{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:31:32Z","timestamp":1788517892674,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1006,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1038\/jid.2012.447","type":"journal-article","created":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T09:23:40Z","timestamp":1360661020000},"page":"597-600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Nevus Sebaceus Is a Mosaic RASopathy"],"prefix":"10.1016","volume":"133","author":[{"given":"Rudolf","family":"Happle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2012.447_bb0010","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/ng2113","article-title":"Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype","volume":"39","author":"Brems","year":"2007","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2012.447_bb0015","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1086\/379793","article-title":"Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations","volume":"73","author":"Eerola","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1038\/jid.2012.447_bb0020","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1365-2133.2011.10593.x","article-title":"Molecular genetic support for the rule of dichotomy in type 2 segmental Darier disease","volume":"166","author":"F\u00f6lster-Holst","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2012.447_bb0025","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1002\/ajmg.a.31456","article-title":"Somatic mosaicism for an HRAS mutation causes Costello syndrome","volume":"140A","author":"Gripp","year":"2006","journal-title":"Am J Med Genet"},{"key":"10.1038\/jid.2012.447_bb0030","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/ng.2316","article-title":"Postzygotic HRAS and KRAS mutations cause nevus sebaceus and Schimmelpenning syndrome","volume":"44","author":"Groesser","year":"2012","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2012.447_bb0035","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/jmedgenet-2011-100637","article-title":"Keratinocytic epidermal nevi are associated with mosaic RAS mutations","volume":"49","author":"Hafner","year":"2012","journal-title":"J Med Genet"},{"key":"10.1038\/jid.2012.447_bb0040","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1056\/NEJMc1109381","article-title":"HRAS mutation mosaicism causing urothelial cancer and epidermal nevus","volume":"365","author":"Hafner","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2012.447_bb0045","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0190-9622(87)80249-9","article-title":"Lethal genes surviving by mosaicism: a possible explanation for sporadic birth defects involving the skin","volume":"16","author":"Happle","year":"1987","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2012.447_bb0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1085-5629(05)80006-9","article-title":"Epidermal nevus syndromes","volume":"14","author":"Happle","year":"1995","journal-title":"Semin Dermatol"},{"key":"10.1038\/jid.2012.447_bb0055","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1001\/archderm.1997.03890480025004","article-title":"A rule concerning the segmental manifestation of autosomal dominant skin disorders: review of clinical examples providing evidence for dichotomous types of severity","volume":"133","author":"Happle","year":"1997","journal-title":"Arch Dermatol"},{"key":"10.1038\/jid.2012.447_bb0060","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/1096-8628(20010201)98:4<363::AID-AJMG1101>3.0.CO;2-A","article-title":"Large plexiform neurofibromas may be explained as a type 2 segmental manifestation of neurofibromatosis 1","volume":"98","author":"Happle","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1038\/jid.2012.447_bb0065","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000321331","article-title":"The rhodoid nevus: a proposed term for a so far unnamed capillary malformation","volume":"221","author":"Happle","year":"2010","journal-title":"Dermatology"},{"key":"10.1038\/jid.2012.447_bb0070","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1365-2133.1999.03014.x","article-title":"Familial naevus sebaceus may be explained by paradominant transmission","volume":"141","author":"Happle","year":"1999","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2012.447_bb0075","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/jid.2012.379","article-title":"Whole exome sequencing reveals somatic mutations in HRAS and KRAS which cause nevus sebaceus","volume":"133","author":"Levinsohn","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2012.447_bb0080","series-title":"Rook\u2019s Textbook of Dermatology","first-page":"18.1","article-title":"Naevi and other developmental defects","author":"Moss","year":"2010"},{"key":"10.1038\/jid.2012.447_bb0085","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/ajmg.a.32639","article-title":"Male-to-male transmission of Costello syndrome: G12S HRAS germline mutation inherited from a father with somatic mosaicism","volume":"149A","author":"Sol-Church","year":"2009","journal-title":"Am J Med Genet"},{"key":"10.1038\/jid.2012.447_bb0090","first-page":"1","article-title":"Epidermal and other congenital organoid nevi","volume":"6","author":"Solomon","year":"1975","journal-title":"Curr Probl Pediatr"},{"key":"10.1038\/jid.2012.447_bb0095","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/jid.2008.274","article-title":"Mechanisms of loss of heterozygosity in neurofibromatosis type 1-associated plexiform neurofibromas","volume":"129","author":"Steinmann","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2012.447_bb0100","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/jid.2012.377","article-title":"Mosaic activating RAS mutations in nevus sebaceus and nevus sebaceus syndrome","volume":"133","author":"Sun","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2012.447_bb0105","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.gde.2009.04.001","article-title":"The RASopathies: developmental syndromes of Ras\/MAPK pathway dysregulation","volume":"19","author":"Tidyman","year":"2009","journal-title":"Curr Opin Genet Dev"},{"key":"10.1038\/jid.2012.447_bb0110","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/sj.ejhg.5200493","article-title":"Segmental neurofibromatosis is caused by somatic mutation of the neurofibromatosis type 1 (NF1) gene","volume":"8","author":"Tinschert","year":"2000","journal-title":"Eur J Hum Genet"},{"key":"10.1038\/jid.2012.447_bb0115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1525-1470.1999.00056.x","article-title":"The spectrum of epidermal nevi: a case of verrucous epidermal nevus contiguous with nevus sebaceus","volume":"16","author":"Waltz","year":"1999","journal-title":"Pediatr Dermatol"},{"key":"10.1038\/jid.2012.447_bb0120","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1002\/ajmg.a.31991","article-title":"LEOPARD syndrome with partly normal skin and sex chromosome mosaicism","volume":"143A","author":"Writzl","year":"2007","journal-title":"Am J Med Genet"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15361285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15361285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T20:37:35Z","timestamp":1743971855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15361285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0022202X15361285"],"URL":"https:\/\/doi.org\/10.1038\/jid.2012.447","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nevus Sebaceus Is a Mosaic RASopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2012.447","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}