{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:37:20Z","timestamp":1790645840777,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":669,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1038\/jid.2013.334","type":"journal-article","created":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T13:46:06Z","timestamp":1375883166000},"page":"366-373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":213,"title":["Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D"],"prefix":"10.1016","volume":"134","author":[{"given":"George W.","family":"Agak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Nobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Hwa","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan R.","family":"Krutzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grogan R.","family":"Tristan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Elashoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermes J.","family":"Garb\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2013.334_bb0010","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/ni1496","article-title":"Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells","volume":"8","author":"Acosta-Rodriguez","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2013.334_bb0015","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nm1585","article-title":"TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27\/STAT1","volume":"13","author":"Amadi-Obi","year":"2007","journal-title":"Nat Med"},{"key":"10.1038\/jid.2013.334_bb0020","first-page":"153","article-title":"Propionibacterium, Corynebacterium, Mycobacterium and Lepra bacilli","volume":"2","author":"Barksdale","year":"1984","journal-title":"Acta Leprol"},{"key":"10.1038\/jid.2013.334_bb0025","doi-asserted-by":"crossref","first-page":"e12925","DOI":"10.1371\/journal.pone.0012925","article-title":"1,25-Dihydroxyvitamin D3 inhibits the differentiation and migration of T(H)17 cells to protect against experimental autoimmune encephalomyelitis","volume":"5","author":"Chang","year":"2010","journal-title":"PloS ONE"},{"key":"10.1038\/jid.2013.334_bb0030","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1172\/JCI40891","article-title":"IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice","volume":"120","author":"Cho","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2013.334_bb0035","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1749-6632.2009.05133.x","article-title":"Th1 and Th17 cells: adversaries and collaborators","volume":"1183","author":"Damsker","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1038\/jid.2013.334_bb0040","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.clindermatol.2004.03.006","article-title":"Acne: inflammation","volume":"22","author":"Farrar","year":"2004","journal-title":"Clin Dermatol"},{"key":"10.1038\/jid.2013.334_bb0045","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.4049\/jimmunol.181.10.7420","article-title":"Low expression of the IL-23\/Th17 pathway in atopic dermatitis compared to psoriasis","volume":"181","author":"Guttman-Yassky","year":"2008","journal-title":"J Immunol"},{"key":"10.1038\/jid.2013.334_bb0050","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2013.334_bb0055","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1468-3083.2010.03714.x","article-title":"Circulating Th17 cell fluctuation in psoriatic patients treated with topical calcipotriol and betamethasone butyrate propionate","volume":"25","author":"Hino","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1038\/jid.2013.334_bb0060","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.imlet.2010.07.002","article-title":"1alpha,25-Dihydroxyvitamin D3 and all-trans retinoic acid synergistically inhibit the differentiation and expansion of Th17 cells","volume":"134","author":"Ikeda","year":"2010","journal-title":"Immunol Lett"},{"key":"10.1038\/jid.2013.334_bb0065","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.4049\/jimmunol.165.11.6107","article-title":"Microbial lipopeptides induce the production of IL-17 in Th cells","volume":"165","author":"Infante-Duarte","year":"2000","journal-title":"J Immunol"},{"key":"10.1038\/jid.2013.334_bb0070","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1128\/IAI.00724-09","article-title":"Superantigenic Staphylococcus aureus stimulates production of interleukin-17 from memory but not naive T cells","volume":"78","author":"Islander","year":"2010","journal-title":"Infect Immun"},{"key":"10.1038\/jid.2013.334_bb0075","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/intimm\/dxg101","article-title":"Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors","volume":"15","author":"Iwata","year":"2003","journal-title":"Int Immunol"},{"key":"10.1038\/jid.2013.334_bb0080","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/jid.2009.399","article-title":"Circulating Th17, Th22, and Th1 cells are increased in psoriasis","volume":"130","author":"Kagami","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2013.334_bb0085","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000087011","article-title":"Review of the innate immune response in acne vulgaris: activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses","volume":"211","author":"Kim","year":"2005","journal-title":"Dermatology"},{"key":"10.1038\/jid.2013.334_bb0090","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.4049\/jimmunol.169.3.1535","article-title":"Activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses","volume":"169","author":"Kim","year":"2002","journal-title":"J Immunol"},{"key":"10.1038\/jid.2013.334_bb0095","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"10.1038\/jid.2013.334_bb0100","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature05970","article-title":"IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells","volume":"448","author":"Korn","year":"2007","journal-title":"Nature"},{"key":"10.1038\/jid.2013.334_bb0105","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20041257","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume":"201","author":"Langrish","year":"2005","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2013.334_bb0110","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.immuni.2007.03.014","article-title":"T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation","volume":"26","author":"Li","year":"2007","journal-title":"Immunity"},{"key":"10.1038\/jid.2013.334_bb0115","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.20061308","article-title":"Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides","volume":"203","author":"Liang","year":"2006","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2013.334_bb0120","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nm0502-500","article-title":"Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis","volume":"8","author":"Lock","year":"2002","journal-title":"Nat Med"},{"key":"10.1038\/jid.2013.334_bb0125","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1099\/mic.0.29219-0","article-title":"Variable expression of immunoreactive surface proteins of Propionibacterium acnes","volume":"152","author":"Lodes","year":"2006","journal-title":"Microbiology"},{"key":"10.1038\/jid.2013.334_bb0130","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","article-title":"Transforming growth factor-beta induces development of the T(H)17 lineage","volume":"441","author":"Mangan","year":"2006","journal-title":"Nature"},{"key":"10.1038\/jid.2013.334_bb0135","doi-asserted-by":"crossref","first-page":"e00279","DOI":"10.1128\/mBio.00279-12","article-title":"Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates","volume":"3","author":"Marinelli","year":"2012","journal-title":"MBio"},{"key":"10.1038\/jid.2013.334_bb0140","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/art.10816","article-title":"Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy","volume":"48","author":"Miossec","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2013.334_bb0145","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/1523-1747.ep12381958","article-title":"Th1-Th2 paradigm: insights from leprosy","volume":"102","author":"Modlin","year":"1994","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2013.334_bb0150","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1046\/j.1523-1747.2003.12550_6.x","article-title":"Propionibacterium acnes-reactive T helper-1 cells in the skin of patients with acne vulgaris","volume":"121","author":"Mouser","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2013.334_bb0155","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1145697","article-title":"Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid","volume":"317","author":"Mucida","year":"2007","journal-title":"Science"},{"key":"10.1038\/jid.2013.334_bb0160","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature05969","article-title":"Essential autocrine regulation by IL-21 in the generation of inflammatory T cells","volume":"448","author":"Nurieva","year":"2007","journal-title":"Nature"},{"key":"10.1038\/jid.2013.334_bb0165","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"Park","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2013.334_bb0170","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.4049\/jimmunol.0901767","article-title":"IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes","volume":"184","author":"Pennino","year":"2010","journal-title":"J Immunol"},{"key":"10.1038\/jid.2013.334_bb0175","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/ni1433","article-title":"DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27","volume":"8","author":"Sigmundsdottir","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2013.334_bb0180","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1084\/jem.20060285","article-title":"A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis","volume":"203","author":"Sutton","year":"2006","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2013.334_bb0185","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1046\/j.1523-1747.1998.00347.x","article-title":"Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes","volume":"111","author":"Teunissen","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2013.334_bb0190","doi-asserted-by":"crossref","first-page":"317","DOI":"10.7888\/juoeh.32.317","article-title":"Psoriasis and other Th17-mediated skin diseases","volume":"32","author":"Tokura","year":"2010","journal-title":"J Uoeh"},{"key":"10.1038\/jid.2013.334_bb0195","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4049\/jimmunol.177.1.36","article-title":"Cutting edge: interleukin 17 signals through a heteromeric receptor complex","volume":"177","author":"Toy","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/jid.2013.334_bb0200","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1128\/iai.63.8.3158-3165.1995","article-title":"Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne","volume":"63","author":"Vowels","year":"1995","journal-title":"Infect Immun"},{"key":"10.1038\/jid.2013.334_bb0205","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ni1497","article-title":"Development, cytokine profile and function of human interleukin 17-producing helper T cells","volume":"8","author":"Wilson","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2013.334_bb0210","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature05505","article-title":"Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis","volume":"445","author":"Zheng","year":"2007","journal-title":"Nature"},{"key":"10.1038\/jid.2013.334_bb0215","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/ni1488","article-title":"IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways","volume":"8","author":"Zhou","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2013.334_bb0220","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000051771","article-title":"Is acne vulgaris a genuine inflammatory disease?","volume":"203","author":"Zouboulis","year":"2001","journal-title":"Dermatology"},{"key":"10.1038\/jid.2013.334_bb0225","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.0906-6705.2005.0285a.x","article-title":"What is the pathogenesis of acne?","volume":"14","author":"Zouboulis","year":"2005","journal-title":"Exp Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15366203?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15366203?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T21:16:42Z","timestamp":1743974202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15366203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0022202X15366203"],"URL":"https:\/\/doi.org\/10.1038\/jid.2013.334","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2013.334","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}