{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:57:25Z","timestamp":1789984645008,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":519,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1038\/jid.2014.76","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T09:27:44Z","timestamp":1394098064000},"page":"1805-1810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["The Inflammasomes in Autoinflammatory Diseases with Skin Involvement"],"prefix":"10.1016","volume":"134","author":[{"given":"Hans-Dietmar","family":"Beer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Contassot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E.","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2014.76_bb0010","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.molcel.2011.07.037","article-title":"Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1alpha","volume":"44","author":"Afonina","year":"2011","journal-title":"Mol Cell"},{"key":"10.1038\/jid.2014.76_bb0015","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","article-title":"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder","volume":"20","author":"Agostini","year":"2004","journal-title":"Immunity"},{"key":"10.1038\/jid.2014.76_bb0020","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1056\/NEJMoa0807865","article-title":"An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist","volume":"360","author":"Aksentijevich","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2014.76_bb0025","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1111\/j.1365-2230.2009.03746.x","article-title":"Schnitzler\u2019s syndrome with prominent neutrophil infiltration misdiagnosed as Sweet\u2019s syndrome: a typical example of urticarial neutrophilic dermatosis","volume":"35","author":"Asahina","year":"2010","journal-title":"Clin Exp Dermatol"},{"key":"10.1038\/jid.2014.76_bb0030","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/jid.2014.76_bb0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: host cell death and inflammation","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"10.1038\/jid.2014.76_bb0040","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1182\/blood-2008-07-019307","article-title":"TLRs and innate immunity","volume":"113","author":"Beutler","year":"2009","journal-title":"Blood"},{"key":"10.1038\/jid.2014.76_bb0045","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/j.1365-2133.2009.09404.x","article-title":"Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra","volume":"161","author":"Brenner","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1038\/jid.2014.76_bb0050","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.immuni.2009.05.005","article-title":"Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity","volume":"30","author":"Brydges","year":"2009","journal-title":"Immunity"},{"key":"10.1038\/jid.2014.76_bb0055","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0952-7915(02)00017-1","article-title":"New insights into the mechanism of IL-1beta maturation","volume":"15","author":"Burns","year":"2003","journal-title":"Curr Opin Immunol"},{"key":"10.1038\/jid.2014.76_bb0060","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jpeds.2004.08.001","article-title":"Abnormal production of tumor necrosis factor (TNF) \u2014 alpha and clinical efficacy of the TNF inhibitor etanercept in a patient with PAPA syndrome [corrected]","volume":"145","author":"Cortis","year":"2004","journal-title":"J Pediatr"},{"key":"10.1038\/jid.2014.76_bb0065","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.jaci.2011.05.023","article-title":"Successful canakinumab treatment identifies IL-1beta as a pivotal mediator in Schnitzler syndrome","volume":"128","author":"de Koning","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/jid.2014.76_bb0070","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/rheumatology\/keh479","article-title":"Anakinra for flares of pyogenic arthritis in PAPA syndrome","volume":"44","author":"Dierselhuis","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"10.1038\/jid.2014.76_bb0075","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/jid.2014.76_bb0080","doi-asserted-by":"crossref","first-page":"82ra38","DOI":"10.1126\/scitranslmed.3002001","article-title":"Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions","volume":"3","author":"Dombrowski","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1038\/jid.2014.76_bb0085","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1111\/all.12022","article-title":"Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes","volume":"67","author":"Dombrowski","year":"2012","journal-title":"Allergy"},{"key":"10.1038\/jid.2014.76_bb0090","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.cub.2007.05.074","article-title":"The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes","volume":"17","author":"Feldmeyer","year":"2007","journal-title":"Curr Biol"},{"key":"10.1038\/jid.2014.76_bb0095","doi-asserted-by":"crossref","first-page":"18055","DOI":"10.1073\/pnas.1109176108","article-title":"Inflammasome activation and IL-1beta target IL-1alpha for secretion as opposed to surface expression","volume":"108","author":"Fettelschoss","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2014.76_bb0100","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.immuni.2012.01.018","article-title":"Inflammasome activators induce interleukin-1alpha secretion via distinct pathways with differential requirement for the protease function of caspase-1","volume":"36","author":"Gross","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/jid.2014.76_bb0105","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ng756","article-title":"Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome","volume":"29","author":"Hoffman","year":"2001","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2014.76_bb0110","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/S0140-6736(04)17401-1","article-title":"Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist","volume":"364","author":"Hoffman","year":"2004","journal-title":"Lancet"},{"key":"10.1038\/jid.2014.76_bb0115","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1002\/art.23687","article-title":"Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies","volume":"58","author":"Hoffman","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2014.76_bb0120","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nature10394","article-title":"Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity","volume":"477","author":"Kofoed","year":"2011","journal-title":"Nature"},{"key":"10.1038\/jid.2014.76_bb0125","doi-asserted-by":"crossref","first-page":"R202","DOI":"10.1186\/ar3535","article-title":"Sustained remission of symptoms and improved health-related quality of life in patients with cryopyrin-associated periodic syndrome treated with canakinumab: results of a double-blind placebo-controlled randomized withdrawal study","volume":"13","author":"Kone-Paut","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1038\/jid.2014.76_bb0130","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1398-9995.2012.02843.x","article-title":"Efficacy and safety of the interleukin-1 antagonist rilonacept in Schnitzler syndrome: an open-label study","volume":"67","author":"Krause","year":"2012","journal-title":"Allergy"},{"key":"10.1038\/jid.2014.76_bb0135","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1056\/NEJMoa0810787","article-title":"Use of canakinumab in the cryopyrin-associated periodic syndrome","volume":"360","author":"Lachmann","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2014.76_bb0140","doi-asserted-by":"crossref","first-page":"e59327","DOI":"10.1371\/journal.pone.0059327","article-title":"Effect of in vitro and in vivo anakinra on cytokines production in Schnitzler syndrome","volume":"8","author":"Launay","year":"2013","journal-title":"PLoS One"},{"key":"10.1038\/jid.2014.76_bb0145","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nature11290","article-title":"Novel role of PKR in inflammasome activation and HMGB1 release","volume":"488","author":"Lu","year":"2012","journal-title":"Nature"},{"key":"10.1038\/jid.2014.76_bb0150","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature12174","article-title":"RIP1-driven autoinflammation targets IL-1alpha independently of inflammasomes and RIP3","volume":"498","author":"Lukens","year":"2013","journal-title":"Nature"},{"key":"10.1038\/jid.2014.76_bb0155","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"10.1038\/jid.2014.76_bb0160","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.25.022106.141627","article-title":"Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease","volume":"27","author":"Masters","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/jid.2014.76_bb0165","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.immuni.2009.04.012","article-title":"A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses","volume":"30","author":"Meng","year":"2009","journal-title":"Immunity"},{"key":"10.1038\/jid.2014.76_bb0170","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/s10875-010-9386-5","article-title":"Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome","volume":"30","author":"Miao","year":"2010","journal-title":"J Clin Immunol"},{"key":"10.1038\/jid.2014.76_bb0175","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.immuni.2012.04.013","article-title":"Critical role for mast cells in interleukin-1beta-driven skin inflammation associated with an activating mutation in the nlrp3 protein","volume":"37","author":"Nakamura","year":"2012","journal-title":"Immunity"},{"key":"10.1038\/jid.2014.76_bb0180","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1084\/jem.20082179","article-title":"Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria","volume":"206","author":"Nakamura","year":"2009","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2014.76_bb0185","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1365-2230.2011.04137.x","article-title":"Mutations in the PSTPIP1 gene and aberrant splicing variants in patients with pyoderma gangrenosum","volume":"36","author":"Nesterovitch","year":"2011","journal-title":"Clin Exp Dermatol"},{"key":"10.1038\/jid.2014.76_bb0190","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nrm2617","article-title":"Mechanisms of regulated unconventional protein secretion","volume":"10","author":"Nickel","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1038\/jid.2014.76_bb0195","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1056\/NEJMoa0809568","article-title":"An autoinflammatory disease due to homozygous deletion of the IL1RN locus","volume":"360","author":"Reddy","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1038\/jid.2014.76_bb0200","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00403-013-1375-0","article-title":"HPV16 activates the AIM2 inflammasome in keratinocytes","volume":"305","author":"Reinholz","year":"2013","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/jid.2014.76_bb0205","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1525-1470.2012.01725.x","article-title":"Deficiency of interleukin-1 receptor antagonist responsive to anakinra","volume":"30","author":"Schnellbacher","year":"2012","journal-title":"Pediatr Dermatol"},{"key":"10.1038\/jid.2014.76_bb0210","doi-asserted-by":"crossref","first-page":"13501","DOI":"10.1073\/pnas.2135380100","article-title":"Pyrin binds the PSTPIP1\/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway","volume":"100","author":"Shoham","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jid.2014.76_bb0215","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.4049\/jimmunol.1101620","article-title":"Caspase-4 is required for activation of inflammasomes","volume":"188","author":"Sollberger","year":"2012","journal-title":"J Immunol"},{"key":"10.1038\/jid.2014.76_bb0220","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"key":"10.1038\/jid.2014.76_bb0225","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2340\/00015555-1307","article-title":"Dermal interleukin-1 expression and effective and long-lasting therapy with interleukin-1 receptor antagonist anakinra in Schnitzler syndrome","volume":"92","author":"Volz","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"10.1038\/jid.2014.76_bb0230","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/art.10539","article-title":"Sustained response to tumor necrosis factor alpha-blocking agents in two patients with SAPHO syndrome","volume":"46","author":"Wagner","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jid.2014.76_bb0235","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.1074\/jbc.M112.443077","article-title":"Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins","volume":"288","author":"Wang","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2014.76_bb0240","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1038\/sj.jid.5700819","article-title":"Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity","volume":"127","author":"Watanabe","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.76_bb0245","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1136\/annrheumdis-2011-200743","article-title":"Anakinra treatment of SAPHO syndrome: short-term results of an open study","volume":"71","author":"Wendling","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1038\/jid.2014.76_bb0250","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10875-010-9425-2","article-title":"Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes","volume":"30","author":"Wu","year":"2010","journal-title":"J Clin Immunol"},{"key":"10.1038\/jid.2014.76_bb0255","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2007.08.029","article-title":"Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants","volume":"28","author":"Yu","year":"2007","journal-title":"Mol Cell"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15368962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15368962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T21:39:15Z","timestamp":1743975555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15368962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0022202X15368962"],"URL":"https:\/\/doi.org\/10.1038\/jid.2014.76","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Inflammasomes in Autoinflammatory Diseases with Skin Involvement","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2014.76","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}