{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:10:11Z","timestamp":1767841811564,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":427,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000545","name":"British Association of Dermatologists","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009360","name":"King\u2019s College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000625","name":"Great Britain Sasakawa Foundation","doi-asserted-by":"publisher","award":["4314"],"award-info":[{"award-number":["4314"]}],"id":[{"id":"10.13039\/501100000625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000625","name":"Great Britain Sasakawa Foundation","doi-asserted-by":"publisher","award":["S2404"],"award-info":[{"award-number":["S2404"]}],"id":[{"id":"10.13039\/501100000625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004941","name":"Guy's and St Thomas' NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004941","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["098439\/Z\/12\/Z"],"award-info":[{"award-number":["098439\/Z\/12\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1038\/jid.2014.164","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T14:05:45Z","timestamp":1396361145000},"page":"2570-2578","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Epithelial Inflammation Resulting from an Inherited Loss-of-Function Mutation in EGFR"],"prefix":"10.1016","volume":"134","author":[{"given":"Patrick","family":"Campbell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penny E.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Takeichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Salam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerys","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura E.","family":"Proudfoot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jemima E.","family":"Mellerio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kingi","family":"Aminu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Wellington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin N.","family":"Patil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"McMillan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Aristodemou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akemi","family":"Ishida-Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alya","family":"Abdul-Wahab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Petrof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Fong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarawin","family":"Harnchoowong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina L.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John I.","family":"Harper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.H.","family":"Irwin McLean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maddy","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2014.164_bb0010","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nrm3048","article-title":"Feedback regulation of EGFR signalling: decision making by early and delayed loops","volume":"12","author":"Avraham","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1038\/jid.2014.164_bb0015","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat Methods"},{"key":"10.1038\/jid.2014.164_bb0020","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1056\/NEJMoa1100721","article-title":"Inflammatory skin and bowel disease linked to ADAM17 deletion","volume":"365","author":"Blaydon","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2014.164_bb0025","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrm1548","article-title":"ADAMs: key components in EGFR signalling and development","volume":"6","author":"Blobel","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1038\/jid.2014.164_bb0030","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/75977","article-title":"Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome","volume":"25","author":"Chavanas","year":"2000","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2014.164_bb0035","doi-asserted-by":"crossref","first-page":"7734","DOI":"10.1128\/MCB.25.17.7734-7742.2005","article-title":"Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface","volume":"25","author":"Dawson","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1038\/jid.2014.164_bb0040","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.atherosclerosis.2005.06.038","article-title":"The epidermal growth factor receptors and their family of ligands: Their putative role in atherogenesis","volume":"186","author":"Dreux","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1038\/jid.2014.164_bb0045","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jaad.2008.02.004","article-title":"The classification of inherited epidermolysis bullosa (EB): report of the third international consensus meeting on diagnosis and classification of EB","volume":"58","author":"Fine","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2014.164_bb0050","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrc1360","article-title":"The discovery of receptor tyrosine kinases: targets for cancer therapy","volume":"4","author":"Gschwind","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/jid.2014.164_bb0055","first-page":"1959","article-title":"Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development","volume":"150","author":"Hansen","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2014.164_bb0060","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0140-6736(03)12190-3","article-title":"Severe acute interstitial pneumonia and gefitinib","volume":"361","author":"Inoue","year":"2003","journal-title":"Lancet"},{"key":"10.1038\/jid.2014.164_bb0065","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.stem.2009.04.014","article-title":"Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis","volume":"4","author":"Jensen","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1038\/jid.2014.164_bb0070","first-page":"505","article-title":"The EGF receptor - an essential regulator of multiple epidermal functions","volume":"10","author":"Jost","year":"2000","journal-title":"Eur J Dermatol"},{"key":"10.1038\/jid.2014.164_bb0075","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4161\/cc.27518","article-title":"EGFR signaling and autophagy dependence for growth, survival, and therapy resistance","volume":"13","author":"Jutten","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1038\/jid.2014.164_bb0080","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1200\/JCO.2007.12.1178","article-title":"Structure and clinical relevance of the epidermal growth factor receptor in human cancer","volume":"26","author":"Kumar","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1038\/jid.2014.164_bb0085","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrc1970","article-title":"Mechanisms of cutaneous toxicities to EGFR inhibitors","volume":"6","author":"Lacouture","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/jid.2014.164_bb0090","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/ncb1401","article-title":"The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis","volume":"8","author":"Lee","year":"2006","journal-title":"Nat Cell Biol"},{"key":"10.1038\/jid.2014.164_bb0095","doi-asserted-by":"crossref","first-page":"199ra111","DOI":"10.1126\/scitranslmed.3005886","article-title":"Epidermal EGFR controls cutaneous host defense and prevents inflammation","volume":"5","author":"Lichtenberger","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1038\/jid.2014.164_bb0100","doi-asserted-by":"crossref","first-page":"e55128","DOI":"10.1371\/journal.pone.0055128","article-title":"Skin rash could predict the response to EGFR tyrosine kinase inhibitor and the prognosis for patients with non-small cell lung cancer: a systematic review and meta-analysis","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1038\/jid.2014.164_bb0105","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.devcel.2006.04.002","article-title":"Dynasore, a cell-permeable inhibitor of dynamin","volume":"10","author":"Macia","year":"2006","journal-title":"Dev Cell"},{"key":"10.1038\/jid.2014.164_bb0110","doi-asserted-by":"crossref","first-page":"199ra110","DOI":"10.1126\/scitranslmed.3005773","article-title":"Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy","volume":"5","author":"Mascia","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1038\/jid.2014.164_bb0115","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/376337a0","article-title":"Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor","volume":"376","author":"Miettinen","year":"1995","journal-title":"Nature"},{"key":"10.1038\/jid.2014.164_bb0120","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jdermsci.2013.05.009","article-title":"Recent advances in the epidermal growth factor\/ligand system biology on skin homeostasis and keratinocyte stem cell regulation","volume":"72","author":"Nanba","year":"2013","journal-title":"J Dermatol Sci"},{"key":"10.1038\/jid.2014.164_bb0125","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1093\/nar\/gkg509","article-title":"SIFT: predicting amino acid changes that affect protein function","volume":"31","author":"Ng","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/jid.2014.164_bb0130","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0092-8674(02)00963-7","article-title":"Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains","volume":"110","author":"Ogiso","year":"2002","journal-title":"Cell"},{"key":"10.1038\/jid.2014.164_bb0135","first-page":"257","article-title":"Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice","volume":"5","author":"Perrotte","year":"1999","journal-title":"Clin Cancer Res"},{"key":"10.1038\/jid.2014.164_bb0140","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/sj.jid.5701184","article-title":"The epidermal growth factor receptor system in skin repair and inflammation","volume":"128","author":"Pastore","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.164_bb0145","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.282.5392.1281","article-title":"An essential role for ectodomain shedding in mammalian development","volume":"282","author":"Peschon","year":"1998","journal-title":"Science"},{"key":"10.1038\/jid.2014.164_bb0150","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1365-2133.2011.10640.x","article-title":"Desmosomal genodermatoses","volume":"166","author":"Petrof","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2014.164_bb0155","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/j.0022-202X.2004.23478.x","article-title":"EGFR enhances early healing after cutaneous incisional wounding","volume":"123","author":"Repertinger","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.164_bb0160","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1242\/jcs.110.2.113","article-title":"EGF-R dependent regulation of keratinocyte survival","volume":"110","author":"Rodeck","year":"1997","journal-title":"J Cell Sci"},{"key":"10.1038\/jid.2014.164_bb0165","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2353\/ajpath.2008.070942","article-title":"Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology","volume":"173","author":"Schneider","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2014.164_bb0170","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/jcp.21635","article-title":"The epidermal growth factor receptor ligands at a glance","volume":"218","author":"Schneider","year":"2009","journal-title":"J Cell Physiol"},{"key":"10.1038\/jid.2014.164_bb0175","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1432-0436.2007.00238.x","article-title":"The epidermal growth factor receptor: from development to tumorigenesis","volume":"75","author":"Sibilia","year":"2007","journal-title":"Differentiation"},{"key":"10.1038\/jid.2014.164_bb0180","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1126\/science.7618085","article-title":"Strain-dependent epithelial defects in mice lacking the EGF receptor","volume":"269","author":"Sibilia","year":"1995","journal-title":"Science"},{"key":"10.1038\/jid.2014.164_bb0185","first-page":"237","article-title":"Severe hypernatraemic dehydration in an infant with Netherton syndrome","volume":"12","author":"Stoll","year":"2001","journal-title":"Genet Counsel"},{"key":"10.1038\/jid.2014.164_bb0190","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1126\/science.7618084","article-title":"Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype","volume":"269","author":"Threadgill","year":"1995","journal-title":"Science"},{"key":"10.1038\/jid.2014.164_bb0195","doi-asserted-by":"crossref","first-page":"859","DOI":"10.4049\/jimmunol.1301062","article-title":"EGFR signaling blunts allergen-induced IL-6 production and Th17 responses in the skin and attenuates development and relapse of atopic dermatitis","volume":"192","author":"Zhang","year":"2014","journal-title":"J Immunol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15365167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15365167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T21:09:06Z","timestamp":1743973746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15365167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0022202X15365167"],"URL":"https:\/\/doi.org\/10.1038\/jid.2014.164","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epithelial Inflammation Resulting from an Inherited Loss-of-Function Mutation in EGFR","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2014.164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}