{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:05:08Z","timestamp":1792674308623,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T00:00:00Z","timestamp":1448496000000},"content-version":"vor","delay-in-days":694,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1038\/jid.2013.319","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T13:45:46Z","timestamp":1375105546000},"page":"123-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":135,"title":["Pro-Invasive Activity of the Hippo Pathway Effectors YAP and TAZ in Cutaneous Melanoma"],"prefix":"10.1016","volume":"134","author":[{"given":"Flore","family":"Nallet-Staub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Marsaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crist\u00e8le","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Dodier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Bataille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Sudol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenhard","family":"Herlyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Mauviel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2013.319_bb0010","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1755-148X.2008.00466.x","article-title":"JNK supports survival in melanoma cells by controlling cell cycle arrest and apoptosis","volume":"21","author":"Alexaki","year":"2008","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1038\/jid.2013.319_bb0015","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/jnci\/djq257","article-title":"GLI2-mediated melanoma invasion and metastasis","volume":"102","author":"Alexaki","year":"2010","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/jid.2013.319_bb0020","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/jb\/mvr021","article-title":"Mammalian Hippo pathway: from development to cancer and beyond","volume":"149","author":"Bao","year":"2011","journal-title":"J Biochem"},{"key":"10.1038\/jid.2013.319_bb0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1097-2765(02)00776-1","article-title":"Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis","volume":"11","author":"Basu","year":"2003","journal-title":"Mol Cell"},{"key":"10.1038\/jid.2013.319_bb0030","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1083\/jcb.200501067","article-title":"Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells","volume":"170","author":"Busca","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1038\/jid.2013.319_bb0035","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/jcp.22435","article-title":"The Hippo pathway in biological control and cancer development","volume":"226","author":"Chan","year":"2011","journal-title":"J Cell Physiol"},{"key":"10.1038\/jid.2013.319_bb0040","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1158\/0008-5472.CAN-07-2696","article-title":"A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells","volume":"68","author":"Chan","year":"2008","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2013.319_bb0045","doi-asserted-by":"crossref","first-page":"14347","DOI":"10.1074\/jbc.M901568200","article-title":"TEADs mediate nuclear retention of TAZ to promote oncogenic transformation","volume":"284","author":"Chan","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2013.319_bb0050","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1101\/gad.1437206","article-title":"Malignant melanoma: genetics and therapeutics in the genomic era","volume":"20","author":"Chin","year":"2006","journal-title":"Genes Dev"},{"key":"10.1038\/jid.2013.319_bb0055","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/08977190802025602","article-title":"Connective tissue growth factor: structure-function relationships of a mosaic, multifunctional protein","volume":"26","author":"de Winter","year":"2008","journal-title":"Growth Factors"},{"key":"10.1038\/jid.2013.319_bb0060","first-page":"2","article-title":"The CCN family proteins in carcinogenesis","volume":"32","author":"Dhar","year":"2010","journal-title":"Exp Oncol"},{"key":"10.1038\/jid.2013.319_bb0065","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a universal size-control mechanism in Drosophila and mammals","volume":"130","author":"Dong","year":"2007","journal-title":"Cell"},{"key":"10.1038\/jid.2013.319_bb0070","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1038\/sj.onc.1205623","article-title":"Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta\/Smad signaling","volume":"21","author":"Ferrigno","year":"2002","journal-title":"Oncogene"},{"key":"10.1038\/jid.2013.319_bb0075","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.gene.2012.08.025","article-title":"Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene","volume":"509","author":"Gaffney","year":"2012","journal-title":"Gene"},{"key":"10.1038\/jid.2013.319_bb0080","doi-asserted-by":"crossref","first-page":"R574","DOI":"10.1016\/j.cub.2010.05.023","article-title":"Upstream regulation of the hippo size control pathway","volume":"20","author":"Grusche","year":"2010","journal-title":"Curr Biol"},{"key":"10.1038\/jid.2013.319_bb0085","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1042\/BST20110619","article-title":"Mammalian Hippo signalling: a kinase network regulated by protein-protein interactions","volume":"40","author":"Hergovich","year":"2012","journal-title":"Biochem Soc Trans"},{"key":"10.1038\/jid.2013.319_bb0090","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1755-148X.2008.00450.x","article-title":"Transforming growth factor-beta in cutaneous melanoma","volume":"21","author":"Javelaud","year":"2008","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1038\/jid.2013.319_bb0095","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/j.1755-148X.2011.00893.x","article-title":"GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells","volume":"24","author":"Javelaud","year":"2011","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1038\/jid.2013.319_bb0100","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1158\/0008-5472.CAN-06-3950","article-title":"Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis","volume":"67","author":"Javelaud","year":"2007","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2013.319_bb0105","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1535-6108(03)00132-6","article-title":"A multigenic program mediating breast cancer metastasis to bone","volume":"3","author":"Kang","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1038\/jid.2013.319_bb0110","doi-asserted-by":"crossref","first-page":"E2441","DOI":"10.1073\/pnas.1212021109","article-title":"The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain","volume":"109","author":"Lamar","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2013.319_bb0115","doi-asserted-by":"crossref","DOI":"10.3791\/2937-v","article-title":"The three-dimensional human skin reconstruct model: a tool to study normal skin and melanoma progression","author":"Li","year":"2011","journal-title":"J Vis Exp"},{"key":"10.1038\/jid.2013.319_bb0120","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1517\/14728222.2012.662958","article-title":"An update on targeting Hippo-YAP signaling in liver cancer","volume":"16","author":"Liu","year":"2012","journal-title":"Expert Opin Ther Targets"},{"key":"10.1038\/jid.2013.319_bb0125","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1101\/gad.192856.112","article-title":"Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP","volume":"26","author":"Liu-Chittenden","year":"2012","journal-title":"Genes Dev"},{"key":"10.1038\/jid.2013.319_bb0130","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1073\/pnas.0911427107","article-title":"Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver","volume":"107","author":"Lu","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2013.319_bb0135","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/onc.2011.363","article-title":"Integrating developmental signals: a Hippo in the (path)way","volume":"31","author":"Mauviel","year":"2012","journal-title":"Oncogene"},{"key":"10.1038\/jid.2013.319_bb0140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1076\/soph.16.4.201.10298","article-title":"Photodynamic therapy with verteporfin: a new treatment in ophthalmology","volume":"16","author":"Michels","year":"2001","journal-title":"Semin Ophthalmol"},{"key":"10.1038\/jid.2013.319_bb0145","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1158\/0008-5472.CAN-10-2651","article-title":"TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases","volume":"71","author":"Mohammad","year":"2011","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2013.319_bb0150","doi-asserted-by":"crossref","first-page":"6726","DOI":"10.1038\/sj.onc.1207675","article-title":"Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation","volume":"23","author":"Moore","year":"2004","journal-title":"Oncogene"},{"key":"10.1038\/jid.2013.319_bb0155","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1242\/dev.027151","article-title":"Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling","volume":"135","author":"Ota","year":"2008","journal-title":"Development"},{"key":"10.1038\/jid.2013.319_bb0160","doi-asserted-by":"crossref","first-page":"12405","DOI":"10.1073\/pnas.0605579103","article-title":"Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon","volume":"103","author":"Overholtzer","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2013.319_bb0165","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.devcel.2010.09.011","article-title":"The hippo signaling pathway in development and cancer","volume":"19","author":"Pan","year":"2010","journal-title":"Dev Cell"},{"key":"10.1038\/jid.2013.319_bb0170","first-page":"547","article-title":"Independent regulation of growth and SMAD-mediated transcription by transforming growth factor beta in human melanoma cells","volume":"59","author":"Rodeck","year":"1999","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2013.319_bb0175","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.cell.2011.02.031","article-title":"Yap1 acts downstream of alpha-catenin to control epidermal proliferation","volume":"144","author":"Schlegelmilch","year":"2011","journal-title":"Cell"},{"key":"10.1038\/jid.2013.319_bb0180","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1073\/pnas.0911409107","article-title":"Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression","volume":"107","author":"Song","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2013.319_bb0185","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/dvdy.22723","article-title":"Hippo signaling in Drosophila: recent advances and insights","volume":"241","author":"Staley","year":"2012","journal-title":"Dev Dyn"},{"key":"10.1038\/jid.2013.319_bb0190","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1177\/1947601911401911","article-title":"Newcomers to the WW domain-mediated network of the Hippo tumor suppressor pathway","volume":"1","author":"Sudol","year":"2010","journal-title":"Genes Cancer"},{"key":"10.1038\/jid.2013.319_bb0195","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.semcdb.2012.05.002","article-title":"Structures of YAP protein domains reveal promising targets for development of new cancer drugs","volume":"23","author":"Sudol","year":"2012","journal-title":"Sem Cell Dev Biol"},{"key":"10.1038\/jid.2013.319_bb0200","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0014-5793(01)02122-6","article-title":"Functions of WW domains in the nucleus","volume":"490","author":"Sudol","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1038\/jid.2013.319_bb0205","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/ncb1748","article-title":"TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal","volume":"10","author":"Varelas","year":"2008","journal-title":"Nat Cell Biol"},{"key":"10.1038\/jid.2013.319_bb0210","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tcb.2011.10.002","article-title":"Coordinating developmental signaling: novel roles for the Hippo pathway","volume":"22","author":"Varelas","year":"2012","journal-title":"Trends Cell Biol"},{"key":"10.1038\/jid.2013.319_bb0215","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1101\/gad.888601","article-title":"TEAD\/TEF transcription factors utilize the activation domain of YAP65, a Src\/Yes-associated protein localized in the cytoplasm","volume":"15","author":"Vassilev","year":"2001","journal-title":"Genes Dev"},{"key":"10.1038\/jid.2013.319_bb0220","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jgg.2011.09.009","article-title":"Hippo signaling: a hub of growth control, tumor suppression and pluripotency maintenance","volume":"38","author":"Yin","year":"2011","journal-title":"J Genet Genomics"},{"key":"10.1038\/jid.2013.319_bb0225","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ccr.2008.02.011","article-title":"The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals","volume":"13","author":"Zeng","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1038\/jid.2013.319_bb0230","doi-asserted-by":"crossref","first-page":"13355","DOI":"10.1074\/jbc.M900843200","article-title":"TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition","volume":"284","author":"Zhang","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2013.319_bb0235","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.ceb.2008.10.001","article-title":"The Hippo-YAP pathway: new connections between regulation of organ size and cancer","volume":"20","author":"Zhao","year":"2008","journal-title":"Curr Opin Cell Biol"},{"key":"10.1038\/jid.2013.319_bb0240","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1101\/gad.1909210","article-title":"The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev"},{"key":"10.1038\/jid.2013.319_bb0245","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD mediates YAP-dependent gene induction and growth control","volume":"22","author":"Zhao","year":"2008","journal-title":"Genes Dev"},{"key":"10.1038\/jid.2013.319_bb0250","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2009.09.026","article-title":"Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene","volume":"16","author":"Zhou","year":"2009","journal-title":"Cancer Cell"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15364769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15364769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T21:05:38Z","timestamp":1743973538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15364769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0022202X15364769"],"URL":"https:\/\/doi.org\/10.1038\/jid.2013.319","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pro-Invasive Activity of the Hippo Pathway Effectors YAP and TAZ in Cutaneous Melanoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2013.319","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}