{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:32:38Z","timestamp":1791405158914,"version":"4.3.3"},"reference-count":29,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":519,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003050","name":"Ministry of Economy, Trade and Industry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006004","name":"Tohoku University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006004","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23659541"],"award-info":[{"award-number":["23659541"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1038\/jid.2014.93","type":"journal-article","created":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T09:51:52Z","timestamp":1392371512000},"page":"1951-1960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Nonmetal Haptens Induce ATP Release from Keratinocytes through Opening of Pannexin Hemichannels by Reactive Oxygen Species"],"prefix":"10.1016","volume":"134","author":[{"given":"Kaoru","family":"Onami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuya","family":"Aiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2014.93_bb0010","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ygeno.2003.09.025","article-title":"The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins","volume":"83","author":"Baranova","year":"2004","journal-title":"Genomics"},{"key":"10.1038\/jid.2014.93_bb0015","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.freeradbiomed.2008.09.042","article-title":"Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy","volume":"46","author":"Batinic-Haberle","year":"2009","journal-title":"Free Rad Biol Med"},{"key":"10.1038\/jid.2014.93_bb0020","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1523-1747.2003.12026.x","article-title":"Coupling of contact sensitizers to thiol groups is a key event for the activation of monocytes and monocyte-derived dendritic cells","volume":"120","author":"Becker","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.93_bb0025","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1038\/jid.2014.93_bb0030","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2174\/0929867023371229","article-title":"Progress towards the discovery of xanthine oxidase inhibitors","volume":"9","author":"Borges","year":"2002","journal-title":"Curr Med Chem"},{"key":"10.1038\/jid.2014.93_bb0035","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nature09413","article-title":"Pannexin 1 channels mediate \u201cfind-me\u201d signal release and membrane permeability during apoptosis","volume":"467","author":"Chekeni","year":"2010","journal-title":"Nature"},{"key":"10.1038\/jid.2014.93_bb0040","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/glia.20958","article-title":"P2X7 receptors mediate ischemic damage to oligodendrocytes","volume":"58","author":"Domercq","year":"2010","journal-title":"Glia"},{"key":"10.1038\/jid.2014.93_bb0045","doi-asserted-by":"crossref","first-page":"e41340","DOI":"10.1371\/journal.pone.0041340","article-title":"Contact sensitizers induce skin inflammation via ROS production and hyaluronic acid degradation","volume":"7","author":"Esser","year":"2012","journal-title":"PLoS One"},{"key":"10.1038\/jid.2014.93_bb0050","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.4049\/jimmunol.1000791","article-title":"Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes","volume":"186","author":"Hirakawa","year":"2011","journal-title":"J Immunol"},{"key":"10.1038\/jid.2014.93_bb0055","first-page":"315941","article-title":"Danger signals activating the immune response after trauma","volume":"2012","author":"Hirsinger","year":"2012","journal-title":"Mediators Inflamm"},{"key":"10.1038\/jid.2014.93_bb0060","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1600-0625.2011.01399.x","article-title":"Different characteristics of reactive oxygen species production by human keratinocyte cell line cells in response to allergens and irritants","volume":"21","author":"Kim","year":"2012","journal-title":"Exp Dermatol"},{"key":"10.1038\/jid.2014.93_bb0065","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0891-5849(02)00989-9","article-title":"Paradoxical effects of metalloporphyrins on doxorubicin-induced apoptosis: scavenging of reactive oxygen species versus induction of heme oxygenase-1","volume":"33","author":"Konorev","year":"2002","journal-title":"Free Rad Biol"},{"key":"10.1038\/jid.2014.93_bb0070","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/cvr\/cvs187","article-title":"Mechanisms of ATP release and signalling in the blood vessel wall","volume":"95","author":"Lohman","year":"2012","journal-title":"Cardiovasc Res"},{"key":"10.1038\/jid.2014.93_bb0075","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1124\/jpet.108.146365","article-title":"Pharmacological characterization of pannexin-1 currents expressed in mammalian cells","volume":"328","author":"Ma","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/jid.2014.93_bb0080","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1084\/jem.20070509","article-title":"Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity","volume":"205","author":"Martin","year":"2008","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2014.93_bb0085","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/15376520500191490","article-title":"Differential regulation of free radicals (reactive oxygen and nitrogen species) by contact allergens and irritants in human keratinocyte cell line","volume":"15","author":"Mehrotra","year":"2005","journal-title":"Toxicol Mech Methods"},{"key":"10.1038\/jid.2014.93_bb0090","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.taap.2010.04.007","article-title":"Responsiveness of human monocyte-derived dendritic cells to thimerosal and mercury derivatives","volume":"246","author":"Migdal","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1038\/jid.2014.93_bb0095","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.0022-202X.2005.23624.x","article-title":"Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells","volume":"124","author":"Mizuashi","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2014.93_bb0100","first-page":"1192","article-title":"Thiol redox transitions in cell signaling: a lesson from N-acetylcysteine","volume":"10","author":"Parasassi","year":"2010","journal-title":"Sci Word J"},{"key":"10.1038\/jid.2014.93_bb0105","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1038\/sj.emboj.7601378","article-title":"Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor","volume":"25","author":"Pelegrin","year":"2006","journal-title":"EMBO J"},{"key":"10.1038\/jid.2014.93_bb0110","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.4049\/jimmunol.177.2.1272","article-title":"Hyaluronan fragments act as an endogenous danger signal by engaging TLR2","volume":"177","author":"Scheibner","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/jid.2014.93_bb0115","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/ni.1919","article-title":"Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel","volume":"11","author":"Schmidt","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1038\/jid.2014.93_bb0120","doi-asserted-by":"crossref","first-page":"C761","DOI":"10.1152\/ajpcell.00227.2008","article-title":"Probenecid, a gout remedy, inhibits pannexin 1 channels","volume":"295","author":"Silverman","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1038\/jid.2014.93_bb0125","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1523\/JNEUROSCI.3902-05.2006","article-title":"P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling","volume":"26","author":"Suadicani","year":"2006","journal-title":"J Neurosci"},{"key":"10.1038\/jid.2014.93_bb0130","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.20001858","article-title":"Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4","volume":"195","author":"Termeer","year":"2002","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2014.93_bb0135","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1182\/blood-2012-01-406496","article-title":"Immunoregulation through extracellular nucleotides","volume":"120","author":"Vitiello","year":"2012","journal-title":"Blood"},{"key":"10.1038\/jid.2014.93_bb0140","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1084\/jem.20092489","article-title":"Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity","volume":"207","author":"Weber","year":"2010","journal-title":"J Exp Med"},{"key":"10.1038\/jid.2014.93_bb0145","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1124\/pr.108.000240","article-title":"Chemistry and antihypertensive effects of tempol and other nitroxides","volume":"60","author":"Wilcox","year":"2008","journal-title":"Pharmacol Rev"},{"key":"10.1038\/jid.2014.93_bb0150","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2222.2008.03118.x","article-title":"The danger within: endogenous danger signals, atopy and asthma","volume":"39","author":"Willart","year":"2009","journal-title":"Clin Exp Allergy"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1536869X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1536869X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T17:37:42Z","timestamp":1743961062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X1536869X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0022202X1536869X"],"URL":"https:\/\/doi.org\/10.1038\/jid.2014.93","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonmetal Haptens Induce ATP Release from Keratinocytes through Opening of Pannexin Hemichannels by Reactive Oxygen Species","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2014.93","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}