{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:25:09Z","timestamp":1792095909288,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":641,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A-120400"],"award-info":[{"award-number":["31003A-120400"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A-135465"],"award-info":[{"award-number":["31003A-135465"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1038\/jid.2013.438","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T13:48:59Z","timestamp":1382622539000},"page":"677-685","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":216,"title":["IL-1\u03b2 Drives Inflammatory Responses to Propionibacterium acnes In Vitro and In Vivo"],"prefix":"10.1016","volume":"134","author":[{"given":"Magdalena","family":"Kistowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Gehrke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Jankovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Kerl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Fettelschoss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Feldmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Fenini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Kolios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Navarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruta","family":"Ganceviciene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Schauber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Contassot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E.","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2013.438_bb0010","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.clindermatol.2004.03.005","article-title":"Acne and Propionibacterium acnes","volume":"22","author":"Bojar","year":"2004","journal-title":"Clin Dermatol"},{"key":"10.1038\/jid.2013.438_bb0015","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jaad.2010.12.025","article-title":"Pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH)\u2014a new autoinflammatory syndrome distinct from PAPA syndrome","volume":"66","author":"Braun-Falco","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2013.438_bb0020","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/j.1365-2133.2009.09404.x","article-title":"Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra","volume":"161","author":"Brenner","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2013.438_bb0025","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1074\/jbc.M608083200","article-title":"ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages","volume":"282","author":"Cruz","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2013.438_bb0030","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1610-0387.2007.06274.x","article-title":"Pathophysiology of acne","volume":"5","author":"Degitz","year":"2007","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1038\/jid.2013.438_bb0035","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095","article-title":"Biologic basis for interleukin-1 in disease","volume":"87","author":"Dinarello","year":"1996","journal-title":"Blood"},{"key":"10.1038\/jid.2013.438_bb0040","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Science"},{"key":"10.1038\/jid.2013.438_bb0045","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.4049\/jimmunol.0802696","article-title":"Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome","volume":"182","author":"Duncan","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/jid.2013.438_bb0050","doi-asserted-by":"crossref","first-page":"17548","DOI":"10.1073\/pnas.0607914103","article-title":"SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes","volume":"103","author":"Fay","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2013.438_bb0055","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.cub.2007.05.074","article-title":"The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes","volume":"17","author":"Feldmeyer","year":"2007","journal-title":"Curr Biol"},{"key":"10.1038\/jid.2013.438_bb0060","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.ejcb.2010.04.008","article-title":"Interleukin-1, inflammasomes and the skin","volume":"89","author":"Feldmeyer","year":"2010","journal-title":"Eur J Cell Biol"},{"key":"10.1038\/jid.2013.438_bb0065","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1038\/jid.2013.21","article-title":"Propionibacterium acnes strain populations in the human skin microbiome associated with acne","volume":"133","author":"Fitz-Gibbon","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2013.438_bb0070","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ni1346","article-title":"Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages","volume":"7","author":"Franchi","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2013.438_bb0075","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.4049\/jimmunol.159.7.3364","article-title":"Phenotypic and functional characterization of mice that lack the type I receptor for IL-1","volume":"159","author":"Glaccum","year":"1997","journal-title":"J Immunol"},{"key":"10.1038\/jid.2013.438_bb0080","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.2165\/00003495-200363150-00005","article-title":"Current concepts of the pathogenesis of acne: implications for drug treatment","volume":"63","author":"Gollnick","year":"2003","journal-title":"Drugs"},{"key":"10.1038\/jid.2013.438_bb0085","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.4049\/jimmunol.0903937","article-title":"Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3\/ASC inflammasome","volume":"184","author":"He","year":"2010","journal-title":"J Immunol"},{"key":"10.1038\/jid.2013.438_bb0090","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization","volume":"9","author":"Hornung","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2013.438_bb0095","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.4049\/jimmunol.0800909","article-title":"Critical role of apoptotic speck protein containing a caspase recruitment domain (ASC) and NLRP3 in causing necrosis and ASC speck formation induced by Porphyromonas gingivalis in human cells","volume":"182","author":"Huang","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/jid.2013.438_bb0100","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1056\/NEJMcp033487","article-title":"Clinical practice. Acne","volume":"352","author":"James","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2013.438_bb0105","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1046\/j.1523-1747.2003.12321.x","article-title":"Inflammatory events are involved in acne lesion initiation","volume":"121","author":"Jeremy","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2013.438_bb0110","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.4049\/jimmunol.0900476","article-title":"Thalidomide inhibits activation of caspase-1","volume":"183","author":"Keller","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/jid.2013.438_bb0115","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1600-0625.2009.00890.x","article-title":"New developments in our understanding of acne pathogenesis and treatment","volume":"18","author":"Kurokawa","year":"2009","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2013.438_bb0120","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1600-0625.1998.tb00323.x","article-title":"Immunohistochemical investigation of evolving inflammation in lesions of acne vulgaris","volume":"7","author":"Layton","year":"1998","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2013.438_bb0125","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2133.1988.tb01775.x","article-title":"The microbial colonization of inflamed acne vulgaris lesions","volume":"118","author":"Leeming","year":"1988","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2013.438_bb0130","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000017868","article-title":"Propionibacterium acnes colonization in acne and nonacne","volume":"196","author":"Leyden","year":"1998","journal-title":"Dermatology"},{"key":"10.1038\/jid.2013.438_bb0135","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0092-8674(95)90490-5","article-title":"Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock","volume":"80","author":"Li","year":"1995","journal-title":"Cell"},{"key":"10.1038\/jid.2013.438_bb0140","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf","volume":"430","author":"Mariathasan","year":"2004","journal-title":"Nature"},{"key":"10.1038\/jid.2013.438_bb0145","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"10.1038\/jid.2013.438_bb0150","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/jid.2013.438_bb0155","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1038\/jid.2013.438_bb0160","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.immuni.2009.04.012","article-title":"A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses","volume":"30","author":"Meng","year":"2009","journal-title":"Immunity"},{"key":"10.1038\/jid.2013.438_bb0165","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/j.1462-5822.2010.01450.x","article-title":"Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3\/ASC inflammasome","volume":"12","author":"Mishra","year":"2010","journal-title":"Cell Microbiol"},{"key":"10.1038\/jid.2013.438_bb0170","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature06664","article-title":"The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response","volume":"452","author":"Muruve","year":"2008","journal-title":"Nature"},{"key":"10.1038\/jid.2013.438_bb0175","doi-asserted-by":"crossref","first-page":"e14797","DOI":"10.1371\/journal.pone.0014797","article-title":"Propionibacterium acnes CAMP factor and host acid sphingomyelinase contribute to bacterial virulence: potential targets for inflammatory acne treatment","volume":"6","author":"Nakatsuji","year":"2011","journal-title":"PLoS One"},{"key":"10.1038\/jid.2013.438_bb0180","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/sj.cdd.4402195","article-title":"Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration","volume":"14","author":"Petrilli","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1038\/jid.2013.438_bb0185","article-title":"Propionibacterium acnes induces IL-1\u03b2 secretion via the NLRP3 inflammasome in human monocytes","author":"Qin","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2013.438_bb0190","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1074\/jbc.M006781200","article-title":"Altered cytokine production in mice lacking P2X(7) receptors","volume":"276","author":"Solle","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2013.438_bb0195","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"key":"10.1038\/jid.2013.438_bb0200","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1172\/JCI40599","article-title":"Inflammasomes: too big to miss","volume":"119","author":"Stutz","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2013.438_bb0205","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.clim.2008.08.011","article-title":"NLRC4\/IPAF: a CARD carrying member of the NLR family","volume":"130","author":"Sutterwala","year":"2009","journal-title":"Clin Immunol"},{"key":"10.1038\/jid.2013.438_bb0210","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s007950100002","article-title":"Pathogenesis of acne","volume":"34","author":"Toyoda","year":"2001","journal-title":"Med Electron Microsc"},{"key":"10.1038\/jid.2013.438_bb0215","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1128\/iai.63.8.3158-3165.1995","article-title":"Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne","volume":"63","author":"Vowels","year":"1995","journal-title":"Infect Immun"},{"key":"10.1038\/jid.2013.438_bb0220","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1038\/sj.jid.5700819","article-title":"Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity","volume":"127","author":"Watanabe","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2013.438_bb0225","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.4049\/jimmunol.180.9.5826","article-title":"Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization","volume":"180","author":"Watanabe","year":"2008","journal-title":"J Immunol"},{"key":"10.1038\/jid.2013.438_bb0230","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1136\/annrheumdis-2011-200743","article-title":"Anakinra treatment of SAPHO syndrome: short-term results of an open study","volume":"71","author":"Wendling","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1038\/jid.2013.438_bb0235","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(11)60321-8","article-title":"Acne vulgaris","volume":"379","author":"Williams","year":"2012","journal-title":"Lancet"},{"key":"10.1038\/jid.2013.438_bb0240","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.4049\/jimmunol.0900138","article-title":"NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways","volume":"183","author":"Willingham","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/jid.2013.438_bb0245","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2007.08.029","article-title":"Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants","volume":"28","author":"Yu","year":"2007","journal-title":"Mol Cell"},{"key":"10.1038\/jid.2013.438_bb0250","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.0906-6705.2005.0285a.x","article-title":"What is the pathogenesis of acne?","volume":"14","author":"Zouboulis","year":"2005","journal-title":"Exp Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1536694X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1536694X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T21:24:26Z","timestamp":1743974666000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X1536694X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0022202X1536694X"],"URL":"https:\/\/doi.org\/10.1038\/jid.2013.438","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-1\u03b2 Drives Inflammatory Responses to Propionibacterium acnes In Vitro and In Vivo","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2013.438","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}