{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:09:05Z","timestamp":1790759345985,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1038\/jid.2015.280","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T09:50:58Z","timestamp":1436781058000},"page":"3086-3095","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in Melanocytes"],"prefix":"10.1016","volume":"135","author":[{"given":"Stuart G.","family":"Jarrett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Wolf Horrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C.","family":"Boulanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"D'Orazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jid.2015.280_bb0010","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1034\/j.1600-0749.13.s8.28.x","article-title":"The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation","volume":"13","author":"Abdel-Malek","year":"2000","journal-title":"Pigment Cell Res"},{"key":"10.1038\/jid.2015.280_bb0015","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.abb.2014.07.002","article-title":"Melanocortins and the melanocortin 1 receptor, moving translationally towards melanoma prevention","volume":"563","author":"Abdel-Malek","year":"2014","journal-title":"Arch Biochem Biophys"},{"key":"10.1038\/jid.2015.280_bb0020","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1126\/science.1147880","article-title":"A -defensin mutation causes black coat color in domestic dogs","volume":"318","author":"Candille","year":"2007","journal-title":"Science"},{"key":"10.1038\/jid.2015.280_bb0025","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm2450","article-title":"ATR: an essential regulator of genome integrity","volume":"9","author":"Cimprich","year":"2008","journal-title":"Nat Rev"},{"key":"10.1038\/jid.2015.280_bb0030","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature05098","article-title":"Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning","volume":"443","author":"D'Orazio","year":"2006","journal-title":"Nature"},{"key":"10.1038\/jid.2015.280_bb0035","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/jid.2011.426","article-title":"Shining a light on xeroderma pigmentosum","volume":"132","author":"DiGiovanna","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2015.280_bb0040","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/pcmr.12257","article-title":"MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation","volume":"27","author":"Garcia-Borron","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1038\/jid.2015.280_bb0045","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0003-2697(05)80006-5","article-title":"Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs","volume":"206","author":"Gopalakrishna","year":"1992","journal-title":"Anal Biochem"},{"key":"10.1038\/jid.2015.280_bb0050","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1600-0749.2006.00315.x","article-title":"Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes","volume":"19","author":"Hauser","year":"2006","journal-title":"Pigment Cell Res"},{"key":"10.1038\/jid.2015.280_bb0055","doi-asserted-by":"crossref","first-page":"e78075","DOI":"10.1371\/journal.pone.0078075","article-title":"The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair","volume":"8","author":"Jagirdar","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1038\/jid.2015.280_bb0060","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.molcel.2014.05.030","article-title":"PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage","volume":"54","author":"Jarrett","year":"2014","journal-title":"Mol Cell"},{"key":"10.1038\/jid.2015.280_bb0065","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1158\/1541-7786.MCR-11-0436","article-title":"Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes","volume":"10","author":"Kadekaro","year":"2012","journal-title":"Mol Cancer Res"},{"issue":"10","key":"10.1038\/jid.2015.280_bb0070","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1096\/fj.10-158485","article-title":"Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation","volume":"24","author":"Kadekaro","year":"2010","journal-title":"FASEB J"},{"key":"10.1038\/jid.2015.280_bb0075","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1093\/nar\/gkq1318","article-title":"Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein","volume":"39","author":"Kang","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/jid.2015.280_bb0080","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1074\/jbc.M113.542787","article-title":"Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system","volume":"289","author":"Lindsey-Boltz","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2015.280_bb0085","doi-asserted-by":"crossref","first-page":"33107","DOI":"10.1074\/jbc.M109.064485","article-title":"Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase","volume":"284","author":"Lindsey-Boltz","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2015.280_bb0090","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"key":"10.1038\/jid.2015.280_bb0095","series-title":"Nucleic Acids Symp Ser (Oxf)","first-page":"437","article-title":"Stereoselective formation of a cyclobutane pyrimidine dimer by using N4-acetyl protection of the cytosine base","author":"Nishiguchi","year":"2008"},{"key":"10.1038\/jid.2015.280_bb0100","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.chembiol.2013.04.015","article-title":"Molecular and functional analysis of human beta-defensin 3 action at melanocortin receptors","volume":"20","author":"Nix","year":"2013","journal-title":"Chem Biol"},{"key":"10.1038\/jid.2015.280_bb0105","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ab.2006.06.002","article-title":"Use of pseudosubstrate affinity to measure active protein kinase A","volume":"355","author":"Paulucci-Holthauzen","year":"2006","journal-title":"Anal Biochem"},{"key":"10.1038\/jid.2015.280_bb0110","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1600-0749.2004.00160.x","article-title":"Agonist-independent, high constitutive activity of the human melanocortin 1 receptor","volume":"17","author":"Sanchez-Mas","year":"2004","journal-title":"Pigment Cell Res"},{"key":"10.1038\/jid.2015.280_bb0115","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1034\/j.1600-0749.2002.02051.x","article-title":"Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation","volume":"15","author":"Scott","year":"2002","journal-title":"Pigment Cell Res"},{"key":"10.1038\/jid.2015.280_bb0120","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1038\/srep04894","article-title":"A rapid assay for measuring nucleotide excision repair by oligonucleotide retrieval","volume":"4","author":"Shen","year":"2014","journal-title":"Sci Rep"},{"key":"10.1038\/jid.2015.280_bb0125","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012724","article-title":"DNA damage response: three levels of DNA repair regulation","volume":"5","author":"Sirbu","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1038\/jid.2015.280_bb0130","doi-asserted-by":"crossref","first-page":"12564","DOI":"10.1074\/jbc.M800480200","article-title":"Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells","volume":"283","author":"Smith","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1038\/jid.2015.280_bb0135","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/1523-1747.ep12292572","article-title":"Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to alpha-melanotropin","volume":"108","author":"Suzuki","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2015.280_bb0140","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/pcmr.12252","article-title":"Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation","volume":"27","author":"Swope","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1038\/jid.2015.280_bb0145","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1038\/jid.2012.135","article-title":"Defining MC1R regulation in human melanocytes by its agonist alpha-melanocortin and antagonists Agouti signaling protein and beta-defensin 3","volume":"132","author":"Swope","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jid.2015.280_bb0150","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ng1195-328","article-title":"Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans","volume":"11","author":"Valverde","year":"1995","journal-title":"Nat Genet"},{"key":"10.1038\/jid.2015.280_bb0155","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1093\/hmg\/5.10.1663","article-title":"The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma","volume":"5","author":"Valverde","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1038\/jid.2015.280_bb0160","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/jid.2011.473","article-title":"MC1R variant allele effects on UVR-induced phosphorylation of p38, p53, and DDB2 repair protein responses in melanocytic cells in culture","volume":"132","author":"Wong","year":"2012","journal-title":"J Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15601506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15601506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T18:16:47Z","timestamp":1743963407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15601506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0022202X15601506"],"URL":"https:\/\/doi.org\/10.1038\/jid.2015.280","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in Melanocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/jid.2015.280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}