{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:36:37Z","timestamp":1780328197015,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR056771"],"award-info":[{"award-number":["AR056771"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR049778"],"award-info":[{"award-number":["AR049778"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1038\/jid.2014.267","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T13:49:03Z","timestamp":1404740943000},"page":"2873-2882","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Complex Changes in the Apoptotic and Cell Differentiation Programs during Initiation of the Hair Follicle Response to Chemotherapy"],"prefix":"10.1016","volume":"134","author":[{"given":"Tatyana Y.","family":"Sharova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Poterlowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia V.","family":"Botchkareva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita A.","family":"Kondratiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmar","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Spiegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir A.","family":"Botchkarev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey A.","family":"Sharov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2014.267_bb0010","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.jid.5700486","article-title":"Chemotherapy targets the hair-follicle vascular network but not the stem cells","volume":"127","author":"Amoh","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.267_bb0015","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1158\/0008-5472.CAN-04-3857","article-title":"Hair follicle-derived blood vessels vascularize tumors in skin and are inhibited by Doxorubicin","volume":"65","author":"Amoh","year":"2005","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2014.267_bb0020","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2353\/ajpath.2007.061164","article-title":"Dissecting the impact of chemotherapy on the human hair follicle: a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy","volume":"171","author":"Bodo","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2014.267_bb0025","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/jid.2008.228","article-title":"Modulation of chemotherapy-induced human hair follicle damage by 17-beta estradiol and prednisolone: potential stimulators of normal hair regrowth by \u2018dystrophic catagen\u2019 promotion?","volume":"129","author":"Bodo","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.267_bb0030","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1046\/j.1523-1747.2003.12175.x","article-title":"Molecular mechanisms of chemotherapy-induced hair loss","volume":"8","author":"Botchkarev","year":"2003","journal-title":"J Invest Dermatol Symp Proc"},{"key":"10.1038\/jid.2014.267_bb0035","first-page":"5002","article-title":"p53 is essential for chemotherapy-induced hair loss","volume":"60","author":"Botchkarev","year":"2000","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2014.267_bb0040","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1046\/j.1523-1747.1999.00791.x","article-title":"Hair cycle-dependent changes in adrenergic skin innervation, and hair growth modulation by adrenergic drugs","volume":"113","author":"Botchkarev","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.267_bb0045","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/sj.jid.5700007","article-title":"Apoptosis in the hair follicle","volume":"126","author":"Botchkareva","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.267_bb0050","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/sj.jid.5700537","article-title":"Survivin in the human hair follicle","volume":"127","author":"Botchkareva","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.267_bb0055","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.molmed.2006.06.002","article-title":"Targeted induction of apoptosis for cancer therapy: current progress and prospects","volume":"12","author":"Bremer","year":"2006","journal-title":"Trends Mol Med"},{"key":"10.1038\/jid.2014.267_bb0060","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/npp.2009.234","article-title":"Neutralization of tumor necrosis factor-related apoptosis-inducing ligand reduces spinal cord injury damage in mice","volume":"35","author":"Cantarella","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1038\/jid.2014.267_bb0065","first-page":"601","article-title":"Apoptosis of hair follicle cells during doxorubicin-induced alopecia in rats","volume":"75","author":"Cece","year":"1996","journal-title":"Lab Invest"},{"key":"10.1038\/jid.2014.267_bb0070","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.4161\/cc.21670","article-title":"Mitomycin C potentiates TRAIL-induced apoptosis through p53-independent upregulation of death receptors: evidence for the role of c-Jun N-terminal kinase activation","volume":"11","author":"Cheng","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1038\/jid.2014.267_bb0075","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0898-6568(03)00093-7","article-title":"Live or let die: regulatory mechanisms in Fas-mediated apoptosis","volume":"15","author":"Curtin","year":"2003","journal-title":"Cell Signalling"},{"key":"10.1038\/jid.2014.267_bb0080","first-page":"145","article-title":"Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu\/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia","volume":"147","author":"Danilenko","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2014.267_bb0085","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/jid.2009.259","article-title":"BMP signaling induces cell-type-specific changes in gene expression programs of human keratinocytes and fibroblasts","volume":"130","author":"Fessing","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.267_bb0090","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1083\/jcb.201101148","article-title":"p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis","volume":"194","author":"Fessing","year":"2011","journal-title":"J Cell Biol"},{"key":"10.1038\/jid.2014.267_bb0095","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2165\/00003495-199142050-00005","article-title":"Cyclophosphamide toxicity: characterising and avoinding the problem","volume":"42","author":"Fraiser","year":"1991","journal-title":"Drugs"},{"key":"10.1038\/jid.2014.267_bb0100","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nm0596-574","article-title":"Involvement of the CD95 (APO-1\/FAS) receptor\/ligand system in drug-induced apoptosis in leukemia cells","volume":"2","author":"Friesen","year":"1996","journal-title":"Nat Med"},{"key":"10.1038\/jid.2014.267_bb0105","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.0022-202X.2005.23787.x","article-title":"A guide to assessing damage response pathways of the hair follicle: lessons from cyclophosphamide-induced alopecia in mice","volume":"125","author":"Hendrix","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.267_bb0110","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.1038\/jid.2014.267_bb0115","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12192-007-0005-1","article-title":"Prevention of chemotherapy-induced alopecia in rodent models","volume":"13","author":"Jimenez","year":"2008","journal-title":"Cell Stress Chaperones"},{"key":"10.1038\/jid.2014.267_bb0120","first-page":"413","article-title":"Protection from 1-beta-d-Arabinofuranosylcytosine-induced alopecia by epidermal growth factor and fibroblast growth factor in the rat model","volume":"52","author":"Jimenez","year":"1992","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2014.267_bb0125","doi-asserted-by":"crossref","first-page":"16631","DOI":"10.1074\/jbc.M110.148585","article-title":"Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex","volume":"286","author":"Kavuri","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2014.267_bb0130","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.4161\/cbt.7.12.7460","article-title":"TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death","volume":"7","author":"Kuribayashi","year":"2008","journal-title":"Cancer Biol Ther"},{"key":"10.1038\/jid.2014.267_bb0135","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1073\/pnas.1213015110","article-title":"Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo","volume":"110","author":"Lee","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2014.267_bb0140","first-page":"553","article-title":"Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes","volume":"60","author":"Leverkus","year":"2000","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2014.267_bb0145","first-page":"1601","article-title":"Analysis of apoptosis during hair follicle regression (catagen)","volume":"151","author":"Lindner","year":"1997","journal-title":"Amer J Pathol"},{"key":"10.1038\/jid.2014.267_bb0150","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1158\/0008-5472.CAN-04-1195","article-title":"p53 upregulates death receptor 4 expression through an intronic p53 binding site","volume":"64","author":"Liu","year":"2004","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2014.267_bb0155","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jsb.2013.06.005","article-title":"Bidirectional binding property of high glycine-tyrosine keratin-associated protein contributes to the mechanical strength and shape of hair","volume":"183","author":"Matsunaga","year":"2013","journal-title":"J Struct Biol"},{"key":"10.1038\/jid.2014.267_bb0160","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/00001813-199506000-00013","article-title":"Apoptosis in murine tumors treated with chemotherapy agents","volume":"6","author":"Meyn","year":"1995","journal-title":"Anticancer Drugs"},{"key":"10.1038\/jid.2014.267_bb0165","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/ijc.2910600526","article-title":"Kinetics of cisplatin-induced apoptosis in murine mammary and ovarian adenocarcinomas","volume":"60","author":"Meyn","year":"1995","journal-title":"Int J Cancer"},{"key":"10.1038\/jid.2014.267_bb0170","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0923-1811(00)00132-8","article-title":"Cyclin-dependent kinase inhibitors, p21(waf1\/cip1) and p27(kip1), are expressed site- and hair cycle-dependently in rat hair follicles","volume":"25","author":"Mitsui","year":"2001","journal-title":"J Dermatol Sci"},{"key":"10.1038\/jid.2014.267_bb0175","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1177\/002215549804601209","article-title":"Distinct patterns of NCAM expression are associated with defined stages of murine hair follicle morphogenesis and regression","volume":"46","author":"Muller-Rover","year":"1998","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/jid.2014.267_bb0180","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1172\/JCI119174","article-title":"Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1\/Fas) receptor\/ligand system and involves activation of wild-type p53","volume":"99","author":"Muller","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2014.267_bb0185","doi-asserted-by":"crossref","first-page":"22503","DOI":"10.1074\/jbc.M602579200","article-title":"Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D","volume":"281","author":"Murata","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2014.267_bb0190","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1056\/NEJM199908123410706","article-title":"The biology of hair follicles","volume":"341","author":"Paus","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2014.267_bb0195","first-page":"719","article-title":"Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone","volume":"144","author":"Paus","year":"1994","journal-title":"Am J Pathol"},{"key":"10.1038\/jid.2014.267_bb0200","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1016\/S1470-2045(12)70553-3","article-title":"Pathobiology of chemotherapy-induced hair loss","volume":"14","author":"Paus","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1038\/jid.2014.267_bb0205","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.cdd.4401186","article-title":"The CD95(Apo-1\/Fas) DISC and beyond","volume":"10","author":"Peter","year":"2003","journal-title":"Cell Death Differ"},{"issue":"Suppl","key":"10.1038\/jid.2014.267_bb0210","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/0923-1811(94)90036-1","article-title":"Human hair growth in vitro: a model for study of hair follcile biology","volume":"7","author":"Philpott","year":"1994","journal-title":"J Dermatol Sci"},{"key":"10.1038\/jid.2014.267_bb0215","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1096\/fj.09-146415","article-title":"Prolactin\u2014a novel neuroendocrine regulator of human keratin expression in situ","volume":"24","author":"Ramot","year":"2010","journal-title":"FASEB J"},{"key":"10.1038\/jid.2014.267_bb0220","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0074-7696(06)51006-X","article-title":"Human hair keratin-associated proteins (KAPs)","volume":"251","author":"Rogers","year":"2006","journal-title":"Int Rev Cytol"},{"key":"10.1038\/jid.2014.267_bb0225","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/jcb.24453","article-title":"New insights into the role of Runx1 in epithelial stem cell biology and pathology","volume":"114","author":"Scheitz","year":"2013","journal-title":"J Cell Biochem"},{"key":"10.1038\/jid.2014.267_bb0230","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/sj.jid.5700175","article-title":"Doxorubicin-induced alopecia is associated with sebaceous gland degeneration","volume":"126","author":"Selleri","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.267_bb0235","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1073\/pnas.0408455102","article-title":"Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway","volume":"102","author":"Sharov","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2014.267_bb0240","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1523-1747.2003.12022.x","article-title":"Fas and c-kit are involved in the control of hair follicle melanocyte apoptosis and migration in chemotherapy-induced hair loss","volume":"120","author":"Sharov","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.267_bb0245","doi-asserted-by":"crossref","first-page":"18166","DOI":"10.1073\/pnas.0608899103","article-title":"Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes","volume":"103","author":"Sharov","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2014.267_bb0250","doi-asserted-by":"crossref","first-page":"6266","DOI":"10.1158\/0008-5472.CAN-04-1367","article-title":"Fas signaling is involved in the control of hair follicle response to chemotherapy","volume":"64","author":"Sharov","year":"2004","journal-title":"Cancer Res"},{"key":"10.1038\/jid.2014.267_bb0255","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/sj.jid.5700704","article-title":"Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata)","volume":"127","author":"Siebenhaar","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.267_bb0260","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1006\/excr.1999.4551","article-title":"Differential responses of proliferating versus quiescent cells to adriamycin","volume":"250","author":"Siu","year":"1999","journal-title":"Exp Cell Res"},{"key":"10.1038\/jid.2014.267_bb0265","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.2042-7158.2012.01567.x","article-title":"Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems","volume":"65","author":"Tacar","year":"2013","journal-title":"J Pharm Pharmacol"},{"key":"10.1038\/jid.2014.267_bb0270","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.sder.2008.12.001","article-title":"Chemotherapy-induced alopecia","volume":"28","author":"Trueb","year":"2009","journal-title":"Semin Cutan Med Surg"},{"key":"10.1038\/jid.2014.267_bb0275","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1111\/j.1349-7006.2007.00632.x","article-title":"Low concentrations of doxorubicin sensitizes human solid cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-receptor (R) 2-mediated apoptosis by inducing TRAIL-R2 expression","volume":"98","author":"Wu","year":"2007","journal-title":"Cancer Sci"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15365842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15365842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T21:14:24Z","timestamp":1743974064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15365842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0022202X15365842"],"URL":"https:\/\/doi.org\/10.1038\/jid.2014.267","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complex Changes in the Apoptotic and Cell Differentiation Programs during Initiation of the Hair Follicle Response to Chemotherapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2014.267","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}