{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:19:29Z","timestamp":1790878769465,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T00:00:00Z","timestamp":1449187200000},"content-version":"vor","delay-in-days":2803,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology Symposium Proceedings"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1038\/jidsymp.2008.3","type":"journal-article","created":{"date-parts":[[2008,3,27]],"date-time":"2008-03-27T15:09:48Z","timestamp":1206630588000},"page":"15-19","source":"Crossref","is-referenced-by-count":76,"title":["Skin Immune Systems and Inflammation: Protector of the Skin or Promoter of Aging?"],"prefix":"10.1016","volume":"13","author":[{"given":"Mary F.","family":"Bennett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elma D.","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jidsymp.2008.3_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0047-6374(98)00119-5","article-title":"Mechanisms of maturation and ageing of collagen","volume":"106","author":"Bailey","year":"1998","journal-title":"Mech Ageing Dev"},{"key":"10.1038\/jidsymp.2008.3_bb0015","doi-asserted-by":"crossref","first-page":"15345","DOI":"10.1074\/jbc.274.22.15345","article-title":"Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion","volume":"274","author":"Berneburg","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1038\/jidsymp.2008.3_bb0020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1046\/j.1365-2133.2002.04549.x","article-title":"Tumour necrosis factor-alpha-induced migration of human Langerhans cells: the influence of ageing","volume":"146","author":"Bhushan","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0025","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/j.1365-2133.2004.05973.x","article-title":"Exogenous interleukin-1beta restores impaired Langerhans cell migration in aged skin","volume":"150","author":"Bhushan","year":"2004","journal-title":"Br J Dermatol"},{"issue":"167","key":"10.1038\/jidsymp.2008.3_bb0030","first-page":"RE2","article-title":"Mitogen-activated protein kinase activation in UV-induced signal transduction","volume":"28","author":"Bode","year":"2003","journal-title":"Sci STKE"},{"key":"10.1038\/jidsymp.2008.3_bb0035","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1046\/j.1365-2133.2003.05456.x","article-title":"Photoageing shows histological features of chronic skin inflammation without clinical and molecular abnormalities","volume":"149","author":"Bosset","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0040","first-page":"27","article-title":"Immunomodulatory properties of defensins and cathelicidins","volume":"306","author":"Bowdish","year":"2006","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1038\/jidsymp.2008.3_bb0045","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0076-6879(00)19016-0","article-title":"Singlet oxygen DNA damage products: formation and measurement","volume":"319","author":"Cadet","year":"2000","journal-title":"Methods Enzymol"},{"key":"10.1038\/jidsymp.2008.3_bb0050","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/1523-1747.ep12285600","article-title":"Antigen-presenting OKM5+ melanophages appear in human epidermis after ultraviolet radiation","volume":"86","author":"Cooper","year":"1986","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0055","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1046\/j.1365-2567.2002.01381.x","article-title":"Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1beta","volume":"105","author":"Cumberbatch","year":"2002","journal-title":"Immunology"},{"key":"10.1038\/jidsymp.2008.3_bb0060","first-page":"330","article-title":"Density of Langerhans cells (LC) in normal vs. chronic actinically damaged skin (CADS) of humans","volume":"76","author":"Delo","year":"1981","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0065","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1034\/j.1600-0625.2002.110502.x","article-title":"Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin","volume":"11","author":"El Domyati","year":"2002","journal-title":"Exp Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0070","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1001\/archderm.138.11.1462","article-title":"Mechanisms of photoaging and chronological skin aging","volume":"138","author":"Fisher","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0075","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1172\/JCI2153","article-title":"Retinoic acid inhibits induction of c-jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo","volume":"101","author":"Fisher","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1038\/jidsymp.2008.3_bb0080","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.0022-202X.2005.23857.x","article-title":"Measurement of sunscreen immune protection factors in humans: a consensus paper","volume":"125","author":"Fourtanier","year":"2005","journal-title":"J Invest Dermatol"},{"issue":"Suppl","key":"10.1038\/jidsymp.2008.3_bb0085","doi-asserted-by":"crossref","first-page":"81S","DOI":"10.1038\/jid.1983.20","article-title":"Chronologic and actinically induced aging in human facial skin","volume":"80","author":"Gilchrest","year":"1983","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0090","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1046\/j.1365-2230.2001.00898.x","article-title":"Chronological ageing and photoageing of dendritic cells","volume":"26","author":"Grewe","year":"2001","journal-title":"Clin Exper Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0095","doi-asserted-by":"crossref","first-page":"26378","DOI":"10.1074\/jbc.274.37.26378","article-title":"Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction","volume":"274","author":"Gross","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1038\/jidsymp.2008.3_bb0100","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.4049\/jimmunol.153.11.4915","article-title":"Active induction of unresponsiveness (tolerance) to DNFB by in vivo ultraviolet exposed epidermal cells is dependent upon infiltrating class II MHC + CD11b bright monocytic\/macrophagic cells","volume":"153","author":"Hammerberg","year":"1994","journal-title":"J Immunol"},{"key":"10.1038\/jidsymp.2008.3_bb0105","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1084\/jem.187.7.1133","article-title":"Activated complement component 3 (C3) is required for ultraviolet induction of immunosuppression and antigenic tolerance","volume":"187","author":"Hammerberg","year":"1998","journal-title":"J Exp Med"},{"key":"10.1038\/jidsymp.2008.3_bb0110","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1523-1747.1998.00121.x","article-title":"In human skin, UVB initiates early induction of IL-10 over IL-12 preferentially in the expanding dermal monocytic\/macrophagic population","volume":"111","author":"Kang","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0115","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1189\/jlb.69.5.719","article-title":"Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress","volume":"69","author":"Katiyar","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1038\/jidsymp.2008.3_bb0120","first-page":"215","article-title":"The nature of photoageing: its prevention and repair","volume":"3","author":"Kligman","year":"1986","journal-title":"Photodermatology"},{"key":"10.1038\/jidsymp.2008.3_bb0125","first-page":"819","article-title":"Cleavable 13C-isotope-coded affinity tag (cICAT) with in-line 2D-LC-ESI mass spectrometry for proteomic analysis of membrane proteins in keratinocytes following UVB exposure","volume":"124","author":"Liu","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0130","first-page":"A1","article-title":"IL-6 is a critical factor in photo-injury mediated by UVB-induced-iC3b","volume":"124","author":"Lu","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0135","first-page":"1555","article-title":"Acute effects of ultraviolet radiation on the skin","author":"McGregor","year":"1999"},{"key":"10.1038\/jidsymp.2008.3_bb0140","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/1523-1747.ep12326032","article-title":"In human dermis, ultraviolet radiation induces expansion of a CD36 + CD11b + CD1-macrophage subset by infiltration and proliferation; CD1+ Langerhans-like dendritic antigen-presenting cells are concomitantly depleted","volume":"105","author":"Meunier","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0145","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1600-0781.2008.00325.x","article-title":"Age and gender effects on contact sensitization and photoimmune suppression in young and middle-aged adults","volume":"24","author":"Morrissey","year":"2008","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.1038\/jidsymp.2008.3_bb0150","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/978-1-4615-1971-3_116","article-title":"Human keratinocyte-derived IL-12 affects LC-induced allogeneic T-cell responses","volume":"378","author":"Muller","year":"1995","journal-title":"Adv Exp Med Biol"},{"key":"10.1038\/jidsymp.2008.3_bb0155","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/1523-1747.ep12276415","article-title":"Hapten-specific tolerance induced by acute, low-dose ultraviolet B radiation of skin is mediated via interleukin-10","volume":"109","author":"Niizeki","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0160","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/1523-1747.ep12525293","article-title":"UVB-induced collagen changes in the skin of the hairless albino mouse","volume":"88","author":"Plastow","year":"1987","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2005.05.010","article-title":"Photoaging: mechanisms and repair","volume":"55","author":"Rabe","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0170","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1111\/j.0022-202X.2004.22620.x","article-title":"Ultraviolet A radiation-induced immediate iron release is a key modulator of the activation of NF-kB in human skin fibroblasts","volume":"122","author":"Reelfs","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0175","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1365-2133.2004.06335.x","article-title":"Skin-infiltrating neutrophils following exposure to solar-simulated radiation could play an important role in photoageing of human skin","volume":"152","author":"Rijken","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0180","series-title":"Immune and inflammatory gene expression profiles of chronological (intrinsic) skin aging and photo-aging","author":"Robinson","year":"2007"},{"key":"10.1038\/jidsymp.2008.3_bb0185","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.imlet.2006.05.010","article-title":"Epidermal Langerhans cells\u2013changing views on their function in vivo","volume":"106","author":"Romani","year":"2006","journal-title":"Immunol Lett"},{"key":"10.1038\/jidsymp.2008.3_bb0190","doi-asserted-by":"crossref","first-page":"5114","DOI":"10.4049\/jimmunol.154.10.5114","article-title":"Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation","volume":"154","author":"Schmitt","year":"1995","journal-title":"J Immunol"},{"key":"10.1038\/jidsymp.2008.3_bb0195","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/1523-1747.ep12347944","article-title":"Interleukin 12 prevents ultraviolet B-induced local immunosuppression and overcomes UVB-induced tolerance","volume":"106","author":"Schwarz","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0200","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.4049\/jimmunol.172.2.1036","article-title":"Ultraviolet radiation-induced regulatory T cells not only inhibit the induction but can suppress the effector phase of contact hypersensitivity","volume":"172","author":"Schwarz","year":"2004","journal-title":"J Immunol"},{"key":"10.1038\/jidsymp.2008.3_bb0205","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0923-1811(01)00135-9","article-title":"Expressions of beta-defensins in human keratinocyte cell lines","volume":"27","author":"Seo","year":"2001","journal-title":"J Dermatol Sci"},{"key":"10.1038\/jidsymp.2008.3_bb0210","first-page":"207","article-title":"CD11b-dependent iC3b transient arrest of dermal and blood monocytic dendritic cell precursor differentiation","volume":"119","author":"Takahara","year":"2002","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0215","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1046\/j.1523-1747.2003.12136.x","article-title":"iC3b arrests monocytic cell differentiation into CD1c-expressing dendritic cell precursors: a mechanism for transiently decreased dendritic cells in vivo after human skin injury by ultraviolet B","volume":"120","author":"Takahara","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0220","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/1523-1747.ep12318471","article-title":"Reduced type I and type III procollagens in photodamaged adult human skin","volume":"105","author":"Talwar","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0225","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/1523-1747.ep12260055","article-title":"The effect of aging and chronic sun exposure on human Langerhans cell populations","volume":"82","author":"Thiers","year":"1984","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0230","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S1046-2023(02)00202-5","article-title":"Cell surface and cytokine phenotypes of skin immunocompetent cells involved in ultraviolet-induced immunosuppression","volume":"28","author":"Toichi","year":"2002","journal-title":"Methods"},{"key":"10.1038\/jidsymp.2008.3_bb0235","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0923-1811(96)00556-7","article-title":"Ultrastructural evidence for the participation of Langerhans cells in cutaneous photoaging processes: a quantitative comparative study","volume":"14","author":"Toyoda","year":"1997","journal-title":"J Dermatol Sci"},{"key":"10.1038\/jidsymp.2008.3_bb0240","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.4049\/jimmunol.178.4.1986","article-title":"Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition","volume":"1578","author":"van der Aar","year":"2007","journal-title":"J Immunol"},{"key":"10.1038\/jidsymp.2008.3_bb0245","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1046\/j.1523-1747.2000.00902.x","article-title":"Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin","volume":"114","author":"Varani","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2008.3_bb0250","doi-asserted-by":"crossref","first-page":"17420","DOI":"10.1073\/pnas.0603119103","article-title":"Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor","volume":"103","author":"Walterscheid","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jidsymp.2008.3_bb0255","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.micron.2003.11.005","article-title":"Skin aging and natural photoprotection","volume":"35","author":"Wulf","year":"2004","journal-title":"Micron"},{"key":"10.1038\/jidsymp.2008.3_bb0260","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.4049\/jimmunol.161.11.5873","article-title":"Monocyte induction of IL-10 and down-regulation of IL-12 by iC3b deposited in ultraviolet-exposed human skin","volume":"161","author":"Yoshida","year":"1998","journal-title":"J Immunol 1"}],"container-title":["Journal of Investigative Dermatology Symposium Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15526614?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15526614?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T09:19:23Z","timestamp":1684315163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15526614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0022202X15526614"],"URL":"https:\/\/doi.org\/10.1038\/jidsymp.2008.3","relation":{},"ISSN":["1087-0024"],"issn-type":[{"value":"1087-0024","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}