{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:17:57Z","timestamp":1791217077775,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1126,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1038\/jid.2012.185","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T08:26:49Z","timestamp":1339057609000},"page":"2593-2600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":116,"title":["Regulation of IL-33 Expression by IFN-\u03b3 and Tumor Necrosis Factor-\u03b1 in Normal Human Epidermal Keratinocytes"],"prefix":"10.1016","volume":"132","author":[{"given":"Jitlada","family":"Meephansan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Tsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Komine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamitaro","family":"Ohtsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2012.185_bb0010","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.4049\/jimmunol.1003080","article-title":"The dual function cytokine IL-33 interacts with the transcription factor NF-\u03baB to dampen NF-\u03baB-stimulated gene transcription","volume":"187","author":"Ali","year":"2011","journal-title":"J Immunol"},{"key":"10.1038\/jid.2012.185_bb0015","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-065X.2008.00624.x","article-title":"IL-1, IL-18, and IL-33 families of cytokines","volume":"223","author":"Arend","year":"2008","journal-title":"Immunol Rev"},{"key":"10.1038\/jid.2012.185_bb0020","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ajpath.2011.03.010","article-title":"The immune-modulating cytokine and endogenous Alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation","volume":"179","author":"Byrne","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2012.185_bb0025","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1073\/pnas.0606854104","article-title":"IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo","volume":"104","author":"Carriere","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2012.185_bb0030","doi-asserted-by":"crossref","first-page":"9021","DOI":"10.1073\/pnas.0812690106","article-title":"The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1","volume":"106","author":"Cayrol","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2012.185_bb0035","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1359-6101(97)00023-3","article-title":"Interleukin-1","volume":"8","author":"Dinarello","year":"1997","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1038\/jid.2012.185_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1998.tb08307.x","article-title":"Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme","volume":"856","author":"Dinarello","year":"1998","journal-title":"Ann NY Acad Sci"},{"key":"10.1038\/jid.2012.185_bb0045","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bbrc.2009.07.018","article-title":"Mature interleukin-33 is produced by calpain-mediated cleavage in vivo","volume":"387","author":"Hayakawa","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/jid.2012.185_bb0050","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1074\/jbc.M004885200","article-title":"ERK1 and ERK2 activate CCAAAT\/Enhancer-binding protein-\u03b2-dependent gene transcription in response to interferon-\u03b3","volume":"276","author":"Hu","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2012.185_bb0055","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1189\/jlb.1207830","article-title":"Induction of IL-33 expression and activity in central nervous system glia","volume":"84","author":"Hudson","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1038\/jid.2012.185_bb0060","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cytogfr.2008.08.004","article-title":"IFNgamma signaling-does it mean JAK-STAT?","volume":"19","author":"Gough","year":"2008","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1038\/jid.2012.185_bb0065","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.1074\/jbc.M111.298703","article-title":"Interleukin 33 as a mechanically responsive cytokine secreted by living cells","volume":"287","author":"Kakkar","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2012.185_bb0070","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.immuni.2009.05.007","article-title":"Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases","volume":"31","author":"Luthi","year":"2009","journal-title":"Immunity"},{"key":"10.1038\/jid.2012.185_bb0075","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1084\/jem.20071632","article-title":"Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8","volume":"205","author":"Maelfait","year":"2008","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2012.185_bb0080","doi-asserted-by":"crossref","first-page":"29138","DOI":"10.1074\/jbc.274.41.29138","article-title":"Regulation of cyclooxygenase-2 by interferon \u03b3 and transforming growth factor \u03b1 in normal human epidermal keratinocytes and squamous carcinoma cells: role of mitogen-activated protein kinases","volume":"274","author":"Matsuura","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2012.185_bb0085","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3899\/jrheum.090492","article-title":"Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis","volume":"37","author":"Matsuyama","year":"2010","journal-title":"J Rheumatol"},{"key":"10.1038\/jid.2012.185_bb0090","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jdermsci.2011.10.004","article-title":"Ultraviolet B irradiation induces the production of IL-33 in normal human epidermal keratinocytes","volume":"65","author":"Meephansan","year":"2012","journal-title":"J Dermatol Sci"},{"key":"10.1038\/jid.2012.185_bb0095","doi-asserted-by":"crossref","first-page":"e3331","DOI":"10.1371\/journal.pone.0003331","article-title":"The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel \u2018alarmin\u2019?","volume":"3","author":"Moussion","year":"2008","journal-title":"PLoS One"},{"key":"10.1038\/jid.2012.185_bb0100","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1365-2567.2009.03221.x","article-title":"Expression and regulation of interleukin-33 in human monocytes","volume":"130","author":"Nile","year":"2010","journal-title":"Immunology"},{"key":"10.1038\/jid.2012.185_bb0105","doi-asserted-by":"crossref","first-page":"7890","DOI":"10.4049\/jimmunol.0802449","article-title":"Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages","volume":"183","author":"Ohno","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/jid.2012.185_bb0110","first-page":"5300","article-title":"Transcriptional inhibition of the interleukin-8 gene by interferon is mediated by the NF-kappa B site","volume":"14","author":"Oliveira","year":"1994","journal-title":"Mol Cell Biol"},{"key":"10.1038\/jid.2012.185_bb0115","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/art.24305","article-title":"Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis","volume":"60","author":"Palmer","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2012.185_bb0120","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.4049\/jimmunol.0802387","article-title":"Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells","volume":"183","author":"Prefontaine","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/jid.2012.185_bb0125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2500\/ajra.2010.24.3446","article-title":"Treatment-recalcitrant chronic rhinosinusitis with polyps is associated with altered epithelial cell expression of interleukin-33","volume":"24","author":"Reh","year":"2010","journal-title":"Am J Rhinol Allergy"},{"key":"10.1038\/jid.2012.185_bb0130","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity"},{"key":"10.1038\/jid.2012.185_bb0135","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bbrc.2010.02.110","article-title":"CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9","volume":"394","author":"Shimosato","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/jid.2012.185_bb0140","doi-asserted-by":"crossref","first-page":"19420","DOI":"10.1074\/jbc.M901744200","article-title":"Interleukin-33 is biologically active independently of caspase-1 cleavage","volume":"284","author":"Talabot-Ayer","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2012.185_bb0145","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbrc.2009.04.081","article-title":"IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes","volume":"384","author":"Wood","year":"2009","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15355056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15355056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T17:41:47Z","timestamp":1743961307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15355056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0022202X15355056"],"URL":"https:\/\/doi.org\/10.1038\/jid.2012.185","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of IL-33 Expression by IFN-\u03b3 and Tumor Necrosis Factor-\u03b1 in Normal Human Epidermal Keratinocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2012.185","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}