{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:25:44Z","timestamp":1791077144347,"version":"4.1.0"},"reference-count":12,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1157,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1038\/jid.2012.146","type":"journal-article","created":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T13:22:20Z","timestamp":1339680140000},"page":"2473-2476","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Mutations in the Prostaglandin Transporter SLCO2A1 Cause Primary Hypertrophic Osteoarthropathy with Digital Clubbing"],"prefix":"10.1016","volume":"132","author":[{"given":"Jutta","family":"Busch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeska","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atoshi","family":"Otsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinzenz","family":"Oji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Metze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krati","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumita","family":"Danda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Watzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Traupe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanno J.","family":"Bolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2012.146_bb0010","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1600-0625.2011.01248.x","article-title":"Primary hypertrophic osteoarthropathy with digital clubbing and palmoplantar hyperhidrosis caused by 15-PGHD\/HPGD loss-of-function mutations","volume":"20","author":"Bergmann","year":"2011","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2012.146_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nprot.2008.197","article-title":"Protein structure homology modeling using SWISS-MODEL workspace","volume":"4","author":"Bordoli","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1038\/jid.2012.146_bb0020","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1399-0004.2005.00533.x","article-title":"Pachydermoperiostosis: an update","volume":"68","author":"Castori","year":"2005","journal-title":"Clin Genet"},{"key":"10.1038\/jid.2012.146_bb0025","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1093\/rheumatology\/keq048","article-title":"Common and recurrent HPGD mutations in Caucasian individuals with primary hypertrophic osteoarthropathy","volume":"49","author":"Diggle","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1038\/jid.2012.146_bb0030","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1126\/science.7754369","article-title":"Identification and characterization of a prostaglandin transporter","volume":"268","author":"Kanai","year":"1995","journal-title":"Science"},{"key":"10.1038\/jid.2012.146_bb0035","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/bbrc.1998.8715","article-title":"Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization","volume":"246","author":"Lu","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/jid.2012.146_bb0040","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/1471-2105-7-339","article-title":"Tools for integrated sequence-structure analysis with UCSF Chimera","volume":"7","author":"Meng","year":"2006","journal-title":"BMC Bioinform"},{"key":"10.1038\/jid.2012.146_bb0045","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1124\/mol.65.4.973","article-title":"The two-step model of prostaglandin signal termination: in vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase","volume":"65","author":"Nomura","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1038\/jid.2012.146_bb0050","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/jmg.2008.061234","article-title":"Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC)","volume":"46","author":"Tariq","year":"2009","journal-title":"J Med Genet"},{"key":"10.1038\/jid.2012.146_bb0055","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/ng.153","article-title":"Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy","volume":"40","author":"Uppal","year":"2008","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2012.146_bb0060","series-title":"J Struct Biol","article-title":"UCSF Chimera, MODELLER, and IMP: an integrated modeling system","author":"Yang","year":"2011"},{"key":"10.1038\/jid.2012.146_bb0065","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ajhg.2011.11.019","article-title":"Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy","volume":"90","author":"Zhang","year":"2012","journal-title":"Am J Hum Genet"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15354749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15354749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T23:59:54Z","timestamp":1743897594000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15354749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0022202X15354749"],"URL":"https:\/\/doi.org\/10.1038\/jid.2012.146","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutations in the Prostaglandin Transporter SLCO2A1 Cause Primary Hypertrophic Osteoarthropathy with Digital Clubbing","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2012.146","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}