{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:52:54Z","timestamp":1790553174406,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":792,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1038\/jid.2013.186","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T13:49:00Z","timestamp":1366206540000},"page":"2480-2483","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Spironolactone May Reduce the Risk of Incident Rosacea"],"prefix":"10.1016","volume":"133","author":[{"given":"Julia","family":"Spoendlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes J.","family":"Voegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan S.","family":"Jick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph R.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2013.186_bb0010","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1346-8138.1992.tb03227.x","article-title":"Oral spironolactone therapy in male patients with rosacea","volume":"19","author":"Aizawa","year":"1992","journal-title":"J Dermatol"},{"key":"10.1038\/jid.2013.186_bb0015","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/1742-2094-9-260","article-title":"Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells","volume":"9","author":"Chantong","year":"2012","journal-title":"J Neuroinflammation"},{"key":"10.1038\/jid.2013.186_bb0020","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1468-3083.2004.01035.x","article-title":"Androgen receptor status in lesional and normal skin of patients with rosacea","volume":"18","author":"Erkek","year":"2004","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1038\/jid.2013.186_bb0025","doi-asserted-by":"crossref","first-page":"e128","DOI":"10.3399\/bjgp10X483562","article-title":"Validity of diagnostic coding within the General Practice Research Database: a systematic review","volume":"60","author":"Khan","year":"2010","journal-title":"Br J Gen Pract"},{"key":"10.1038\/jid.2013.186_bb0030","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00403-012-1265-x","article-title":"The role of androgen and androgen receptor in skin-related disorders","volume":"304","author":"Lai","year":"2012","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/jid.2013.186_bb0035","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1111\/j.0022-202X.2004.23494.x","article-title":"A role for the androgen receptor in collagen content of the skin","volume":"123","author":"Markova","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2013.186_bb0040","first-page":"49","article-title":"Oral and topical spironolactone therapies in skin androgenization","volume":"32","author":"Messina","year":"1990","journal-title":"Panminerva medica"},{"key":"10.1038\/jid.2013.186_bb0045","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.mce.2011.07.020","article-title":"Tissue-specific modulation of mineralocorticoid receptor function by 11beta-hydroxysteroid dehydrogenases: an overview","volume":"350","author":"Odermatt","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"10.1038\/jid.2013.186_bb0050","doi-asserted-by":"crossref","first-page":"H1301","DOI":"10.1152\/ajpheart.00753.2009","article-title":"Do androgens play a beneficial role in the regulation of vascular tone? Nongenomic vascular effects of testosterone metabolites","volume":"298","author":"Perusquia","year":"2010","journal-title":"Am J Physiol Heart Circul Physiol"},{"key":"10.1038\/jid.2013.186_bb0055","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMcp042829","article-title":"Clinical practice. Rosacea","volume":"352","author":"Powell","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2013.186_bb0060","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2133.1976.tb04365.x","article-title":"Skin surface lipid composition in rosacea","volume":"94","author":"Pye","year":"1976","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2013.186_bb0065","first-page":"328","article-title":"Use of spironolactone in dermatology","volume":"8","author":"Rathnayake","year":"2010","journal-title":"Skinmed"},{"key":"10.1038\/jid.2013.186_bb0070","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1365-2133.2012.11037.x","article-title":"A study on the epidemiology of rosacea in the U.K","volume":"167","author":"Spoendlin","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2013.186_bb0075","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/jidsymp.2011.7","article-title":"Clinical, cellular, and molecular aspects in the pathophysiology of rosacea","volume":"15","author":"Steinhoff","year":"2011","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1038\/jid.2013.186_bb0080","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1346-8138.1996.tb04006.x","article-title":"Topical spironolactone reduces sebum secretion rates in young adults","volume":"23","author":"Yamamoto","year":"1996","journal-title":"J Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15360036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15360036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T08:59:09Z","timestamp":1743929949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15360036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0022202X15360036"],"URL":"https:\/\/doi.org\/10.1038\/jid.2013.186","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spironolactone May Reduce the Risk of Incident Rosacea","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2013.186","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}