{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:40:39Z","timestamp":1792431639833,"version":"4.5.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":853,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HA 5531\/1-1"],"award-info":[{"award-number":["HA 5531\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1038\/jid.2013.24","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T14:49:20Z","timestamp":1358779760000},"page":"1998-2003","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":115,"title":["Phacomatosis Pigmentokeratotica Is Caused by a Postzygotic HRAS Mutation in a Multipotent Progenitor Cell"],"prefix":"10.1016","volume":"133","author":[{"given":"Leopold","family":"Groesser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Herschberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Sagrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor","family":"Shwayder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Flux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wollenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Torrelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorea","family":"Bagazgoitia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Diaz-Ley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Tinschert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilske","family":"Oschlies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Singer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Mickler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agusti","family":"Toll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Landthaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco X.","family":"Real","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hafner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2013.24_bb0010","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0002-9440(10)64609-3","article-title":"Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features","volume":"157","author":"Bastian","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2013.24_bb0015","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1525-1470.2011.01655.x","article-title":"Phacomatosis pigmentokeratotica: a further case without extracutaneous anomalies and review of the condition","volume":"28","author":"Chantorn","year":"2011","journal-title":"Pediatr Dermatol"},{"key":"10.1038\/jid.2013.24_bb0020","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1365-2133.2009.09181.x","article-title":"BRAF, NRAS and HRAS mutations in spitzoid tumours and their possible pathogenetic significance","volume":"161","author":"Da Forno","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2013.24_bb0025","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0092-8674(86)90495-2","article-title":"Biological and biochemical properties of human rasH genes mutated at codon 61","volume":"44","author":"Der","year":"1986","journal-title":"Cell"},{"key":"10.1038\/jid.2013.24_bb0030","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/ng.2316","article-title":"Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome","volume":"44","author":"Groesser","year":"2012","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2013.24_bb0035","series-title":"Br J Dermatol","article-title":"Nevus marginatus revisited: a combined orgaoid and non-organoid epidermal nevus caused by HRAS mutation","author":"Groesser","year":"2012"},{"key":"10.1038\/jid.2013.24_bb0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4161\/cc.23108","article-title":"Mosaic RASopathies","volume":"12","author":"Hafner","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1038\/jid.2013.24_bb0045","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/jmedgenet-2011-100637","article-title":"Keratinocytic epidermal nevi are associated with mosaic RAS mutations","volume":"49","author":"Hafner","year":"2012","journal-title":"J Med Genet"},{"key":"10.1038\/jid.2013.24_bb0050","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1056\/NEJMc1109381","article-title":"HRAS mutation mosaicism causing urothelial cancer and epidermal nevus","volume":"365","author":"Hafner","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2013.24_bb0055","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1172\/JCI28163","article-title":"Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi","volume":"116","author":"Hafner","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2013.24_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2010.01.017","article-title":"The group of epidermal nevus syndromes Part I. Well defined phenotypes","volume":"63","author":"Happle","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2013.24_bb0065","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/(SICI)1096-8628(19961111)65:4<363::AID-AJMG27>3.0.CO;2-R","article-title":"Phacomatosis pigmentokeratotica: a melanocytic-epidermal twin nevus syndrome","volume":"65","author":"Happle","year":"1996","journal-title":"Am J Med Genet"},{"key":"10.1038\/jid.2013.24_bb0070","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/0140-6736(90)90209-N","article-title":"Hypothesis: vascular twin naevi and somatic recombination in man","volume":"335","author":"Happle","year":"1990","journal-title":"Lancet"},{"key":"10.1038\/jid.2013.24_bb0075","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1756-0500-2-66","article-title":"A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene","volume":"2","author":"Hurst","year":"2009","journal-title":"BMC Res Notes"},{"key":"10.1038\/jid.2013.24_bb0080","doi-asserted-by":"crossref","first-page":"e13821","DOI":"10.1371\/journal.pone.0013821","article-title":"FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy","volume":"5","author":"Kompier","year":"2010","journal-title":"PLoS One"},{"key":"10.1038\/jid.2013.24_bb0085","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/(SICI)1096-8628(19990806)85:4<355::AID-AJMG9>3.0.CO;2-U","article-title":"Concept of twin spotting","volume":"85","author":"Koopman","year":"1999","journal-title":"Am J Med Genet"},{"key":"10.1038\/jid.2013.24_bb0090","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.gde.2009.04.001","article-title":"The RASopathies: developmental syndromes of Ras\/MAPK pathway dysregulation","volume":"19","author":"Tidyman","year":"2009","journal-title":"Curr Opin Genet Dev"},{"key":"10.1038\/jid.2013.24_bb0095","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1525-1470.1998.tb01350.x","article-title":"What syndrome is this. Phakomatosis pigmentokeratotica (Happle)","volume":"15","author":"Torrelo","year":"1998","journal-title":"Pediatr Dermatol"},{"key":"10.1038\/jid.2013.24_bb0100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000089023","article-title":"Two distinct types of speckled lentiginous nevi characterized by macular versus papular speckles","volume":"212","author":"Vidaurri-de la Cruz","year":"2006","journal-title":"Dermatology"},{"key":"10.1038\/jid.2013.24_bb0105","first-page":"10","article-title":"Systematized sebaceous, pigmented and epithelial nevi with neurologic symptoms. Neuroectodermal Feuerstein-Mims syndrome","volume":"22","author":"Wauschkuhn","year":"1971","journal-title":"Hautarzt"},{"key":"10.1038\/jid.2013.24_bb0110","first-page":"612","article-title":"Trichoblastomas with Merkel cell proliferation in nevi sebacei in Schimmelpenning-Feuerstein-Mims syndrome\u2014histological differentiation between trichoblastomas and basal cell carcinomas","volume":"7","author":"Wiedemeyer","year":"2009","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1038\/jid.2013.24_bb0115","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/000155502753600911","article-title":"Phacomatosis pigmentokeratotica (Happle) in a 23-year-old man","volume":"82","author":"Wollenberg","year":"2002","journal-title":"Acta Derm Venereol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15363570?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15363570?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T20:56:31Z","timestamp":1743972991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15363570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0022202X15363570"],"URL":"https:\/\/doi.org\/10.1038\/jid.2013.24","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phacomatosis Pigmentokeratotica Is Caused by a Postzygotic HRAS Mutation in a Multipotent Progenitor Cell","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2013.24","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}