-21: a new modulator of immunity, infection, and cancer","volume":"18","author":"Brandt","year":"2007","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1038\/jid.2011.73_bb0020","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.4049\/jimmunol.178.12.7640","article-title":"IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype","volume":"178","author":"Casey","year":"2007","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.73_bb0025","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.4049\/jimmunol.178.5.2827","article-title":"IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production","volume":"178","author":"Coquet","year":"2007","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.73_bb0030","doi-asserted-by":"crossref","first-page":"7867","DOI":"10.4049\/jimmunol.175.12.7867","article-title":"IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells","volume":"175","author":"Ettinger","year":"2005","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.73_bb0035","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1182\/blood-2006-05-021600","article-title":"IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo","volume":"109","author":"Fr\u00f6hlich","year":"2007","journal-title":"Blood"},{"key":"10.1038\/jid.2011.73_bb0040","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni1158","article-title":"Mast cells in the development of adaptive immune responses","volume":"6","author":"Galli","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2011.73_bb0045","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/365340a0","article-title":"Induction of human IgE synthesis in B cells by mast cells and basophils","volume":"365","author":"Gauchat","year":"1993","journal-title":"Nature"},{"key":"10.1038\/jid.2011.73_bb0050","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.4049\/jimmunol.134.5.3291","article-title":"Clearance of IgE from serum of normal and hybridoma-bearing mice","volume":"134","author":"Haba","year":"1985","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.73_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1600-0625.2001.100101.x","article-title":"Mast cells as initiators of immunity and host defense","volume":"10","author":"Henz","year":"2001","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2011.73_bb0060","doi-asserted-by":"crossref","first-page":"7157","DOI":"10.4049\/jimmunol.179.10.7157","article-title":"IL-21 administration into the nostril alleviates murine allergic rhinitis","volume":"179","author":"Hiromura","year":"2007","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.73_bb0065","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.4049\/jimmunol.173.8.5275","article-title":"IgE-mediated mast cell activation induces Langerhans cell migration in vivo","volume":"173","author":"Jawdat","year":"2004","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.73_bb0070","doi-asserted-by":"crossref","first-page":"657","DOI":"10.4049\/jimmunol.173.1.657","article-title":"Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or bim-dependent apoptosis","volume":"173","author":"Jin","year":"2004","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.73_bb0075","first-page":"47","article-title":"IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice","volume":"119","author":"Jin","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2011.73_bb0080","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1046\/j.1523-1747.2003.12407.x","article-title":"Exacerbated and prolonged allergic and non-allergic inflammatory cutaneous reaction in mice with targeted interleukin-18 expression in the skin","volume":"121","author":"Kawase","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2011.73_bb0085","doi-asserted-by":"crossref","first-page":"8554","DOI":"10.4049\/jimmunol.179.12.8554","article-title":"IL-21 induces inhibitor of differentiation 2 and leads to complete abrogation of anaphylaxis in mice","volume":"179","author":"Kishida","year":"2007","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.73_bb0090","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1093\/intimm\/dxl113","article-title":"IgE-activated mast cells in combination with pro-inflammatory factors induce Th2-promoting dendritic cells","volume":"18","author":"Kitawaki","year":"2006","journal-title":"Int Immunol"},{"key":"10.1038\/jid.2011.73_bb0095","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.4049\/jimmunol.0803009","article-title":"IL-21: an executor of B cell fate","volume":"182","author":"Konforte","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.73_bb0100","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4049\/jimmunol.168.1.421","article-title":"Role of STAT6 in IgE receptor\/Fc\u03b5RI-mediated late phase allergic responses of mast cells","volume":"168","author":"Malaviya","year":"2002","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.73_bb0105","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.4049\/jimmunol.170.8.4111","article-title":"IL-21 induces the apoptosis of resting and activated primary B cells","volume":"170","author":"Mehta","year":"2003","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.73_bb0110","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0091-6749(99)70316-7","article-title":"Mast cell-T cell interactions","volume":"104","author":"Mekori","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.73_bb0115","doi-asserted-by":"crossref","first-page":"900","DOI":"10.4049\/jimmunol.173.2.900","article-title":"IL-21 enhances and sustains CD8+ T Cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21","volume":"173","author":"Moroz","year":"2004","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.73_bb0120","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1084\/jem.162.3.1025","article-title":"Fate of bonemarrow-derived cultured mastcells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mastcell-deficient W\/Wv mice: evidence that cultured mastcells can give rise to both connective tissue type and mucosal mastcells","volume":"162","author":"Nakano","year":"1985","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2011.73_bb0125","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.1077002","article-title":"A critical role for IL-21 in regulating immunoglobulin production","volume":"298","author":"Ozaki","year":"2002","journal-title":"Science"},{"key":"10.1038\/jid.2011.73_bb0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/35040504","article-title":"Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function","volume":"408","author":"Parrish-Novak","year":"2000","journal-title":"Nature"},{"key":"10.1038\/jid.2011.73_bb0135","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.4049\/jimmunol.177.8.5006","article-title":"IFN-\u03b3-mediated inhibition of human IgE synthesis by IL-21 is associated with a polymorphism in the IL-21R gene","volume":"177","author":"Pene","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/jid.2011.73_bb0140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2222.1997.tb00697.x","article-title":"The expression of murine cutaneous late phase reaction requires both IgE antibodies and CD4 T cells","volume":"27","author":"Sawada","year":"1997","journal-title":"Clin Exp Allergy"},{"key":"10.1038\/jid.2011.73_bb0145","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.immunol.26.021607.090316","article-title":"Interleukin-21: basic biology and implications for cancer and autoimmunity","volume":"26","author":"Spolski","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/jid.2011.73_bb0150","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1182\/blood-2002-04-1115","article-title":"Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C\u00e5 transcription of IL-4-stimulated B cells","volume":"100","author":"Suto","year":"2002","journal-title":"Blood"},{"key":"10.1038\/jid.2011.73_bb0155","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jaci.2008.12.1114","article-title":"Platelets play important roles in the late phase of the immediate hypersensitivity reaction","volume":"123","author":"Tamagawa-Mineoka","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2011.73_bb0160","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/eji.1830180221","article-title":"The half-lives of serum immunoglobulins in adult mice","volume":"18","author":"Vieira","year":"1988","journal-title":"Eur J Immunol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15353197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15353197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T17:40:47Z","timestamp":1743961247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15353197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0022202X15353197"],"URL":"https:\/\/doi.org\/10.1038\/jid.2011.73","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-21 Reduces Immediate Hypersensitivity Reactions in Mouse Skin by Suppressing Mast Cell Activation or IgE Production","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2011.73","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}