{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:24:08Z","timestamp":1761895448372,"version":"3.40.3"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1279,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1038\/jid.2012.19","type":"journal-article","created":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T09:45:14Z","timestamp":1330595114000},"page":"1665-1671","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Transcutaneous Gene Gun Delivery of hNC16A Induces BPAG2-Specific Tolerance"],"prefix":"10.1016","volume":"132","author":[{"given":"Monika","family":"Ettinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Peckl-Schmid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Laimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Thalhamer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Hintner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris K.","family":"Gratz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann W.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2012.19_bb0010","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nm1096-1122","article-title":"DNA-based immunization by in vivo transfection of dendritic cells","volume":"2","author":"Condon","year":"1996","journal-title":"Nat Med"},{"key":"10.1038\/jid.2012.19_bb0015","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S1525-0016(03)00013-3","article-title":"Immune-mediated loss of transgene expression in skin: Implications for cutaneous gene therapy","volume":"7","author":"Ghazizadeh","year":"2003","journal-title":"Mol Ther"},{"key":"10.1038\/jid.2012.19_bb0020","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.clim.2008.06.001","article-title":"Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice","volume":"129","author":"Goudy","year":"2008","journal-title":"Clin Immunol"},{"key":"10.1038\/jid.2012.19_bb0025","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.4049\/jimmunol.1100596","article-title":"Repetitive immunization breaks tolerance to type XVII collagen and leads to bullous PEMPHIGOID in mice","volume":"187","author":"Hirose","year":"2011","journal-title":"J Immunol"},{"key":"10.1038\/jid.2012.19_bb0030","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1365-2133.2005.06988.x","article-title":"Skin grafting as a therapeutic approach in pretibially restricted junctional epidermolysis bullosa","volume":"154","author":"Laimer","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2012.19_bb0035","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1365-2796.2011.02386.x","article-title":"Vaccination against type 1 diabetes","volume":"269","author":"Larsson","year":"2011","journal-title":"J Intern Med"},{"key":"10.1038\/jid.2012.19_bb0040","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.4049\/jimmunol.170.4.1806","article-title":"Suppressive DNA vaccination in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis involves a T1-biased immune response","volume":"170","author":"Lobell","year":"2003","journal-title":"J Immunol"},{"key":"10.1038\/jid.2012.19_bb0045","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/nm1504","article-title":"Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells","volume":"12","author":"Mavilio","year":"2006","journal-title":"Nat Med"},{"key":"10.1038\/jid.2012.19_bb0050","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nri2153","article-title":"Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease","volume":"7","author":"Miller","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1038\/jid.2012.19_bb0055","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/jid.2010.249","article-title":"Functional correction of type VII collagen expression in dystrophic epidermolysis bullosa","volume":"131","author":"Murauer","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2012.19_bb0060","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1038\/sj.jid.5700970","article-title":"Human bullous pemphigoid antigen 2 transgenic skin elicits specific IgG in wild-type mice","volume":"127","author":"Olasz","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2012.19_bb0065","doi-asserted-by":"crossref","first-page":"7739","DOI":"10.1073\/pnas.85.20.7739","article-title":"Evidence that the effector mechanism of skin allograft rejection is antigen-specific","volume":"85","author":"Rosenberg","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2012.19_bb0070","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nature10664","article-title":"Response to self antigen imprints regulatory memory in tissues","volume":"480","author":"Rosenblum","year":"2011","journal-title":"Nature"},{"key":"10.1038\/jid.2012.19_bb0075","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.4049\/jimmunol.162.6.3336","article-title":"Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: modulation of T cell costimulation","volume":"162","author":"Ruiz","year":"1999","journal-title":"J Immunol"},{"key":"10.1038\/jid.2012.19_bb0080","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T cells and immune tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell"},{"key":"10.1038\/jid.2012.19_bb0085","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.4049\/jimmunol.177.5.3461","article-title":"Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice","volume":"177","author":"Sitaru","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/jid.2012.19_bb0090","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/1521-2254(2000)9999:9999<::AID-JGM156>3.0.CO;2-I","article-title":"Cutaneous gene transfer and therapy: the present and the future","volume":"3","author":"Spirito","year":"2001","journal-title":"J Gene Med"},{"key":"10.1038\/jid.2012.19_bb0095","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1126\/science.1099896","article-title":"Immune therapy for autoimmune diseases","volume":"305","author":"Steinman","year":"2004","journal-title":"Science"},{"issue":"Suppl 2","key":"10.1038\/jid.2012.19_bb0100","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1017\/S0317167100022435","article-title":"Inverse vaccination to silence immunity to myelin in multiple sclerosis","volume":"37","author":"Steinman","year":"2010","journal-title":"Can J Neurol Sci"},{"key":"10.1038\/jid.2012.19_bb0105","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1365-2796.2010.02224.x","article-title":"Inverse vaccination, the opposite of Jenner's concept, for therapy of autoimmunity","volume":"267","author":"Steinman","year":"2010","journal-title":"J Intern Med"},{"key":"10.1038\/jid.2012.19_bb0110","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.4049\/jimmunol.1002557","article-title":"Langerin+ dermal dendritic cells are critical for CD8+ T cell activation and IgH {gamma}-1 class swithcing in response to gene gun vaccines","volume":"186","author":"Stoecklinger","year":"2011","journal-title":"J Immunol"},{"key":"10.1038\/jid.2012.19_bb0115","doi-asserted-by":"crossref","first-page":"886","DOI":"10.4049\/jimmunol.179.2.886","article-title":"Epidermal langerhans cells are dispensable for humoral and cell-mediated immunity elicited by gene gun immunization","volume":"179","author":"Stoecklinger","year":"2007","journal-title":"J Immunol"},{"key":"10.1038\/jid.2012.19_bb0120","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/356152a0","article-title":"Genetic immunization is a simple method for eliciting an immune response","volume":"356","author":"Tang","year":"1992","journal-title":"Nature"},{"key":"10.1038\/jid.2012.19_bb0125","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/sj.jid.5701152","article-title":"5\u2032 trans-splicing repair of the PLEC1 gene","volume":"128","author":"Wally","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2012.19_bb0130","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/ni.1818","article-title":"Regulatory T cells exert checks and balances on self tolerance and autoimmunity","volume":"11","author":"Wing","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2012.19_bb0135","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/gt.2009.67","article-title":"Transgene-specific host responses in cutaneous gene therapy: the role of cells expressing the transgene","volume":"16","author":"Zhang","year":"2009","journal-title":"Gene Ther"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15357651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15357651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T17:54:45Z","timestamp":1743962085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15357651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0022202X15357651"],"URL":"https:\/\/doi.org\/10.1038\/jid.2012.19","relation":{},"ISSN":["0022-202X"],"issn-type":[{"type":"print","value":"0022-202X"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcutaneous Gene Gun Delivery of hNC16A Induces BPAG2-Specific Tolerance","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2012.19","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}