{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:32:40Z","timestamp":1783128760865,"version":"3.54.6"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1038\/jid.2014.426","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T14:18:36Z","timestamp":1412086716000},"page":"445-453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Psoriatic Inflammation Facilitates the Onset of Arthritis in a Mouse Model"],"prefix":"10.1016","volume":"135","author":[{"given":"Mayuko","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiko","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiro","family":"Takaishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Kitaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Magata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayo","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetoshi","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2014.426_bb0010","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1084\/jem.20020619","article-title":"A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis","volume":"196","author":"Atsumi","year":"2002","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2014.426_bb0015","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/jdv.12222","article-title":"New developments in our understanding of psoriatic arthritis and their impact on the diagnosis and clinical management of the disease","volume":"28","author":"Boehncke","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1038\/jid.2014.426_bb0020","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/clin.1996.4313","article-title":"Increased interleukin-7 concentrations in lesional skin and in the sera of patients with plaque-type psoriasis","volume":"83","author":"Bonifati","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1038\/jid.2014.426_bb0025","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.humimm.2012.10.019","article-title":"Influence of the STAT3 genetic variants in the susceptibility to psoriatic arthritis and Behcet\u2019s disease","volume":"74","author":"Cenit","year":"2013","journal-title":"Hum Immunol"},{"key":"10.1038\/jid.2014.426_bb0030","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/path.2153","article-title":"Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFalpha, and IL-7 in an in vitro model derived from human psoriatic arthritis","volume":"212","author":"Colucci","year":"2007","journal-title":"J Pathol"},{"key":"10.1038\/jid.2014.426_bb0035","doi-asserted-by":"crossref","first-page":"e1001195","DOI":"10.1371\/journal.pgen.1001195","article-title":"Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn\u2019s disease","volume":"6","author":"Danoy","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1038\/jid.2014.426_bb0040","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/jid.2009.319","article-title":"Molecular dissection of psoriasis: integrating genetics and biology","volume":"130","author":"Elder","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.426_bb0045","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s11926-007-0075-1","article-title":"Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines","volume":"9","author":"Fitch","year":"2007","journal-title":"Curr Rheumatol Rep"},{"issue":"Suppl 2","key":"10.1038\/jid.2014.426_bb0050","doi-asserted-by":"crossref","first-page":"ii14","DOI":"10.1136\/ard.2004.032482","article-title":"Psoriatic arthritis: epidemiology, clinical features, course, and outcome","volume":"64","author":"Gladman","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1038\/jid.2014.426_bb0055","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jaad.2008.02.040","article-title":"Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 2. Psoriatic arthritis: overview and guidelines of care for treatment with an emphasis on the biologics","volume":"58","author":"Gottlieb","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jid.2014.426_bb0060","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/jid.2009.65","article-title":"Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis","volume":"129","author":"Harper","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.426_bb0065","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1172\/JCI37378","article-title":"CCR6 is required for IL-23-induced psoriasis-like inflammation in mice","volume":"119","author":"Hedrick","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1038\/jid.2014.426_bb0070","doi-asserted-by":"crossref","first-page":"11566","DOI":"10.1073\/pnas.1019658108","article-title":"Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation","volume":"108","author":"Hwang","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2014.426_bb0075","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1002\/art.23655","article-title":"Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides","volume":"58","author":"Jandus","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2014.426_bb0080","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1056\/NEJMoa062382","article-title":"A human interleukin-12\/23 monoclonal antibody for the treatment of psoriasis","volume":"356","author":"Krueger","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2014.426_bb0085","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1002\/art.27622","article-title":"Role of Th17 cells in human autoimmune arthritis","volume":"62","author":"Leipe","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2014.426_bb0090","doi-asserted-by":"crossref","first-page":"176298","DOI":"10.1155\/2012\/176298","article-title":"Psoriatic arthritis: an update","volume":"2012","author":"Lloyd","year":"2012","journal-title":"Arthritis"},{"key":"10.1038\/jid.2014.426_bb0095","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s11926-012-0257-3","article-title":"Is psoriatic arthritis a result of abnormalities in acquired or innate immunity?","volume":"14","author":"Lories","year":"2012","journal-title":"Curr Rheumatol Rep"},{"key":"10.1038\/jid.2014.426_bb0100","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00281-009-0189-9","article-title":"Th17 cytokines and arthritis","volume":"32","author":"Lubberts","year":"2010","journal-title":"Semin Immunopathol"},{"issue":"Suppl 1","key":"10.1038\/jid.2014.426_bb0105","doi-asserted-by":"crossref","first-page":"i71","DOI":"10.1136\/ard.2010.144097","article-title":"The early phase of psoriatic arthritis","volume":"70","author":"McGonagle","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1038\/jid.2014.426_bb0110","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1002\/art.22758","article-title":"The concept of a \u201csynovio-entheseal complex\u201d and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyond","volume":"56","author":"McGonagle","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2014.426_bb0115","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000182250","article-title":"The nail as a musculoskeletal appendage\u2014implications for an improved understanding of the link between psoriasis and arthritis","volume":"218","author":"McGonagle","year":"2009","journal-title":"Dermatology"},{"key":"10.1038\/jid.2014.426_bb0120","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.7150\/ijbs.4828","article-title":"The pathological and physiological roles of IL-6 amplifier activation","volume":"8","author":"Murakami","year":"2012","journal-title":"Int J Biol Sci"},{"key":"10.1038\/jid.2014.426_bb0125","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1084\/jem.20100900","article-title":"Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells","volume":"208","author":"Murakami","year":"2011","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2014.426_bb0130","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.4049\/jimmunol.1000148","article-title":"Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model","volume":"186","author":"Nakajima","year":"2011","journal-title":"J Immunol"},{"key":"10.1038\/jid.2014.426_bb0135","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ncprheum0987","article-title":"New insights into the pathogenesis and genetics of psoriatic arthritis","volume":"5","author":"Nograles","year":"2009","journal-title":"Nat Clin Pract Rheumatol"},{"key":"10.1038\/jid.2014.426_bb0140","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.yexcr.2011.01.024","article-title":"Anti-cytokine therapies for psoriasis","volume":"317","author":"Nograles","year":"2011","journal-title":"Exp Cell Res"},{"key":"10.1038\/jid.2014.426_bb0145","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.immuni.2008.07.018","article-title":"Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction","volume":"29","author":"Ogura","year":"2008","journal-title":"Immunity"},{"key":"10.1038\/jid.2014.426_bb0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1074-7613(00)80162-4","article-title":"Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses","volume":"12","author":"Ohtani","year":"2000","journal-title":"Immunity"},{"key":"10.1038\/jid.2014.426_bb0155","first-page":"277","article-title":"Clinical, laboratory and immunogenetic aspects of post-traumatic psoriatic arthritis: a study of 25 patients","volume":"16","author":"Punzi","year":"1998","journal-title":"Clin Exp Rheumatol"},{"key":"10.1038\/jid.2014.426_bb0160","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1468-3083.2009.03159.x","article-title":"Prevalence and clinical features of psoriatic arthritis and joint complaints in 2009 patients with psoriasis: results of a German national survey","volume":"23","author":"Radtke","year":"2009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1038\/jid.2014.426_bb0165","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3899\/jrheum.111242","article-title":"Genetics of psoriasis and psoriatic arthritis: a report from the GRAPPA 2010 annual meeting","volume":"39","author":"Rahman","year":"2012","journal-title":"J Rheumatol"},{"key":"10.1038\/jid.2014.426_bb0170","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11010-011-1036-6","article-title":"IL-17 receptor and its functional significance in psoriatic arthritis","volume":"359","author":"Raychaudhuri","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"10.1038\/jid.2014.426_bb0175","first-page":"1544","article-title":"Patterns of cytokine production in psoriatic synovium","volume":"25","author":"Ritchlin","year":"1998","journal-title":"J Rheumatol"},{"key":"10.1038\/jid.2014.426_bb0180","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nm1162","article-title":"Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model","volume":"11","author":"Sano","year":"2005","journal-title":"Nat Med"},{"key":"10.1038\/jid.2014.426_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdermsci.2007.05.016","article-title":"Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases","volume":"50","author":"Sano","year":"2008","journal-title":"J Dermatol Sci"},{"key":"10.1038\/jid.2014.426_bb0190","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1084\/jem.20052187","article-title":"Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3\/IL-7-dependent homeostatic proliferation of CD4+ T cells","volume":"203","author":"Sawa","year":"2006","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2014.426_bb0195","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/bjd.12025","article-title":"Brodalumab and ixekizumab, anti-interleukin-17-receptor antibodies for psoriasis: a critical appraisal","volume":"167","author":"Spuls","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2014.426_bb0200","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jdermsci.2011.08.002","article-title":"18)FDG PET\/CT is a powerful tool for detecting subclinical arthritis in patients with psoriatic arthritis and\/or psoriasis vulgaris","volume":"64","author":"Takata","year":"2011","journal-title":"J Dermatol Sci"},{"key":"10.1038\/jid.2014.426_bb0205","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/rheumatology\/kel214","article-title":"The relationship between the extensor tendon enthesis and the nail in distal interphalangeal joint disease in psoriatic arthritis\u2014a high-resolution MRI and histological study","volume":"46","author":"Tan","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"10.1038\/jid.2014.426_bb0210","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/art.21736","article-title":"A high-resolution magnetic resonance imaging study of distal interphalangeal joint arthropathy in psoriatic arthritis and osteoarthritis: are they the same?","volume":"54","author":"Tan","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2014.426_bb0215","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2165\/11597000-000000000-00000","article-title":"Nail psoriasis: a review","volume":"13","author":"Tan","year":"2012","journal-title":"Am J Clin Dermatol"},{"key":"10.1038\/jid.2014.426_bb0220","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng.2467","article-title":"Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity","volume":"44","author":"Tsoi","year":"2012","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2014.426_bb0225","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1084\/jem.20071094","article-title":"Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses","volume":"204","author":"Zaba","year":"2007","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2014.426_bb0230","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature03963","article-title":"Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins","volume":"437","author":"Zenz","year":"2005","journal-title":"Nature"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15371001?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15371001?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T21:49:29Z","timestamp":1743976169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15371001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0022202X15371001"],"URL":"https:\/\/doi.org\/10.1038\/jid.2014.426","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Psoriatic Inflammation Facilitates the Onset of Arthritis in a Mouse Model","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2014.426","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}